PRODUCTS

O-TOLUIDINE

o-Toluidine is used in the manufacture ofvarious dyes, in printing textiles blue-blackand as an intermediate in rubber chemicals,pesticides, and pharmaceuticals.
o-Toluidine is used or applied in different circumstances.
o-Toluidine is used the most for dye, especially for coloring hair.

CAS Number: 95-53-4
EC Number: 202-429-0
Molecular Formula: C₇H₉N
Molecular Weight: 107.15 g/mol

SYNONYMS:
o-Toluidine, 2-Toluidine, ortho-Toluidine, o-Methylaniline, 2-Methylaniline, ortho-Methylaniline, 1-Amino-2-methylbenzene, 2-Aminotoluene, 2-Methylbenzenamine, o-Aminotoluene, o-Tolylamine, 2-Methylaniline, NSC 8788, UNII-2F8R0T4J2H, 2-Methylaniline[1], o-Methylaniline, o-Toluidine, 1-Amino-2-methylbenzene, 2-Aminotoluene, 2-Toluamine, 2-METHYLANILINE, ORTHO-TOLUIDINE, o-Toluidin, 2-Toluidine, 2-AMINOTOLUENE, 2-AMINO-1-METHYLBENZENE, toluidines, 0-Toluidine, o-Tolylamine, o-Aminotoluene, 2-Aminotoluene, 2-Methylaniline, o-Toluidine, 2-Methylaniline, 95-53-4, 2-Toluidine, o-Tolylamine, o-Methylaniline, 2-AMINOTOLUENE, 2-Methylbenzenamine, o-Aminotoluene, ortho-toluidine, 2-Methyl-1-aminobenzene, o-Methylbenzenamine, 1-Amino-2-methylbenzene, Benzenamine, 2-methyl-, 2-Amino-1-methylbenzene, o-Toluidin, o-Toluidyna, 1-Methyl-2-aminobenzene, Aniline, 2-methyl-, 2-Methylbenzamine, RCRA waste number U328, 2-methylphenylamine, DTXSID1026164, C.I. 37077, B635MZ0ZLU, NSC-15348, DTXCID206164, CHEBI:66892, NSC15348, RefChem:6080, CI 37077, 202-429-0, ortho Toluidine, 2-methyl-aniline, Benzenamine, methyl-, o-Toluidin [Czech], 2-Toluidine-d7, o-Toluidyna [Polish], o-Toluide, NSC 15348, MFCD00007730, 121536-13-8, O-Toluidin (CZECH), O-Toluidyna (POLISH), 68408-22-0, CAS-95-53-4, CCRIS 597, HSDB 2042, Prilocaine EP impurity B, EINECS 202-429-0, RCRA waste no. U328, UNII-B635MZ0ZLU, ortho-tolylamine, AI3-24383, o-tolyl-amine, 2-tolylamine, 2-amino toluene, 2 -methylaniline, 2-methyl aniline, 2-(methyl)aniline, 51V, o-Toluidine, liquid, 2-methyl-benzenamine, o-Toluidine, 98%, Prilocaine Impurity 31, o-Toluidine, >=99%, O-TOLUIDINE [MI], O-TOLUIDINE(1%), EC 202-429-0, CHEMBL1381, WLN: ZR B1, O-Toluidine-d3(methyl-d3), SCHEMBL11863, SCHEMBL15789, SCHEMBL61229, SCHEMBL67429, SCHEMBL74259, SCHEMBL75807, o-Toluidine, liquid or solid, MLS002415766, 2-Aminotoluene (o-toluidine), BIDD:ER0679, SCHEMBL138256, SCHEMBL294766, 2-AMINOTOLUENE [HSDB], ORTHO-TOLUIDINE [IARC], SCHEMBL1077811, SCHEMBL2155182, o-Toluidine, analytical standard, SCHEMBL29441724, O-Toluidine (ACD/Name 4.0), o-Toluidine, p.a., 99.5%, MSK1218, 2-Methylbenzenamine (o-Toluidine), HMS3039B11, STR00213, Tox21_201256, Tox21_300179, EBC-41021, SBB028141, 2-Methylphenylamine (ACD/Name 4.0), AKOS000119109, o-Toluidine 500 microg/mL in Methanol, NCGC00091368-01, NCGC00091368-02, NCGC00091368-03, NCGC00091368-04, NCGC00253986-01, NCGC00258808-01, o-Toluidine 10 microg/mL in Cyclohexane, BP-21341, SMR001370921, o-Toluidine 100 microg/mL in Cyclohexane, PRILOCAINE IMPURITY B [EP IMPURITY], NS00008265, o-Toluidine, SAJ special grade, >=99.0%, ST45255278, EN300-33459, o-Toluidine, purum p.a., >=99.5% (GC), C90102, O-TOLUIDINE-D3 (METHYL-D3), o-Toluidine-d3, F043316, Q311695, o-Toluidine, liquid or solid [UN1708] [Poison], Z57127943, F2190-0418, PRILOCAINE HYDROCHLORIDE IMPURITY B [EP IMPURITY], InChI=1/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H, 97917-08-3, Benzenamine, 2-methyl-, o-Aminotoluene, o-Methylaniline, o-Methylbenzenamine, o-Tolylamine, 1-Amino-2-methylbenzene, 2-Aminotoluene, 2-Methyl-1-aminobenzene, 2-Methylaniline, 2-Methylbenzenamine, 2-Toluidine, 2-Amino-1-methylbenzene, 1-Methyl-2-aminobenzene, o-Toluide, o-Toluidin, o-Toluidyna, Aniline, 2-methyl-, C.I. 37077, Rcra waste number U328, NSC 15348, nci-c02335, o-ToluidineHCL, 2-Toluidine HCl, o-Tolidine hydroch, ORTHO-TOLUIDINEHCL, rcrawastenumberu222, o-Toluidine Chloride, Prilocaine impurity B, PRILOCAINE RC A/ORTHO, O-TOLUIDINIUM CHLORIDE

