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Palmitoyl Isoleucine is a lipophilic amino acid derived from the essential amino acid isoleucine.
Palmitoyl Isoleucine is an isoleucine derivative.
Palmitoyl Isoleucine is a lipo-aminoacid derived from the naturally occurring essential amino acid isoleucine that is known for its ability to support tissue repair and lift vital proteins on the skin, purity > 98% (remaining content: free palmitic acid).
CAS Number: 54617-29-7
Molecular Formula: C22H43NO3
Molecular Weight: 369.58
Synonyms: Palmitoyl isoleucine, 54617-29-7, Voluform, N-Palmitoyl-L-isoleucine, L-Isoleucine, N-(1-oxohexadecyl)-, DTXSID60203050, Isoleucine, N-(1-oxohexadecyl)-, DTXSID401020251, 957769006D, DTXCID60125541, DTXCID701527068, PALMITOYL ISOLEUCINE [INCI], RefChem:858427, palmitoyl-L-isoleucine, N-palmitoyl isoleucine, N-hexadecanoyl-isoleucine, (2S,3S)-2-(hexadecanoylamino)-3-methylpentanoic acid, UNII-957769006D, starbld0010583, 101541-04-2, SCHEMBL897944, orb1985499, CHEBI:165554, NGYZAEAXQQNUBZ-FPOVZHCZSA-N, LMFA08020112, AKOS040753419, Q27271751, Palmitoyl Isoleucine;Palmitoyl-L-isoleucine;L-Isoleucine, N-(1-oxohexadecyl)-
Palmitoyl Isoleucine is used in anti-aging-, anti-wrinkle- & detoxifying skin care and lip care products. The shelf life is 36 months.
It is a white to off-white crystalline powder that is soluble in ethanol and dimethyl sulfoxide but not in water.
Acts as a plumping agent for a natural alternative to lipo-filling and detoxifying anti-pollution agent.
Has the ability to fill wrinkles and reshape volume of the cheeks.
Facial volume is redefined and elasticity is increased after 2 months of treatment.
Palmitoyl Isoleucine is a synthetic or semi-synthetic derivative of the essential amino acid L-isoleucine, in which the amino group of isoleucine is covalently bonded to a palmitoyl group, a 16-carbon saturated fatty acid chain also known as hexadecanoyl.
This chemical modification results in an N-acyl amino acid with both hydrophilic (amino acid) and lipophilic (fatty acid) components, giving the molecule amphiphilic properties that allow it to interact with both water and lipid environments.
The full IUPAC name for the compound is (2S,3S)-2-(hexadecanoylamino)-3-methylpentanoic acid, and it is also referred to in various chemical registries as N-Palmitoyl-L-isoleucine, L-isoleucine N-(1-oxohexadecyl)-, or N-hexadecanoyl-isoleucine.
Palmitoyl Isoleucine acts as an anti-wrinkle agent.
It also acts as a plumping agent for a natural alternative to lipo-filling and detoxifying anti-pollution agent.
This lipo-amino acid is synthetically modified from the naturally occurring essential amino acid isoleucine, known for its ability to support tissue repair and lift vital proteins on the skin.
Palmitoyl Isoleucine is vegn, GMO and preservative-free.
Palmitoyl Isoleucine has an ability to fill wrinkles and reshape volume of the cheeks.
It helps to redefine facial volume and increase elasticity after 2 months of treatment.
Palmitoyl Isoleucine is a lipo-aminoacid derived from the naturally occurring essential amino acid isoleucine that is known for its ability to support tissue repair and lift vital proteins on the skin.
Palmitoyl Isoleucine, also known as N-palmitoyl-L-isoleucine, is a synthetic compound that has garnered attention in the cosmetic and pharmaceutical industries due to its potential skin benefits and biological properties.
Palmitoyl Isoleucine is a derivative of the amino acid L-isoleucine, where the amino group is acylated with a palmitoyl group, a 16-carbon fatty acid chain.
Chemically, the palmitoyl group increases the lipophilicity of isoleucine, which enhances its ability to penetrate lipid membranes, interact with skin barriers, or stabilize formulations in cosmetic and pharmaceutical applications.
Unlike free amino acids, which are highly water-soluble and polar, palmitoyl isoleucine exhibits moderate solubility in water but good solubility in oils, esters, and organic solvents, making it highly versatile in formulations that require both hydrophilic and lipophilic compatibility.
In practice, palmitoyl isoleucine is commonly used in cosmetic and personal care products, particularly in skin care and hair care formulations, where it functions as a skin-conditioning agent, emollient, or peptide mimic.
