Quick Search
Potassium citrates is a urinary alkalinizer and mineral supplement used to make urine less acidic.
Potassium citrates is primarily prescribed to prevent kidney stones and gout, and is widely available over-the-counter as a liquid mixture or capsule to soothe the painful burning symptoms of cystitis and mild urinary tract infections.
Potassium citrates is a type of potassium salt that makes your pee less acidic.
CAS: 866-84-2
MF: C6H9KO7
MW: 232.23
EINECS: 212-755-5
Synonyms
tripotassium 2-hydroxypropane-1,2,3-tricarboxylate;sdTripotassium Citrate;HYDROXY CITRIC ACID SYNTHETIC;2-Hydroxy-1,2,3-propanetricarboxylic acid tripotassium salt;POTASSIUM CITRATE TRIBASIC SOLUTION;Tripotassium-2-hydroxypropane-1,2,3-tricarboxylateanhydrous;Tripotassiumcitrate:forfood,E332;1,2,3-Propanetricarboxylicacid,2-hydroxy-,tripotassiumsalt
The applications of Potassium citrates mainly derive from its alkaline properties.
Potassium citrates is used to treat kidney stones composed of uric acid and cysteine, as well as other renal failures caused by excess acidity, including in veterinary applications.
As an additive to soft drinks and other edibles, Potassium citrates also functions as an acid buffer, less bitter than other potassium salts, and with less sodium than trisodium citrate.
An additional use of Potassium citrates is to supplement potassium in patients with hypokalemia, preventing and treating gout and arrhythmia.
Potassium citrates is the drug which is most commonly used to prevent calculus.
Potassium citrates was found that in the urine pH value and citric acid value and have a very close relationship with the formation urinary tract calculus.
In an acidic urine (pH <5.5), the uric acid solubility is very low, so Potassium citrates is likely to cause uric acid calculus; while in alkaline urine (pH> 7), it is easy to form calcium or magnesium phosphate calculus.
63% of urinary calculus patients are below normal urine citrate, and potassium citrate can provide a lot of citric acid to enhance the urine pH value.
So for uric acid calculus, Potassium citrates has a very significant therapeutic effect to low calcium citrate calculus disease and tubular poisoning calcium calculus disease.
But Potassium citrates will raise the concentration of potassium and lower the concentration of ammonium ion in urinary, which is because not only complements the citric acid, but also supplements of potassium.
Since potassium metabolism is very quickly in the body, there is no change in blood potassium concentration.
Potassium citrates has little effect on the body.
The daily amount of total urine, oxalate, phosphate, sodium, magnesium, sulfate and uric acid and other aspects test from patients with uric acid calculus, Potassium citrates is found that it is not affected by taking potassium citrate.
Potassium citrate is a potassium salt of citric acid with the molecular formula C6H5K3O7.
Potassium citrates is a white, slightly hygroscopic crystalline powder.
Potassium citrates is odorless with a saline taste.
As a food additive, potassium citrate is used to regulate acidity and is known as E number E332.
Medicinally, Potassium citrates may be used to control kidney stones derived from either uric acid or cystine.
The anhydrous form of the tripotassium salt of citric acid.
Potassium citrates is a salt of potassium and citric acid.
Potassium citrates is used as an antacid to help relieve the symptoms of heartburn, sour stomach, and acid indigestion.
Potassium citrates can also be used as a supplement when the body does not produce enough of this chemical on its own.
Potassium citrates is usually taken with calcium pantothenate to provide additional relief for people who have low levels of these chemicals in their urine.
The phase transition temperature for potassium citrate is approximately 33°C (91°F).
Potassium citrates is a potassium salt of citric acid with the molecular formula K3C6H5O7.
Potassium citrates is a white, hygroscopic crystalline powder.
Potassium citrates is odorless with a saline taste.
Potassium citrates contains 38.28% potassium by mass.
In the monohydrate form, Potassium citrates is highly hygroscopic and deliquescent.
As a food additive, Potassium citrates is used to regulate acidity, and is known as E number E332.
Medicinally, Potassium citrates may be used to control kidney stones derived from uric acid or cystine.
In 2020, Potassium citrates was the 297th most commonly prescribed medication in the United States, with more than 1 million prescriptions.
Potassium Citrate is a potassium salt of citric acid.
Potassium citrates is a white, slightly hygroscopic crystalline powder, odorless with a saline taste.