o-Toluidine (ortho-toluidine) is an organic compound with the chemical formula C7H9N.
o-Toluidine is primarily used in the manufacture of dyes.
o-toluidine is an aminotoluene in which the amino substituent is ortho to the methyl group.

o-Toluidine is a clear colorless or light yellow liquid.
o-Toluidine is an organic compound with the chemical formula CH3C6H4NH2.
o-Toluidine is the most important of the three isomeric toluidines.

o-Toluidine undergoes chemically oxidative polymerization with aniline in the presence of ammonium persulfate as an oxidant in HCl medium.
o-Toluidine is soluble in water(15g/L).
Commercial production of o-toluidine was first reported in the United States in 1922.

o-Toluidine (2-Toluidine) is an aromatic primary amine in which a methyl group and an amino group are attached to adjacent carbon atoms on a benzene ring.
o-Toluidine is an important industrial intermediate used in the manufacture of dyes, pigments, rubber chemicals, pharmaceuticals, pesticides, photographic chemicals, and specialty organic compounds.

Due to the presence of the amino group, o-toluidine readily undergoes diazotization, electrophilic substitution, acylation, alkylation, and condensation reactions, making it a valuable building block in organic synthesis.
o-Toluidine is one of the three toluidine isomers (ortho-, meta-, and para-toluidine), with the ortho isomer exhibiting distinct chemical reactivity due to steric interactions between the amino and methyl substituents.

o-Toluidine (ortho-toluidine) is an organic compound with the chemical formula CH3C6H4NH2.
o-Toluidine is the most important of the three isomeric toluidines.

o-Toluidine is a colorless liquid although commercial samples are often yellowish.
o-Toluidine is a precursor to the herbicides metolachlor and acetochlor.
o-Toluidine (ortho-toluidine) is an organic compound with the chemical formula C7H9N.

USES and APPLICATIONS of O-TOLUIDINE:
o-Toluidine is used in the production of dye products such as date red base GBC, scarlet base G, red base RL, naphthol ASD, acid pink 3B, basic magenta and basic pink T, as well as pesticides insecticidal amidine, saccharin, vulcanization accelerator, Beneficiation agent toluene arsenic acid, etc.
o-toluidine appears as a clear colorless or light yellow liquid.

o-Toluidine may become reddish brown on exposure to air and light.
o-Toluidine has about the same density as water and is very slightly soluble in water.
O-toluidine is an aminotoluene in which the amino substituent is ortho to the methyl group.

o-Toluidine has a role as a carcinogenic agent.
o-Toluidine is aka ortho metyl aniiline, a potentially useful synthetic reagent.
o-Toluidine (ortho-toluidine) is an organic compound with the chemical formula C7H9N.

