PRODUCTS

POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE)

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate), is used extensively in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.).
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is also used for body mists and linen sprays.

CAS Number: 9005-64-5
EC Number: 500-018-3
MDL Number: MFCD00165986
Chemical Family: Polyethoxylated Sorbitan Ester, Polysorbates
Chemical Name: Sorbitan monolaurate, ethoxylated 1 - 6.5 moles ethoxylated
E number: E432 (thickeners, ...)
Chemical formula: C58H114O26
Molar mass: 1226 g/mol

SYNONYMS:
Polysorbate 20, Polyoxyethylene (20) sorbitan monolaurate, 7T1F30V5YH, Polyethylene glycol (44) sorbitan monolaurate, Polyethylene glycol (80) sorbitan monolaurate, Polyethylene glycol 4000 sorbitan monolaurate, Polyethylene glycol 500 sorbitan monolaurate, Polyoxyethylene (10) sorbitan monolaurate, Polyoxyethylene (44) sorbitan monolaurate, Polyoxyethylene (75) sorbitan monolaurate, Polyoxyethylene (80) sorbitan monolaurate, Polyoxyethylene 20 sorbitan monolaurate, FEMA No. 2915, POE 20 Sorbitan monolaurate, PSML, Polyethylene glycol 2000 Sorbitan Laurate, Polyoxyethylene (4) sorbitan monolaurate, Sorbimacrogol laurate 300, Sorbitan monolaurate, ethoxylated, 20s, Polysorbate, Armotan pml-20, CCRIS 699, DTXSID3031949, Dxewmulse poe-sml, E-432, EC 500-018-3, Emsorb 6915, Glycosperse L-20, Glycosperse L-20X, HSDB 7824, Hodag psml-20, INS NO.432, INS-432, Liposorb L-20, PEG-20 SORBITAN, PEG-40 Sorbitan laurate, POLY(OXY-1,2-ETHANEDIYL) DERIVATIVE, POLYSORBATA 20, POLYSORBATE 20 (EP MONOGRAPH), POLYSORBATE 20 (II), POLYSORBATE 20 (MART.), POLYSORBATE 20 (USP-RS), Peg sorbitan laurate, Peg-20 sorbitan laurate, Poly(oxy-1,2-ethanediyl) derivatives, Polyoxyethylene (40) sorbitan laurate, Polyoxyethylene 20 laurate, Polysorbate 20s, Polysorbatum 20, Protasorb L-20, Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monododecanote, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monolaurate, polyoxyethylene derivs., TWEEN-20, UNII-239B50Y732, UNII-31JQ3WOL8T, UNII-4Z93U4C2WN, UNII-59IO08SBZU, UNII-7T1F30V5YH, UNII-I42X3Q0FMF, Montanox 20, Polysorbate 20, PEG(20)sorbitan monolaurate, Alkest TW 20, Tween 20, Polyoxyethylene 20 sorbitan fatty acid ester, Tween 20, Surfacare T20, Sorbitan monolaureate, ethoxylated, Sorbitan, monododecanoate, poly(oxy-1, 2-ethanediyl) derivs., Polyoxyethylene sorbitanmonolaurate, polysorbate 2, Tween 20, Polyoxyethylene sorbitan laurate, Polyoxyethylene sorbitan laurate, Polyoxyethylene sorbitan monolaurate, Emulsifier T-20, Polyoxyethylene (20) Sorbitan Alcohol monolaurate, Polysorbate 20, TWEEN 20, SORBITAN MONOLAURATE, capmul, PEG-80 SORBITAN LAURATE, Polisorbate 20- PS 20, POLYSORBATE 21, POLYOXYETHYLENE SORBITAN MONOLAUREATE, POLYETHYLENE GLYCOL SORBITAN MONOLAURATE, Tween 20, POLYOXYETHYLENE (20) SORBITAN MONOLAURATE, Polisorbate 20- PS 20, Tween 20 (Trademark of ICI America, Inc.), Tween 20?, Tween 20 1LT, Twain 20, TWEEN(R) 20 Vetec(TM) reagent grade, 40%, ACRYL/BIS 37.5:1 PREMIXED PWD ULTRA PURE, TWEEN 20 ELECTROPHORESIS GRADE, Polyoxyethylene (20) sorbitan monolaurate, Kolliphor PS 20, Montanox 20, Polysorbate 20, PEG(20)sorbitan