ORTHO CHLORO BENZALDEHYDE

ORTHO CHLORO BENZALDEHYDE

cas no : 89-98-5

synonym : 2-Chlorobenzaldehyde; o-Chlorobenzaldehyde; OCBA; 2-Chlorobenzaldehyde [ACD/IUPAC Name]; 201-956-3 [EINECS]; 2-Chlorbenzaldehyd [German] [ACD/IUPAC Name]; 2-Chlorobenzaldéhyde [French] [ACD/IUPAC Name]; 385877 [Beilstein]; 89-98-5 [RN]; Benzaldehyde, 2-chloro- [ACD/Index Name]; o-Chlorobenzaldehyde; VHR BG [WLN]; 2-​chlorobenzaldehyde; 2-Chloorbenzaldehyde; 2-Chloorbenzaldehyde [Dutch]; 2-Chlorbenzaldehyd [ACD/IUPAC Name]; 2-chlorobenzaldehyde 98%; 2-Clorobenzaldeide [Italian]; Benzaldehyde, chloro- (9CI); o-Chloorbenzaldehyde [Dutch]; O-Chloro Benzaldehyde; o-Chlorobenzenecarboxaldehyde; o-chlorobenzenecarboxyaldehyde; ORTHO CHLORO BENZALDEHYDE; ortho chloro benzaldehyde; ortho chlorobenzaldehyde; orthochloro benzaldehyde; orthochlorobenzaldehyde; ortho chloro benzaldehyd; orthochlorbenzaldehyde; orthochlorobenzaldehyd; o-Chlorobenzenecarboxyaldehyde; OCAD; 2-Chlorobenzene Carbonal; o-Chloorbenzaldehyde (Dutch); 2-Chloorbenzaldehyde (Dutch); 2-chlorbenzaldehyd (German); o-Chlorobenzaldehyde; 2-clorobenzaldeide (Italian); 2-Clorobenzaldehído (Spanish); 2-Chlorobenzaldéhyde (French); 2-Chlorobenzaldehyde; 89-98-5; O-CHLOROBENZALDEHYDE; Chlorobenzaldehyde; Benzaldehyde, 2-chloro-; Benzaldehyde, o-chloro-; 2-Chlorbenzaldehyd; 2-Clorobenzaldeide; o-Chloorbenzaldehyde; 2-chloro-benzaldehyde; 2-Chloorbenzaldehyde; o-Chlorobenzenecarboxaldehyde; 2-chloro benzaldehyde; 2-Chlorbenzaldehyd [German]; o-Chloorbenzaldehyde [Dutch]; 2-Chloorbenzaldehyde [Dutch]; 2-Clorobenzaldeide [Italian]; EINECS 201-956-3; 35913-09-8; BENZALDEHYDE,CHLORO-; 2-Chlorobenzaldehyde, 99%; Benzaldehyde, chloro-; chlorotoluon; Benzaldehyde, chloro- (9CI); o-chlorobezaldehyde; 2-chlorobezaldehyde; 6-chlorobenzaldehyde; o-Chloroformylbenzene; o-chloro benzaldehyde; OCAD; orthochlorobenzaldehyde; 2- chlorobenzaldehyde; 2-chlorobenzenaldehyde; (2-chloro)benzaldehye; ortho-chlorobenzaldehyde; (2-chloro)benzaldehyde; (2-chloro) benzaldehyde; ORTHO CHLORO BENZALDEHYDE; CAS-89-98-5; 2-Chlorobenzaldehyde, purum, dist., >=98.0% (GC); 2-chlorobenzaldehyde radical; Amlodipine Impurity T; OCBA(2-Chlorobenzaldehyde); o-Chlorobenzaldehyde; 2-Chlorobenzaldehyde; ORTHO CHLORO BENZALDEHYDE; 2-CHLOROBENZALDEHYDE, DIST.; 2-Chlorobenzaldehyde; ForSynthesis2-Chlorobenzaldehyde,>98%OCBA16); ORTHO CHLORO BENZALDEHYDE; 2-chlorobenzaldehyde; o-chlorobenzaldehyde; o-CHLOROBENZALDEHYDE pure; O-CHLORO BENZALDEHYDE ( OCAD ); 2-Chlorobenzaldehyde,99% ; 2-Chlorobenzaldehyde, 99%; 2-Chlorobenzaldehyde, 99%; 2-Chlorobenzaldehyde, 99% ;2-Chlorobenzaldehyde, 99%; 2-Chlorobenzoic Aldehyde; 2-Chlorophenylcarboxaldehyde; O-ChloroforMylbenzene; O-chlorobenzaldehyde (OCBA); O-CHLOROBENZALDEHYDE; o-Chlorobenzenecarboxyaldehyde; OCAD; 2-chloorbenzaldehyde; 2-Chlorbenzaldehyd; 2-chloro-benzaldehyd; 2-Clorobenzaldeide; Benzaldehyde, o-chloro-Benzaldehyde,2-chlor; o--Chloroformylbenzene; o-Chloorbenzaldehyde; o-Chlor-benzaldehydo-chloro-benzaldehyd; o-Chlorobenzenecarboxaldehyde; 2-Chlorobenzaldehyde; Additive GA 78; Magalvan ZTC-OCB; 2-Chlorobenzaldehyde; 2-Chlorobenzoic Aldehyde; 2-Chlorophenylcarboxaldehyde; NSC 15347; O-Chlorobenzaldehyde; O-Chlorobenzenecarboxaldehyde; O-Chloroformylbenzene; 2-Chlorbenzaldehyd; 2-chloro-benzaldehyde; o-chloro-benzaldehyd; ortho-chloro benzaldehyde; OCBA; 2-Clorobenzaldeide; Benzaldehyde, 2-chloro-; USAF m-7; 2-Chlorobenzaldehyde for pharma synthesis; CAS 89-98-5.