This arylamine, o-Toluidine, is a colorless to pale-yellow liquid with a poor solubility in water.
o-Toluidine is used in determination of glucose in biological materials.
o-Toluidine is used in the production of dyes, as a presumptive test for blood in forensic science.

o-Toluidine is also used in determination of glucose in biological materials, as a precursor in the synthesis of poly(o-toluidine) and copper nanoparticle composite material.
o-Toluidine is used in the manufacture ofvarious dyes, in printing textiles blue-blackand as an intermediate in rubber chemicals,pesticides, and pharmaceuticals.
o-Toluidine and its hydrochloride salt are used primarily as intermediates in the manufacture of dyes and pigments for printing textiles, in color photography, and as biologic stains.

In addition, o-toluidine is used as an intermediate for rubber vulcanizing chemicals, pharmaceuticals, and pesticides.
Other minor uses include intermediate for organic synthesis and clinical laboratory reagent for glucose analysis.
o-Toluidine was used in determination of glucose in biological materials.

o-Toluidine was used as precursor in the synthesis of poly(o-toluidine) and copper nanoparticle composite material.
o-Toluidine is used or applied in different circumstances.
o-Toluidine is used the most for dye, especially for coloring hair.

The other usages of o-toluidine are specific determination of glucose in blood and the most recent one, the separation of toxic metal ions, which is still in the research phase.
o-Toluidine is extensively used in the production of azo dyes and high-performance pigments, as well as in the synthesis of herbicides, fungicides, antioxidants, and pharmaceutical intermediates.

o-Toluidine is primarily used as an intermediate in the manufacture of dyes and pigments, especially azo dyes that are widely employed in textile dyeing, printing inks, plastics, paper, and leather industries.
o-Toluidine's amino group enables efficient diazotization and azo coupling reactions, making it one of the most important aromatic amines for colorant synthesis.

In the rubber industry, o-toluidine serves as a raw material for the production of rubber antioxidants, vulcanization accelerators, stabilizers, and specialty processing chemicals that improve the durability and aging resistance of elastomeric products.
o-Toluidine is extensively utilized in the pharmaceutical industry for synthesizing active pharmaceutical ingredients, intermediates, local anesthetics, veterinary medicines, and heterocyclic compounds.

o-Toluidine is also employed in the preparation of agrochemicals, including herbicides, fungicides, insecticides, and plant growth regulators.
o-Toluidine is an important precursor in the manufacture of high-performance pigments, photographic chemicals, epoxy curing agents, corrosion inhibitors, and specialty polymers.

o-Toluidine is also used in research laboratories for aromatic substitution reactions, heterocyclic synthesis, catalyst development, and medicinal chemistry.
In analytical chemistry, o-toluidine has historically been used as a reagent for glucose determination and for detecting aldehydes through colorimetric reactions.

Although many of these analytical applications have largely been replaced by safer alternatives, the compound remains important in chemical research and industrial synthesis.
o-Toluidine is primarily used in the manufacture of dyes.
Major Application of o-Toluidine: cleaning products, cosmetics, environmental, food and beverages, personal care.

-Dye uses of o-Toluidine:
o-Toluidine has been used as a dye precursor since the 19th century, when synthetic dye was produced.
In the years that followed, the aromatic amine functioned as a precursor of many dyes and pigments for consumer goods.
But when the carcinogenicity of o-toluidine for animals was recognized, and that it potentiality could be carcinogenic for humans, the production of o-toluidine and its use in dye manufacturing has been largely banned in the Western world and in many parts of the East.

But there are still a few dyes that are based on o-Toluidine.
The most known compounds are petroleum products and yellow organic pigments.
o-Toluidine is also an essential compound in the production of 4-chloro-o-toluidine and 4-amino-2′,3-dimethylazobenzene, which are also dyes.

-Specific determination of glucose uses of o-Toluidine:
o-Toluidine can also be used for measuring serum glucose concentration, in the form of acetic acid–o-toluidine.
The o-toluidine reaction for the estimation of glucose concentration in the serum gained massive popularity in the 1970s.
This method was mostly used by clinical laboratories.
Because of the potential health hazard, the laboratories now have a modified method by using alternative compounds.

