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EC / List no.: 202-498-7
CAS no.: 96-31-1
Mol. formula: C3H8N2O
N,N-Dimethylurea is a urea derivative and used as an intermediate in organic synthesis.
N,N-Dimethylurea is a colorless crystalline powder with little toxicity.
N,N-Dimethylurea is a urea derivative and used as an intermediate in organic synthesis.
N,N-Dimethylurea is also used for synthesis of caffeine, pharmachemicals, textile aids, herbicides and other.
In the textile processing industry N,N-Dimethylurea is used as intermediate for the production of formaldehyde-free easy-care finishing agents for textiles.
In the Swiss Product Register there are 38 products containing N,N-Dimethylurea, among them 17 products intended for consumer use.
Product types are e.g. paints and cleaning agents.
The content of N,N-Dimethylurea in consumer products is up to 10 % (Swiss Product Register, 2003). Use in cosmetics has been proposed, but there is no information available as to its actual use in such applications.
N,N-Dimethylurea belongs to the class of organic compounds known as ureas.
Ureas are compounds containing two amine groups joined by a carbonyl (C=O) functional group.
N,N-Dimethylurea is an extremely weak basic (essentially neutral) compound (based on its pKa).
N,N-Dimethylurea (DMU) (IUPAC systematic name: Dimethylurea ) is a urea derivative and used as an intermediate in organic synthesis.
Belongs to the class of organic compounds known as ureas.
Ureas are compounds containing two amine groups joined by a carbonyl (C=O) functional group.
Uses:
N,N-Dimethylurea is used for synthesis of caffeine, theophylline, pharmachemicals, textile aids, herbicides and others.
In the textile processing industry N,N-Dimethylurea is used as intermediate for the production of formaldehyde-free easy-care finishing agents for textiles.
The estimated world production of DMU is estimated to be less than 25,000 tons.
N,N-Dimethylurea belongs to the class of organic compounds known as ureas.
Ureas are compounds containing two amine groups joined by a carbonyl (C=O) functional group.
N,N-Dimethylurea is an extremely weak basic (essentially neutral) compound (based on its pKa).
N,N-Dimethylurea (DMU) is a urea derivative and used as an intermediate in organic synthesis.
Typical applications:
Agriculture
Urea-herbicide
Carbamate-herbicide
Textile additives
Formaldehyde-free textile additives
Cross linking agent for textiles made of cellulose fibers and their synthetic mixtures
Pharmaceuticals
Reagant for the synthesis of active ingredients, such as bronchodilators.
N,N-Dimethylurea is a colorless powder, used as building block for active ingredients or intermediate for formaldehyde-free textile additives.
Sources/Uses
Used in pharmaceutical manufacturing; [Hawley] Used as an intermediate to make caffeine, pharmachemicals, textile aids, herbicides, paints, and cleaning products.
General Manufacturing Information
Industry Processing Sectors
Paint and coating manufacturing
Textiles, apparel, and leather manufacturing
N,N-Dimethylurea is widely used in the printing, food and preservative industries.
In industrial production, urea is utilized for the production of N,N-Dimethylurea through ammonolysis reaction with methylamine.
However, in this reaction urea and urea compounds have poor thermal stability, which can result inside reactions.
Impurities produced by side reactions are the source of pollution once evacuated into the environment (Koyuncu et al., 2001), the treatment of impurities also consumes high cost and energy.
Reactivity Profile
N,N-Dimethylurea is an amide.
Amides/imides react with azo and diazo compounds to generate toxic gases.
Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents.
Amides are very weak bases (weaker than water).
Imides are less basic yet and in fact react with strong bases to form salts.
That is, they can react as acids.
Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile.
The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Since N,N-Dimethylurea have widespread applications in medicine and polymer industry, many papers focus on the pharmaceutical synthesis, analysis, and applications of its downstream products.
In 1952, The rate constants and the activation energies of the thermal dissociation of sym-dimethylurea, asym-dimethylurea and asym-phenylethylurea in Butyric Acid were studied.
While in 1984, the initial decomposition temperatures of various areas by using thermal gravimetry and infrared analyses.
However, to the best of our knowledge, there is no report on the thermal behavior of synthesizing 1,3- dimethylurea.
At present, the big flaw of using urea and methylamine to produce N,N-Dimethylurea is the thermal instability of products.
Only a few data are available on the kinetics and thermodynamics data.
In 1978, Shigeru systematically studied the kinetics and thermodynamics of synthesizing N, N'-dimethylurea from monomethyl amine and carbon.
The parameters obtained can help to predict the kinetics and thermodynamics of other ways to synthesize N,N-Dimethylurea .
In this study, kinetics and thermodynamics of synthesizing N,N-Dimethylurea were explored to help to understand the trend, degree, and driving force of the reaction, and they also play an important role to explain the characteristics, laws, and possible mechanisms.
The kinetic study contains reaction order and rates constant.
HPLC spectrograms were used to study the impacts of reaction time and temperature on the thermal behavior of the ammonolysis reaction system.
The main objective of this study is to develop a thermal stability curve from the ammonolysis reaction of urea with methylamine, to provide guidance for energy saving and emission reduction.
About N,N-Dimethylurea
Helpful information
N,N-Dimethylurea is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.
N,N-Dimethylurea is used by professional workers (widespread uses), in formulation or re-packing and at industrial sites.
Consumer Uses
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which N,N-Dimethylurea is most likely to be released to the environment.
Article service life
ECHA has no public registered data on the routes by which N,N-Dimethylurea is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.