2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde) is a chlorinated derivative of benzaldehyde that is used in production of CS gas. It reacts with malononitrile to form CS.[1]
Properties of ortho chloro benzaldehyde
Chemical formula    C7H5ClO
Molar mass    140.57 g·mol−1
Density    1.25
Melting point    9–12 °C (48–54 °F; 282–285 K)
Boiling point    209–215 °C (408–419 °F; 482–488 K)
Benzaldehyde(also called Benzenecarbonal) is the simplest representative of the aromatic aldehydes. Ortho chloro benzaldehyde is a colorless liquid aldehyde with a characteristic almond odor. Ortho chloro benzaldehyde boils at 180°C, is soluble in ethanol, but is insoluble in water. Benzaldehyde is formed by partial oxidation of benzyl alcohol and readily oxidized to benzoic acid and is converted to addition products by hydrocyanic acid or sodium bisulfite. Ortho chloro benzaldehyde is also prepared by oxidation of toluene or benzyl chloride or by treating benzal chloride with an alkali, e.g., sodium hydroxide. Ortho chloro benzaldehyde is used chiefly in the synthesis of other organic compounds, ranging from pharmaceuticals to plastic additives and benzaldehyde is an important intermediate for the processing of perfume and flavouring compounds and in the preparation of certain aniline dyes . Ortho chloro benzaldehyde (OCBA) is the first step in the synthesis for fragrances. It undergoes simultaneous oxidation and reduction with alcoholic potassium hydroxide, giving potassium benzoate and benzyl alcohol. Ortho chloro benzaldehyde is converted to benzoin with alcoholic potassium cyanide, with anhydrous sodium acetate and acetic anhydride, giving cinnamic acid. Compounds which do not have alpha-hydrogen atoms cannot form an enolate ion and do not undergo electrophilic alpha-substitution and aldol condensation. Aromatic aldehydes such as benzaldehyde and formaldehyde may undergo disproportionation in concentrated alkali (Cannizaro's reaction); one molecule of the aldehyde is reduced to the corresponding alcohol and another molecule is simultaneously oxidized to the salt of a carboxylic acid. The speed of the reaction depends on the substituents in the aromatic ring. Two different types of aldehydes (aromatic and aliphatic) can undergo crossing reaction to form fomaldehyde and aromatic alcohols. 2-Chlorobenzaldehyde is used as an intermediate for the manufacture of dyestuffs, optical brighteners, pharmaceuticals, agricultural chemicals and metal finishing products.
Stability:Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, iron, strong reducing agents. Moisture and light-sensitive.
ortho chloro benzaldehyde is a clear colorless to yellowish liquid. Colorless to yellowish liquid

