PRODUCTS

POLYOXYETHYLENE SORBITAN MONOLAURATE

Polyoxyethylene sorbitan monolaurate is used as a surfactant in cosmetic and personal care products such as creams, lotions, shampoos, and soaps.
Polyoxyethylene sorbitan monolaurate is used as a washing agent in immunological analyses such as western blot and ELISA.
Polyoxyethylene sorbitan monolaurate is also used in some biotechnological processes in cell cultures.

CAS Number: 9005-64-5
EC Number: 500-018-3
MDL Number: MFCD00165986
Chemical Family: Polyethoxylated Sorbitan Ester, Polysorbates
Chemical Name: Sorbitan monolaurate, ethoxylated 1 - 6.5 moles ethoxylated
Chemical formula: C58H114O26
Molar mass: 1226 g/mol

SYNONYMS:
Polysorbate 20, Polyoxyethylene (20) sorbitan monolaurate, 7T1F30V5YH, Polyethylene glycol (44) sorbitan monolaurate, Polyethylene glycol (80) sorbitan monolaurate, Polyethylene glycol 4000 sorbitan monolaurate, Polyethylene glycol 500 sorbitan monolaurate, Polyoxyethylene (10) sorbitan monolaurate, Polyoxyethylene (44) sorbitan monolaurate, Polyoxyethylene (75) sorbitan monolaurate, Polyoxyethylene (80) sorbitan monolaurate, Polyoxyethylene 20 sorbitan monolaurate, FEMA No. 2915, POE 20 Sorbitan monolaurate, PSML, Polyethylene glycol 2000 Sorbitan Laurate, Polyoxyethylene (4) sorbitan monolaurate, Sorbimacrogol laurate 300, Sorbitan monolaurate, ethoxylated, 20s, Polysorbate, Armotan pml-20, CCRIS 699, DTXSID3031949, Dxewmulse poe-sml, E-432, EC 500-018-3, Emsorb 6915, Glycosperse L-20, Glycosperse L-20X, HSDB 7824, Hodag psml-20, INS NO.432, INS-432, Liposorb L-20, PEG-20 SORBITAN, PEG-40 Sorbitan laurate, POLY(OXY-1,2-ETHANEDIYL) DERIVATIVE, POLYSORBATA 20, POLYSORBATE 20 (EP MONOGRAPH), POLYSORBATE 20 (II), POLYSORBATE 20 (MART.), POLYSORBATE 20 (USP-RS), Peg sorbitan laurate, Peg-20 sorbitan laurate, Poly(oxy-1,2-ethanediyl) derivatives, Polyoxyethylene (40) sorbitan laurate, Polyoxyethylene 20 laurate, Polysorbate 20s, Polysorbatum 20, Protasorb L-20, Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monododecanote, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monolaurate, polyoxyethylene derivs., TWEEN-20, UNII-239B50Y732, UNII-31JQ3WOL8T, UNII-4Z93U4C2WN, UNII-59IO08SBZU, UNII-7T1F30V5YH, UNII-I42X3Q0FMF, Montanox 20, Polysorbate 20, PEG(20)sorbitan monolaurate, Alkest TW 20, Tween 20, Polyoxyethylene 20 sorbitan fatty acid ester, Tween 20, Surfacare T20, Sorbitan monolaureate, ethoxylated, Sorbitan, monododecanoate, poly(oxy-1, 2-ethanediyl) derivs., Polyoxyethylene sorbitanmonolaurate, polysorbate 2, Tween 20, Polyoxyethylene sorbitan laurate, Polyoxyethylene sorbitan laurate, Polyoxyethylene sorbitan monolaurate, Emulsifier T-20, Polyoxyethylene (20) Sorbitan Alcohol monolaurate, Polysorbate 20, TWEEN 20, SORBITAN MONOLAURATE, capmul, PEG-80 SORBITAN LAURATE, Polisorbate 20- PS 20, POLYSORBATE 21, POLYOXYETHYLENE SORBITAN MONOLAUREATE, POLYETHYLENE GLYCOL SORBITAN MONOLAURATE, Tween 20, POLYOXYETHYLENE (20) SORBITAN MONOLAURATE, Polisorbate 20- PS 20, Tween 20 (Trademark of ICI America, Inc.), Tween 20?, Tween 20 1LT, Twain 20, TWEEN(R) 20 Vetec(TM) reagent grade, 40%, ACRYL/BIS 37.5:1 PREMIXED PWD ULTRA PURE, TWEEN 20 ELECTROPHORESIS GRADE, Polyoxyethylene (20) sorbitan monolaurate, Kolliphor PS 20, Montanox 20, Polysorbate 20, PEG(20)sorbitan monolaurate, Alkest TW 20, Tween 20, Kotilen-20, Polysorbate 20, Polyoxyethylene (20) sorbitan monolaurate, 7T1F30V5YH, Polyethylene glycol (44) sorbitan monolaurate, Polyethylene glycol (80) sorbitan monolaurate, Polyethylene glycol 4000 sorbitan monolaurate, Polyethylene glycol 500 sorbitan monolaurate, Polyoxyethylene (10) sorbitan monolaurate, Polyoxyethylene (44) sorbitan monolaurate, Polyoxyethylene (75) sorbitan monolaurate, Polyoxyethylene (80) sorbitan monolaurate, Polyoxyethylene 20 sorbitan monolaurate, FEMA No. 2915, POE 20 Sorbitan monolaurate, PSML, Polyethylene glycol 2000 Sorbitan Laurate, Polyoxyethylene (4) sorbitan monolaurate, Sorbimacrogol laurate 300, Sorbitan monolaurate, ethoxylated, 20s, Polysorbate, Armotan pml-20, CCRIS 699, DTXSID3031949, Dxewmulse poe-sml, E-432, EC 500-018-3, Emsorb 6915, Glycosperse L-20, Glycosperse L-20X, HSDB 7824, Hodag psml-20, INS NO.432, INS-432, Liposorb L-20, PEG-20 SORBITAN, PEG-40 Sorbitan laurate, POLY(OXY-1,2-ETHANEDIYL) DERIVATIVE, POLYSORBATA 20, POLYSORBATE 20 (EP MONOGRAPH), POLYSORBATE 20 (II), POLYSORBATE 20 (MART.), POLYSORBATE 20 (USP-RS), Peg sorbitan laurate, Peg-20 sorbitan laurate, Poly(oxy-1,2-ethanediyl) derivatives, Polyoxyethylene (40) sorbitan laurate, Polyoxyethylene 20 laurate, Polysorbate 20s, Polysorbatum 20, Protasorb L-20, Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monododecanote, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monolaurate, polyoxyethylene derivs., TWEEN-20, UNII-239B50Y732, UNII-31JQ3WOL8T, UNII-4Z93U4C2WN, UNII-59IO08SBZU, UNII-7T1F30V5YH, UNII-I42X3Q0FMF, E-432, FEMA NO. 2915, INS NO.432, INS-432, PEG-20 SORBITAN, PEG-20 SORBITAN [VANDF], POLY(OXY-1,2-ETHANEDIYL) DERIVATIVE, POLYOXYETHYLENE 20 SORBITAN MONOLAURATE, POLYOXYETHYLENE 20 SORBITAN MONOLAURATE [WHO-IP], POLYOXYETHYLENE SORBITAN MONOLAURATE, POLYSORBATA 20 [WHO-IP LATIN], POLYSORBATE 20, POLYSORBATE 20 [EP MONOGRAPH], POLYSORBATE 20 [FCC], POLYSORBATE 20 [FHFI], POLYSORBATE 20 [HSDB], POLYSORBATE 20 [II], POLYSORBATE 20 [MART.], POLYSORBATE 20 [USAN], POLYSORBATE 20 [USP-RS], POLYSORBATE 20 [VANDF], POLYSORBATE 20 [WHO-DD], POLYSORBATE 20 [WHO-IP], SORBIMACROGOL LAURATE 300, SORBITAN MONODODECANOATE, TWEEN 20, TWEEN-20, alkamuls PSML-20, cremophor PS 20, emasol L-120V, glycosperse L-20 KFG, hetsorb L-20, kaopan TW-L-120, liposorb L-20, lonzest SML-20, monebatt - 20, mulsifan SML-20, nikkol TL-10, norfox sorbo T-20, peg-20 sorbitan laurate, peg-20 sorbitan monolaurate, polyethylene glycol (20) sorbitan laurate, polyethylene glycol (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan laurate, polyoxyethylene (20) sorbitan monolaurate, rheodol TW-L120, super refined polysorbate 20, T-maz 20K, tween 20, E 432, POE (20) Sorbitan Monolaurate, Polyoxyethylene (20) Sorbitan Monolaurate, PEG 20 Sorbitan Monolaurate, Polysorbate 20, Montanox 20, Polyoxyethylene (20) sorbitan monolaurate, Polysorbate 20, Polyethylene glycol sorbitan monolaurate, Polyoxyethylenesorbitan monolaurate, Polysorbate 20, Polyoxyethylene (20) sorbitan monolaurate, 7T1F30V5YH, Polyethylene glycol (44) sorbitan monolaurate, Polyethylene glycol (80) sorbitan monolaurate, Polyethylene glycol 4000 sorbitan monolaurate, Polyethylene glycol 500 sorbitan monolaurate, Polyoxyethylene (10) sorbitan monolaurate, Polyoxyethylene (44) sorbitan monolaurate, Polyoxyethylene (75) sorbitan monolaurate, Polyoxyethylene (80) sorbitan monolaurate, Polyoxyethylene 20 sorbitan monolaurate, FEMA No. 2915, POE 20 Sorbitan monolaurate, PSML, Polyethylene glycol 2000 Sorbitan Laurate, Polyoxyethylene (4) sorbitan monolaurate, Sorbimacrogol laurate 300, Sorbitan monolaurate, ethoxylated, 20s, Polysorbate, Armotan pml-20, CCRIS 699, DTXSID3031949, Dxewmulse poe-sml, E-432, EC 500-018-3, Emsorb 6915, Glycosperse L-20, Glycosperse L-20X, HSDB 7824, Hodag psml-20, INS NO.432, INS-432, Liposorb L-20, PEG-20 Sorbitan, PEG-40 Sorbitan laurate, POLY(OXY-1,2-ETHANEDIYL) DERIVATIVE, POLYSORBATA 20, POLYSORBATE 20 (EP MONOGRAPH), POLYSORBATE 20 (II), POLYSORBATE 20 (MARCH.), POLYSORBATE 20 (USP-RS), PEG sorbitan laurate, Peg-20 sorbitan laurate, Poly(oxy-1,2-ethanediyl) derivatives, Polyoxyethylene (40) sorbitan laurate, Polyoxyethylene 20 laurate, Polysorbate 20s, Polysorbatum 20, Protasorb L-20, Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monododecanote, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monolaurate, polyoxyethylene derivs., TWEEN-20, UNII-239B50Y732, UNII-31JQ3WOL8T, UNII-4Z93U4C2WN, UNII-59IO08SBZU, UNII-7T1F30V5YH, Polyoxyethylene Sorbitan Monolaurate, 2-(2-(3,4-bis(2-hydroxyethoxy)oxolan-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyl dodecanoate, 618-897-8, DTXSID3031949, E-432, INS NO.432, INS-432, Peg-20 sorbitan, Polysorbata 20, Polysorbate 20, RefChem:929816, Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivs., Tween 20, Tween-20, 7T1F30V5YH, 9005-64-5, CHEBI:53424, FEMA No. 2915, Polyethylene glycol 2000 sorbitan laurate, Polyoxyethylene 20 sorbitan monolaurate, Sorbimacrogol laurate 300, POE 20 Sorbitan monolaurate, Polyethylene glycol (44) sorbitan monolaurate, Polyethylene glycol (80) sorbitan monolaurate, Polyethylene glycol 4000 sorbitan monolaurate, Polyethylene glycol 500 sorbitan monolaurate, Polyoxyethylene (10) sorbitan monolaurate, Polyoxyethylene (20) sorbitan monolaurate, Polyoxyethylene (4) sorbitan monolaurate, Polyoxyethylene (44) sorbitan monolaurate, Polyoxyethylene (75) sorbitan monolaurate, Polyoxyethylene (80) sorbitan monolaurate, 20s, Polysorbate, 20s, Tween, Emsorb 6915, Peg sorbitan laurate, Polyoxyethylene (40) sorbitan laurate, Polysorbate 20s, Sorbitan, monolaurate, polyoxyethylene derivs., Tween 20s