Potassium Citrate Chemical Properties
Melting point: decomposes at 230℃ [KIR78]
density: 1.187
solubility: H2O: 1 M at 20 °C, clear, colorless
PH: 8.59(1 mM solution);8.9(10 mM solution);9.01(100 mM solution);7.47(1000 mM solution)
Odor: at 100.00%. odorless
Water Solubility: 60.91 g/100g saturated solution in water (25°C) [MER06]
λmax λ: 260 nm Amax: 0.045
λ: 280 nm Amax: 0.025
Cosmetics Ingredients Functions :BUFFERING CHELATING
InChI: InChI=1S/C6H8O7.K.H/c7-3(8)1-6(13,5(11)12)2-4(9)10;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;
InChIKey: JOSYFFAWJFRGHM-UHFFFAOYSA-N
LogP: -0.280 (est)
CAS DataBase Reference: 866-84-2(CAS DataBase Reference)
EPA Substance Registry System: Potassium citrates (866-84-2)
Colorless crystals or white crystalline powder, odorless, cool and salty, slight deliquescence, soluble in water and glycerin, insoluble in ethanol.
Tests show that the product had no significant harm to the human body, ADI doesn’t need special provision (FAO/WHO, 1994).
Colorless or white crystals or powder; cooling, saline taste; odorless; deliquescent. Soluble in water and glycerol; almost insoluble in alcohol.
Uses
As a preservative, stabilizing and pH buffering agents and others.
China provides for various types of food, according to production needs to use appropriately.
Used in the food, pharmaceutical and other industries, as buffering agents
Potassium citrate is rapidly absorbed when given by mouth and is excreted in the urine.
Since Potassium citrates is an alkaline salt it is effective in reducing the pain and frequency of urination when these are caused by highly acidic urine.
Potassium citrates is used for this purpose in dogs and cats, but is chiefly employed as a non-irritating diuretic.
Potassium citrates is an effective way to treat/manage gout and arrhythmia, if the patient is hypokalemic.
Potassium citrates is widely used to treat urinary calculi (kidney stones) and is often used by patients with cystinuria.
For use as an electrolyte replenisher and in the treatment of hypokalemia.
potassium citrates is it acts as a buffer, maintaining product pH constant, a pH adjuster and a product stabilizer.
Potassium citrates is a potassium salt.
Potassium citrate is rapidly absorbed when given by mouth, and is excreted in the urine.
Since Potassium citrates is an alkaline salt, it is effective in reducing the pain and frequency of urination when these are caused by highly acidic urine.
Potassium citrates is used for this purpose in dogs and cats, but is chiefly employed as a non-irritating diuretic.
Potassium citrates is an effective way to treat/manage arrhythmia,if the patient is hypokalemic.
Potassium citrates is widely used to treat urinary calculi (kidney stones) and bladder stones, and is often used by patients with cystinuria.
A systematic review showed a significant reduction in the incidence of kidney stone formation RR 0.26, 95% CI 0.10 to 0.68.
Potassium citrates is also used as an alkalizing agent in the treatment of mild urinary tract infections, such as cystitis.
Potassium citrates is also used in many soft drinks as a buffering agent.
Frequently used in an aqueous solution with other potassium salts, it is a wet chemical fire suppressant that is particularly useful against kitchen fires.
Potassium citrates's alkaline pH encourages saponification to insulate the fuel from oxidizing air, and the endothermic dehydration reaction absorbs heat energy to reduce temperatures.
Industrial uses
Potassium citrates is used in the United Kingdom as an over-the-counter drug for the relief from discomfort experienced in mild urinary-tract infections by increasing the urinary pH.
Potassium citrates should be not given to men if they experience pain in the kidney area (risk of kidney stones) or if blood or pus is present in the urine.
Also, patients with raised blood pressure or diabetes should avoid taking Potassium citrates without consultation with their general practitioner (GP).
Caution is generally advised to patients with renal impairment, cardiac problems and the elderly.
Production methods
Citric acid and potassium hydroxide or potassium bicarbonate derived products.
C6H8O7 + 3KHCO3 → CaH5K3O7 · H2O + 3CO2 ↑ + 2H2O
Production Methods
Potassium citrates is produced by adding potassium bicarbonate or potassium carbonate to a solution of citric acid until effervescence ceases, filtering the solution and evaporating to granulation.
Synthesis
Potassium citrates can be synthesized by the neutralization of citric acid which is achieved by the addition of potassium bicarbonate, potassium carbonate or potassium hydroxide to it.
The solution can then be filtered and the solvent can be evaporated till granulation.