-Separation of toxic metal ions using o-Toluidine:
The increasing level of heavy metals in the environment is a serious environmental problem.
Various methods have been developed to remove these metals from aqueous systems, but these methods have limitations.
Because of the limitations, researchers prompted to exploit inorganic materials as ion exchangers.

These inorganic ion exchangers are able to obtain specific metal ions/anions or organic molecules.
Following research in 2010, there has been a synthesis and analytical application on a new thermally stable composite cation exchange material: poly-o-toluidine stannic molybdate.
o-Toluidine showed a high selectivity for Pb2+ and Hg2+ metal ions.

-Industrial uses of o-Toluidine:
O-Toluidine is used as an intermediate of the manufacturing of triphenylmethane dyes and safranine colors.
o-Toluidine is an antioxidant in rubber manufacturing and a pharmaceutical intermediate.
o-Toluidine has been used as a laboratory reagent in glucose analysis and also used in the preparation of ion exchange resins and making various colors fast to acid.

BENEFITS and CHARACTERISTICS of O-TOLUIDINE:
o-Toluidine possesses a highly reactive aromatic amino group combined with a methyl substituent, providing excellent versatility in a wide range of organic synthesis reactions.
The methyl group influences both the electronic properties and steric behavior of the molecule, allowing selective chemical transformations that are valuable in industrial chemistry.

o-Toluidine readily undergoes diazotization, azo coupling, acylation, alkylation, condensation, oxidation, reduction, and electrophilic aromatic substitution reactions, making it one of the most versatile aromatic amine intermediates available.
o-Toluidine's relatively low molecular weight and good compatibility with many organic solvents enable efficient processing in laboratory and industrial manufacturing.

o-Toluidine serves as an excellent precursor for producing complex aromatic molecules, heterocyclic compounds, pigments, dyes, pharmaceuticals, and specialty chemicals.
o-Toluidine contributes to high reaction yields and efficient synthesis routes for numerous commercially valuable products.

o-Toluidine is widely available in high purity and remains an essential raw material in fine chemical manufacturing due to its well-established chemistry and broad industrial utility.
Its predictable reactivity and extensive industrial experience have made o-Toluidine a standard intermediate in organic synthesis, despite the need for careful handling because of its hazardous toxicological profile.

SYNTHESIS and REACTIONS of O-TOLUIDINE:
o-Toluidine is produced industrially by nitration of toluene to give a mixture of nitrotoluenes, favoring the ortho isomer.
This mixture is separated by distillation.
2-Nitrotoluene is hydrogenated to give o-toluidine.
The conversion of o-toluidine to the diazonium salt gives access to the 2-bromo, 2-cyano-, and 2-chlorotoluene derivatives.
N-acetylation is also demonstrated.

CHEMICAL PROPERTIES of O-TOLUIDINE:
o-Toluidine is a light-yellow liquid, becomes reddishbrown on exposure to air and light.
o-Toluidine is soluble in alcohol and ether; very slightly soluble in water.
O-Toluidine is a light yellow to reddish brown liquid.

o-Toluidine has extensive use in a large number of industries around the world.
o-Toluidine is used as an intermediate in the manufacture of azo and indigo dyes, pigments, sulfur dyes, pesticides, pharmaceutical products, rubber and vulcanizing chemicals, and similar products.

o-Toluidine is a colorless to pale yellow liquid with a weak, pleasant, aromatic odor.
o-Toluidine is a colorless to pale yellow liquid with an aromatic, aniline-like odor.
o-Toluidine becomes reddish-brown on exposure to air and light.

SYNTHESIS METHOD of O-TOLUIDINE:
o-Toluidine can be synthesized from toluene.
The direct aromatic amination is very effective when done with a parent nitrenium ion, but o-toluidine can also be synthesized in other ways.
For example, by the amination of toluene with methylhydroxylamine or hydroxylammonium salts in presence of aluminum trichloride.