monolaurate, Alkest TW 20, Tween 20, Kotilen-20, Polysorbate 20, Polyoxyethylene (20) sorbitan monolaurate, 7T1F30V5YH, Polyethylene glycol (44) sorbitan monolaurate, Polyethylene glycol (80) sorbitan monolaurate, Polyethylene glycol 4000 sorbitan monolaurate, Polyethylene glycol 500 sorbitan monolaurate, Polyoxyethylene (10) sorbitan monolaurate, Polyoxyethylene (44) sorbitan monolaurate, Polyoxyethylene (75) sorbitan monolaurate, Polyoxyethylene (80) sorbitan monolaurate, Polyoxyethylene 20 sorbitan monolaurate, FEMA No. 2915, POE 20 Sorbitan monolaurate, PSML, Polyethylene glycol 2000 Sorbitan Laurate, Polyoxyethylene (4) sorbitan monolaurate, Sorbimacrogol laurate 300, Sorbitan monolaurate, ethoxylated, 20s, Polysorbate, Armotan pml-20, CCRIS 699, DTXSID3031949, Dxewmulse poe-sml, E-432, EC 500-018-3, Emsorb 6915, Glycosperse L-20, Glycosperse L-20X, HSDB 7824, Hodag psml-20, INS NO.432, INS-432, Liposorb L-20, PEG-20 SORBITAN, PEG-40 Sorbitan laurate, POLY(OXY-1,2-ETHANEDIYL) DERIVATIVE, POLYSORBATA 20, POLYSORBATE 20 (EP MONOGRAPH), POLYSORBATE 20 (II), POLYSORBATE 20 (MART.), POLYSORBATE 20 (USP-RS), Peg sorbitan laurate, Peg-20 sorbitan laurate, Poly(oxy-1,2-ethanediyl) derivatives, Polyoxyethylene (40) sorbitan laurate, Polyoxyethylene 20 laurate, Polysorbate 20s, Polysorbatum 20, Protasorb L-20, Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monododecanote, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monolaurate, polyoxyethylene derivs., TWEEN-20, UNII-239B50Y732, UNII-31JQ3WOL8T, UNII-4Z93U4C2WN, UNII-59IO08SBZU, UNII-7T1F30V5YH, UNII-I42X3Q0FMF, E-432, FEMA NO. 2915, INS NO.432, INS-432, PEG-20 SORBITAN, PEG-20 SORBITAN [VANDF], POLY(OXY-1,2-ETHANEDIYL) DERIVATIVE, POLYOXYETHYLENE 20 SORBITAN MONOLAURATE, POLYOXYETHYLENE 20 SORBITAN MONOLAURATE [WHO-IP], POLYOXYETHYLENE SORBITAN MONOLAURATE, POLYSORBATA 20 [WHO-IP LATIN], POLYSORBATE 20, POLYSORBATE 20 [EP MONOGRAPH], POLYSORBATE 20 [FCC], POLYSORBATE 20 [FHFI], POLYSORBATE 20 [HSDB], POLYSORBATE 20 [II], POLYSORBATE 20 [MART.], POLYSORBATE 20 [USAN], POLYSORBATE 20 [USP-RS], POLYSORBATE 20 [VANDF], POLYSORBATE 20 [WHO-DD], POLYSORBATE 20 [WHO-IP], SORBIMACROGOL LAURATE 300, SORBITAN MONODODECANOATE, TWEEN 20, TWEEN-20, alkamuls PSML-20, cremophor PS 20, emasol L-120V, glycosperse L-20 KFG, hetsorb L-20, kaopan TW-L-120, liposorb L-20, lonzest SML-20, monebatt - 20, mulsifan SML-20, nikkol TL-10, norfox sorbo T-20, peg-20 sorbitan laurate, peg-20 sorbitan monolaurate, polyethylene glycol (20) sorbitan laurate, polyethylene glycol (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan laurate, polyoxyethylene (20) sorbitan monolaurate, rheodol TW-L120, super refined polysorbate 20, T-maz 20K, tween 20, E 432, POE (20) Sorbitan Monolaurate, Polyoxyethylene (20) Sorbitan Monolaurate, PEG 20 Sorbitan Monolaurate, Polysorbate 20

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is a polyoxyethylene 20 sorbitan monolaurate, which can be used as an emulsifier for o/w emulsions and is also a highly effective solubiliser for lipophilic oils.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is suitable for cosmetic and pharmaceutical applications and complies with the current European Pharmacopoeia.

