Quick Search
Polysorbate 80 (E 433) is also extensively applied in pharmaceutical industry, where it can be found in some vaccines, vitamins and supplements.
Polysorbate 80 (E 433) is occasionally used for a test to identify the phenotype of a strain or isolate, such as mycobacteria.
Polysorbate 80 (E 433) is a polyethylene sorbitol ester, with a calculated molecular weight of 1,310 daltons, assuming 20 ethylene oxide units, sorbitol, and 1 oleic acid as the primary fatty acid.
Polysorbate 80 (E 433) are a series of nonionic surfactants derived from sorbitan esters.
They are soluble or dispersible in water but differ widely in organic and oil solubilities.
Polysorbate 80 (E 433) has been widely used in biochemical applications including: solubilizing proteins, isolating nuclei from cells in culture,5 growing of tubercule bacilli,6 and emulsifying and dispersing substances in medicinal and food products.
CAS Number: 9005-65-6
Molecular Formula: C24H44O6
Molecular Weight: 428.600006103516
EINECS Number: 500-019-9
Synonyms: Polysorbate 80 (E 433), 6OZP39ZG8H, Monitan, Sorbimacrogol oleate 300, Armotan PMO-20, Atlox 1087, Capmul POE-O, Crillet 4, Drewmulse poe-smo, Durfax 80, Emsorb 6900, Ethoxylated sorbitan monooleate, MO 55F, Montanox 80, NCI-C60286, Polyethylene glycol 300 sorbitan monooleate, Polyethylene oxide sorbitan mono-oleate, Polyoxyethylene (5) sorbitan monooleate, Polyoxyethylene 20 sorbitan monooleate, Polyoxyethylene sorbitan oleate, Polysorban 80, Protasorb O-20, Romulgin O, SVO 9, Sorbon T 80, Sorlate, Atlox 8916TF, Avitears, CHEBI:53426, Cemerol T 80, Cemesol TW 1020, Crill 10, Crill 11, Crill S 10, Crillet 4 Super, Crillet 41, Disponil SMO 120, Eumulgin SMO 20, FEMA No. 2917, Flo Mo SMO 20, Glycol (Polysorbate 80 (E 433)), Glycols, polyethylene, ether with sorbitan monooleate, Glycosperse O 20, Glycosperse O 5, Glycosperse O-20, Glycosperse O-20 VEG, Glycosperse O-20X, Hodag SVO 9, IV Solution Stabilizer, Myvatex MSPS, Nikkol TO, Nikkol TO 10, Nikkol TO 10M, Nissan Nonion OT 221, Nonion OT 221, Olothorb, PEG-3 Sorbitan oleate, Peg-20 sorbitan oleate, Polisorbac 60, Polyethylene glycol (3) sorbitan monooleate, Polyoxyethylene (20) sorbitan monooleate, Polyoxyethylene (3) sorbitan monooleate, Polysorbate 80 (E 433) B.P.C., Polysorbate 80 (E 433) BPC, Polysorbate 80 (E 433), USP, Sorbimacrogol oleate, Sorbitan, monooleate polyoxyethylene deriv., Sorbitan, monooleate, polyoxyethylene derivs, T-Maz 80, TO 10, (X)-SORBITAN MONO-9-OCTADECENOATE POLY(OXY-1,2-ETHANEDIYL) DERIVS, (Z)-sorbitan mono-9-octadecenoate poly(oxy 1,2-ethanediyl) derivatives, 80s, Polysorbate, ALKAMULS PSMO 20, Akamuls PSMO 20, Alkamuls T 80, Atlas E, Atolox 8916TF, CCRIS 700, Cremophor PS 80, Crillet 50, DTXSID0021175, Drewpone 80K, E-433, EC 500-019-9, EMULSON 10OM, ETHYLENE OXIDE-SORBITAN MONOOLEATE POLYMER, Ecoteric T 80, Emasol O 105R, Emrite 6120, Emulson 100M, Eumulgin SMO, GLYCOSPERSE 0-20, GLYCOSPERSE 0-20 VEG, GLYCOSPERSE 0-20X, HEXAETHYLENE