2-Chlorobenzaldehyde (ortho chloro benzaldehyde) might be produced when a moist skin is exposed to the riot control agent CS. CS-hydrolysis to ortho chloro benzaldehyde and malononitrile occurs both in vitro and in vivo. No quantitative data have thus far been reported with respect to the percutaneous absorption and the cutaneous biotransformation of ortho chloro benzaldehyde. Percutaneous absorption, biotransformation and elimination of (14)C-labeled ortho chloro benzaldehyde was investigated in the rat. Following IV (25 uL/kg) and IP (37.5 uL/kg) (14)C-2-chlorobenzaldehyde administration to rats, the plasma radioactivity declined rapidly over a 24 hr period with similar plasma radioactivity-time profiles. Following cutaneous administration (75 uL/kg) in a closed glass-cup on the skin a slow skin penetration occurred as indicated by plasma radioactivity levels. A slow increase in plasma radioactivity was followed by a slow decline of radioactivity in plasma over a 3-day period. Most of the radioactivity was found in the urine with low levels in feces and exhaled air. The cutaneously administered radioactivity was also partly recovered from the glass-cup. For the qualitative and quantitative determination of metabolites in urine, a thin layer chromatography-radioautography method was used. The metabolic patterns of urinary excreted metabolites following cutaneous application and systemic administration of ortho chloro benzaldehyde to rats were very similar. No parent compound was recovered from the rat urine. 2-Chlorohippuric acid was the principal urinary metabolite. Quantitatively, the urinary excretion of (14)C-2-chlorobenzyl alcohol following cutaneous application differed substantially from that after the systemic administration. There was no evidence of storage in the skin or skin toxicity of 2-chlorobenzaldehyde following cutaneous application.
Main metabolic pathways of o-chlorobenzylidene malononitrile (CS) in rabbits were estimated quantitatively following iv administration. The products of hydrolysis were ortho chloro benzaldehyde (o-Cbald) and malononitrile. The toxic actions of CS can be ascribed to o-Cbald.