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is an emulsifying agent consisting of laurate esters of sorbitol consisting of the monoester condensed with ethylene oxide (polyoxyethylene-20 sorbitan monostearate).
HLB Value of Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is 16-17 (gives oil-in-water emulsions).

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) ion-ionic emulsifier (enables water and oil to mix).
Emulsifying efficacy of Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is increased further when combined with cetyl alcohol or sorbitan stearate.

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) acts as dispersing agent and anti-static thickener.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is very useful as solubilizer and stabilizer of essential oils.

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is a polysorbate surfactant whose stability and relative non-toxicity allow it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is a polyoxyethylene derivative of sorbitan monolaurate, and is distinguished from the other members in the Tween range by the length of the polyoxyethylene chain.

The commercial product, Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate), contains a range of chemical species.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) (common commercial brand names include Kolliphor PS 20, Scattics, Alkest TW 20, Tween 20, and Kotilen-20) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan monolaurate.

Its stability and relative nontoxicity allows Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.
As the name implies, the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol.

In practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is derived from coconut oil.
Polysorbate 20 (commercially also known as Tween 20) is a polysorbate surfactant whose stability and relative non-toxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is a polyoxyethylene derivative of sorbitan monolaurate, and is distinguished from the other members in the Tween range by the length of the polyoxyethylene chain.

The commercial product, Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate), contains a range of chemical species.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is a non-ionic detergent that is routinely used in biochemical and life science research.

USES and APPLICATIONS of POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE):
Food applications: Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used non-ionic detergent for solubilizing membrane proteins during isolation of membrane-protein complexes

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used ultra low concentrations of contaminating peroxides, aldehydes, salts and carbonyl compounds
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is a non-toxic, nonionic surfactant/emulsifier and a water-soluble yellowish liquid used as a dispersing agent which allows oil and water to mix without the use of alcohol.

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is a fragrance solubilizer and stabilizer.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) lubricates and has a soothing effect on the skin.
This skin-safe ingredient, Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate), is used extensively in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.).

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is also used for body mists and linen sprays.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) will be found as an ingredient in the majority of body toiletries, cosmetics and wipes now in the market.

Polysorbates are generally used in combination with other emulsifiers such as mono- and diglycerides or sorbitan monostearates for various purposes such as to disperse flavors and colors.
They are used to make essential oils and vitamins soluble.

They are used to improve volume and texture in baked goods.
Use Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) when very little foaming action (or none at all) is desired in the finished product.
Tween 20, or Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate), is a nonionic surfactant used as a detergent and emulsifier in a number of biochemical applications.

The molecule of Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is formed of 20 repeating polyethylene glycol units, which are hydrophilic in nature, attached to a hydrophobic hydrocarbon tail.
Pharmaceutical applications: Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.

Pharmaceutical applications: Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used as in pharmaceutical applications to stabilize emulsions and suspensions.
Industrial and domestic applications of Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate): The Clorox-made cleaning solution used by the iRobot Scooba floor-washing robot lists Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) as one of its major ingredients on its MSDS.

-Industrial and domestic applications of Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate):
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used in many brands of baby wipes.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is also used as wetting agent in rubber balers in the elastomer industry.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies.

-Food applications of Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate):
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used as a wetting agent in flavored mouth drops, helping to provide the spreading feeling of the other ingredients like SD alcohol and mint flavor.
The World Health Organization has suggested acceptable daily intake limits of 0-25 mg of polyoxyethylene sorbitan esters per kg body weight.

-Biotechnical applications of Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate):
In biological techniques and sciences, Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) has a broad range of applications.
For example, Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used as a washing agent in immunoassays, such as Western blots and ELISAs.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) helps to prevent non-specific antibody binding.