Its structure allows it to bind to or penetrate the stratum corneum, enhancing the delivery of active ingredients or improving the overall texture and moisture retention of creams, lotions, and serums.
Additionally, it can act as a bioactive compound, potentially influencing cell signaling or protein interactions in the skin due to its peptide-like backbone coupled with a hydrophobic fatty acid tail.
Palmitoyl Isoleucine represents a strategically modified amino acid that combines the biological activity of L-isoleucine with the lipophilicity and membrane-penetrating properties of palmitic acid, making it a highly functional ingredient in cosmetic chemistry, dermatology, and experimental pharmaceutical applications.
Melting point: 68.5-69.5 °C
Boiling point: 528.2±33.0 °C(Predicted)
Density: 0.940±0.06 g/cm3(Predicted)
pka: 3.67±0.10(Predicted)
Palmitoyl isoleucine is a lipid-modified amino acid derivative in which the amino group of L-isoleucine is covalently linked to a palmitoyl (C16) fatty acid chain, creating an amphiphilic molecule that exhibits both hydrophilic and lipophilic characteristics.
This dual nature allows it to interact efficiently with both aqueous and lipid environments, making it highly versatile in cosmetic, dermatological, and pharmaceutical formulations.
The addition of the palmitoyl chain not only increases the molecular lipophilicity but also enhances the stability of the molecule against enzymatic degradation, which is a common limitation of free amino acids and short peptides in biological and topical applications.
Chemically, palmitoyl isoleucine belongs to the class of N-acyl amino acids, where the acylation of the amino group creates a peptide-mimetic structure that can interact with biological membranes or proteins while maintaining a fatty acid tail capable of penetrating lipid layers such as the stratum corneum of the skin.
This structural modification enables palmitoyl isoleucine to function as a skin-conditioning agent, emollient, or peptide analogue in formulations, where it contributes to enhanced skin hydration, improved texture, and delivery of bioactive ingredients.
Its amphiphilic nature also allows it to stabilize emulsions, acting as a mild surfactant or co-surfactant that supports the homogeneous dispersion of water- and oil-soluble components in creams, lotions, or serums.
In cosmetic and personal care applications, palmitoyl isoleucine is often included for its anti-aging, moisturizing, and skin-repairing properties, as it can mimic small peptide sequences that influence cell signaling and protein interactions in the epidermis.
This can help stimulate the skin’s natural repair processes, improve barrier function, and increase skin elasticity over time.
Palmitoyl Isoleucine is particularly valued in high-end skincare products, serums, and hair care formulations, where its ability to penetrate lipid-rich layers and maintain moisture balance contributes to overall product efficacy.
The chemical structure of palmitoyl isoleucine consists of the L-isoleucine backbone attached to a palmitic acid moiety.
This modification confers the compound with amphiphilic properties, meaning it has both hydrophilic (water-attracting) and hydrophobic (water-repelling) regions.
This characteristic allows palmitoyl isoleucine to interact with both aqueous and lipid environments, which can be beneficial in various applications, including skincare formulations.
From a structural perspective, palmitoyl isoleucine represents a hybrid molecule combining the functional properties of amino acids with the stability and lipophilicity of fatty acids, which is why it is widely favored in cosmetic chemistry, dermatological products, and experimental skin formulations.
Its ability to function in both aqueous and lipid phases makes it particularly valuable in products that require emulsification, controlled delivery of actives, or skin barrier enhancement.
Palmitoyl Isoleucine’s chemical stability and compatibility with a wide range of cosmetic excipients make it suitable for long-term formulation use, allowing it to retain its functional properties under different pH conditions, temperatures, and solvent environments.
This stability, combined with its bioactive potential, has also prompted research into its use in dermatological or experimental pharmaceutical products, where lipid-modified amino acids are investigated for enhanced skin delivery of active molecules or as functional peptide mimetics in topical therapeutics.
Uses Of Palmitoyl Isoleucine:
Palmitoyl isoleucine is used in various cosmetic products due to its potential to enhance skin appearance.
Palmitoyl Isoleucine is known to improve skin elasticity and reduce the appearance of fine lines and wrinkles.
Additionally, its ability to modulate the barrier function of the skin can help in maintaining skin hydration and reducing water loss.
In pharmaceutical applications, compounds like Palmitoyl Isoleucine are researched for their potential therapeutic effects, including their role in drug delivery systems and as bioactive molecules.
Palmitoyl Isoleucine is widely used in cosmetic, personal care, and dermatological formulations due to its unique combination of amphiphilic properties, skin-penetrating ability, and peptide-mimetic functionality, which make it effective as both a functional and bioactive ingredient.