Widespread uses by professional workers
N,N-Dimethylurea is used in the following products: pH regulators and water treatment products and laboratory chemicals.
N,N-Dimethylurea is used in the following areas: health services and scientific research and development.
Other release to the environment of N,N-Dimethylurea is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).
Formulation or re-packing
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. Release to the environment of N,N-Dimethylurea can occur from industrial use: formulation of mixtures.
Uses at industrial sites
N,N-Dimethylurea is used in the following products: pH regulators and water treatment products and laboratory chemicals.
N,N-Dimethylurea is used in the following areas: health services and scientific research and development.
N,N-Dimethylurea is used for the manufacture of: chemicals.
Release to the environment of N,N-Dimethylurea can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites and as processing aid.
Manufacture
ECHA has no public registered data on the routes by which N,N-Dimethylurea is most likely to be released to the environment.
Applications
N,N-Dimethylurea has been to study, the quantitative structure-activity relations of substituted phenylureas on the Hill inhibitory activity; Simple and rapid screening method for photosystem II inhibitory herbicides using photoautotrophically cultured plant cells with chlorophyll fluorescence monitoring.
Separation of N,N-Dimethylurea on Newcrom R1 HPLC column
N,N-Dimethylurea can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid.
For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications.
This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation.
N,N-Dimethylurea also suitable for pharmacokinetics.
Description
N,N-Dimethylurea is a urea derivative and used as an intermediate in organic synthesis.
N,N-Dimethylurea is used for synthesis of caffeine, theophylline, pharmachemicals, textile aids, herbicides and others.
In the textile processing industry N,N-Dimethylurea is used as intermediate for the production of formaldehyde-free easy-care finishing agents for textiles.
N,N-Dimethylurea (DMU) is a solid in the form of white crystals with a faint ammonia-like odor N,N-Dimethylurea is soluble in water.
N,N-Dimethylurea acts as a radical scavenger that protects isolated pancreatic islets from the effects of alloxan and dihydroxyfumarate exposure.
Methyl amine and N,N-Dimethylurea are hydrolysis products of methyl isocyanate.
N,N-Dimethylurea is used in manufacturing synthetic caffeine, resins and drugs.
N,N-Dimethylurea is used as a catalyst for condensation of methylamine with urea.
N,N-Dimethylurea is used for synthesis of caffeine, pharmachemicals, textile aids, herbicides and other.
In the textile processing industry N,N-dimethylurea is used as intermediate for the production of formaldehyde-free easy-care finishing agents for textiles.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use.
DESCRIPTION AND APPLICATIONS
N,N-Dimethylurea (DMU) is a solid in the form of white crystals with a faint ammonia-like odor N,N-Dimethylurea is soluble in water.
N,N-Dimethylurea acts as a radical scavenger that protects isolated pancreatic islets from the effects of alloxan and dihydroxyfumarate exposure.
Methyl amine and N,N-dimethylurea are hydrolysis products of methyl isocyanate.
N,N-Dimethylurea is used in manufacturing synthetic caffeine, resins and drugs.
N,N-Dimethylurea is used as a catalyst for condensation of methylamine with urea.
N,N-Dimethylurea is used as an intermediate in organic synthesis.
Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
IUPAC NAMES
1,3-Dimethylurea
1,3-dimethylurea
1,3-DIMETHYLUREA
1,3-dimethylurea
1,3-dimethylurea (DMU)
Dimethylharnstoff , N,N'-Dimethylharnstoff , N,N'-Dimethylurea
Urea, N,N'-dimethyl-
SYNONYMS
1,3-DIMETHYLUREA
N,N'-Dimethylurea
96-31-1
sym-Dimethylurea
Urea, N,N'-dimethyl-
Urea, 1,3-dimethyl-
Symmetric dimethylurea
N,N'-Dimethylharnstoff
1,3-Dimethyl urea
N,N'-Dimethylharnstoff [German]
UNII-WAM6DR9I4X
MFCD00008286
NSC 14910
BRN 1740672
AI3-24386
WAM6DR9I4X
1,3-Dimethylurea, 98%
CHEBI:80472
Urea,3-dimethyl-
Urea,N'-dimethyl-
WLN: 1MVM1
CCRIS 2509
HSDB 3423
EINECS 202-498-7
Dimethylharnstoff
1.3-Dimethylurea
N,N-Dimethyl-Urea
1,3 dimethyl urea
N,N'-dimethyl urea
N,N'-dimethylurea
1,1'-Dimethylurea
1,3-Dimethylcarbamide
3k3g
DSSTox_CID_5156
ACMC-209s6t
bmse000248
EC 202-498-7
UREA,1,3-DIMETHYL
(CH3NH)2CO
DSSTox_RID_77691
DSSTox_GSID_25156
N,N'-Dimethylurea, ~98%
CHEMBL1234380
DTXSID5025156
NSC14910
NSC24823
ZINC1653257
Tox21_200794
ANW-40803
BBL011513
NSC-14910
NSC-24823
STL146629
AKOS000120912
CS-W013749
MCULE-5319497155
NE10567
CAS-96-31-1
NCGC00248834-01
NCGC00258348-01
AK209010
K738
SY004507
N,N inverted exclamation mark -Dimethylurea
A4569
D0289
FT-0606700
C16364
ethyl 5-oxo-2,3-diphenyl-cyclopentanecarboxylate
N,N'-Dimethylurea, (sym.), >=99% (from N)
Q419740
W-100145
N,N'-Dimethylurea, PESTANAL(R), analytical standard
F0001-2292
N,N'-Dimethylurea, (sym.), >=95.0% (HPLC), technical
