PRODUCTS

POLYOXYETHYLENE (20) SORBITAN MONOOLEATE

CAS NUMBER: 9005-65-6

EC NUMBER: 500-019-9

MOLECULAR FORMULA: C32H60O10

MOLECULAR WEIGHT: 604.8

IUPAC NAME: 2-[2-[3,5-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (E)-octadec-9-enoate

Polyoxyethylene (20) Sorbitan Monooleate is an amber-colored viscous liquid.
Polyoxyethylene (20) Sorbitan Monooleate's pH (5% aqueous solution) 5-7.

Polyoxyethylene (20) Sorbitan Monooleate has faint odor and bitter taste.
Polyoxyethylene (20) Sorbitan Monooleate is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.

This synthetic compound is a viscous, water-soluble yellow liquid.
Polyoxyethylene (20) Sorbitan Monooleate is derived from polyethoxylated sorbitan and oleic acid. The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.

In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid
Polyoxyethylene (20) Sorbitan Monooleate is a non-toxic, nonionic surfactant/emulsifier and a water-soluble yellowish liquid used as a dispersing agent which allows oil and water to mix without the use of alcohol.
Polyoxyethylene (20) Sorbitan Monooleate is a fragrance solubilizer and stabilizer

Polyoxyethylene (20) Sorbitan Monooleate lubricates and has a soothing effect on the skin.
Polyoxyethylene (20) Sorbitan Monooleate is generally used in combination with other emulsifiers such as mono- and diglycerides or sorbitan monostearates for various purposes such as to disperse flavors and colors, to make essential oils and vitamins soluble and to improve volume and texture in baked goods.

Polyoxyethylene (20) Sorbitan Monooleate is a highly hydrophilic surfactant and approved as a food additives.
Polyoxyethylene (20) Sorbitan Monooleate is a usuful emulsifier, dispersant and solubilizer for aroma chemiclas and oils

Polyoxyethylene (20) Sorbitan Monooleate is a nonionic, solubilizer.
Polyoxyethylene (20) Sorbitan Monooleate is used in textile industry

Polyoxyethylene (20) Sorbitan Monooleate is also used as wetting agent
Polyoxyethylene (20) Sorbitan Monooleate is also suspending agent used in food industry
Polyoxyethylene (20) Sorbitan Monooleate is solubilizer for perfumes and flavours

Polyoxyethylene (20) Sorbitan Monooleate is a polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group.
Polyoxyethylene (20) Sorbitan Monooleate has a role as a nonionic surfactant.

USES:
Polyoxyethylene (20) Sorbitan Monooleate is used as an emulsifier in foods.
Adding this substance prevents milk proteins from completely coating the fat droplets.
This allows them to join in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.

Polyoxyethylene (20) Sorbitan Monooleate is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash.
The cosmetic grade of Polyoxyethylene (20) Sorbitan Monooleate may have more impurities than the food grade

Polyoxyethylene (20) Sorbitan Monooleate is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.
Polyoxyethylene (20) Sorbitan Monooleate is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.
Polyoxyethylene (20) Sorbitan Monooleate is also used as an excipient in some European and Canadian influenza vaccines.

Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules); when these species are added to a mixture of Polyoxyethylene (20) Sorbitan Monooleate and phenol red, they cause the solution to change color, so this is used as a test to identify the phenotype of a strain or isolate.
Polyoxyethylene (20) Sorbitan Monooleate (common commercial brand names include Scattics, Alkest TW 20, Tween 20, and Kotilen-20) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan monolaurate.

Polyoxyethylene (20) Sorbitan Monooleate's stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.
As the name implies the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species

APPLICAIONS:
Food applications:
Polyoxyethylene (20) Sorbitan Monooleate is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.

Biotechnical applications:
In biological techniques and sciences, Polyoxyethylene (20) Sorbitan Monooleate has a broad range of applications.
For example, Polyoxyethylene (20) Sorbitan Monooleate is used:

*as a washing agent in immunoassays, such as Western blots and ELISAs.
Polyoxyethylene (20) Sorbitan Monooleate helps to prevent non-specific antibody binding.
In this major application, Polyoxyethylene (20) Sorbitan Monooleate is dissolved in Tris-buffered saline or phosphate buffered saline at dilutions of 0.05% to 0.5% v/v.
These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific background.