ortho chloro benzaldehyde is a colorless or yellowish liquid or needles. It has a penetrating odor. ortho chloro benzaldehyde is slightly soluble in water. USE: ortho chloro benzaldehyde is used to make other chemicals. EXPOSURE: Workers that use o-chlorobenzaldehyde (ortho chloro benzaldehyde) may breathe in vapors or have direct skin contact. The general population is not likely to be exposed to o-chlorobenzaldehyde (ortho chloro benzaldehyde). If o-chlorobenzaldehyde ( ortho chloro benzaldehyde) is released to the environment, it will be broken down in air. It may be broken down by sunlight. ortho chloro benzaldehyde will move into air from moist soil and water. ortho chloro benzaldehyde is expected to move through soil. ortho chloro benzaldehyde will be broken down by microorganisms, and is not expected to build up in fish. RISK: Skin and eye irritation and pain may occur with direct contact to o-chlorobenzaldhyde (ortho chloro benzaldehyde). Coughing, sore throat, and a burning sensation may occur following exposure to o-chlorobenzaldehyde (ortho chloro benzaldehyde) vapors. Stomach cramps and a burning sensation may result from ingestion. A few laboratory animal toxicity studies of o-chlorobenzaldehyde (ortho chloro benzaldehyde) are available in the published scientific literature, but the studies are inadequate to identify potential health effects. Data on the potential for o-chlorobenzaldehyde (ortho chloro benzaldehyde) to cause cancer, birth defects or reproductive effects in laboratory animals were not available. The potential for o-chlorobenzaldehyde (ortho chloro benzaldehyde) to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens.
Adhesive    General adhesives and binding agents for a variety of uses 2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Arts_crafts, child_use, detected    Chemicals detected in substances or products (note that these chemicals may be absent from an 'ingredient list' for the product and thus unexpected, but have been detected in product testing studies)  2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Colorant    Term used for colorants, dyes, or pigments; includes colorants for drugs, textiles, personal care products (cosmetics, tatoo inks, hair dye), food colorants, and inks for printing; modifiers included when application is known 2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Consumer_use    Term applied when the only information the source indicates is 'consumer' or 'consumer product' ; also applied to terms that the source indicates are for consumer use, yet the descriptor term is ambivalent about usage (e.g., cleaning_washing products may be for industrial or consumer use, when the source indicates consumer use, the consumer_use term is also applied) - see appendix for full list of unambiguous consumer related terms plus ambiguous consumer related terms which if indicated are labeled with 'consumer_use 2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Electronics    Consumer electronic equipment of all types, including phones, computers, cameras etc. and related electronic componenets (motherboards, software, chargers) 2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Manufacturing, adhesive    General adhesives and binding agents for a variety of uses 2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Manufacturing, building_material, paving    Related to cement, concrete, or asphalt materials 2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Manufacturing, building_material, roofing    Roofing materials or roofing activities 2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Manufacturing, chemical    General term used only when the only information known from the source is 'chemical,' typically related to manufacturing of chemicals, or laboratory chemicals  2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Manufacturing, export    Related to manufacturing for export (additional information unknown 2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Manufacturing, metals    Related to metals - manufacturing of metals, casting of metals, pro duction of metals, surface treatment of metals, etc 2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Surface_treatment    Surface treatments for metals, hardening agents, corrosion inhibitors, polishing agents, rust inhibitors, water repellants, etc (surfaces to be applied to often not indicated in source description)  2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Surface_treatment, metals    Related to metals - manufacturing of metals, casting of metals, production of metals, surface treatment of metals, etc 2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)
Toys, child_use, detected    Chemicals detected in substances or products (note that these chemicals may be absent from an 'ingredient list' for the product and thus unexpected, but have been detected in product testing studies)  2-Chlorobenzaldehyde (o-Chlorobenzaldehyde, ortho chloro benzaldehyde)

Industry Uses of ortho chloro benzaldehyde : Brightener; Corrosion inhibitors and anti-scaling agents; Dyes; Intermediates ; Plating agents and surface treating agents
Consumer Uses of ortho chloro benzaldehyde : Automotive care products, Ink, toner, and colorant products, Metal products not covered elsewhere

2-Chlorobenzaldehyde (ortho chloro benzaldehyde) is produced mainly by chlorination of 2-chlorotoluene to form 2-chlorobenzal chloride, which is then subjected to acid hydrolysis. Metal salts, such as iron(III) chloride, are used as catalysts. The hydrolysis can also be accomplished using formic acid without a catalyst. 2-Chlorobenzaldehyde (ortho chloro benzaldehyde) can also be produced by oxidation of 2-chlorobenzyl chloride with N-oxides of tertiary amines or with dilute nitric acid.