Polyoxyethylene sorbitan monolaurate is derived from coconut oil.
Polyoxyethylene sorbitan monolaurate is a non-toxic, nonionic surfactant/emulsifier and a water-soluble yellowish liquid used as a dispersing agent which allows oil and water to mix without the use of alcohol.
Polyoxyethylene sorbitan monolaurate is a fragrance solubilizer and stabilizer; it lubricates and has a soothing effect on the skin.

This skin- safe ingredient, Polyoxyethylene sorbitan monolaurate, is used extensively in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.) and also for body mists and linen sprays.
Polyoxyethylene sorbitan monolaurate will be found as an ingredient in the majority of body toiletries, cosmetics and wipes now in the market.

Polysorbates are generally used in combination with other emulsifiers such as mono- and diglycerides or sorbitan monostearates for various purposes such as to disperse flavors and colors, to make essential oils and vitamins soluble and to improve volume and texture in baked goods.
Polyoxyethylene sorbitan monolaurate when very little foaming action (or none at all) is desired in the finished product.

Polyoxyethylene sorbitan monolaurate or Tween 20 is a nonionic surfactant and a sorbitol-derived emulsifier based on fruits and berries.
Polyoxyethylene sorbitan monolaurate helps to dilute essential oils or perfume in water-based cosmetics like lotions, creams, gels.
Polyoxyethylene sorbitan monolaurate is produced by ethoxylation.

The number indicates the average number of moles of ethylene oxide reacted per mole of sorbitol.
Polyoxyethylene sorbitan monolaurate is a ubiquitous nonionic surfactant employed in the formulation of countless cosmetic and personal care products.
Polyoxyethylene sorbitan monolaurate can function as a solubilizer, emulsifier, stabilizer, dispersing agent or a wetting agent, among other functions.

Beyond personal care, Polyoxyethylene sorbitan monolaurate has similar functions in the formulation and processing of pharmaceuticals, food and beverage products, agricultural chemicals and household and industrial cleaning products.
Polyoxyethylene sorbitan monolaurate is a complex mixture of laurate esters of sorbitol and sorbitol anhydrides (sorbitans), consisting predominantly of the monoester condensed with approximately 20 moles of ethylene oxide.

Polyoxyethylene sorbitan monolaurate generally conforms to the idealized structure shown in Figure 1—i.e., a four-arm, star-shaped oligomer of polyethylene glycol (PEG) grown from a sorbitan core with a laurate ester end-capping one of the PEG arms.
This representative form of Polyoxyethylene sorbitan monolaurate has an average molecular weight of 1,228 g/mol.

Polyoxyethylene sorbitan monolaurate is synthetic food additive with emulsifying and flavoring role.
Polyoxyethylene sorbitan monolaurate is also used as a solvent for other food additives.
Polyoxyethylene sorbitan monolaurate is not recommended for vegetarians, because it can come from animal fats.

Polyoxyethylene sorbitan monolaurate, commonly referred to as TW20 by us, is a light yellow to yellow liquid, no.: 9005-64-5, E code E432.
Polyoxyethylene sorbitan monolaurate is soluble in water, ethanol, ethyl acetate, and toluene, but insoluble in mineral oils and vegetable oils.
Polyoxyethylene sorbitan monolaurate possesses emulsifying, wetting, and foaming properties.

Polyoxyethylene sorbitan monolaurate belongs to the O/W emulsifier category and has an HLB value of 16.7.
Polyoxyethylene sorbitan monolaurate is a nonionic surfactant used as an emulsifier.
Polyoxyethylene sorbitan monolaurate is soluble in water and its addition to a product makes it more fluid.

Polyoxyethylene sorbitan monolaurate is a nonionic surfactant and an emulsifier used much in cosmetics than in food.
Polyoxyethylene sorbitan monolaurate is distinguished from other polysorbates due to the shortest length of the fatty acid and the highest HLB value.
The number 20 after polysorbate stands for the type of fatty acid linked to the ethoxylated sorbitan part of the molecule, here is monolaurate or lauric acid.

The number 20 following polyoxyethylene means the total number of oxyethylene groups (CH2CH2O) in the molecule of Polyoxyethylene sorbitan monolaurate.
Polyoxyethylene sorbitan monolaurate is the INCI name for sorbitan monolaurate, which primarily finds use in the cosmetics industry but also performs similar functions in the production of pharmaceuticals, food, agricultural chemicals, and household and industrial cleaners.
Polyoxyethylene sorbitan monolaurate, also known as Tween 20, is a widely used non-ionic surfactant and emulsifier in the food, cosmetics, and pharmaceutical industries.