*to saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA).

*to stabilize proteins purified protein derivative (PPD) solution used in skin testing for tuberculosis exposure

*as a solubilizing agent of membrane proteins

*for lysing mammalian cells, at a concentration of 0.05% to 0.5% v/v, generally combined with other detergents, salts and additives.

Pharmaceutical applications:
Polyoxyethylene (20) Sorbitan Monooleate is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.

Industrial and domestic applications:
Polyoxyethylene (20) Sorbitan Monooleate is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.

Polyoxyethylene (20) Sorbitan Monooleate is also used as wetting agent in rubber balers in the elastomer industry.
Polyoxyethylene (20) Sorbitan Monooleate has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies

The additive is a mixture of the partial esters of sorbitol and its mono- and dianhydrides with edible commercial oleic acid and condensed with approximately 20 moles of ethylene oxide per mole of sorbitol and its anhydrides.
The use of Polyoxyethylene (20) Sorbitan Monooleate as feed additive for all animal species at the maximum concentration proposed of 5,000 mg/kg complete feedingstuffs would not raise concerns for the consumer.

Polyoxyethylene (20) Sorbitan Monooleate is a recognised emulsifier used in food and it is expected to have the same effect when applied to feed.
From the practical examples provided, Polyoxyethylene (20) Sorbitan Monooleate appears to be effective in aiding and maintaining the homogeneous distribution of feed materials and/or additives in feedingstuffs.

Polyoxyethylene (20) Sorbitan Monooleate is derived from coconut oil.
Polyoxyethylene (20) Sorbitan Monooleate is a non-toxic, nonionic surfactant/emulsifier and a water-soluble yellowish liquid used as a dispersing agent which allows oil and water to mix without the use of alcohol.

Polyoxyethylene (20) Sorbitan Monooleate is a fragrance solubilizer and stabilizer
Polyoxyethylene (20) Sorbitan Monooleate lubricates and has a soothing effect on the skin.

This skin- safe ingredient is used extensively in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.) and also for body mists and linen sprays.
Will be found as an ingredient in the majority of body toiletries, cosmetics and wipes now in the market.

Polyoxyethylene (20) Sorbitan Monooleate is generally used in combination with other emulsifiers such as mono- and diglycerides or sorbitan monostearates for various purposes such as to disperse flavors and colors, to make essential oils and vitamins soluble and to improve volume and texture in baked goods.
Use Polyoxyethylene (20) Sorbitan Monooleate when very little foaming action (or none at all) is desired in the finished product.

Polyoxyethylene (20) Sorbitan Monooleate is a nonionic, solubilizer, o/w emulsifier, antistat and fiber lubricant used in:
-textile industry
-wetting agent
-viscosity modifier

Polyoxyethylene (20) Sorbitan Monooleate is also suspending agent used in:
-food
-cosmetics
-drugs
-textile
-metal working industries

Polyoxyethylene (20) Sorbitan Monooleate is solubilizer for:
-perfumes and flavours
-insecticides
-herbicides
-paints and inks
-pharmaceutical

PHYSICAL PROPERTIES:

-Molecular Weight: 604.8

-XLogP3-AA: 5.3

-Rotatable Bond Count: 31

-Exact Mass: 604.41864811

-Monoisotopic Mass: 604.41864811

-Topological Polar Surface Area: 133 Å²

-Physical Description: Lemon to amber colored liquid

-Color: Yellow to orange colored

-Form: oily liquid

-Flash Point: > 300 °F

-Solubility: In water, 1.9X10-2 mg/L

-Density: 1.06-1.10

-Viscosity: 300-500 cSt

-Acid Value: Not more than 2

-Chemical Classes: Other Classes -> Polyoxyethylenes

Polyoxyethylene (20) Sorbitan Monooleate is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
This synthetic compound is a viscous, water-soluble yellow liquid.
Polyoxyethylene (20) Sorbitan Monooleate is derived from polyethoxylated sorbitan and oleic acid. The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.

Polyoxyethylene (20) Sorbitan Monooleate is an amber-colored viscous liquid.
Polyoxyethylene (20) Sorbitan Monooleate's pH (5% aqueous solution) 5-7.

Polyoxyethylene (20) Sorbitan Monooleate has faint odor and bitter taste.
Polyoxyethylene (20) Sorbitan Monooleate is a polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group.
Polyoxyethylene (20) Sorbitan Monooleate has a role as a nonionic surfactant.