The reaction using a nitrenium ion is not regionselective and multiple structural isomers will be present in the product.
To obtain pure o-toluidine, the isomers need to be separated.
In the dilute acid medium, o-nitrotoluene heated together with iron powder and water to synthesize o-toluidine.

synthesis process
O-nitrotoluene is preheated with hydrogen in the induction heater and hydrogenated in the presence of copper catalyst to prepare o-toluidine.

synthsis process
3.Toluene is aminated by ammonia sodium with the rhodium-carbon catalyst to produce o-toluidine.

4.Aniline is alkylated with methanol under the catalysis of ferric nitrate and germanium dioxide to produce the finished product o-toluidine.

ISOMERS of O-TOLUIDINE:
Toluidine has three isomers: o-toluidine, m-toluidine and p-toluidine, while o-toluidine is the situ substitution product and m-toluidine is the shift substitution product.
O-toluidine is an important intermediate for the production of dyes and pigments and can be used to prepare direct red 62, red base RL, red base G, juvenile base GBC, alkaloid, peptone AS-D, acid red 35,158 265, solvent red 124, diazo group of azo dyes and coupling component, pigment yellow 14, yellow 17, Blue 19; raw materials of pesticide like Tricyclazole, insecticide Chlordimeform, chloromethiuron; acetochlor; raw materials of Thiofide; raw material of saccharin; corrosion inhibitor and other raw materials.
In organic synthesis, o-toluidine are also used in synthesis of heterocyclic compounds indole and its derivatives.

CHEMICAL and PHYSICAL PROPERTIES of O-TOLUIDINE:
O-toluidine is a clear colorless or light yellow liquid, may become reddish brown on exposure to air and light, and white precipitate at the presence of formaldehyde.
o-Toluidine is slightly soluble in water, soluble in dilute acid, alcohol and ether.
relative density: 1.004(20℃);

melting point:-16.3℃ (β),-24.4℃(α);
boiling point: 199.7℃;
Flash point 185°F;

spontaneous ignition point: 482.2℃;
vapor density: 3.69.
o-Toluidine's vapor can form explosive mixture with air.
The maximum allowable concentration of o-Toluidine in air is 5ppm.

O-toluidine is flammable when exposed to heat or flame.
o-Toluidine will, when heated, emit toxic gases toxic similar to that of aniline.
The chemical properties of the toluidines are quite similar to those of aniline and toluidines have properties in common with other aromatic amines.
Due to the amino group bonded to the aromatic ring, the toluidines are weakly basic.

OCCURRENCE/USE of O-TOLUIDINE:
Production of dyes, vulcanization accelerator, organic synthesis; photographic dye; reagent in clinical assay for glucose and hemoglobin; component of tobacco smoke

METHODS OF MANUFACTURING
The preparation method is prepared by catalytic hydrogenation reduction of o-nitrotoluene.
Due to the different hydrogenation catalysts, the reaction conditions are different.
For example, a copper catalyst is used and the reaction temperature is 260°C, and a nickel catalyst can also be used.

OCCURRENCE of O-TOLUIDINE:
O-Toluidine has been reported to be a component of tar produced by low-temperature carbonization of coal and has been detected in gasoline fractions from arlan petroleum, tobacco leaf extracts, and in the aroma components of black tea.
Patrianakos and Hoffmann (1979) detected it in tobacco smoke.
o-Toluidine is a metabolite of prilocaine anesthetic in rats (Akerman et al 1966) and humans.

o-Toluidine is a possible contaminant of bootleg methaqualone but is not a methaqualone metabolite.
o-Toluidine is also a metabolite of the dye Poncean 3R.
O-Toluidine has been detected as a contaminant in injectables stored in polystyrene.

PRODUCTION METHODS of O-TOLUIDINE:
The production of O-toluidine is based on the catalytic hydrogenation of O-nitrotoluene or the amination of toluene with methylhydroxylamine in the presence of aluminum trichloride.
o-Toluidine is available as a technical grade with a minimum of 99.5% purity containing m-toluidine (0.4% maximum) and/or ptoluidine (0.1% maximum) as impurities.
The stabilized technical grade may also contain less than 0.5% of unidentified stabilizing agents to prevent darkening.

NOTES of O-TOLUIDINE:
o-Toluidine is air & Light Sensitive.
Keep o-Toluidine container tightly closed.
Store o-Toluidine in cool, dry conditions in well sealed containers.

PHYSICAL and CHEMICAL PROPERTIES of O-TOLUIDINE:
Appearance: Colorless to pale yellow oily liquid; gradually darkens to yellow, brown, or reddish upon exposure to air and light.
Odor: Characteristic aromatic amine odor.
Physical State: Liquid at room temperature.
Molecular Formula: C₇H₉N.
Molecular Weight: 107.15 g/mol.
Density: Approximately 0.998–1.003 g/cm³ at 20°C.
Melting Point: Approximately −16°C.
Boiling Point: Approximately 199–201°C.
Flash Point: Approximately 85°C (closed cup).

Auto-ignition Temperature: Approximately 480–500°C.
Vapor Pressure: Approximately 0.25–0.35 mmHg at 25°C.
Water Solubility: Slightly soluble in water (approximately 15–20 g/L at 25°C).
Solubility: Miscible with ethanol, ether, acetone, benzene, toluene, chloroform, and many organic solvents.
Partition Coefficient (log Kow): Approximately 2.3–2.5.
pKa (Conjugate Acid): Approximately 4.4–4.5.
Refractive Index: Approximately 1.57 at 20°C.
Viscosity: Low-viscosity liquid.

Chemical Nature: Aromatic primary amine.
Functional Groups: Primary amino group and methyl-substituted aromatic ring.
Stability: Stable under recommended storage conditions.
Air Sensitivity: Slowly oxidizes upon prolonged exposure to oxygen.
Light Sensitivity: Prolonged exposure to light accelerates discoloration.
Oxidation Behavior: Oxidizes to form colored quinone-imine and polymeric oxidation products.
Reactivity: Reacts readily with oxidizing agents, nitrous acid, acid chlorides, aldehydes, ketones, and electrophilic aromatic substitution reagents.
Basicity: Weak organic base typical of aromatic amines.
Thermal Stability: Stable under normal handling conditions; decomposes at elevated temperatures.

Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, ammonia, and aromatic nitrogen-containing compounds.
Flammability: Combustible liquid.
Chemical Name: o-Toluidine
Other Name: 2-Toluidine
CAS Number: 95-53-4
EC Number: 202-429-0
Molecular Formula: C₇H₉N
Molecular Weight: 107.15 g/mol
IUPAC Name: 2-Methylaniline
Chemical formula: C7H9N
Molar mass: 107.156 g·mol−1

Appearance: Colorless liquid
Odor: Aromatic, aniline-like odor
Density: 1.004 g/cm3
Melting point: −23.68 °C (−10.62 °F; 249.47 K)
Boiling point: 200 to 202 °C (392 to 396 °F; 473 to 475 K)
Solubility in water: 0.19 g/100 ml at 20 °C
Vapor pressure: 0.307531 mmHg (25 °C)
Refractive index (nD): 1.56987
Viscosity: 4.4335 (20 °C)

CBNumber: CB6854698
Molecular Formula: C7H9N
Molecular Weight: 107.15
MDL Number: MFCD00007730
MOL File: 95-53-4.mol
Melting point: -23 °C
Boiling point: 199-200 °C(lit.)
Density: 1.008 g/mL at 25 °C(lit.)
vapor density: 3.7 (vs air)
vapor pressure: 0.26 mm Hg ( 25 °C)
refractive index: n20/D 1.572(lit.)

Flash point: 185 °F
storage temp.: 2-8°C
solubility: 1.5 g/100 mL (25°C)
Colour Index: 37077
form: liquid
pka: 4.44(at 25℃)
color: light yellow to light amber
PH: 7.4 (H2O, 20℃)Aqueous solution
Odor: Aromatic, aniline-like.
explosive limit: 1.5-7.5%(V)

Water Solubility: 1.5 g/100 mL (25 ºC)
Thermal Conductivity: 0.162 W/(m·K) at 25 ℃
Specific Heat Capacity: Cp(gas): 1.22 J/(g·K), at 25℃
Sensitive: Air & Light Sensitive
Merck: 14,9536
BRN: 741981
Henry's Law Constant: 1.98 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)
Dielectric constant: 6.3399999999999999
Exposure limits: ACGIH TLV-TWA:2 ppm (8.8 mg/m3)

OSHA PEL-TWA:5 ppm (22 mg/m³)
NIOSH REL-TWA:5 ppm (～22 mg/m3);IDLH level:100 ppm
InChI: 1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3
InChIKey: RNVCVTLRINQCPJ-UHFFFAOYSA-N
SMILES: Cc1ccccc1N
LogP: 1.4 at 24.5℃
Substances of Very High Concern (SVHC) Candidate List: o-toluidine (95-53-4)
CAS DataBase Reference: 95-53-4(CAS DataBase Reference)
EWG's Food Scores: 6-9
FDA UNII: B635MZ0ZLU

Proposition 65 List: o-Toluidine
IARC: 1 (Vol. Sup 7, 77, 99, 100F) 2012
NIST Chemistry Reference: Benzenamine, 2-methyl-(95-53-4)
EPA Substance Registry System: o-Toluidine (95-53-4)
UNSPSC Code: 41116107
NACRES: NA.24
Linear Formula: CH3C6H4NH2
CAS Number: 95-53-4
Molecular Weight: 107.15
UNSPSC Code: 12352100
NACRES: NA.22

PubChem Substance ID: 24851137
EC Number: 202-429-0
Beilstein/REAXYS Number: 741981
MDL number: MFCD00007730
Assay: ≥99%
Form: liquid
Physical state: liquid (20 °C, 1.013 hPa)
Color: light yellow
Odor: characteristic
Melting point/ range: -28 °C

Boiling point/boiling range: 200,2 °C (1.013 hPa)
(ECHA)
Flammability: No data available
Upper explosion limit / Upper flammability limit: Upper explosion limit 7,5 %(V)
Lower explosion limit / Lower flammability limit: Lower explosion limit 1,5 %(V)
Flash point: 85 °C(1.013 hPa)
Method: closed cup
Autoignition temperature: 482 °C (1.013 hPa)
Decomposition temperature: No data available

pH: ca. 7,4 (20 °C)
Aqueous solution
Viscosity, dynamic: No data available
Viscosity, kinematic: No data available
Flow time: No data available
Solubility(ies)
Water solubility: 16,6 g/l (20 °C)
Partition coefficient: noctanol/water: log Pow: 1,4 (24,5 °C)
Method: OECD Test Guideline 107
GLP: yes
Bioaccumulation is not expected.

Vapor pressure: 0,35 hPa (25 °C)
Relative density: No data available
Density: 1,008 g/cm3
Relative vapour density: 3,7
(Air = 1.0)
Explosives: Not classified as explosive.
Oxidizing properties: none
Burning rate: No data available
Self-ignition: 480 °C 1.013 hPa
Evaporation rate: No data available

Molecular weight: 107,15 g/mol
Molecular Weight: 107.15 g/mol
XLogP3: 1.3
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 0
Exact Mass: 107.073499291 Da
Monoisotopic Mass: 107.073499291 Da
Topological Polar Surface Area: 26 Å²
Heavy Atom Count: 8
Formal Charge: 0

Complexity: 70.8
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Melting point: 215-217 °C(lit.)
Boiling point: 242 °C
Density: 1.0968 (rough estimate)
Refractive index: 1.5760 (estimate)

Storage temp.: 2-8°C
Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Color: White to Grey
BRN: 3558629
Stability: Stable. Incompatible with oxidizing agents, alkalies. Light and moisture sensitive.
InChI: InChI=1S/C7H9N.ClH/c1-6-4-2-3-5-7(6)8;/h2-5H,8H2,1H3;1H
InChIKey: OGVXWEOZQMAAIM-UHFFFAOYSA-N
SMILES: C1(C)=CC=CC=C1N.Cl
Toxicology and Carcinogenesis: Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CASRN 636-21-5)
CAS DataBase Reference: 636-21-5(CAS DataBase Reference)
FDA UNII: DX2X117B81
Proposition 65 List: o-Toluidine Hydrochloride
EPA Substance Registry System: o-Toluidine hydrochloride (636-21-5)
UNSPSC Code: 41116107
NACRES: NA.24

FIRST AID MEASURES of O-TOLUIDINE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of O-TOLUIDINE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of O-TOLUIDINE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of O-TOLUIDINE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of O-TOLUIDINE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of O-TOLUIDINE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available