Polyoxyethylene sorbitan monolaurate helps water and oil-based ingredients mix and stay stable over time, making it an essential additive in many processed products.
But what exactly is Polyoxyethylene sorbitan monolaurate, how is it made, comprehensive uses in food, is it safe, and how does it compare to Polysorbate 80?
Polyoxyethylene sorbitan monolaurate, also known as TN20 or Tween 20, is a plant-derived non-ionic surfactant widely used as an emulsifier.

Adding Polyoxyethylene sorbitan monolaurate to your essential or carrier oils means they can be mixed homogeneously with water or alcohol.
Polyoxyethylene sorbitan monolaurate is a clear yellow to brown liquid with a freezing point of -5°C.
Polyoxyethylene sorbitan monolaurate contains 99% active ingredient.

Polyoxyethylene sorbitan monolaurate is well soluble in water and methanol.
Polyoxyethylene sorbitan monolaurate is capable of forming an O/W emulsion (oil-in-water).
Polyoxyethylene sorbitan monolaurate is a non-ionic surfactant and emulsifier used primarily in the cosmetics industry.

Polyoxyethylene sorbitan monolaurate's generic chemical name is ethoxylated sorbitan monolaurate.
Polyoxyethylene sorbitan monolaurate is an amphipathic compound composed of polyoxyethylene sorbitan fatty acid esters.
Polyoxyethylene sorbitan monolaurate is a complex material given the number of possible compounds and structural isomers that can be formed during synthesis.

Polyoxyethylene sorbitan monolaurate is a synthetic compound made by ethoxylating sorbitan monolaurate—a compound derived from sorbitol (a sugar alcohol) and lauric acid (a saturated fatty acid from coconut oil or palm kernel oil).
In skin care, Polyoxyethylene sorbitan monolaurate belongs to a group of cleansing agents most often derived from lauric acid, which is a medium-chain triglyceride (a type of fatty acid) found in coconuts.

Polysorbates for skin function as emulsifiers and have mild surfactant properties; some polysorbates are derived from the food ingredient sorbitol, which occurs naturally in many fruits, while others have a fatty acid component.
Polyoxyethylene sorbitan monolaurate is a chemical compound, a derivative of sorbitan monolaurate and ethylene oxide, commonly used as an emulsifier and surfactant.

Polyoxyethylene sorbitan monolaurate, thanks to its structure containing hydrophilic and lipophilic regions, holds oil and water phases together.
This allows Polyoxyethylene sorbitan monolaurate to form stable emulsions.
This property enables Polyoxyethylene sorbitan monolaurate's widespread use in cosmetic products, as a food additive, and in pharmaceutical formulations.

Polyoxyethylene sorbitan monolaurate is an emulsifying agent consisting of laurate esters of sorbitol consisting of the monoester condensed with ethylene oxide (polyoxyethylene-20 sorbitan monostearate).
HLB Value of Polyoxyethylene sorbitan monolaurate is 16-17 (gives oil-in-water emulsions).
Polyoxyethylene sorbitan monolaurate is non-ionic emulsifier (enables water and oil to mix).

Emulsifying efficacy is increased further when combined with cetyl alcohol or sorbitan stearate.
Polyoxyethylene sorbitan monolaurate acts as dispersing agent and anti-static thickener.
Polyoxyethylene sorbitan monolaurate is very useful as solubilizer and stabilizer of essential oils.

Polyoxyethylene sorbitan monolaurate product is derived from coconut oil.
Polyoxyethylene sorbitan monolaurate is a non-toxic, nonionic surfactant and emulsifier.
Polyoxyethylene sorbitan monolaurate allows for homogeneous mixing of oil and water without the use of alcohol.

Polyoxyethylene sorbitan monolaurate has a moisturizing, nourishing, and soothing effect on the skin.
Polyoxyethylene sorbitan monolaurate is a highly water-loving surfactant and is approved as a food additive.
Polyoxyethylene sorbitan monolaurate is a useful emulsifier, dispersant, and solvent for aromas and oils.

Polyoxyethylene sorbitan monolaurate is also rarely referred to as Tween 20.
Polyoxyethylene sorbitan monolaurate is a surfactant and emulsifier used in many products in the cosmetics field, primarily in cleaning and personal care products.
Polyoxyethylene sorbitan monolaurate is an excellent solvent for essential oils and is also used as a wetting agent, dispersant, and viscosity stabilizer.

Polyoxyethylene sorbitan monolaurate consists of a combination of sorbitan (derived from sorbitol) and ethylene oxide, which is then combined with lauric acid.
The number 20 indicates the number of ethylene oxide units that react with the sorbitan.
Polyoxyethylene sorbitan monolaurate is a yellow liquid, odorless, and soluble in water.

Polyoxyethylene sorbitan monolaurate is a surfactant and emulsifier used in cleaners and personal care products.
Polyoxyethylene sorbitan monolaurate (common commercial brand names include Kolliphor PS 20, Scattics, Alkest TW 20, Tween 20, and Kotilen-20) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan monolaurate.

Polyoxyethylene sorbitan monolaurate's stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.
As the name implies, the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.

USES and APPLICATIONS of POLYOXYETHYLENE SORBITAN MONOLAURATE:
Cosmetics Industry: Polyoxyethylene sorbitan monolaurate is used as a surfactant in cosmetic and personal care products such as creams, lotions, shampoos, and soaps.
Polyoxyethylene sorbitan monolaurate is also used as an emulsifier in shampoos and conditioners.
Chemical Industry: Polyoxyethylene sorbitan monolaurate is used as a washing agent in immunological analyses such as western blot and ELISA.

Polyoxyethylene sorbitan monolaurate is also used in some biotechnological processes in cell cultures.
Cleaning Industry: Polyoxyethylene sorbitan monolaurate is used in cleaning and disinfectant products as a degreaser and remover of dirt, helping to clean surfaces.
Plastics & Rubber Industry: Polyoxyethylene sorbitan monolaurate is used as a wetting agent in rubber baling machines in the elastomer industry.

Textile Industry: Polyoxyethylene sorbitan monolaurate is used during dyeing processes to ensure even dyeing of fabrics and homogeneous distribution of colors on the fabric surface.
Paint Industry: In some paints and varnishes, Polyoxyethylene sorbitan monolaurate is used as a solubility enhancer, helping the product to disperse better and facilitating the mixing of water-based and oil-based components.

Photography Industry: Polyoxyethylene sorbitan monolaurate is used in some photographic solutions and dyes to increase solubility and obtain homogeneous mixtures.
Furthermore, adding Polyoxyethylene sorbitan monolaurate to your essential or fixed oils means you can mix them homogeneously with water or alcohol.
You can experiment with ratios of 1:1 to 1:3 for your essential and fixed oils to Polyoxyethylene sorbitan monolaurate, and distilled water can be added afterwards.

Polyoxyethylene sorbitan monolaurate is also commonly used in candle making.
Emulsifying agent consisting of laurate esters of sorbitol consisting of the monoester condensed with ethylene oxide (polyoxyethylene-20 sorbitan monostearate).
HLB Value of Polyoxyethylene sorbitan monolaurate is 16-17 (gives oil-in-water emulsions).

Polyoxyethylene sorbitan monolaurate can be used as a cleaner and defoamer in industrial uses.
Polyoxyethylene sorbitan monolaurate is an ingredient that is generally used for its emulsifying, stabilizing, wetting and dispersing properties in food, cosmetics and personal care products.
Polyoxyethylene sorbitan monolaurate is a class of nonionic surfactants with emulsification, diffusion, solubility, and stabilization properties.

Polyoxyethylene sorbitan monolaurate is widely used in the pharmaceutical, daily chemical, food, and textile industries as an emulsifier, dispersant, solvent, stabilizer, and similar agent.
As an emulsifier, changes in high electrolyte concentration and pH value have little effect on its emulsifying ability.
Polyoxyethylene sorbitan monolaurate is a good class of oil/water type emulsifier.

When preparing oil/water emulsifiers, Polyoxyethylene sorbitan monolaurate is mostly used in combination with anhydrous sorbitol ester, and the emulsion has better stability.
By changing the type and amount of emulsifier used together, water/oil type or oil/water type emulsions and creams with different textures and consistencies can be produced.
Due to their good emulsification, dispersion, and solubility of various oils such as mineral oil, vegetable oil, and animal fat, these excipients are mainly used in the manufacture of various liquid preparations such as perfumes, mixtures, lotions, emulsions, etc., and semi-solid preparations (e.g., ointments, creams, suppositories, etc.).

Sterile and sterile preparations (eye drops, eye ointments, injections, etc.).
When selecting such excipients, in addition to factors such as the stability of the preparations, special attention should be paid to safety.
Polyoxyethylene sorbitan monolaurate is widely used in science.