GLYCOL SORBITAN MONOOLEATE, HSDB 4359, Hodag PSMO-20, INS NO.433, INS-433, IONET T 80, IONET T 80C, IV STABILIZER, LIPOSORB 0-20, Liposorb O-20, MF59 COMPONENT TWEEN 80, NIKKOL TO 106, POLYETHOXYLATED SORBITAN MONOOLEATE, POLYETHYLENE GLYCOL SORBITAN ETHER MONOOLEATE, POLYETHYLENE GLYCOL SORBITAN MONOOLEATE, POLYOXYETHYLATED SORBITAN MONOOLEATE, POLYOXYETHYLENE MONOSORBITAN MONOOLEATE, POLYOXYETHYLENE(20)SORBITAN MONO-OLEATE, POLYOXYETHYLENE(20)SORBITAN MONOOLEATE, POLYOXYETHYLENESORBITAN OLEATE, POLYSORBATA 80, Polysorbate 80 (E 433) (EP MONOGRAPH), Polysorbate 80 (E 433) (II), Polysorbate 80 (E 433) (MART.), Polysorbate 80 (E 433) (USP-RS), Polysorbate 80 (E 433),U.S.P., Peg sorbitan oleate, Poly(20)oxyethylene sorbitan monooleate, Polyethylene sorbitan monooleate, Polyoxyethylene 20 oleate, Polyoxyethylene(20) sorbitan monooleate, Polysorbate 80 (E 433), U.S.P., Polysorbate 80 (E 433)s, Polysorbatum 80, RADIASURF 7157, RHEODOL SUPER TW-O 120, RHEODOL TW-O 106
It has little or no activity as an anti-bacterial agent except it has been shown to have an adverse effect on the antibacterial effect of methyl paraben and related compounds.
It is a mixture of oleate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its
mono- and dianhydrides.
Polysorbate 80 (E 433), commercially known as Polysorbate-80, is a viscous, water-soluble Yellow to amber liquid derived from polyethoxylated sorbitan and oleic acid.
Polysorbate 80 (E 433) is structurally similar to the (polyethylene) glycols and used both in injections (0.8-8.0%) and in oral suspension (0.375% w/v).
A number of anticancer drugs can be formulated by Polysorbate 80 (E 433).
Typical examples include etoposide and minor groove-binding cyclopropylpyrroloindole analogues like carzelesin.
Polysorbate 80 (E 433) is derived from polyethoxylated sorbitan and oleic acid.
It is an effective excipient to stabilize aqueous formulations of medications for parenteral administration and to improve the consistency of gel capsules, thus to make pills disperse in the stomach.
Besides, Polysorbate 80 (E 433) commonly serve as a surfactant and solubilizer in the production of soaps and cosmetics, which is effective to help dissolve ingredients and make products look creamier and more attractive.
Specific Gravity: 1.080 (25/4℃)
PH Range: 6
Odor: mild alcoholic
PH: 5-7 (50g/l, H2O, 20℃)
Odor Type: alcoholic
Water Solubility: 5-10 g/100 mL at 23 ºC
Merck: 14,7582
Hydrophilic-Lipophilic Balance (HLB): 10
LogP: 4.392 (est)
Polysorbate 80 (E 433)s have been reported to be incompatible with alkalis, heavy metal salts, phenols, and tannic acid.
They may reduce the activity of many preservatives.
Polysorbate 80 (E 433) has a faint, characteristic odor and a warm, somewhat bitter taste.
This synthetic compound is a viscous, water-soluble yellow liquid.
The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.
In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid (see polysorbate for more detail).
