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CAS: 2634-33-5
MF: C7H5NOS
MW: 151.19
EINECS: 220-120-9
Description
PARMETOL D 11 is an irritant and also a skin sensitizer.
Occupational allergie contact dermatitis has been reported mainly related to the use of cutting oils and greases in paint manufacturers, pottery mouldmakers, acrylic emulsion manufacturers, plumbers, printers and lithoprinters, paper makers, an analyticallaboratory, a rubber factory, and in employees manufacturing air fresheners.
An organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.
PARMETOL D 11 is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria.
PARMETOL D 11 is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants.
PARMETOL D 11 is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
PARMETOL D 11 is used by consumers, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.
PARMETOL D 11 is an organic compound with the formula C6H4SN(H)CO.
A white solid, PARMETOL D 11 is structurally related to isothiazole, and is part of a class of molecules called isothiazolinones.
PARMETOL D 11 is widely used as a preservative and antimicrobial.
Product Benefits
Broad spectrum activity in high pH systems, controlling bacteria, fungi and yeasts.
Stable in the presence of amines.
Non specific mode of action, resulting in reduced microbial resistance potential.
Ease of handling due to PARMETOL D 11's liquid form and good compatibility in most aqueous compositions.
Excellent performance with co-biocides like CMI/MI, bronopol or formaldehyde releasers, which allow performance enhancements and cost reduction.
The active ingredient is non-volatile and has a comparatively high heat stability which allows the incorporation in fluids which are still hot.
High purity active ingredient, made evident by its clear light colour.
PARMETOL D 11 Chemical Properties
Melting point: 154-158 °C(lit.)
Boiling point: 360°C (rough estimate)
Density: 1.2170 (rough estimate)
Vapor pressure: 0Pa at 25℃
Refractive index: 1.5500 (estimate)
Storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Solubility: Soluble in dichloromethane, dimethyl sulfoxide, methanol.
Form: neat
pka: 10.19±0.20(Predicted)
Color: White to Light yellow to Light orange
Water Solubility: 1.288g/L at 20℃
InChIKey: DMSMPAJRVJJAGA-UHFFFAOYSA-N
LogP: 0.7 at 20℃
CAS DataBase Reference: 2634-33-5
EPA Substance Registry System: PARMETOL D 11 (2634-33-5)
Uses
PARMETOL D 11 is widely used in industry as a preservative in water-based solutions, such as pastes, paints and cutting oils.
PARMETOL D 11 exists at different concentrations in the different Proxel AB, GXL, CRL, XL2, XL, HL, TN, and in Mergal K-10.
PARMETOL D 11 has been widely used in high concentrations for microbial growth control in many domestic and industrial processes, PARMETOL D 11's potential eco-risk should be assessed.
PARMETOL D 11 is being reviewed for use as a biocide in the EEA and/or Switzerland, for: disinfection, product preservation, preservation of fibres, leather, rubber, or polymers, preservation for construction materials, preservation for liquid systems, controlling slimes, preservation for working / cutting fluids.
PARMETOL D 11 is used in the following products: plant protection products and cosmetics and personal care products.
Other release to the environment of PARMETOL D 11 is likely to occur from: outdoor use as processing aid and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).
PARMETOL D 11 has a microbicide and a fungicide mode of action.
PARMETOL D 11 is widely used as a preservative, for example in:
1-emulsion paints, caulks, varnishes, adhesives, inks, and photographic processing solutions
2-home cleaning and car care products; laundry detergents, stain removers and fabric softeners;
3-industrial settings, for example in textile spin-finish solutions, leather processing solutions, preservation of fresh animal hides and skins
4-agriculture in pesticide formulations
5-gas and oil drilling in muds and packer fluids preservation.
In paints, PARMETOL D 11 is commonly used alone or as a mixture with methylisothiazolinone.
Typical concentrations in products are 200–400 ppm depending on the application area and the combination with other biocides.
According to a study in Switzerland, 19% of the paints, varnishes and coatings contained PARMETOL D 11 in 2000.
The fraction in adhesives, sealants, plasters and fillers was shown at that time as 25%.
A later study in 2014 shows a dramatic rise in usage, to 95.8% of house paints.
Home cleaning and other care products that are high in water are easily contaminated by microorganisms, so isothiazolinones are often used as a preservatives in PARMETOL D 11 because they are good at combatting a broad array of bacteria, fungi, and yeasts.
A Swiss investigation found that PARMETOL D 11 is used in concentrations between 50 and 500 ppm in tattooing ink.
According to regulations in the EU and Switzerland, PARMETOL D 11 cannot be used in cosmetics.
However, PARMETOL D 11 is allowed in the United States and Canada.
Synonyms
BIT
MFR
BIT-85
BIT-20
Proxan
proxel
proxil
proxelpl
PROXELHL
Benzocil
Proxel AB
Proxel XL
BIOCIDE--BIT
Acticide BIT
Apizas AP-DS
Canguard BIT
Bestcide 200K
Bioban BIT 20DPG
BENZISOTHIAZOLONE
Canguard BIT 20DPG
1,2-Benzisothiazol
BENZISOTHIAZOLINONE
1,2-Benzisothiazolin
Benzoisothiazol-3-one
1,2-Benzisothiazolone
1,2-benzothiazol-3-one
Benzisothiazolin-3-one
Benzo[d]Isothiazol-3-ol
1,2-Benzisothiazol-3-ol
1-Thia-2-azaindan-3-one
2-Benzisothiazolin-3-one
inhibitory receptor SHPS-1
Macrophage fusion receptor
1,2-BENZISOTHLAZOLIN-3-ONE
1,2-BENZISOTHIAZOLIN-3-ONE
1,2-BENZISOTHAZOL-3(2H)-ONE
1,2-benzisothiazoline-3-one
1.2-Benzisothiazol-3(2H)-on
Benziothiazolinone solution
Benzisothiazolin-3-on (BIT)
Benzo[d]isothiazol-3(2H)-one
Benzisothiazolin-3-one (BIT)
1,2-BENZOISOTHIAZOLINE-3-ONE
1,2-BENZISOTHIAZOLINON-3-ONE
1,2-BENZISOTHIAZOL-3(2H)-ONE
3-Hydroxy-1,2-benzisothiazole
1,2-BENZISOTHIAZOL-3-ONE (BIT)
1,2-Bezisothiazolin-3-One(Bit)
1,2-Benzisothiazolin-3-One(Bit)
1,2-Benzisothiazoline-3(2H)-one
2-Hydrobenzo[d]isothiazol-3-one
1,2-Benzisothiazolin-3-One(MIT)
1,2-benzo-isothiazolin-3-ketone
1,2-Benzisothiazol-3(2H)-one ,98%
Benziothiazolinone solution,100ppm
1,2-Benzisothiazol-3(2H-)-one
1,2-BENZISOTHIAZOL-3(2H)-ONE HYDRATE
2,3-Dihydro-1,2-benzisothiazole-3-one
Benzo[d]isothiazol-3(2H)-one, 98% 99%
1,2-BENZISOTHIAZOLIN-3-ONE (BIT) 98.5%
1,2-Benisothiazolin-3-One-2-Sodium Salt
Anti-SIRP α1, C-Terminal antibody produced in rabbit
1,2-Benzisothiazol-3(2H)-one [for BiocheMical Research]
1,2-benzisothiazol-3(2H)-one 1,2-benzisothiazolin-3-one
brain Ig-like molecule with tyrosine-based activation motifs
2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(7),8,10-trien-5-one