o-Chlorobenzaldehyde (ortho chloro benzaldehyde)'s production and use as an intermediate for the manufacture of optical brighteners may result in its limited release to the environment through various waste streams. If released to air, a vapor pressure of 0.230 mm Hg at 20 °C indicates o-chlorobenzaldehyde (ortho chloro benzaldehyde) will exist solely as a vapor in the atmosphere. Vapor-phase o-chlorobenzaldehyde (ortho chloro benzaldehyde) will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 22 hours. o-Chlorobenzaldehyde (ortho chloro benzaldehyde) contains chromophores that absorb at wavelengths >290 nm and, therefore, is expected to be susceptible to direct photolysis by sunlight. If released to soil, o-chlorobenzaldehyde (ortho chloro benzaldehyde) is expected to have high mobility based upon an estimated Koc of 97. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 2.4X10-5 atm-cu m/mole. o-Chlorobenzaldehyde (ortho chloro benzaldehyde) has a vapor pressure of 0.230 mm Hg and exists as a liquid under environmental conditions; therefore, o-chlorobenzaldehyde (ortho chloro benzaldehyde) may volatilize from dry soil. Utilizing the Japanese MITI test, 8% of the Theoretical BOD was reached in 4 weeks. Utilizing Zahn-Wellens inherent biodegradability tests, o-chlorobenzaldehyde (ortho chloro benzaldehyde) reached 90-100% biodegradation in 13-15 days. These tests suggest that under certain environmental conditions biodegradation may be an important environmental fate process in soil and water. If released into water, o-chlorobenzaldehyde (ortho chloro benzaldehyde) is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 30 hours and 18 days, respectively. An estimated BCF of 16 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to o-chlorobenzaldehyde (ortho chloro benzaldehyde) may occur through inhalation and dermal contact with this compound at workplaces where o-chlorobenzaldehyde (ortho chloro benzaldehyde) is produced or used. Use data as a commercial chemical intermediate indicate that the general population will have limited or no exposure to o-chlorobenzaldehyde (ortho chloro benzaldehyde). (SRC)
o-Chlorobenzaldehyde (ortho chloro benzaldehyde) 's production and use as an intermediate for the manufacture of optical brighteners(1) may result in its limited release to the environment through various waste streams
o-Chlorobenzaldehyde (ortho chloro benzaldehyde) , present at 100 mg/L, reached 8% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). In the test solution, primary degradation of o-chlorobenzaldehyde formed o-chlorobenzoic acid and o-chlorobenzylalcohol(1). Utilizing a Zahn-Wellens inherent biodegradability test, o-chlorobenzaldehyde reached 100% biodegradation within 3 days after an acclimation period of 10 days(2). Another Zahn-Wellens test gave similar results, greater than 90% biodegradation after 15 days(2), suggesting that this compound may biodegrade under certain environmental conditions(SRC).
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, iron, strong reducing agents. Moisture and light-sensitive.

Chemical Properties of ortho chloro benzaldehyde : colourless to brown liquid
Uses of ortho chloro benzaldehyde : Acid zinc plating brightener, also be used for organic synthesis, agricultural pesticide and pharmaceutical industries.
General Description of ortho chloro benzaldehyde : Clear colorless to yellowish liquid.
Air & Water Reactions : 2-Chlorobenzaldehyde (ortho chloro benzaldehyde) is moisture and light sensitive. Slightly water soluble.
Reactivity Profile : 2-Chlorobenzaldehyde ( ortho chloro benzaldehyde) reacts with iron and strong oxidizers, strong bases and strong reducing agents.
Fire Hazard : 2-Chlorobenzaldehyde (ortho chloro benzaldehyde) is combustible.
Safety Profile Poison by intraperitoneal and intravenous routes. When heated to decomposition it emits toxic fumes of Cl-. See also ALDEHYDES and CHLORIDES.