Polyoxyethylene sorbitan monolaurate has become an excipient in biopharmaceutical preparations, some of which may possess enzymatic activity.
The effect of Polyoxyethylene sorbitan monolaurate in biopharmaceuticals is based on its role as a stabilizer.
Therefore, Polyoxyethylene sorbitan monolaurate is necessary to keep the structure of the surfactant intact.

If it undergoes auto-oxidation, a Polyoxyethylene sorbitan monolaurate side-chain cleavage occurs, ultimately forming short-chain acids such as formic acid, which can affect the stability of the biopharmaceutical product.
Other pharmaceutical uses include topical analgesics, anti-rheumatic drugs, and sunscreens.
Like Polysorbate 80, Polyoxyethylene sorbitan monolaurate is also listed as a clarifying agent in ophthalmic preparations and as contact lens cleaners or solvents in concentrations not exceeding 1.0%.

In addition to the aforementioned uses, Polyoxyethylene sorbitan monolaurate also acts as an emulsifier in fire-resistant hydraulic fluids.
These are primarily HFA, HFB, HFC, and HFD-U fluids.
In metalworking, Polyoxyethylene sorbitan monolaurate is used as a component of processing fluids.
Polyoxyethylene sorbitan monolaurate increases emulsion stability and improves the foaming properties of fluids used in metalworking processes.

In addition, commercial products containing up to 99% Polyoxyethylene sorbitan monolaurate, such as ROKwinol offered by PCC Group, are used as emulsifiers for pesticide formulations in the agricultural chemicals industry.
Polyoxyethylene sorbitan monolaurate's a common little helper ingredient that helps water and oil to mix together.

Also, Polyoxyethylene sorbitan monolaurate can help to increase the solubility of some other ingredients in the formula.
Polyoxyethylene sorbitan monolaurate is a nonionic emulsifier that dissolves essential oils and essences in water.
Polyoxyethylene sorbitan monolaurate provides a transparent and stable solution in cosmetic, cleaning, and perfume products.

Polyoxyethylene sorbitan monolaurate is a nonionic (non-ionic) surfactant and emulsifier obtained by the reaction of sorbitol and ethylene oxide.
Polyoxyethylene sorbitan monolaurate is widely used as a solvent, emulsifier, and stabilizer in cosmetics, personal care, and cleaning products.
Polyoxyethylene sorbitan monolaurate's most well-known function is to enable oil-based components to mix with water-based formulations.

This property makes Polyoxyethylene sorbitan monolaurate an ideal auxiliary ingredient in making essential oils, perfume essences, and aromas water-soluble.
Polyoxyethylene sorbitan monolaurate's ability to form a transparent solution is a great advantage, especially for room sprays, toners, perfume-based products, shower gels, and shampoos.
Furthermore, Polyoxyethylene sorbitan monolaurate's gentle nature on skin and hair makes it a preferred choice for sensitive formulations.

Polyoxyethylene sorbitan monolaurate yields positive results in oil-in-water emulsions such as lotions, creams, conditioners, cream rinses, and other preparations.
Polyoxyethylene sorbitan monolaurate is commonly used in room sprays, body sprays, and candle making.
You can experiment with mixing your essential and carrier oils with Polyoxyethylene sorbitan monolaurate at ratios ranging from 1:1 to 1:3, and distilled water can be added.

Polyoxyethylene sorbitan monolaurate is used as a high HLB emulsifier in combination with a variety low HLB emulsifiers to cover a wide range of oil in water, and water in oil emulsion systems.
Alone, Polyoxyethylene sorbitan monolaurate is an excellent solubilizer of essential oils, a wetting agent, viscosity modifier, stabilizer and dispersing agent.
Use Polyoxyethylene sorbitan monolaurate in the creation of linen and room sprays, body sprays and other products where oils need to be solubilized in water.

Polyoxyethylene sorbitan monolaurate is used to saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA).
Polyoxyethylene sorbitan monolaurate is used to stabilize proteins purified protein derivative (PPD) solution used in skin testing for tuberculosis exposure.
Polyoxyethylene sorbitan monolaurate is used as a solubilizing agent of membrane proteins

Polyoxyethylene sorbitan monolaurate is used for lysing mammalian cells, at a concentration of 0.05% to 0.5% v/v, generally combined with other detergents, salts and additives.
Pharmaceutical applications: Polyoxyethylene sorbitan monolaurate is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.
Polyoxyethylene sorbitan monolaurate helps to prevent non-specific antibody binding.

In this major application, Polyoxyethylene sorbitan monolaurate is dissolved in Tris-buffered saline or phosphate buffered saline at dilutions of 0.05% to 0.5% v/v.
These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific background.

Polyoxyethylene sorbitan monolaurate is used Hair washing, conditioning and styling products, Cosmetics for washing and caring for the body and face.
Polyoxyethylene sorbitan monolaurate is used makeup products and makeup removers, Preparations for hair dyeing and color removal.
Polyoxyethylene sorbitan monolaurate is used aftershave and other alcohol-based products, sunscreens, perfumes, body fragrances, intimate hygiene lotions and gels, lip care products, Anti-acne preparations, air fresheners, nail polish and nail polish removers, fire-resistant hydraulic fluids, oils and cutting fluids, agricultural chemicals.

The many uses of Polyoxyethylene sorbitan monolaurate in personal care, as previously mentioned, are well-known.
Polyoxyethylene sorbitan monolaurate was a key material employed by Griffin in pioneering the development of the HLB system for emulsifier selection more than 60 years ago, a system still used today.
With an HLB value of 16.7, Polyoxyethylene sorbitan monolaurate is a potent micro-emulsifier for the solubilization of water-insoluble compounds, e.g. active ingredients, fragrance oils, etc., and in combination with SL, Polyoxyethylene sorbitan monolaurate is a highly effective o/w emulsifier.

Like other high-HLB ethoxylated nonionic surfactants, Polyoxyethylene sorbitan monolaurate may be used to decrease the irritation potential of harsh detersive surfactants; in fact, it was employed in the development of the first baby shampoo products.
Polyoxyethylene sorbitan monolaurate is also used to decrease the viscosity of surfactant solutions, presumably due to its ability to disrupt the formation of entangled worm-like micelles.

Polyoxyethylene sorbitan monolaurate can be added to formulas as is.
Typical use level of Polyoxyethylene sorbitan monolaurate is 2 - 10%.
Polyoxyethylene sorbitan monolaurate is used for external use only.

Applications of Polyoxyethylene sorbitan monolaurate: Creams, salves, ointments, balms, pomades, lipsticks, mascaras, glosses.
Uses of Polyoxyethylene sorbitan monolaurate: Emulsifiers, Cosmetics, Topical medications, Surfactants, Dispersing agents, Defoamers, Oral and parenteral medicatons.
Polyoxyethylene sorbitan monolaurate is used in fine bakery products, sauces, desserts, confectioneries, fat emulsions for pastry, instant soups, ice, dietetic foods for body weight control.

In addition to its use in both leave-on and rinse-off skin care products, Polyoxyethylene sorbitan monolaurate is also used as a food additive to create a “spreading” feel (such as in cooling mint drops).
Because of its stability, Polyoxyethylene sorbitan monolaurate is also used in drug delivery systems for oral medications to help keep them stable in the presence of digestive enzymes.
The highest concentration of Polyoxyethylene sorbitan monolaurate as used in cosmetics is in spray deodorants, where it is used in a concentration of 4%.

Polyoxyethylene sorbitan monolaurate is commonly used as an emulsifier and surfactant.
Polyoxyethylene sorbitan monolaurate is a chemical compound that is a derivative of sorbitan monolaurate and ethylene oxide.
Polyoxyethylene sorbitan monolaurate has a wide range of applications in the cosmetics, food, and pharmaceutical industries.

-Food uses of Polyoxyethylene sorbitan monolaurate:
Different with polysorbate 60 and 80, Polyoxyethylene sorbitan monolaurate is used less as an emulsifier and stabilizer in food, and if it is in food, it is commonly used as an indirect additive instead of a direct additive.
However, in Europe, Polyoxyethylene sorbitan monolaurate is a direct additive sharing the same applications with other polysorbates.

