PRODUCTS

POTASSIUM FUMARATE

Potassium Fumarate=Dipotassium fumarate =Fumaric acid potassium salt =Potassium (e)-butenedioate.

CAS Number: 7704-72-5 or 4151-35-3

European Community (EC) Number: 223-979-8 or 233-569-0

Chemical Formula: C4H2K2O4

Molar mass: 192.253g/mol

IUPAC name: Dipotassium (2E)-but-2-enedioate

DESCRIPTION:

Potassium fumarate is a compound with formula K2C4H2O4.
Potassium fumarate is the potassium salt of fumaric acid.
Potassium fumarate has E number E366.
Potassium fumarate is a white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives.
dipotassium (2E)-but-2-enedioate belongs to the class of organic compounds known as dicarboxylic acids and derivatives.
These are organic compounds containing exactly two carboxylic acid groups.

Sources/Uses:

Potassium fumarate is used as a nutritional supplement.
Potassium fumarate is used as an acidity regulator for foods.
Potassium fumarate is a dietary supplement and pH control agent in foods
The use of potassium fumarate in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern and when low doses of the diuretic are used.
Serum potassium fumarate should be checked periodically, however, and if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases, and if dose adjustment of the diuretic is ineffective or unwarranted, supplementation with potassium fumarate may be indicated.

Potassium Fumarate Interactions: Disturbs absorption of orally administered drugs.

Chemical and Physical Properties of Potassium fumarate:

Molecular Weight: 192.25 g/mol
Hydrogen Bond Donor Count:   0
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count:   0
Exact Mass: 191.92272151 g/mol
Monoisotopic Mass: 191.92272151 g/mol
Topological Polar Surface Area:   80.3 Å²
Heavy Atom Count: 10
Formal Charge:   0
Complexity: 108
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 1
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes
Water Solubility: 57.5 g/L
logP: 0.27
logP: -0.041
logS: -0.52
pKa (Strongest Acidic):   3.55
Physiological Charge:   -2
Hydrogen Acceptor Count: 4
Hydrogen Donor Count: 0
Polar Surface Area: 80.26 Å²
Rotatable Bond Count: 2
Refractivity:   46.28 m³•mol⁻¹
Polarizability:   8.65 Å³
Number of Rings: 0
Bioavailability:   Yes
Rule of Five:   Yes
Ghose Filter:   No
Veber's Rule:   No
MDDR-like Rule   :No

Boiling point: 355℃
Major Category: Metals
Category: Organic Acids, Metal Salts
Appearance: White powder solid
Odor: Potassium fumarate is odorless.

SAFETY INFORMATION:

Signal Words: Warning
Hazard statements:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary statements:
P264: Wash thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN: Wash with plenty of soap and water.
P305+P351+P338:
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do.
Continue rinsing.
P332+P313:
If skin irritation occurs: Get medical advice/attention.
P337+P313:
If eye irritation persists: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol: Xi Irritant
Risk Phrases: R36/37/38 Irritating to eyes, respiratory system, and skin

First Aid Measures:

Always seek medical attention after first aid measures are provided.
Inhalation of potassium fumarate:
Remove to fresh air.
If not breathing, give artificial respiration.
If breathing is difficult, give oxygen.
Get medical attention.
Ingestion of potassium fumarate:
Never give anything by mouth to an unconscious person.
Get medical attention.
Skin Contact:
Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes.
Remove contaminated clothing and shoes.
Get medical attention.
Wash clothing before reuse.
Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally.
Get medical attention immediately.

Fire Fighting Measures:

Flammability of the potassium fumarate:
Non-flammable.
Products of Combustion: Oxides of Carbon and Oxides of Potassium etc.
Explosion: Not an Explosive item.
Fire Extinguishing Media:
Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Use any means suitable for extinguishing surrounding fire.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.
At high temperatures under fire conditions, potassium fumarate may produce toxic or irritating fumes.
Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used.
Uninvolved persons should evacuate to a safe place.

Accidental Release Measures:

Personal precautions, protective equipment, and emergency procedures:
Avoid breathing dust/fumes/gas/mist/vapors/spray.
Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses)
Restrict unprotected personnel from the area.
Prevent any contact with hot surfaces.
Do not approach facing the wind.
Do not touch the spilled material.
Environmental precautions:
Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill of potassium fumarate:
Avoid dust formation.
Avoid breathing dust.
Ensure adequate ventilation.
Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill of potassium fumarate:
Do not inhale dust, vapors, mist, or gas.
Avoid dust formation.
Contain spilled material.
Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite).
Use a shovel to put the material into a convenient waste disposal container.
Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Handling and Storage of potassium fumarate:

Precautions for safe handling:
Apply according to good manufacturing and industrial hygiene practices.
Ensure proper ventilation.
In case of insufficient ventilation, wear suitable respiratory equipment.
Wash thoroughly after handling.
Do not drink, eat, or smoke while handling.
Avoid contact with skin, eyes, and clothing.
Minimize dust generation.
Avoid breathing dust/fumes/gas/mist/vapors/spray.
Avoid contact with eyes, skin, and clothing.
Keep container tightly closed.

Avoid ingestion and inhalation.
Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.).

Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities:
Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container.
Keep air contact to a minimum.
Store protected from heat, sparks and ignition sources and incompatible materials.
Avoid contact with skin and eyes.
Avoid inhalation of dust/mist/vapor.
Do not store with incompatible materials like strong oxidizing agents, highly alkaline or acidic materials.

Exposure Controls/Personal Protection:

Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures as low as possible.
Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn.
For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible.

Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures:
Maintain good housekeeping in work area.
Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards.
Handle in accordance with good industrial hygiene and safety practice.
Wash hands after handling.

Stability and Reactivity of potassium fumarate:

Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Potassium fumarate emits oxides of carbon, potassium and fumes when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizing agents, highly alkaline or acidic materials.
Conditions to Avoid:
Incompatibles heat, light and moisture.

Substituents of Potassium fumarate:

Fatty acyl
Fatty acid
Unsaturated fatty acid
Dicarboxylic acid or derivatives
Carboxylic acid salt
Organic alkali metal salt
Carboxylic acid
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organic potassium salt
Organic salt
Organooxygen compound
Carbonyl group
Aliphatic acyclic compound
Molecular Framework: Aliphatic acyclic compounds

SYNONYMS:

Depositor-Supplied Synonyms:

Dipotassium fumarate

7704-72-5

4151-35-3

UNII-8Z42Z85852

FUMARIC ACID DIPOTASSIUM SALT

8Z42Z85852

Fumaric acid, potassium salt

2-Butenedioic acid (Z)-, potassium salt

2-Butenedioic acid (E)-, dipotassium salt

Potassium 2-butenedioate, (E)-

EINECS 223-979-8

EINECS 233-569-0

2-Butenedioic acid (E)-, potassium salt

Potassium fumarat-2-hydrate

SCHEMBL105897

SCHEMBL105898

C4H2K2O4

DTXSID40894985

2015AC

MFCD00151400

AKOS016010123

A865369

Q723321