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Plasdone S-630 is a brand name for a specific grade of Polyvinylpyrrolidone (PVP), a water-soluble polymer commonly used as a binder, film former, and stabilizer in pharmaceutical, cosmetic, and industrial applications.
The S-630 grade is notable for its medium molecular weight and high solubility, making it useful in tablet formulations, suspensions, and other pharmaceutical preparations.
CAS Number:
25086-89-9
Synonyms:
Polyvinylpyrrolidone K-30 (PVP K-30) — S-630 is often related or equivalent to PVP K-30, Povidone,Polyvidone,PVP,Plasdone (brand family name),Kollidon K-30
Introduction
Polyvinylpyrrolidone (PVP) is a versatile synthetic polymer widely used across pharmaceutical, cosmetic, and industrial applications.
Among its various grades, Plasdone S-630, corresponding roughly to PVP K-30, is recognized for its optimal balance between molecular weight, solubility, and viscosity, making it a preferred excipient in numerous formulations.
The origin of PVP dates back to early 20th century polymer chemistry advancements, with commercial-scale production beginning mid-century.
The Plasdone brand, produced by Ashland Inc., encompasses a range of PVP grades; S-630 is particularly prominent due to its consistent quality and reliable performance.
This article aims to provide an exhaustive review of Plasdone S-630, covering its chemical and physical properties, synthesis methods, characterization techniques, diverse applications, safety profile, and future prospects.
The comprehensive overview will assist researchers, formulators, and industry professionals in understanding and leveraging the potential of this polymer.
Chemical Structure and Properties
Molecular Structure
Plasdone S-630 is a polymer of N-vinylpyrrolidone monomers, with each repeating unit featuring a five-membered lactam ring. This cyclic amide imparts hydrophilicity, enabling excellent water solubility.
The polymer backbone is linear, with a degree of polymerization that corresponds to an average molecular weight of ~40,000–60,000 Daltons for this grade.
Physical Properties
The polymer appears as a white to off-white powder with hygroscopic tendencies.
It readily dissolves in water and alcohols but is insoluble in nonpolar solvents.
A 1% aqueous solution typically exhibits a pH between 4.0 and 7.5. The viscosity of such solutions is moderate, facilitating its use as a binder and film former.
Molecular Weight Distribution
Plasdone S-630’s molecular weight distribution influences its rheological and film-forming properties. The polymerization process is controlled to yield a narrow distribution, ensuring batch-to-batch consistency.
Comparison with Other Grades
Compared to lower molecular weight grades like PVP K-12, S-630 offers better film strength and viscosity, while still maintaining excellent solubility.
Higher grades like K-90 have higher molecular weights but are less soluble and more viscous, making S-630 an ideal intermediate choice.
Synthesis and Production
Raw Materials
The monomer, N-vinylpyrrolidone (NVP), is synthesized via the reaction of 2-pyrrolidone with acetylene or derived via other industrial routes.
Polymerization Process
Polymerization is typically conducted via free radical polymerization, using initiators such as azo or peroxide compounds.
The reaction occurs in aqueous or organic solvent media under controlled temperature and pressure.
Molecular Weight Control
Reaction conditions (temperature, initiator concentration, solvent) and termination techniques are optimized to achieve the desired molecular weight corresponding to the S-630 grade.
Purification
Post-polymerization, the polymer is purified by precipitation, filtration, and drying to remove residual monomers, initiators, and impurities, ensuring pharmaceutical grade quality.
Quality Control
Analytical techniques such as HPLC for monomer content, viscosity testing, and microbial contamination assays are employed to assure consistency.
Physicochemical Characterization
Gel Permeation Chromatography (GPC)
Used to determine molecular weight distribution and polydispersity index.
Infrared Spectroscopy (FTIR)
Confirms the presence of characteristic functional groups such as the lactam ring.
Nuclear Magnetic Resonance (NMR) Spectroscopy
Elucidates the chemical structure and verifies the polymer backbone integrity.
Thermal Analysis (DSC, TGA)
Measures thermal transitions and stability; Plasdone S-630 exhibits glass transition temperatures around 150–180 °C.
Rheological Testing
Viscosity measurements of aqueous solutions define flow properties critical for formulation.
SAFETY INFORMATION ABOUT PLASDONE S-630
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product