-Cosmetics use of Polyoxyethylene sorbitan monolaurate:
Polyoxyethylene sorbitan monolaurate functions as an emulsifying and surfactant (4) in cosmetics and skin care products.
Also, Polyoxyethylene sorbitan monolaurate acts as a viscosity modifier, dispersing agent, solubilizer and stabilizer to help blend oil and water together.
Mostly, Polyoxyethylene sorbitan monolaurate is a solubilizing agent to distribute fragrance, colors and essential oils into water, if without it, these ingredients and water will separate.
As a high HLB emulsifier, Polyoxyethylene sorbitan monolaurate can also be combined with a low HLB emulsifier (e.g. sorbitan esters) to provide either oil in water, or water in oil emulsion.
Following cosmetic products may contain Polyoxyethylene sorbitan monolaurate:
*skin care products
*hair products
*Bath oils
*shampoos
*body sprays
*face wash
*Lotions
*deodorant
*Industrial

-Uses of Polyoxyethylene sorbitan monolaurate in Cosmetics and Personal Care:
Polyoxyethylene sorbitan monolaurate is used as an emulsifier in skincare products, shampoos, and makeup.
Polyoxyethylene sorbitan monolaurate improves product stability and extends shelf life.

-Applications of Polyoxyethylene sorbitan monolaurate in the Food Industry:
Polyoxyethylene sorbitan monolaurate is used as a food additive, especially as an emulsifier in sauces, desserts, and ice cream.
This improves the freshness and safety of foods.

-Polyoxyethylene sorbitan monolaurate's Role in the Pharmaceutical Industry:
Polyoxyethylene sorbitan monolaurate is used as a stabilizer in medicinal products, particularly syrups, creams, and eye drops.
Polyoxyethylene sorbitan monolaurate increases the efficacy and stability of the drug.

-Besides its role in food, Polyoxyethylene sorbitan monolaurate is also used in:
● Cosmetics and personal care (e.g. facial sprays, makeup removers)
● Pharmaceuticals (e.g. stabilizing proteins in biologics)
● Laboratory reagents (e.g. cell lysis buffers, cleaning agents)

-Cosmetics and Personal Care Products use of Polyoxyethylene sorbitan monolaurate:
Applications: Polyoxyethylene sorbitan monolaurate is used as an emulsifier in shampoos, conditioners, skin care products, body lotions, and makeup products.
Polyoxyethylene sorbitan monolaurate is also used as a stabilizer in products.
Dosage Rate of Polyoxyethylene sorbitan monolaurate:
Typically ranges from 0.5% to 5%.
This rate can be adjusted depending on the product formulation and intended effect.

-Food Industry uses of Polyoxyethylene sorbitan monolaurate:
Application Area: Polyoxyethylene sorbitan monolaurate is used as a food additive, especially as an emulsifier in ice creams, sauces, and desserts.
Usage Rate of Polyoxyethylene sorbitan monolaurate: Usage rates in food products generally range from 0.1% to 1%.
The FDA has set maximum usage limits for specific foods.

-Pharmaceutical Industry uses of Polyoxyethylene sorbitan monolaurate:
Application Area: Polyoxyethylene sorbitan monolaurate is used as a stabilizer and emulsifier in pharmaceutical formulations.
Particularly common in syrups, creams, and eye drops.
Usage Rate of Polyoxyethylene sorbitan monolaurate: Usage rates in pharmaceutical formulations are typically between 0.5% and 5%.

-Food applications of Polyoxyethylene sorbitan monolaurate:
Polyoxyethylene sorbitan monolaurate is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.
The World Health Organization has suggested acceptable daily intake limits of 0–25 mg of polyoxyethylene sorbitan esters per kg body weight.

-Cleaning Products use of Polyoxyethylene sorbitan monolaurate:
Application Area: Polyoxyethylene sorbitan monolaurate is used as a surfactant in detergents, dishwashing liquids, and laundry detergents.
Usage Rate of Polyoxyethylene sorbitan monolaurate: Usage rates in cleaning products can vary between 0.1% and 2%.

-Effectiveness in Industrial Applications:
Polyoxyethylene sorbitan monolaurate improves product quality by being used as a surfactant in cleaning products.
Polyoxyethylene sorbitan monolaurate provides effective cleaning, especially in detergents.

High pH Stability:
Polyoxyethylene sorbitan monolaurate has the ability to remain stable over a wide pH range.
This makes Polyoxyethylene sorbitan monolaurate effective in both acidic and basic environments.
In skincare, Polyoxyethylene sorbitan monolaurate belongs to a group of cleansing agents derived from lauric acid, a medium-chain triglyceride (a type of fatty acid) most commonly found in coconut.

Polysorbates for skin act as emulsifiers and possess mild surfactant properties; some polysorbates are derived from sorbitol, a food component naturally found in many fruits, while others contain a fatty acid component.
Besides its use in non-foaming and rinse-off skincare products, Polyoxyethylene sorbitan monolaurate is also used as a food additive to create a "melting" sensation (e.g., in cooling mints).

Due to its stability, Polyoxyethylene sorbitan monolaurate is also used in drug delivery systems for oral medications to maintain their stability in the presence of digestive enzymes.
Although there are some concerns about the safety of Polyoxyethylene sorbitan monolaurate, an independent cosmetic ingredient review panel has found its use in cosmetics to be safe.
The highest concentration of Polyoxyethylene sorbitan monolaurate used in cosmetics is in deodorant sprays, where it is used at a concentration of 4%.

-Industrial and domestic applications of Polyoxyethylene sorbitan monolaurate:
Polyoxyethylene sorbitan monolaurate is used in many brands of baby wipes.
Polyoxyethylene sorbitan monolaurate is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.
Polyoxyethylene sorbitan monolaurate is also used as wetting agent in rubber balers in the elastomer industry.
Polyoxyethylene sorbitan monolaurate has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies

-Biotechnical applications of Polyoxyethylene sorbitan monolaurate:
In biological techniques and sciences, Polyoxyethylene sorbitan monolaurate has a broad range of applications.
For example, Polyoxyethylene sorbitan monolaurate is used: as a washing agent in immunoassays, such as Western blots and ELISAs.

HOW IS POLYOXYETHYLENE SORBITAN MONOLAURATE USED IN FOOD?
In the food industry, Polyoxyethylene sorbitan monolaurate (E432) is used primarily as an emulsifier, dispersing agent, and stabilizer.
Polyoxyethylene sorbitan monolaurate is especially valuable in systems where oil and water need to remain mixed during processing, packaging, and shelf life.
Polyoxyethylene sorbitan monolaurate is classified as a hydrophilic emulsifier, meaning it favors the water phase and helps stabilize oil-in-water emulsions.

USAGE AND BENEFITS of POLYOXYETHYLENE SORBITAN MONOLAURATE:
Polyoxyethylene sorbitan monolaurate functions as a surfactant and emulsifier in cosmetic products.
As a surfactant, Polyoxyethylene sorbitan monolaurate reduces the surface tension between two components of the product, such as two liquids or a liquid and a solid.
Because Polyoxyethylene sorbitan monolaurate contains both hydrophilic (water-loving) and hydrophobic (oil-loving) ends in a single molecule, it attracts dirt, oil, and other impurities accumulated on the skin surface from the oil-loving end, which can then be washed away easily with water from the water-loving end.

As an emulsifier, Polyoxyethylene sorbitan monolaurate provides stability to the product.
Polyoxyethylene sorbitan monolaurate is a product with oil and water-based components will separate into its constituent parts.
Polyoxyethylene sorbitan monolaurate acts as an interface between oil and water to hold them together in a product.

Polyoxyethylene sorbitan monolaurate stabilizes the product, prevents the separation of components, and ensures even distribution of product components when used.
Many environmental conditions, such as temperature fluctuations and humidity changes, can also disrupt the stability of a product without an emulsifier.
Polyoxyethylene sorbitan monolaurate is used in the formulations of cleansing products, makeup bases, foundations, shampoos, and other skin and personal care products.

BENEFITS AND PROPERTIES OF POLYOXYETHYLENE SORBITAN MONOLAURATE:
Formulation Advantages:
Polyoxyethylene sorbitan monolaurate enables the mixing of oil-based raw materials with water-based products.
Polyoxyethylene sorbitan monolaurate forms homogeneous and transparent solutions.
Polyoxyethylene sorbitan monolaurate enhances foam stability, supporting the longevity of lather in shampoos and shower gels.

In Skin and Hair Products:
Its gentle formula makes Polyoxyethylene sorbitan monolaurate suitable for use in formulations that include sensitive skin.
Polyoxyethylene sorbitan monolaurate supports the hair care products' moisture retention capacity.
Polyoxyethylene sorbitan monolaurate is ideal for dissolving essential oils in tonics and lotions.

For Industrial Use:
Polyoxyethylene sorbitan monolaurate is commonly used to dissolve fragrances in room and textile sprays.
Polyoxyethylene sorbitan monolaurate provides transparency in perfumes and deodorants.
Polyoxyethylene sorbitan monolaurate acts as a degreaser and emulsifier in cleaning products.