In skincare products, it is commonly incorporated as a skin-conditioning agent, moisturizer, and emollient, where the palmitoyl fatty acid tail allows the molecule to penetrate the lipid-rich layers of the stratum corneum, while the isoleucine moiety interacts with skin proteins, helping to enhance hydration, improve skin barrier function, and promote overall skin softness and elasticity.
Its ability to mimic small peptide sequences allows it to stimulate cellular activity in the epidermis, potentially influencing collagen synthesis, protein expression, and other biological pathways that contribute to anti-aging and skin-repair effects.
Beyond moisturizing and anti-aging applications, Palmitoyl Isoleucine is used in formulations as an emulsifier or co-emulsifier, where its amphiphilic nature enables stable dispersion of water- and oil-soluble ingredients, ensuring uniform texture, appearance, and long-term stability of creams, lotions, serums, and hair care products.
In hair care formulations, it can act as a conditioning agent, improving hair smoothness, manageability, and overall appearance by interacting with the hair cuticle and surface proteins.
Additionally, its chemical stability under a range of pH, temperature, and solvent conditions makes it particularly suitable for long-lasting, high-performance cosmetic formulations, including serums and specialty creams that require both bioactivity and structural integrity.
Palmitoyl Isoleucine is also being explored in experimental dermatological and pharmaceutical applications, where its lipid-modified amino acid structure enables enhanced transdermal delivery of active molecules or acts as a peptide mimic to influence specific biological pathways in the skin.
In this context, it may serve as a carrier or co-ingredient in formulations designed to target skin repair, anti-inflammatory effects, or cellular signaling modulation, broadening its use beyond traditional cosmetic applications.
In short, palmitoyl isoleucine is a highly versatile ingredient primarily used in skin care, hair care, and dermatological formulations, functioning as a moisturizer, emollient, peptide-mimetic, and emulsifier, with additional potential in experimental pharmaceutical products due to its amphiphilic properties, stability, and ability to penetrate lipid layers while interacting with skin proteins.
Palmitoyl Isoleucine is extensively used in advanced cosmetic and dermatological formulations because it combines the bioactive properties of amino acids with the lipophilic characteristics of a fatty acid chain, allowing it to penetrate the stratum corneum effectively while interacting with cellular components in the epidermis, which contributes to enhanced skin hydration, improved barrier function, and reduced transepidermal water loss.
Its structure also enables it to act as a peptide-mimetic ingredient, which can influence cell signaling pathways related to collagen production, skin elasticity, and repair mechanisms, making it a highly sought-after compound in anti-aging creams, serums, and rejuvenating skincare products.
In addition to its skin-conditioning effects, palmitoyl isoleucine is widely employed as a formulation stabilizer and emulsifier due to its amphiphilic nature, which allows it to maintain uniform dispersion of both hydrophilic and lipophilic components in complex emulsions, resulting in creams, lotions, and serums that retain their texture, consistency, and bioavailability of active ingredients over time.
This makes it particularly valuable in high-end cosmetic products, where product stability and long-term efficacy are critical.
Furthermore, its compatibility with a broad range of cosmetic excipients enables formulators to incorporate it into multi-component formulations without compromising the stability or sensory characteristics of the final product.
Safety Profile Of Palmitoyl Isoleucine:
For most cosmetic or personal care applications, palmitoyl isoleucine is regarded as non-irritating and non-sensitizing at typical use concentrations.
However, in higher concentrations or in raw form, it could potentially cause mild skin or eye irritation upon direct contact, particularly for individuals with sensitive skin or pre-existing dermatological conditions.
Inhalation of powders or aerosols during manufacturing could also cause respiratory irritation, although this risk is minimal in finished cosmetic products.
Palmitoyl Isoleucine is not classified as acutely toxic, and systemic toxicity is very low because it is derived from naturally occurring amino acids and fatty acids.
Palmitoyl Isoleucine is biodegradable due to its amino acid and fatty acid components, so it is generally considered low risk to aquatic or terrestrial ecosystems under normal usage.
However, large-scale industrial releases or improper disposal of concentrated material could lead to localized environmental effects, such as minor oxygen depletion in water due to biodegradation processes.
In industrial or laboratory settings, standard good laboratory practices should be followed.
This includes wearing gloves, goggles, and protective clothing when handling the raw powder or concentrated solutions, using dust-control measures or fume hoods to prevent inhalation, and storing the compound in a cool, dry place away from strong oxidizing agents or acids.
Although palmitoyl isoleucine is chemically stable, it should be kept in tightly sealed containers to avoid contamination or moisture uptake.