CHEMICAL PROPERTIES:

-Hydrogen Bond Donor Count: 3

-Hydrogen Bond Acceptor Count: 10

-Heavy Atom Count: 42

-Formal Charge: 0

-Complexity: 632

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 0

-Undefined Atom Stereocenter Count: 4

-Defined Bond Stereocenter Count: 1

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

-Compound Is Canonicalized: Yes

Polyoxyethylene (20) Sorbitan Monooleate is used as an emulsifier in foods.
Polyoxyethylene (20) Sorbitan Monooleate is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash.
Polyoxyethylene (20) Sorbitan Monooleate is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.

Polyoxyethylene (20) Sorbitan Monooleate is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.
Polyoxyethylene (20) Sorbitan Monooleate is also used as an excipient in some European and Canadian influenza vaccines.

Polyoxyethylene (20) Sorbitan Monooleate is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan monolaurate.
Polyoxyethylene (20) Sorbitan Monooleate's stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.

Polyoxyethylene (20) Sorbitan Monooleate is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.
Polyoxyethylene (20) Sorbitan Monooleate has a broad range of applications.
Polyoxyethylene (20) Sorbitan Monooleate is used as a washing agent in immunoassays, such as Western blots and ELISAs.

Polyoxyethylene (20) Sorbitan Monooleate helps to prevent non-specific antibody binding.
Polyoxyethylene (20) Sorbitan Monooleate is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.

Polyoxyethylene (20) Sorbitan Monooleate is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.
Polyoxyethylene (20) Sorbitan Monooleate is also used as wetting agent in rubber balers in the elastomer industry.

Polyoxyethylene (20) Sorbitan Monooleate has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies
Polyoxyethylene (20) Sorbitan Monooleate is a recognised emulsifier used in food and it is expected to have the same effect when applied to feed.
Polyoxyethylene (20) Sorbitan Monooleate is derived from coconut oil.

Polyoxyethylene (20) Sorbitan Monooleate is a non-toxic, nonionic surfactant/emulsifier and a water-soluble yellowish liquid used as a dispersing agent which allows oil and water to mix without the use of alcohol.
Polyoxyethylene (20) Sorbitan Monooleate is a fragrance solubilizer and stabilizer

Polyoxyethylene (20) Sorbitan Monooleate is a nonionic, solubilizer.
Polyoxyethylene (20) Sorbitan Monooleate is used in textile industry

SYNONYMS:

Inhibited ethylene glycol, antifreeze
Polysorbate 80 (glycol)
sorbate80
EG Coolant 1
EG Coolant 2
EG Coolant 3
Tween™ 80
Polyoxyethylene 20 sorbitan monooleate
Polyoxyethylene (20)
Inhibited ethylene glycol
2-hydroxyethyl 2-deoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-{2-[(9E)-octadec-9-enoyloxy]ethyl}hexofuranoside
CAS-9005-65-6
Glycol (polysorbate 80)
Polyoxyethylene sorbitan oleate
CHEBI:53426
9005-65-6
Polyethylene oxide sorbitan mono-oleate
Polyoxyethylene (20) sorbitan monooleate
Tween 20
9005-64-5
Polyoxyethylene (20) sorbitan monolaurate
POLYOXYETHYLENE SORBITAN MONOLAURATE
Polysorbate (INN)
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate
2-(2-(3,4-Bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyl dodecanoate
2-[2-[3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
9005-66-7
Alkest TW 20
Polysorbate 20
Polysorbate 40
Polysorbate 60
Tween 20
Tween 40
Tween 60
POE (6) sorbitol monolaurate
POE(20) sorbitan monolaurate
Ethoxylated Sorbitan monolaurate
POE (20) sorbitan monolaurate
Polyoxyethylenesorbitan monolaurate
PEG-3 SORBITAN STEA- RATE
E432
Polyoxyethylene Sorbitan Monolaurate Kosher
Polyoxyethylene Sorbitan Monolaurate 20 NF
C12 sorbitan monoester, 20 EO (polysorbate 20)
3,6-Anhydro-1-O-[2-(dodecanoyloxy)ethyl]-2,4,5-tris-O-(2-hydroxyethyl)hexitol