POLYOXYETHYLENE SORBITAN MONOLAURATE AT A GLANCE:
Polyoxyethylene sorbitan monolaurate is used as a mild cleansing agent
Derived from lauric acid, the primary fatty acid in coconuts
Polyoxyethylene sorbitan monolaurate is also used as a food additive
Polyoxyethylene sorbitan monolaurate can be used to keep oral medications stable

BENEFITS of POLYOXYETHYLENE SORBITAN MONOLAURATE:
Non-ionic emulsifier (enables water and oil to mix)
Emulsifying efficacy is increased further when combined with cetyl alcohol or sorbitan stearate
Polyoxyethylene sorbitan monolaurate acts as dispersing agent and anti-static thickener
Very useful as solubilizer and stabilizer of essential oils.

INTERESTING FACTS ABOUT POLYOXYETHYLENE SORBITAN MONOLAURATE:
Emulsifier Properties:
Polyoxyethylene sorbitan monolaurate, thanks to its hydrophilic and lipophilic domains, holds oil and water phases together.
This allows Polyoxyethylene sorbitan monolaurate to form stable emulsions.
This property makes Polyoxyethylene sorbitan monolaurate indispensable in many industries.

History and Discovery:
Polyoxyethylene sorbitan monolaurate is a surfactant developed in the 1940s.
Since then, Polyoxyethylene sorbitan monolaurate has found widespread use in the cosmetics, food, and pharmaceutical industries.

Environmental Safety:
Polyoxyethylene sorbitan monolaurate is a biodegradable and environmentally friendly chemical.
Polyoxyethylene sorbitan monolaurate does not persist in the aquatic environment for long and is generally broken down by microorganisms.

HOW IS POLYOXYETHYLENE SORBITAN MONOLAURATE MADE?
Generally, it is produced by the reaction among sorbitol, lauric acid and ethylene oxide.
The manufacturing process is similar with that of polysorbate 80, esterification between sorbitol and lauric acid first to synthesize sorbitan esters and then condensed with ethylene oxide OR by reacting sorbitol and ethylene oxide initially then esterified with lauric acid.

Lauric Acid
Lauric acid (C12H24O2) is a saturated fatty acid found naturally and the following are its common food sources:
coconut oil
palm kernel oil
yeast extract
butter

Commercial lauric acid is not pure and is a mixture of several fatty acids.
Lauric acid is the shortest length compared with the other three following fatty acids that are linked to the ethoxylated sorbitan part to produce polysorbate 40, 60, 65, 80.
Oleic Acid (C18H34O2)
Stearic acid (C18H36O2)
Palmitic acid (C16H32O2)

PROPERTIES of POLYOXYETHYLENE SORBITAN MONOLAURATE:
an oily, viscous liquid,
from lemon to amber color,
light, distinct scent,
Polyoxyethylene sorbitan monolaurate is soluble in water (cold or hot), methanol, ethanol, ethyl acetate, and dioxane.
Polyoxyethylene sorbitan monolaurate is insoluble in mineral oil and petroleum ether.
Polyoxyethylene sorbitan monolaurate is stable in the presence of weak acids and bases.
hygroscopic (material may contain up to 3% water by weight),
Long-term storage can lead to peroxide formation.
biodegradble,
Polyoxyethylene sorbitan monolaurate is highly effective in oil-in-water emulsions (O/W emulsions),
paraben-containing preservatives can reduce their effectiveness.
Polyoxyethylene sorbitan monolaurate shows resistance in hard water.
non-toxic.

THE FUNCTIONS AND EFFECTS OF POLYOXYETHYLENE SORBITAN MONOLAURATE IN COSMETICS
The most common application for Polyoxyethylene sorbitan monolaurate is in all types of cosmetic and personal care products.
Among other things, Polyoxyethylene sorbitan monolaurate is used as a solvent for other components of cosmetic formulations, and as an emulsifier allowing the combination of hydrophilic and hydrophobic components (primarily used in oil-in-water emulsions).
Polyoxyethylene sorbitan monolaurate also acts as a stabilizer for the resulting product (preventing phase separation in the emulsion) and the resulting foam.

Polyoxyethylene sorbitan monolaurate is also used to reduce the viscosity of surfactant solutions.
Polyoxyethylene sorbitan monolaurate is considered a mild cleaning detergent that does not cause irritation.
As a cosmetic component, Polyoxyethylene sorbitan monolaurate moisturizes and soothes the skin.

Polyoxyethylene sorbitan monolaurate reduces the potential irritating and drying properties of other cosmetic components.
Polyoxyethylene sorbitan monolaurate was even used in the first shampoos designed for children.
Polyoxyethylene sorbitan monolaurate is an effective microemulsifier and solvent for dissolving compounds such as essential oils and perfumes in water.

Among all compounds in the polysorbate group, Polyoxyethylene sorbitan monolaurate has the mildest effect.
Products containing Polyoxyethylene sorbitan monolaurate: lotions, liquid soaps, hair conditioner, shampoos, body scrub, body mists, hair styling products, gargles.

CHARACTERISTICS of POLYOXYETHYLENE SORBITAN MONOLAURATE:
Polyoxyethylene sorbitan monolaurate is a non-ionic surfactant and emulsifier primarily used in the cosmetics industry.
Polyoxyethylene sorbitan monolaurate's generic chemical name is ethoxylated sorbitan monolaurate.
Polyoxyethylene sorbitan monolaurate's CAS number is 9005-64-5 .
Polyoxyethylene sorbitan monolaurate is an amphipathic compound composed of polyoxyethylene sorbitan fatty acid esters.
Polyoxyethylene sorbitan monolaurate is a complex material given the number of possible compounds and structural isomers that can be formed during synthesis.

ALTERNATIVE PARENTS of POLYOXYETHYLENE SORBITAN MONOLAURATE:
*Tetrahydrofurans
*Carboxylic acid esters
*Oxacyclic compounds
*Monocarboxylic acids and derivatives
*Dialkyl ethers
*Primary alcohols
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds

SUBSTITUENTS of POLYOXYETHYLENE SORBITAN MONOLAURATE:
*Fatty acid ester
*Tetrahydrofuran
*Carboxylic acid ester
*Carboxylic acid derivative
*Dialkyl ether
*Ether
*Monocarboxylic acid or derivatives
*Organoheterocyclic compound
*Oxacycle
*Organic oxide
*Carbonyl group
*Alcohol
*Organooxygen compound
*Primary alcohol
*Hydrocarbon derivative
*Organic oxygen compound
*Aliphatic heteromonocyclic compound

PROPERTIES of POLYOXYETHYLENE SORBITAN MONOLAURATE:
Appearance
Polyoxyethylene sorbitan monolaurate is a clear, yellow to yellow-green viscous liquid.
Hydrophilic – Lipophilic Balance (HLB)
16.7, oil-in-water (O/W) emulsion

Solubility
Polyoxyethylene sorbitan monolaurate is soluble in water
Polyoxyethylene sorbitan monolaurate is soluble in ethanol, methanol, and ethyl acetate.

FORMULATION GUIDELINES of POLYOXYETHYLENE SORBITAN MONOLAURATE:
Polyoxyethylene sorbitan monolaurate is known to deactivate preservatives (parabens) and antimicrobials due to its propensity to sequester these compounds into its nonionic micelles.
Although parabens are the most notable example, Polyoxyethylene sorbitan monolaurate may also deactivate organic acids such as benzoic acid and sorbic acid as well as benzyl alcohol.

In addition, Polyoxyethylene sorbitan monolaurate may deactivate antimicrobials such as the cationic surfactants benzalkonium chloride and cetylpyridinium chloride.
Therefore, Polyoxyethylene sorbitan monolaurate must be used judiciously and the activity of preservatives and antimicrobials should always be verified via the appropriate efficacy tests when used with Polyoxyethylene sorbitan monolaurate.

FEATURES AND APPLICATIONS OF POLYOXYETHYLENE SORBITAN MONOLAURATE:
Polyoxyethylene sorbitan monolaurate advantages:
strong emulsifying properties,
The active ingredient content in the product should be at the level of 99%.
High solubility in water and methanol,
safe for aquatic environments,
biodegradable product.