The full chemical names for Polysorbate 80 (E 433) are: Polyoxyethylene (80) sorbitan monooleate (x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl) The critical micelle concentration of Polysorbate 80 (E 433) in pure water is reported as 0.012 mM.
Polysorbate 80 (E 433) is found in many vaccines used in the United States.
Polysorbate 80 (E 433) is also used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
It is also used as an emulsifier in the estrogen-regulating drug Estrasorb.
Also used in granulation for stabilization of drug and excipients while doing IPA binding
Polysorbate 80 (E 433), a substance formulated by the reaction of sorbitan fatty acid ester (a nonionic surfactant) with ethylene oxide, is used in many foreign countries, including the U.S. and the EU, where it acts as an emulsifier, a solubilizer in many foods, including bread, cake mix, salad dressing, shortening oil and chocolate 18.
Polysorbate 80 (E 433) is a hydrophilic nonionic surfactant.
Polysorbate 80 (E 433) is utilized as a surfactant in soaps and cosmetics and also as a lubricant in eye drops.
In food or pharmaceutical products, it can act as an emulsifier.
Polysorbate 80 (E 433) is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration or vaccinations.
A solubilizing agent acts as a surfactant and increases the solubility of one agent in another.
A substance that would not normally dissolve in a particular solution is able to dissolve with the use of a solubilizing agent.
It is also known as an emulsifier, which helps ingredients mix together and prevent separation, and water-containing small amounts of salts, and is included in several vaccines licensed in the USA.
On RODAC agar plates used in microbiological control, Polysorbate 80 (E 433) counteracts any disinfectants often found on sampled surfaces, thereby allowing the microbes found on these surfaces to grow.
Polysorbate 80 (E 433), also known as Tween 80, is a synthetic nonionic surfactant commonly used in food, cosmetics, and drug formulations as a solubilizer, stabilizer, or emulsifier.
Polysorbate 80 (E 433) are also included in this family of surfactants.
Polysorbate 80 (E 433) has also been used to prevent protein adsorption and/or aggregation.
A wide range of pharmaceutical agents are available in formulations that contain Polysorbate 80 (E 433), including amiodarone, vitamin K, etoposide, docetaxel, various vaccines, protein biotherapeutics, erythropoietin-stimulating agents, and fosaprepitant.
Recent data have indicated that Polysorbate 80 (E 433) is a biologically and possibly pharmacologically active compound and consequently may alter the pharmacologic properties of the drug it is formulated with or may itself directly mediate adverse events.
Consequently, Polysorbate 80 (E 433) has been implicated in some of the adverse reactions associated with drugs formulated with this vehicle.
His review covers the safety of Polysorbate 80 (E 433) in the oncology setting, focusing on Polysorbate 80 (E 433)-associated adverse events that may have occurred with the use of docetaxel, darbepoetin alfa, epoetin alfa, and fosaprepitant.
This article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors.
Polysorbate 80 (E 433)s are derived from ethoxylated sorbitan (a derivative of sorbitol) esterified with fatty acids and exist as oily liquids.
These Polysorbates belong to the class of emulsifiers used in pharmaceuticals and food preparations (salad dressing, ice cream, chocolates, baked goods and confectionery).
They are used in cosmetics to solubilize essential oils into water-based products, pharmaceuticals, detergents, paints, and plastic applications.
These Polysorbates surfactants consist primarily of oleic, stearic or lauric fatty acid esters with sorbitol-derived cyclic ethers (sorbitans and sorbides) and further polymerized with approximately 20 molecules of oxirane per molecule of Polysorbates.
Polysorbate 80 (E 433) is derived from sorbitol, a natural sugar alcohol and forms a polysorbate-type nonionic surfactant by the ethoxylation of sorbitan (derived from the dehydration of sorbitol) before the addition of lauric acid.
Polysorbate 80 (E 433) is relatively nontoxic and stable therefore can be used as a emulsifier and detergent in a number of domestic, scientific, and pharmacological applications.
Polysorbate 80 (E 433) functions as a good wetting agent having food application in flavoured mouth drops, providing a spreading feeling to other added flavour ingredients.
In biochemical applications, Polysorbate 80 (E 433) finds use as washing agent in immunoassays, solubilizing agent for membrane proteins, and lysis solutions for mammalian cells.
While in the pharma sector, it functions as an excipient helping to stabilize emulsions and suspensions.
The Cosmetics Ingredient Review (CIR) Expert Panel evaluated the scientific data and concluded that polysorbate 20 is safe for use in cosmetic formulations.
Polysorbate 80 (E 433)s are a group of synthetic emulsifiers widely used in the food and cosmetic industries.
Polysorbate 80 (E 433) influenza vaccines contain 2.5 μg of Polysorbate 80 (E 433) per dose.
They are derived from sorbitol, a sugar alcohol, and ethylene oxide.
Polysorbate 80 (E 433) is characterized by their ability to lower the surface tension between ingredients, which helps to stabilize mixtures of oil and water.
Polysorbate 80 (E 433) can function as emulsifiers, stabilizers, and solubilizers.
The most commonly used polysorbates are Polysorbate 20, Polysorbate 40, Polysorbate 60, and Polysorbate 80 (E 433), each differing in the number of ethylene oxide units attached.
Polysorbate 80 (E 433), is a synthetic compound that is widely applied in a variety of fields, including foods, medicines, and cosmetics.
In food production, it is commonly used as a defoamer for the fermenting process of some wines and as a emulsifier in ice-cream or “puddings” to keep the creamy texture without separating.
Polysorbate 80 (E 433) is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
Polysorbate 80 (E 433) is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the popular antiarrhythmic amiodarone.
Polysorbate 80 (E 433) is also used as an excipient in some European and Canadian influenza vaccines.
Melting point: -25 °C
Boiling point: >100°C
Density: 1.08 g/mL at 20 °C
vapor pressure: <1 mm Hg ( 20 °C)
refractive index: n20/D 1.473
FEMA: 2917 | Polysorbate 80 (E 433)
Flash point: >230 °F
storage temp.: -20°C
solubility: DMSO (Soluble), Methanol (Slightly)
form: viscous liquid
color: Amber
Polysorbate 80 (E 433) is a synthetic surfactant composed of fatty acid esters of polyoxyethylene sorbitan.
Polysorbate 80 (E 433) is usually available as a chemically diverse mixture of different fatty acid esters, with the oleic acid comprising?>?58% of the mix.
However, the main component of Polysorbate 80 (E 433), which is structurally similar to polyethylene glycols.
Polysorbate 80 (E 433) has a molecular weight of 1309.7 Da and a 1.064 g/ml density[1].
Polysorbate 80 (E 433) is derived from polyethoxylated sorbitan and oleic acid.
The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.
In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid (see polysorbate for more detail).
Polysorbate 80 (E 433) has both hydrophobic and hydrophilic moieties.
The hydrophobic moieties drive an interaction with the air-water interface or a solid-water interface, such as that found in vials, syringes, and other glass and plastic containers.
The hydrophobic moieties of Polysorbate 80 (E 433) also result in the formation of micelles at concentrations above the critical micelle concentration of 0.01% (weight/volume) in protein-free aqueous solution.
This formation of micelles may play a critical role in the mechanism of action of Polysorbate 80 (E 433).
Enzyme-linked immunosorbent assays have shown that Polysorbate 80 (E 433) could activate the complement system, a multiprotein immune mechanism.
Activating the complement system may lead to phagocytosis, stimulation, and recruitment of white blood cells, or perforation of plasma membranes, possibly leading to immunologic side effects such as acute hypersensitivity and systemic immune reactions.
This possibility has been tested in a zebrafish model, where oxidized fatty acid residues in Polysorbate 80 (E 433) samples caused anaphylactoid reactions at the highest tested concentrations.
Polysorbate 80 (E 433) substituted for human serum albumin in an epoetin alfa preparation in Europe is thought to have played a role in the development of neutralizing antibodies and pure red blood cell aplasia.
However, Polysorbate 80 (E 433) is not yet known which specific parts of the chemical structure of Polysorbate 80 (E 433) are responsible for adverse events such as systemic and administration-site reactions.
Aqueous solutions of Polysorbate 80 (E 433), as well as the undiluted liquid, undergo auto-oxidation over time, with changes being catalyzed by light, increased temperature, and copper sulfate.
Auto-oxidation leads to the formation of a variety of hydroperoxides, peroxides, and carbonyl compounds that may readily degrade proteins.
During the initial stages of propagation, the peroxide formation is usually faster than its decomposition; eventually, the rates of formation and decomposition equalize, and then decomposition occurs faster than formation.
Parameters such as surface tension and cloud point properties may be used to establish degradation in the hydrophilic chains.
Polysorbate 80 (E 433) is rapidly removed from systemic circulation.
The Polysorbate 80 (E 433) plasma concentration-time curve (AUC) in a patient administered an intravenous (IV) infusion of docetaxel 35 mg/m2 (Polysorbate 80 (E 433) 1.75 g) showed a Polysorbate 80 (E 433) peak concentration of 304 μg/ml.
The AUC for Polysorbate 80 (E 433) was 321.7 mg h/ml, with a short disposition half-life of 1.07 h and a total plasma clearance of 5.44 l/h.
The distribution of Polysorbate 80 (E 433) at steady state was similar to the total blood volume (4.16 l), suggesting that Polysorbate 80 (E 433) circulates as large micelles and does not significantly distribute outside the central compartment.
In vitro studies suggest that Polysorbate 80 (E 433) is metabolized by rapid carboxylesterase-mediated hydrolysis.
Polysorbate 80 (E 433) for sale is also referred to as polyoxyethylene (20) sorbitan monooleate.
It is a nonionic surfactant and emulsifier extensively utilized across numerous industries, such as food, cosmetics, and pharmaceuticals.
Similar to other polysorbates, it is produced through the chemical reaction between sorbitol (sugar alcohol) and ethylene oxide.
The "80" indicates the type of fatty acid ester (oleic acid) used in its synthesis.
Polysorbate 80 (E 433) excels at mixing water and oil-based substances, making it crucial in processed foods like ice cream, salad dressings, and baked goods.
It also serves as a stabilizer in vaccines and medicines, ensuring even distribution of active ingredients.
Uses Of Polysorbate 80 (E 433):
Polysorbate 80 (E 433) is used as an antistat for PVC and as an antifog for PP, PE, PVC, PS.
Polysorbate 80 (E 433) is used as an emulsifier (ice cream, whipped topping) and as a solubilizing and dispersing agent in pickles and special vitamin-mineral preparations.
For example, in ice cream, Polysorbate 80 (E 433) is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.
Adding polysorbate prevents milk proteins from completely coating the fat droplets.
This allows them to join in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.
Polysorbate 80 (E 433) is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash.
The cosmetic grade of Polysorbate 80 (E 433) may have more impurities than the food grade.
Polysorbate 80 (E 433) is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.
Polysorbate 80 (E 433) is also an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.
It is also used as an excipient in some European and Canadian influenza vaccines.
Influenza vaccines contain 2.5 μg of Polysorbate 80 (E 433) per dose.
Polysorbate 80 (E 433) is found in many vaccines used in the United States, including the Janssen COVID-19 vaccine.
It is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
It is also used as an emulsifier in the estrogen-regulating drug Estrasorb.
Polysorbate 80 (E 433) is also used in granulation for stabilization of drugs and excipients when IPA binding.
Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules); when these species are added to a mixture of Polysorbate 80 (E 433) and phenol red, they cause the solution to change color, so this is used as a test to identify the phenotype of a strain or isolate.
Polysorbate 80 (E 433) counteracts disinfectants often found on sampled surfaces, thereby allowing the microbes found on these surfaces to grow.
It is used to emulsify oils and water in various food products, such as ice cream, margarine, and dressings.
Helps in stabilizing food products like salad dressings, mayonnaise, and cake mixes by preventing the separation of ingredients.
Polysorbate 80 (E 433) aids in enhancing and dispersing flavors and colorants in beverages and confections.
It is used as an emulsifier and solubilizing agent in oral and injectable drug formulations, particularly for hydrophobic drugs.
Polysorbate 80 (E 433) is used in vaccines to stabilize active ingredients and enhance the efficacy and shelf life of the vaccine.
Polysorbate 80 (E 433) is used to formulate emulsions in creams and lotions, improving texture and absorption.
It is used as a surfactant, emulsifier, and stabilizer in lotions, creams, and moisturizers.
Polysorbate 80 (E 433) is used to blend ingredients and enhance the spreadability of hair care products.
Polysorbate 80 (E 433) is found in foundation, mascaras, and other makeup items for even distribution and smooth application.
Used in industrial cleaning formulations to break down oils and greases.
Polysorbate 80 (E 433) is used in machinery lubricants and metalworking fluids to improve performance and extend equipment life.
Used to improve dispersion and prevent clumping in the manufacturing of paints and coatings.
Polysorbate 80 (E 433) is used in agricultural formulations to improve the spreading and penetration of pesticides, herbicides, and fungicides on plant surfaces.
It is used in cell culture media as a surfactant to help maintain the integrity and dispersion of cells.
Polysorbate 80 (E 433) is used in laboratory reagents and experiments for solubilizing hydrophobic compounds.
Polysorbate 80 (E 433) is the trade name of a detergent that can be useful in identifying mycobacteria that possess a lipase that splits the compound into oleic acid and polyoxyethylated sorbitol.
Polysorbate 80 (E 433) is used as an additive for cell culture media.
It has numerous effects, e.g. increasing the transformation frequency of Brevibacterium lactofermentum or enhancing the secretion of acid and alkaline phosphatase by Neurospora crassa.
Polysorbate 80 (E 433) is used as an emulsifier in foods, though research suggests it may "profoundly impact intestinal microbiota in a manner that promotes gut inflammation and associated disease states."
Polysorbate 80 (E 433) is a general purpose mid-range HLB, ethoxylated, nonionic surfactant suggested for use in textile chemicals (emulsifier, lubricant), household products and cosmetic formulations (o/w emulsifier, viscosity modifier).
Polysorbate 80 (E 433) is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.
Safety Profile Of Polysorbate 80 (E 433):
It can cause mild eye irritation upon contact.
It may cause redness or discomfort, but severe reactions are rare.
Inhalation of large quantities of Polysorbate 80 (E 433) aerosols or vapors is not likely in typical uses.
However, it may cause respiratory irritation if inhaled in very high concentrations.
Some individuals may be allergic to Polysorbate 80 (E 433), experiencing symptoms such as skin rashes, itching, or swelling.
These reactions are more likely in individuals with a sensitivity to ethoxylated compounds or other ingredients in the formulation.
Moderately toxic by intravenous route.
Polysorbate 80 (E 433) experimental reproductive effects.
Questionable carcinogen with experimental tumorigenic data.
Polysorbate 80 (E 433) when heated to decomposition it emits acrid smoke and irritating fumes.
Polysorbate 80 (E 433) is considered to have low toxicity when ingested in small quantities, as typically found in food products.
However, excessive consumption may cause digestive discomfort such as nausea, vomiting, or diarrhea.
It is generally not irritating to the skin in low concentrations.
However, prolonged or high concentrations of Polysorbate 80 (E 433) may cause mild irritation or allergic reactions in sensitive individuals.