In this major application, Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is dissolved in Tris-buffered saline or phosphate buffered saline at dilutions of 0.05% to 0.5% v/v.
These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific background.

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used to saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA).
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used to stabilize proteins purified protein derivative (PPD) solution used in skin testing for tuberculosis exposure.

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used as a solubilizing agent of membrane proteins.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used for lysing mammalian cells, at a concentration of 0.05% to 0.5% v/v, generally combined with other detergents, salts and additives.

-Biological Applications of Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate):
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) has a broad range of applications.
For example, Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used:
to stabilize purified protein derivative (PPD) solution, used in skin testing for tuberculosis exposure,
as a blocking agent in immunologic assays, such as Western blots and ELISA
and as a solubilizing agent of membrane proteins for lysing mammalian cells, at a concentration of 0.05 to 0.5%.

SOURCES AND USES of POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE):
"Complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals."
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used as an emulsifier/solubilizer in a wide range of foods, cosmetics, and other products.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is also used as a delivery vehicle for other chemicals in animal developmental toxicity studies.

Polysorbates are used in cosmetics, foods, pharmacy, the textile industry (antistatic agents, fiber lubricants, and finish emulsifiers), and in biological research.
Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is used as a flavoring agent, boiler water additive, emulsifier, surface-active agent, and stabilizer or thickener for foods.

Polysorbate 20 (Polyoxyethylene Sorbitan Monolaurate) is permitted for use as an inert ingredient in non-food pesticide products.
Polysorbate 20 (common commercial brand names include Alkest TW 20 and Tween 20) is a polysorbate surfactant whose stability and relative non-toxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.

ALTERNATIVE PARENTS of POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE):
*Tetrahydrofurans
*Carboxylic acid esters
*Oxacyclic compounds
*Monocarboxylic acids and derivatives
*Dialkyl ethers
*Primary alcohols
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds

SUBSTITUENTS of POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE):
*Fatty acid ester
*Tetrahydrofuran
*Carboxylic acid ester
*Carboxylic acid derivative
*Dialkyl ether
*Ether
*Monocarboxylic acid or derivatives
*Organoheterocyclic compound
*Oxacycle
*Organic oxide
*Carbonyl group
*Alcohol
*Organooxygen compound
*Primary alcohol
*Hydrocarbon derivative
*Organic oxygen compound
*Aliphatic heteromonocyclic compound

PHYSICAL and CHEMICAL PROPERTIES of POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE):
Melting point: 98.9 °C (decomposition)
Boiling point: 100 °C
Density: 1.11 g/mL at 20 °C
Vapor pressure: <1.4 hPa (20 °C)
FEMA: 2915 | POLYSORBATE 20
Refractive index: n20/D 1.468 (literature value)
Flash point: >230 °F
Storage temperature: Store below +30°C
Solubility: 100 g/L

Form: Viscous liquid
Color: Amber
Specific Gravity: 1.090 to 1.130 (20/20℃)
pH: 6-8 (50g/l, H2O, 20℃)
pH Range: 7
Odor: Mild alcohol odor
Odor Type: Alcoholic
Water Solubility: 100 g/L
Hydrophilic-Lipophilic Balance (HLB): 16.7
Stability: Stable. Incompatible with strong oxidizing agents

Substances Added to Food (formerly EAFUS): POLYSORBATE 20
EWG's Food Scores: 3-8
FDA UNII: PEG-80 SORBITAN LAURATE (239B50Y732), PEG-75 SORBITAN LAURATE (31JQ3WOL8T),
PEG-10 SORBITAN LAURATE (4Z93U4C2WN), POLYSORBATE 21 (59IO08SBZU), POLYSORBATE 20 (7T1F30V5YH)
EPA Substance Registry System: Polysorbate 20 (9005-64-5)
Cosmetics Info: Polysorbate 20
Chemical formula: C58H114O26
Molar mass: 1226 g/mol

Appearance: Clear, yellow to yellow-green viscous liquid
Density: 1.1 g/mL (approximate)
Boiling point: > 100 °C (212 °F; 373 K)
Surface tension:
CMC: 8.04×10^−5 M at 21 °C
HLB: 16.7
Relative Density: About 1.10
Viscosity: About 400 mPa s at 25°C
IUPAC: Polyoxyethylene (20) sorbitan monooleate