FUNCTIONS (INCI) of POLYOXYETHYLENE SORBITAN MONOLAURATE:
Emulsifying :
Polyoxyethylene sorbitan monolaurate promotes the formation of intimate mixtures between immiscible liquids by modifying the interfacial tension (water and oil)
Surfactant :
Polyoxyethylene sorbitan monolaurate reduces the surface tension of cosmetics and contributes to the even distribution of the product when it is used

POLYOXYETHYLENE SORBITAN MONOLAURATE IS PRESENT IN:
Polyoxyethylene sorbitan monolaurate is present in 5.27% of cosmetics.
*Baby cleaning wipes (31.46%)
*Face cleansing wipes (29.3%)
*Intimate wipes (26.19%)
*Moist toilet tissue (22.65%)
*Cleansing wipes (20.72%)

PROPERTIES of POLYOXYETHYLENE SORBITAN MONOLAURATE:
Polyoxyethylene sorbitan monolaurate is a clear, yellow to amber colored, slightly viscous liquid nominally supplied as 100% active product; however, most grades of this hygroscopic material may contain up to 3% w/w water.
Polyoxyethylene sorbitan monolaurate is readily soluble in cold or hot water and has a cloud point in excess of 100°C at 2% w/w.
Polyoxyethylene sorbitan monolaurate is nontoxic, nonirritating and remarkably mild to skin and eyes.

Impurities in Polyoxyethylene sorbitan monolauratel may include nonesterified ethoxylates, e.g. sorbeth-20; unreacted fatty acids, 1,4-dioxane and peroxides formed by auto-oxidation of the PEG chains.

Peroxide formation in Polyoxyethylene sorbitan monolaurate is of particular concern because it may degrade the purity, performance and appearance of the material and promote degradation of other compounds in a given formulation.

High purity grades of Polyoxyethylene sorbitan monolaurate minimize peroxide formation by eliminating the bleaching step during manufacturing and by transporting and storing the material in an inert atmosphere, e.g. under nitrogen.
Polyoxyethylene sorbitan monolaurate is a non-ionic surfactant based on natural raw materials.

CHEMISTRY AND MANUFACTURE of POLYOXYETHYLENE SORBITAN MONOLAURATE:
The key commodity feedstocks for Polyoxyethylene sorbitan monolaurate are sorbitol, fatty acids with an average alkyl chain length of 12 carbon atoms, and ethylene oxide (EO).
Sorbitol is a six-carbon sugar alcohol obtained from either the catalytic hydrogenation of glucose or the simultaneous hydrolysis and hydrogenation of starch, cotton cellulose or sucrose.

The fatty acids consisting primarily of the C12 lauric acid are usually isolated by distillation of coconut or palm kernel fatty acids, which are obtained from saponification and hydrogenation of the respective oils.
EO is a petrochemical intermediate produced by direct oxidation of ethylene gas using air or oxygen and a silver-based catalyst.

Polyoxyethylene sorbitan monolaurate may be synthesized by one of two possible routes:
anhydrization and ethoxylation of sorbitol with 20 moles of EO to form sorbeth-20, followed by esterification with lauric acid; or anhydrization of sorbitol and esterification with lauric acid to form sorbitan laurate (SL), followed by ethoxylation with 20 moles of EO.
In practice, the latter route, shown in Figure 2, is employed commercially and depending on the exact process, may utilize either base catalysis as shown or a combination of acid and base catalysis.

Polyoxyethylene sorbitan monolaurate is a complex material due to the number of possible compounds and structural isomers that may form during its synthesis.
For example, in the first step, sorbitol is anhydridized using either an acidic or alkaline catalyst to form sorbitan, the cyclic ether of sorbitol obtained upon the loss of an equivalent of water.
Depicts the four isomers of sorbitan that may form during the anhydrization of sorbitol—in this case, acid-catalyzed.

The major product is 1,4-sorbitan (typically ≥ 85%), yet three other isomers may also form in minor amounts; namely the 3,6-, 2,5- and 1,5-sorbitans.
Further anhydridization of the 1,4- and 3,6-sorbitans inevitably occurs during sorbitan synthesis and results in the formation of small amounts of isosorbide.
If isosorbide is the desired product, it is obtained in high yield simply by driving the anhydridization of the 1,4- and 3,6-sorbitans with longer reaction times, higher temperatures, and/or by reacting under vacuum.

In the first step of Polyoxyethylene sorbitan monolaurate synthesis, shown in Figure 2a, the base-catalyzed anhydrization of sorbitol to sorbitan is accompanied by simultaneous esterification with lauric acid to yield SL as the major product (1,4-sorbitan isomer, shown) producing water as a by-product.
Esterification is possible at any of the four available hydroxyl (–OH) positions on the sorbitan; however, ester formation at the primary –OH groups is most favorable.

Also formed in this reaction are minor amounts of the monolaurate ester of isosorbide, as well as diesters of sorbitan and isosorbide.
Thus, SL is truly a complex composition of various species, not one distinct molecule.
In addition to being a precursor for other nonionic surfactants, SL itself is useful as a low hydrophilic-lipophilic balance (HLB = 8.6) nonionic emulsifier.
SL is converted to Polyoxyethylene sorbitan monolaurate by base-catalyzed oligomerization of EO initiated from the –OH groups of SL to add short PEG chains to the molecule, as illustrated in Figure 2b.

Under these reaction conditions, extensive transesterification occurs and upon completion of the ethoxylation reaction, the laurate esters are positioned at the ends of the PEG chains.
A broad distribution of molecular configurations is possible but on average, the resulting product comprises a 20-mol ethoxylate of sorbitan bearing one laurate ester.

Crude Polyoxyethylene sorbitan monolaurate may be bleached and/or treated with activated carbon and filtered to lighten the color of the product.
Additionally, steam- and/or vacuum-stripping techniques are employed to eliminate residual EO and reduce 1,4-dioxane by-product to levels of ≤ 5 ppm

WHAT IS IT?
Polyoxyethylene sorbitan monolaurate and the other Polysorbate ingredients (Polysorbate 21, Polysorbate 40, Polysorbate 60, Polysorbate 61, Polysorbate 65, Polysorbate 65, Polysorbate 80, Polysorbate 81, Polysorbate 85) are a series of general purpose hydrophilic, nonionic surfactants.
The Polysorbates are used in a variety of products including skin fresheners, skin care products, skin cleansing products, makeup bases and foundations, shampoos, permanent waves and fragrance powders.

WHY IS IT USED?
The Polysorbate ingredients help other ingredients to dissolve in a solvent in which they would not normally dissolve.
They also help to form emulsions by reducing the surface tension of the substances to be emulsified.

SCIENTIFIC FACTS
Polysorbates are surfactants that are produced by reacting the polyol, sorbitol, with ethylene oxide.
The number in the name of the Polysorbate indicates the average number of moles of ethylene oxide that has been reacted per mole of sorbitol.
The polyoxyethylenated sorbitan is then reacted with fatty acids obtained from vegetable fats and oils such as lauric acid, palmitic acid, stearic acid and oleic acid.
Polysorbates function to disperse oil in water as opposed to water in oil

PHYSICAL and CHEMICAL PROPERTIES of POLYOXYETHYLENE SORBITAN MONOLAURATE:
Melting point: 98.9 °C (decomposition)
Boiling point: 100 °C
Density: 1.11 g/mL at 20 °C
Vapor pressure: <1.4 hPa (20 °C)
FEMA: 2915 | POLYOXYETHYLENE SORBITAN MONOLAURATE
Refractive index: n20/D 1.468 (literature value)
Flash point: >230 °F
Storage temperature: Store below +30°C
Solubility: 100 g/L

Form: Viscous liquid
Color: Amber
Specific Gravity: 1.090 to 1.130 (20/20℃)
pH: 6-8 (50g/l, H2O, 20℃)
pH Range: 7
Odor: Mild alcohol odor
Odor Type: Alcoholic
Water Solubility: 100 g/L
Hydrophilic-Lipophilic Balance (HLB): 16.7
Stability: Stable. Incompatible with strong oxidizing agents

Substances Added to Food (formerly EAFUS): POLYOXYETHYLENE SORBITAN MONOLAURATE
EWG's Food Scores: 3-8
FDA UNII: PEG-80 SORBITAN LAURATE (239B50Y732), PEG-75 SORBITAN LAURATE (31JQ3WOL8T),
PEG-10 SORBITAN LAURATE (4Z93U4C2WN), POLYSORBATE 21 (59IO08SBZU), POLYOXYETHYLENE SORBITAN MONOLAURATE (7T1F30V5YH)
EPA Substance Registry System: Polyoxyethylene sorbitan monolaurate (9005-64-5)
Cosmetics Info: Polyoxyethylene sorbitan monolaurate
Chemical formula: C58H114O26
Molar mass: 1226 g/mol

Appearance: Clear, yellow to yellow-green viscous liquid
Density: 1.1 g/mL (approximate)
Boiling point: > 100 °C (212 °F; 373 K)
Surface tension:
CMC: 8.04×10^−5 M at 21 °C
HLB: 16.7
Relative Density: About 1.10
Viscosity: About 400 mPa s at 25°C
IUPAC: Polyoxyethylene (20) sorbitan monooleate

INCI: POLYOXYETHYLENE SORBITAN MONOLAURATE
CAS: 9005-64-5
Molar mass: 522.70 g/mol
Density: 1.10 g/mL at 20 °C
Solubility: Soluble in water, alcohols, glycerol ethers,
glycols, esters, ketones, aromatic and aliphatic hydrocarbons
CBNumber: CB3462544
Molecular Formula: C26H50O10
Molecular Weight: 522.6692 g/mol

MDL Number: MFCD00165986
MOL File: 9005-64-5.mol
Appearance: Pale yellow clear viscous liquid (estimated)
Assay: 96.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 1.09100 to 1.09600 @ 25.00 °C
Pounds per Gallon - (estimated): 9.078 to 9.120

Refractive Index: 1.45900 to 1.47000 @ 20.00 °C
Acid Value: 3.00 max. KOH/g
pH Number: 5.71
Flash Point: > 230.00 °F. TCC (> 110.00 °C)
Shelf Life: 24.00 month(s) or longer if stored properly
Storage: Store in cool, dry place in tightly sealed containers,
protected from heat and light
Soluble in: alcohol, oils, water

Appearance at 25ºC: Clear liquid
Active content %: 97
Nature: Nonionic
Acid value mg KOH/gm max: 2
Color gardner: 3
Hydroxyl value mg KOH/gm: 96-108
% Moisture content by KF: 3
pH: 5-7
Saponification value: 40-50

Molecular Formula: C58H114O26
Molecular Weight: 1127.48
Grade: Pharmaceutical Excipients
Description: This product is an amber viscous liquid with a
slight special odor and slightly bitter taste.
UNII: 7T1F30V5YH
Chemical Name: Polyoxyethylene 20 sorbitan monolaurate
CAS Number: 9005-64-5

Product Name: Polyoxyethylene sorbitan monolaurate
CAS No.: 9005-64-5
InChIKeys: HMFKFHLTUCJZJO-UHFFFAOYSA-N
Molecular Weight: 346.459991455078
Exact Mass: 604.418640
EC Number: 500-018-3
DSSTox ID: DTXSID3031949
Color/Form: Lemon- to amber-colored liquid
HScode: 34021300

Categories: Emulsifier
PSA: 133.14000
XLogP3: 5.37
Appearance: Amber viscous liquid
Density: 1.1±0.1 g/cm3
Melting Point: 98.9 °C (decomp)
Boiling Point: 100 °C
Flash Point: >230 °F
Refractive Index: 1.502
Water Solubility: 100 g/L

Storage Conditions: 0-6°C
Vapor Pressure: <1.4 hPa (20 °C)
Odor: Characteristic odor
Taste: Bitter
Melting point: 98.9 °C (decomposition)
Boiling point: 100 °C
Density: 1.11 g/mL at 20 °C
Vapor pressure: <1.4 hPa (20 °C)

FEMA: 2915 | POLYOXYETHYLENE SORBITAN MONOLAURATE
Refractive index: n20/D 1.468 (literature value)
Flash point: >230 °F
Storage temperature: Store below +30°C
Solubility: 100 g/L
Form: Viscous liquid
Color: Amber
Specific Gravity: 1.090 to 1.130 (20/20℃)

pH: 6-8 (50g/l, H2O, 20℃)
pH Range: 7
Odor: Mild alcohol odor
Odor Type: Alcoholic
Water Solubility: 100 g/L
Hydrophilic-Lipophilic Balance (HLB): 16.7
Stability: Stable. Incompatible with strong oxidizing agents
Substances Added to Food (formerly EAFUS): POLYOXYETHYLENE SORBITAN MONOLAURATE

EWG's Food Scores: 3-8
FDA UNII: PEG-80 SORBITAN LAURATE (239B50Y732), PEG-75 SORBITAN LAURATE (31JQ3WOL8T),
PEG-10 SORBITAN LAURATE (4Z93U4C2WN), POLYSORBATE 21 (59IO08SBZU), POLYOXYETHYLENE SORBITAN MONOLAURATE (7T1F30V5YH)
EPA Substance Registry System: Polyoxyethylene sorbitan monolaurate (9005-64-5)
Cosmetics Info: Polyoxyethylene sorbitan monolaurate
Chemical formula: C58H114O26
Molar mass: 1226 g/mol
Appearance: Clear, yellow to yellow-green viscous liquid

Density: 1.1 g/mL (approximate)
Boiling point: > 100 °C (212 °F; 373 K)
Surface tension:
CMC: 8.04×10^−5 M at 21 °C
HLB: 16.7
Relative Density: About 1.10
Viscosity: About 400 mPa s at 25°C
IUPAC: Polyoxyethylene (20) sorbitan monooleate

Acid Value: 3.00 max. KOH/g
pH Number: 5.71
Flash Point: > 230.00 °F. TCC (> 110.00 °C)
Shelf Life: 24.00 month(s) or longer if stored properly
Storage: Store in cool, dry place in tightly sealed containers,
protected from heat and light
Soluble in: alcohol, oils, water
Appearance at 25ºC: Clear liquid

Active content %: 97
Nature: Nonionic
Acid value mg KOH/gm max: 2
Color gardner: 3
Hydroxyl value mg KOH/gm: 96-108
% Moisture content by KF: 3
pH: 5-7
Saponification value: 40-50
Molecular Formula: C58H114O26
Molecular Weight: 1127.48

Grade: Pharmaceutical Excipients
Description: This product is an amber viscous liquid with a
slight special odor and slightly bitter taste.
UNII: 7T1F30V5YH
Chemical Name: Polyoxyethylene 20 sorbitan monolaurate
CAS Number: 9005-64-5
Chemical Formula: C58H114O26
Molar mass: 1226 g/mol

Appearance: Clear, yellow to yellow-green viscous liquid.
Density: 1.1 g/mL (approximate)
Boiling point: > 100 °C (212 °F; 373 K)
Surface tension: CMC 8.04×10−5 M at 21 °C
HLB: 16.7
Water Solubility: 0.018 g/L
logP: 2.75
logP: 2.39
logS: -4.5

pKa (Strongest Acidic): 14.64
pKa (Strongest Basic): -2.7
Physiological Charge: 0
Hydrogen Acceptor Count: 9
Hydrogen Donor Count: 3
Polar Surface Area: 133.14 Å²
Rotatable Bond Count: 26
Refractivity: 134.25 m³•mol⁻¹
Polarizability: 60.33 Å³

Number of Rings: 1
Bioavailability: No
Rule of Five: No
Ghose Filter: No
Veber's Rule: No
MDDR-like Rule: No
Chemical Formula: C26H50O10
IUPAC name: 2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate

InChI Identifier: InChI=1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3
InChI Key: HMFKFHLTUCJZJO-UHFFFAOYSA-N
Isomeric SMILES: CCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO
Average Molecular Weight: 522.6692
Monoisotopic Molecular Weight: 522.34039782
Appearance: Oily, yellow to brownish-yellow, clear or slightly opalescent liquid.
Solubility: Soluble in water, ethanol, ethyl acetate and methanol, practically insoluble in fatty oils and liquid paraffin.
Relative Density: About 1.10.

Viscosity: About 400 mPa s at 25°C.
Full Name: Polyethylene glycol sorbitan monolaurate
Synonym: Polyoxyethylene sorbitan monolaurate
CAS Number: 9005-64-5
Molecular Formula: C18H34O6•[C2H4O]w+x+y+z for w+x+y+z =20
Molecular Weight: ~1227 (for w+x+y+z =20)
Absorbance (215nm): 0.05 (0.05% w/v)
Critical Micelle Concentration (CMC): ~0.06 x 10-3M (25ºC)
Cloud Point: 76ºC

FIRST AID MEASURES of POLYOXYETHYLENE SORBITAN MONOLAURATE:
-Description of first-aid measures:
*After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*After swallowing:
Make victim drink water (two glasses at most).

ACCIDENTAL RELEASE MEASURES of POLYOXYETHYLENE SORBITAN MONOLAURATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of POLYOXYETHYLENE SORBITAN MONOLAURATE:
-Extinguishing media:
*Suitable extinguishing media:
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of POLYOXYETHYLENE SORBITAN MONOLAURATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Safety glasses.
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 30 min
*Respiratory protection:
Not required.
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of POLYOXYETHYLENE SORBITAN MONOLAURATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Store at room temperature.
-Specific end use(s):
No other specific uses are stipulated

STABILITY and REACTIVITY of POLYOXYETHYLENE SORBITAN MONOLAURATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .