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Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is a non-ionic surfactant and emulsifier produced from sorbitan, oleic acid, and ethylene oxide, commonly used in food, cosmetic, pharmaceutical, and industrial applications.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 improves the dispersion of oils, flavors, fragrances, and active ingredients in water-based systems, and is regarded as an emulsifier, dispersant, wetting agent, solubilizer, and stabilizer.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is the most widely used product in the polysorbate series, with a high HLB value of approximately 15, making it highly effective for oil-in-water emulsification.
CAS Number: 9005-65-6
EC Number: 500-019-9
Molecular Formula: C64H124O26
Molecular Weight: 1310 g/mol
Synonyms: Polysorbate 80, E433, INS 433, Polyoxyethylene Sorbitan Monooleate, Polyoxyethylene(20) Sorbitan Monooleate, PEG-20 Sorbitan Monooleate, Sorbitan Monooleate Ethoxylated, Ethoxylated Sorbitan Monooleate, Polyethylene Glycol Sorbitan Monooleate, Sorbitan Oleate Polyoxyethylene Ether, Polyoxyethylene Sorbitan Oleate, POE Sorbitan Monooleate, Tween 80
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is an amber to yellow viscous liquid that is easily soluble in water, methanol, and ethanol, and soluble in cottonseed oil, corn oil, ethyl acetate, and toluene, but insoluble in mineral oil.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is a synthetic substance obtained by esterifying vegetable oil (typically soybean oil) with sorbitol and then ethoxylating the resulting product.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is characterized by its ability to form stable oil-in-water emulsions by reducing the surface tension between immiscible liquids, allowing a larger contact surface to develop between the two phases.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 has a critical micelle concentration of 0.012 mM in pure water, and the hydrophilic groups in its structure are polyoxyethylene groups, which are polymers of ethylene oxide.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 has significant electrolyte resistance and can effectively reduce foam surface tension, improve foam stability, and enhance foam performance and quality in polyurethane foam production.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 can be applied to various industries including medicine, cosmetics, food, paint and pigment, textiles, and pesticides.
Uses of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is widely used in the food industry as an emulsifier, foaming agent, stabilizer, defoamer, solubilizer, and dispersing agent in ice cream, desserts, sauces, dressings, bakery products, confectionery, beverages, and flavor systems.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 provides a smoother texture and slower melting in ice cream by preventing milk proteins from completely coating fat droplets, producing a firmer texture that retains shape as the ice cream melts.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is used as a dissolver in pickles to disperse flavor and color, as a defoamer in the fermentation process of some wines, and as a dispersing agent for fat-soluble vitamins and vitamin-mineral preparations in dietary supplements.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 helps bind foods together, keeps sauces smooth, and prevents the separation of fat and water in sauces and dressings.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 functions in pharmaceuticals as an emulsifier, solubilizing agent, and suspension stabilizer in solid, semi-solid, and liquid dosage forms, as an emulsifier and stabilizer in various vaccines and injections, and as a lubricant in eye drops.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is used to improve the consistency of gel capsules, facilitate the dissolution of tablets in the stomach, and increase the bioavailability of active pharmaceutical ingredients by ensuring their homogeneous distribution in the formulation.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is used in cosmetic and personal care products including shampoos, facial cleansers, mouthwashes, hair care products, body oils, cleansing oils, skin care creams, and soaps, enabling the combination of oils with water-based formulas and making products appear creamier and more homogeneous.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is used to dissolve essential oils in water and to improve the rinsing of waterless scrubs and cleansing oils.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is used as a stabilizer and co-foaming agent in the production of polyurethane foam.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is used in industrial applications as an emulsifier in pesticide production, a surface active agent in cleaning products, a stabilizer in chemical formulations, and a solvent for pigments and fragrances.
Benefits or Advantages of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 has a high HLB value of approximately 15, providing strong oil-in-water emulsifying performance across a wide range of food, pharmaceutical, cosmetic, and industrial applications.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is a non-ionic surfactant with a neutral charge, making it compatible with a broad range of ingredients and formulation systems including ionic, cationic, and anionic components.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is a multifunctional compound that can be used safely in food as an emulsifier, defoamer, solubilizer, dispersing agent, surfactant, wetting agent, and adjuvant in a single ingredient.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is soluble in water and most common solvents, allowing easy incorporation into aqueous formulations without additional co-solvents.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 helps improve texture, uniformity, stability, and ingredient distribution in oil-in-water systems, extending product shelf life and improving consumer appeal.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is especially useful where oils, flavors, fragrances, active ingredients, or hydrophobic materials need to be dispersed into water-based formulations.
Features of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is an amber to yellow colored viscous oily liquid with a mild characteristic odor, soluble or dispersible in water and alcohol.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 has a viscosity of 300 to 500 centistokes at 25 degrees C, a density of 1.102 g/mL, and a pH of 6 to 8 in a 5% aqueous solution.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 has an HLB value of approximately 15.0, a hydroxyl value of 65 to 82 mg KOH/g, a saponification value of 43 to 55 mg KOH/g, and an acid value of not more than 2 mg KOH/g.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 has a boiling point above 100 degrees C, a flash point of approximately 113 degrees C, and a water solubility of 100 mL/L.
Chemical Properties of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is derived from polyethoxylated sorbitan and oleic acid, with the hydrophilic groups being polyoxyethylene groups (polymers of ethylene oxide) and the lipophilic group being the oleic acid moiety.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 has the full chemical names polyoxyethylene(20) sorbitan monooleate and (x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl), with the designation 80 referring to the oleic acid (C18:1) lipophilic group and 20 indicating approximately 20 moles of ethylene oxide per molecule.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is chemically stable under recommended storage and handling conditions and does not react dangerously under normal conditions of use.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 may react with strong oxidizing agents, strong acids, or strong bases, and thermal decomposition or combustion may produce carbon monoxide, carbon dioxide, smoke, and irritating organic fumes.
Production and Chemical Reactions of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is manufactured by first esterifying oleic acid with sorbitol to obtain sorbitan esters, and then condensing the sorbitan esters with an average of 20 moles of ethylene oxide per molecule.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 can also be produced by partially dehydrating sorbitol to obtain a sorbitol-sorbitan mixture, adding ethylene oxide to obtain sorbitan polyethylene ether, and then reacting with oleic acid.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 production is carried out under controlled conditions to ensure consistent HLB value, saponification value, hydroxyl value, and acid value within specification limits.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 quality control checks parameters such as acid value, saponification value, hydroxyl value, moisture content, oxyethylene content, residue on ignition, arsenic, and lead content.
Material Safety Data Sheet (MSDS) of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Handling of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 should be handled in accordance with good industrial hygiene and safety practices.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 handling requires avoiding contact with eyes, skin, and clothing, and avoiding breathing mist, vapors, or aerosols.
SDS of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Stability and Reactivity of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Chemical stability:
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 is stable under recommended storage and handling conditions.
Reactivity:
No dangerous reaction is expected under normal conditions of use.
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 may react with strong oxidizing agents, strong acids, or strong bases.
Conditions to avoid:
Excessive heat.
Open flames.
Direct sunlight.
Freezing.
Moisture and contamination.
Incompatible materials:
Strong oxidizing agents.
Strong acids.
Strong bases.
Reactive chemicals.
Hazardous decomposition products:
Carbon monoxide (CO).
Carbon dioxide (CO2).
Irritating organic fumes.
Handling and Storage of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Handling:
Handle in accordance with good industrial hygiene and safety practices.
Avoid contact with eyes, skin, and clothing.
Avoid breathing mist, vapors, or aerosols.
Storage:
Store in a cool, dry, and well-ventilated area.
Keep container tightly closed when not in use.
Protect from heat, direct sunlight, moisture, freezing, and contamination.
Keep in original sealed containers or suitable plastic drums, metal drums, IBC containers, or lined industrial packaging.
First Aid Measures of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Inhalation:
Move person to fresh air.
If breathing difficulty, coughing, or irritation occurs, seek medical attention.
Skin contact:
Wash affected area with soap and plenty of water.
Remove contaminated clothing if necessary.
Seek medical attention if irritation persists.
Eye contact:
Rinse cautiously with clean water for several minutes.
Remove contact lenses if present and easy to do.
Continue rinsing and seek medical attention if irritation persists.
Ingestion:
Rinse mouth with water.
Do not induce vomiting unless instructed by medical personnel.
Seek medical attention if discomfort occurs.
Firefighting Measures of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Suitable extinguishing media:
Water spray.
Foam.
Dry chemical powder.
Carbon dioxide (CO2).
Unsuitable extinguishing media:
Do not use a direct high-pressure water jet as it may spread the material or fire.
Specific hazards:
Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433 may burn under fire conditions.
Combustion may produce carbon monoxide, carbon dioxide, smoke, and irritating organic fumes.
Protective equipment for firefighters:
Wear self-contained breathing apparatus (SCBA).
Wear full protective clothing during firefighting operations.
Firefighting instructions:
Cool containers exposed to fire with water spray.
Prevent contaminated firefighting water from entering drains or waterways.
Accidental Release Measures of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Personal precautions:
Avoid contact with eyes, skin, and clothing.
Avoid breathing mist, vapors, or aerosols.
Spilled material may create a slippery surface; use appropriate personal protective equipment.
Environmental precautions:
Prevent material from entering drains, soil, surface water, or waterways.
Methods for cleaning up:
Stop the leak if it is safe to do so.
Absorb with sand, earth, vermiculite, or other inert absorbent material.
Collect into suitable labeled containers for disposal.
Clean the contaminated area with water and detergent.
Disposal:
Dispose of collected material according to local, regional, and national regulations.
Exposure Controls / Personal Protective Equipment of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Engineering controls:
Use adequate ventilation, especially where mist, vapor, or aerosols may be generated.
Respiratory protection:
Not normally required under standard handling conditions.
Use suitable respiratory protection if ventilation is insufficient or aerosol formation occurs.
Eye protection:
Wear safety glasses or chemical splash goggles.
Hand protection:
Wear protective gloves suitable for chemical handling.
Skin and body protection:
Wear suitable protective clothing to prevent prolonged or repeated skin contact.
Hygiene measures:
Wash hands after handling and before eating, drinking, or smoking.
Remove contaminated clothing and wash before reuse.
Keep away from food, beverages, and animal feed.
Identifiers of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
E Number: E433
INS Number: 433
CAS No.: 9005-65-6
EC No.: 500-019-9
UNII: 6OZP39ZG8H
RTECS Number: WG2932500
ECHA InfoCard: 100.105.529
CompTox Dashboard (EPA): DTXSID0021175
Chemical type: Non-ionic surfactant
Function: Emulsifier, stabilizer, solubilizer, dispersant, wetting agent, foaming agent, antifoaming agent
Properties of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Physical state: Liquid
Appearance: Amber to yellow colored viscous oily liquid
Odor: Mild characteristic odor
Solubility: Soluble or dispersible in water and alcohol; soluble in ethanol, methanol, ethyl acetate, toluene, cottonseed oil, and corn oil; insoluble in mineral oil
Ionic nature: Non-ionic
HLB value: Approximately 15.0
Density: 1.102 g/mL
Boiling point: >100 degrees C
Flash point: Approximately 113 degrees C
Viscosity: 300 to 500 centistokes at 25 degrees C
pH (5% solution): 6 to 8
Water solubility: 100 mL/L
Specifications of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Chemical name: Polyoxyethylene(20) Sorbitan Monooleate (Polysorbate 80)
Acid value (mg KOH/g): ≤2.0
Saponification value (mg KOH/g): 43-55
Hydroxyl value (mg KOH/g): 65-82
Moisture (w/%): ≤3.0
Residue on ignition (w/%): ≤0.25
Oxyethylene (w/%): 65.0-69.5
Arsenic (As) (mg/kg): ≤3
Lead (Pb) (mg/kg): ≤2
Storage conditions: Store in a cool, dry, well-ventilated area in original sealed containers
Names of Polyoxyethylene Sorbitan Monooleate (Polysorbate 80) E433:
Polyoxyethylene Sorbitan Monooleate
Polysorbate 80
E433
INS 433
Polyoxyethylene(20) Sorbitan Monooleate
PEG-20 Sorbitan Monooleate
Sorbitan Monooleate Ethoxylated
Ethoxylated Sorbitan Monooleate
Polyethylene Glycol Sorbitan Monooleate
Sorbitan Oleate Polyoxyethylene Ether
Polyoxyethylene Sorbitan Oleate
POE Sorbitan Monooleate
Tween 80