Ortho Chloro Benzaldehyde Chloride with CAS number 89-98-5 under the brand names Magalvan ZTC-OCB. We manufacture and export this product used as a special additive in zinc metal electroplating. Its similar names are 2-Chlorbenzaldehyd; 2-chloro-benzaldehyde; o-chloro-benzaldehyd.
Product Applications: Finishing of metals, Pharmaceutical industry Biotechnology, Optical brighteners, Pesticides, Photography, Manufacturing of textile dyestuffs, Manufacturing of photochemicals, Manufacturing of textiles dyestuffs, Chemical Industry, Dyestuffs pigments and optical brighteners, Textile industry, Metal industry, Manufacturing of dyestuffs, Manufacturing of insecticides acaricides, Manufacturing of pharmaceutical agents, Agriculture, Chemical synthesis, Textile dyestuffs, Manufacturing of antibiotics, Manufacturing of antibiotics

Rubber and tanning industries use a lot of chemicals. After all, they need to remove all that harmful bacteria from the skin of the animal. One of the most important chemicals that they use is ortho chloro benzaldehye. It is an important in the synthesis of alcohol and in the agriculture industry. So, if you’re thinking of starting a brewery or agriculture, then you know you need this chemical. It is a colourless to yellow liquid and dangerous if swallowed so be careful. We are one of the biggest and the best Ortho Chloro Benzaldehyde Manufacturers in India
Ortho Chloro benzaldehyde is used in manufacturing of electroplating, Dyes and API intermediates. Ortho Chloro benzaldehyde can be used as zinc plating brightener. Ortho Chloro benzaldehyde can also be used for organic synthesis, agricultural pesticide and pharmaceutical industries. Ortho Chloro benzaldehyde is a kind of organic synthetic raw material; it can be applied in making of pharmacy and pesticide etc. Ortho Chloro benzaldehyde can be used to make Chlorobenzylpenicillin sodium etc., as well as high efficient medical acaricide etc.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
Colorless or light yellow oily liquid. The melting point is 11.6℃, the boiling point is 212.5℃, the relative density is 1.2483(20/4℃), the refractive index is 1.5662, and the flash point is 87.7℃. Slightly soluble in water, soluble in ethanol, ether, acetone and benzene. Has a strong aldehyde smell.
2-Chlorobenzaldehyde (ortho chloro benzaldehyde) might be produced when a moist skin is exposed to the riot control agent CS. CS-hydrolysis to 2-chlorobenzaldehyde (ortho chloro benzaldehyde) and malononitrile occurs both in vitro and in vivo. No quantitative data have thus far been reported with respect to the percutaneous absorption and the cutaneous biotransformation of 2-chlorobenzaldehyde (ortho chloro benzaldehyde). Percutaneous absorption, biotransformation and elimination of (14)C-labeled 2-chlorobenzaldehyde (ortho chloro benzaldehyde) was investigated in the rat. Following IV (25 uL/kg) and IP (37.5 uL/kg) (14)C-2-chlorobenzaldehyde (ortho chloro benzaldehyde) administration to rats, the plasma radioactivity declined rapidly over a 24 hr period with similar plasma radioactivity-time profiles. Following cutaneous administration (75 uL/kg) in a closed glass-cup on the skin a slow skin penetration occurred as indicated by plasma radioactivity levels. A slow increase in plasma radioactivity was followed by a slow decline of radioactivity in plasma over a 3-day period. Most of the radioactivity was found in the urine with low levels in feces and exhaled air. The cutaneously administered radioactivity was also partly recovered from the glass-cup. For the qualitative and quantitative determination of metabolites in urine, a thin layer chromatography-radioautography method was used. The metabolic patterns of urinary excreted metabolites following cutaneous application and systemic administration of (14)C-2-chlorobenzaldehyde to rats were very similar. No parent compound was recovered from the rat urine. 2-Chlorohippuric acid was the principal urinary metabolite. Quantitatively, the urinary excretion of (14)C-2-chlorobenzyl alcohol following cutaneous application differed substantially from that after the systemic administration. There was no evidence of storage in the skin or skin toxicity of 2-chlorobenzaldehyde (ortho chloro benzaldehyde) following cutaneous application.
2-CHLOROBENZALDEHYDE (ortho chloro benzaldehyde) reacts with iron and strong oxidizers, strong bases and strong reducing agents.
This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Chlorobenzaldehyde is produced, as an intermediate or a final product, by process units covered under this subpart. /Chlorobenzaldehyde/