INCI: POLYSORBATE 20
CAS: 9005-64-5
Molar mass: 522.70 g/mol
Density: 1.10 g/mL at 20 °C
Solubility: Soluble in water, alcohols, glycerol ethers,
glycols, esters, ketones, aromatic and aliphatic hydrocarbons
CBNumber: CB3462544
Molecular Formula: C26H50O10
Molecular Weight: 522.6692 g/mol

MDL Number: MFCD00165986
MOL File: 9005-64-5.mol
Appearance: Pale yellow clear viscous liquid (estimated)
Assay: 96.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 1.09100 to 1.09600 @ 25.00 °C
Pounds per Gallon - (estimated): 9.078 to 9.120

Refractive Index: 1.45900 to 1.47000 @ 20.00 °C
Acid Value: 3.00 max. KOH/g
pH Number: 5.71
Flash Point: > 230.00 °F. TCC (> 110.00 °C)
Shelf Life: 24.00 month(s) or longer if stored properly
Storage: Store in cool, dry place in tightly sealed containers,
protected from heat and light
Soluble in: alcohol, oils, water

Appearance at 25ºC: Clear liquid
Active content %: 97
Nature: Nonionic
Acid value mg KOH/gm max: 2
Color gardner: 3
Hydroxyl value mg KOH/gm: 96-108
% Moisture content by KF: 3
pH: 5-7
Saponification value: 40-50

Molecular Formula: C58H114O26
Molecular Weight: 1127.48
Grade: Pharmaceutical Excipients
Description: This product is an amber viscous liquid with a
slight special odor and slightly bitter taste.
UNII: 7T1F30V5YH
Chemical Name: Polyoxyethylene 20 sorbitan monolaurate
CAS Number: 9005-64-5

Product Name: Polyoxyethylene sorbitan monolaurate
CAS No.: 9005-64-5
InChIKeys: HMFKFHLTUCJZJO-UHFFFAOYSA-N
Molecular Weight: 346.459991455078
Exact Mass: 604.418640
EC Number: 500-018-3
DSSTox ID: DTXSID3031949
Color/Form: Lemon- to amber-colored liquid
HScode: 34021300

Categories: Emulsifier
PSA: 133.14000
XLogP3: 5.37
Appearance: Amber viscous liquid
Density: 1.1±0.1 g/cm3
Melting Point: 98.9 °C (decomp)
Boiling Point: 100 °C
Flash Point: >230 °F
Refractive Index: 1.502
Water Solubility: 100 g/L

Storage Conditions: 0-6°C
Vapor Pressure: <1.4 hPa (20 °C)
Odor: Characteristic odor
Taste: Bitter
Melting point: 98.9 °C (decomposition)
Boiling point: 100 °C
Density: 1.11 g/mL at 20 °C
Vapor pressure: <1.4 hPa (20 °C)

FEMA: 2915 | POLYSORBATE 20
Refractive index: n20/D 1.468 (literature value)
Flash point: >230 °F
Storage temperature: Store below +30°C
Solubility: 100 g/L
Form: Viscous liquid
Color: Amber
Specific Gravity: 1.090 to 1.130 (20/20℃)

pH: 6-8 (50g/l, H2O, 20℃)
pH Range: 7
Odor: Mild alcohol odor
Odor Type: Alcoholic
Water Solubility: 100 g/L
Hydrophilic-Lipophilic Balance (HLB): 16.7
Stability: Stable. Incompatible with strong oxidizing agents
Substances Added to Food (formerly EAFUS): POLYSORBATE 20

EWG's Food Scores: 3-8
FDA UNII: PEG-80 SORBITAN LAURATE (239B50Y732), PEG-75 SORBITAN LAURATE (31JQ3WOL8T),
PEG-10 SORBITAN LAURATE (4Z93U4C2WN), POLYSORBATE 21 (59IO08SBZU), POLYSORBATE 20 (7T1F30V5YH)
EPA Substance Registry System: Polysorbate 20 (9005-64-5)
Cosmetics Info: Polysorbate 20
Chemical formula: C58H114O26
Molar mass: 1226 g/mol
Appearance: Clear, yellow to yellow-green viscous liquid

Density: 1.1 g/mL (approximate)
Boiling point: > 100 °C (212 °F; 373 K)
Surface tension:
CMC: 8.04×10^−5 M at 21 °C
HLB: 16.7
Relative Density: About 1.10
Viscosity: About 400 mPa s at 25°C
IUPAC: Polyoxyethylene (20) sorbitan monooleate

Acid Value: 3.00 max. KOH/g
pH Number: 5.71
Flash Point: > 230.00 °F. TCC (> 110.00 °C)
Shelf Life: 24.00 month(s) or longer if stored properly
Storage: Store in cool, dry place in tightly sealed containers,
protected from heat and light
Soluble in: alcohol, oils, water
Appearance at 25ºC: Clear liquid

Active content %: 97
Nature: Nonionic
Acid value mg KOH/gm max: 2
Color gardner: 3
Hydroxyl value mg KOH/gm: 96-108
% Moisture content by KF: 3
pH: 5-7
Saponification value: 40-50
Molecular Formula: C58H114O26
Molecular Weight: 1127.48

Grade: Pharmaceutical Excipients
Description: This product is an amber viscous liquid with a
slight special odor and slightly bitter taste.
UNII: 7T1F30V5YH
Chemical Name: Polyoxyethylene 20 sorbitan monolaurate
CAS Number: 9005-64-5
Chemical Formula: C58H114O26
Molar mass: 1226 g/mol

Appearance: Clear, yellow to yellow-green viscous liquid.
Density: 1.1 g/mL (approximate)
Boiling point: > 100 °C (212 °F; 373 K)
Surface tension: CMC 8.04×10−5 M at 21 °C[1]
HLB: 16.7[1]
Water Solubility: 0.018 g/L
logP: 2.75
logP: 2.39
logS: -4.5

pKa (Strongest Acidic): 14.64
pKa (Strongest Basic): -2.7
Physiological Charge: 0
Hydrogen Acceptor Count: 9
Hydrogen Donor Count: 3
Polar Surface Area: 133.14 Å²
Rotatable Bond Count: 26
Refractivity: 134.25 m³•mol⁻¹
Polarizability: 60.33 Å³

Number of Rings: 1
Bioavailability: No
Rule of Five: No
Ghose Filter: No
Veber's Rule: No
MDDR-like Rule: No
Chemical Formula: C26H50O10
IUPAC name: 2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate

InChI Identifier: InChI=1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3
InChI Key: HMFKFHLTUCJZJO-UHFFFAOYSA-N
Isomeric SMILES: CCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO
Average Molecular Weight: 522.6692
Monoisotopic Molecular Weight: 522.34039782
Appearance: Oily, yellow to brownish-yellow, clear or slightly opalescent liquid.
Solubility: Soluble in water, ethanol, ethyl acetate and methanol, practically insoluble in fatty oils and liquid paraffin.
Relative Density: About 1.10.

Viscosity: About 400 mPa s at 25°C.
Full Name: Polyethylene glycol sorbitan monolaurate
Synonym: Polysorbate 20
CAS Number: 9005-64-5
Molecular Formula: C18H34O6•[C2H4O]w+x+y+z for w+x+y+z =20
Molecular Weight: ~1227 (for w+x+y+z =20)
Absorbance (215nm): 0.05 (0.05% w/v)
Critical Micelle Concentration (CMC): ~0.06 x 10-3M (25ºC)
Cloud Point: 76ºC

FIRST AID MEASURES of POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE):
-Description of first-aid measures:
*After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*After swallowing:
Make victim drink water (two glasses at most).

ACCIDENTAL RELEASE MEASURES of POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE):
-Extinguishing media:
*Suitable extinguishing media:
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Safety glasses.
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 30 min
*Respiratory protection:
Not required.
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Store at room temperature.
-Specific end use(s):
No other specific uses are stipulated

STABILITY and REACTIVITY of POLYSORBATE 20 (POLYOXYETHYLENE SORBITAN MONOLAURATE):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .