PRODUCTS

PROPANEDIOL (TRIMETHYLENE GLYCOL)

Propanediol (Trimethylene glycol) has many household and manufacturing uses.
Propanediol (Trimethylene glycol) is found in a variety of products, from skin cream to printer ink to auto antifreeze.
Propanediol (Trimethylene glycol) can help your skin quickly absorb other ingredients in your product of choice.

CAS Number: 504-63-2
EC (EINECS) Number: 207-997-3
IUPAC Name: Propane-1,3-diol
Chemical Name: 1,3-Propanediol (PDO), also known as Trimethylene Glycol
Molecular Formula: C₃H₈O₂
Molecular Weight: 76.10 g/mol

SYNONYMS:
1,3-Propanediol, Trimethylene glycol, Propane-1,3-diol, 1,3-Dihydroxypropane, 2-Deoxyglycerol, 1,3-Propandiol, 1,3-Propylene glycol, Beta-propylene glycol, Omega-propanediol, 2-(Hydroxymethyl)ethanol, 1,3-Propanediol, 504-63-2, DTXSID8041246, CHEBI:16109, 5965N8W85T, DTXCID6021246, GlyTouCan:G36565LB, 207-997-3, RefChem:906914, 1,3-PROPANDIOL, MFCD00002949, NSC 65426, AI3-01851, HOCH2CH2CH2OH, HO(CH2)3OH, 345260-48-2, EINECS 207-997-3, BRN 0969155, UNII-5965N8W85T, 3-Hydroxypropanol, propane-1,3diol, propane1,3-diol, propane1.3-diol, propan-1,3-diol, 1,3-propanediol, 1,3-propane diol, 1,3-propane-diol, Trimethylene glycol, 1,3-propyleneglycol, propane-1,3-diol, propanediol-(1,3), Tirofiban Impurity 112, bmse000303, EC 207-997-3, 1,3-Propanediol, 98%, SCHEMBL15135, SCHEMBL74393, SCHEMBL95369, SCHEMBL96504, 1,3-Propanediol (Standard), (HOCH2)2CH2, CH2(CH2OH)2, SCHEMBL105133, SCHEMBL465048, SCHEMBL702020, CHEMBL379652, orb1303220, SCHEMBL4723167, SCHEMBL6818842, SCHEMBL18154859, SCHEMBL27465327, TRIMETHYLENE GLYCOL [MI], HSDB 8263, 1,3-Propanediol, >=99.6%, HY-W017758R, JLA47477, NSC65426, Tox21_300750, STL282728, AKOS000269061, CS-W018490, DB02774, FP33131, HY-W017758, NCGC00248157-01, NCGC00254655-01, BP-30193, CAS-504-63-2, PD007650, DB-071203, NS00005983, P0486, EN300-19343, 1,3-Propanediol, puriss., >=99.0% (GC), C02457, D77845, A828134, Q161514, 1,3-Propanediol (Discontinued, See C4X-1254112), InChI=1/C3H8O2/c4-2-1-3-5/h4-5H,1-3H, F1908-0064, Z104473578, 7AB97F71-EF6B-4C05-8084-541427B9306C, 1,3-Propanediol, United States Pharmacopeia (USP) Reference Standard, 31714-45-1, Trimethylene glycol, Zemea propanediol, PG, Susterra, Bio-PDO, methyl propaneediol, (HOCH2)2CH2, CH2(CH2OH)2, β-Propylene glycol, Propane-1,3-diol, PG, Trimethylene glycol, 1,3-Dihydroxypropane, 1,3-Propylene glycol, 2-Deoxyglycerol, Propanediol-(1,3), ω-Propanediol, 1,3-Propylenediol, 2-(Hydroxymethyl)ethanol, NSC 65426, Polypropylene glycol 425

In the chemical industry and manufacturing sphere, Propanediol (Trimethylene glycol), also called trimethylene glycol or 1-3 propylene glycol but more commonly known as PDO, is a valuable component for a variety of processes and products.
Diols are a subset of molecules known for their usefulness in a multitude of chemical reactions, including the formation of polyesters and polyurethanes, and Propanediol (Trimethylene glycol) is no exception.

Propanediol (Trimethylene glycol)’s high reactivity leads to its use as a primary diol, its use in chain extension reactions for the formation of polyurethanes, and as an intermediate in the formation of polyester polyols.
Traditionally, Propanediol (Trimethylene glycol) has been derived from petrochemicals, such as propylene and ethylene glycol.

This route makes use of the hydration of acrolein, a toxic petrochemical derivative of propylene, to produce Propanediol (Trimethylene glycol) in large quantities.
In recent years, technology has emerged to derive Propanediol (Trimethylene glycol) from corn and other biological sources via sugar fermentation, allowing for a smaller ecological footprint and safer manufacturing.

In tandem with bio-based succinic and sebacic acids, bio-based Propanediol (Trimethylene glycol) can be used to produce 100 percent renewably sourced polyesters.
Propanediol (Trimethylene glycol) is a colorless and odorless liquid with a large assortment of useful properties in various applications.

Propanediol (Trimethylene glycol), also propane-1,3-diol or trimethylene glycol, is a three-carbon diol.
Propanediol (Trimethylene glycol) is a clear, colorless viscous liquid that is miscible with water and ethanol.
Propanediol (Trimethylene glycol) can be formulated into a variety of industrial products including composites, adhesives, laminates, coatings, moldings, novel aliphatic polyesters, copolyesters, solvents, antifreeze and other end uses.

Propanediol (Trimethylene glycol) does not appear to pose a significant hazard via inhalation of either the vapor or a vapor/aerosol mixture.
Dubbed Bio-Propanediol (Trimethylene glycol), it's being produced with genetically modified strain of E. coli that's fed a refined corn syrup.
The bacteria, after a fermentation process, then produces Bio-Propanediol (Trimethylene glycol).

Most in the industry refer to Bio-Propanediol (Trimethylene glycol) as "Liquid Diamonds", due to the crystal clear liquid that is the final product.
Propanediol (Trimethylene glycol) is produced from plant-sourced glycerin through microbial transformation, serving as an eco-friendly alternative to petrochemical products like 1,4-butanediol in polyurethane production.

Propanediol (Trimethylene glycol) is used as a urethane chain extender and building block for polyester polyols, resulting in sustainable polyurethanes with improved low temperature flexibility, higher melting points (Tm), lower water absorption, and better processing.
Propanediol (Trimethylene glycol) can replace 1,4-butanediol in polyurethanes without extensive re-formulation.

Propanediol (Trimethylene glycol) is a common ingredient in cosmetics and personal care products such as lotions, cleansers, and other skin treatments.
Propanediol (Trimethylene glycol)’s a chemical similar to propylene glycol, but thought to be safer.

However, there haven’t been enough studies yet to definitively determine safety.
But considering current data, it’s most likely that topical Propanediol (Trimethylene glycol) in cosmetics carries a low risk for serious problems.

Propanediol (Trimethylene glycol) is currently approved for use in cosmetics, in restricted amounts, in the United States, Canada, and Europe.
1,3-Propanediol (Trimethylene Glycol) is a versatile and widely used diol with a clear safety and environmental profile when handled properly.
Propanediol (Trimethylene glycol) is commonly valued in cosmetics for its skin compatibility and in industry for polymer and solvent applications.

Propanediol (Trimethylene glycol) is the organic compound with the formula CH2(CH2OH)2.
This 3-carbon diol, Propanediol (Trimethylene glycol), is a colorless viscous liquid that is miscible with water.
Propanediol (Trimethylene glycol) is a chemical substance.

Propanediol (Trimethylene glycol) originates either from corn or petroleum.
Propanediol (Trimethylene glycol) often occupies color clear or very lightly yellowish.
Propanediol (Trimethylene glycol) is almost odorless.

You can find Propanediol (Trimethylene glycol) on the ingredient list in almost all categories in cosmetics and skin care products.
Propanediol (Trimethylene glycol) is a chemical compound with various industrial and commercial applications.
Propanediol (Trimethylene glycol) is the organic compound with the formula CH2(CH2OH)2.

Propanediol (Trimethylene glycol) is a colorless viscous liquid that is miscible with water.
Propanediol (Trimethylene glycol) is the organic compound with the formula CH2(CH2OH)2.
Propanediol (Trimethylene glycol) is a colorless viscous liquid that is miscible with wate

USES and APPLICATIONS of PROPANEDIOL (TRIMETHYLENE GLYCOL):
Cosmetics & Personal Care: Propanediol (Trimethylene glycol) is used as a moisturizer, solvent, humectant, viscosity enhancer, carrier, and booster; often replacing propylene glycol due to perceived safety benefits.

Industrial & Polymer Manufacture: Solvent for thin film preparations; Propanediol (Trimethylene glycol) is used in the production of polytrimethylene terephthalate (PTT), adhesives, laminates, coatings, moldings, aliphatic polyesters; in antifreeze and wood paint formulations; reagent in polymerization and natural product synthesis.

Other: Propanediol (Trimethylene glycol) functions as a solvent, antifreeze, viscosity agent, and polymer building block; used in various industrial applications.
Uses of Propanediol (Trimethylene glycol): Cosmetics (moisturizer, solvent), polymers (PTT), coatings, antifreeze, solvents, reagents.

In industrial spheres and in the pharmaceutical industry, PDO is used as a basis or as a solvent for advanced syntheses.
Propanediol (Trimethylene glycol) is an important building block for the formulation of multiple polyesters, including polytrimethylene terephthalate (PPT).

Propanediol (Trimethylene glycol)’s use as a solvent allows it to fill a niche that water and other solvents cannot, providing a different array of compounds that it can successfully dissolve.
The capability of Propanediol (Trimethylene glycol) to raise the freezing temperature of mixtures makes it a potent antifreeze, and when included in mixtures, it can be used industrially for a variety of purposes, such as in engine coolants.

Propanediol (Trimethylene glycol) is also used in the printing industry for ink, toner, and colorant products.
In the cosmetic industry, Propanediol (Trimethylene glycol) works as a non-toxic and biodegradable humectant, meaning it retains moisture and is safe for human use.

Thus, Propanediol (Trimethylene glycol) is used in a variety of cosmetics and personal care products such as shampoos, conditioners, and lotions for its moisturizing and cleaning properties.
Diols are a subset of molecules known for their usefulness in a multitude of chemical reactions, including the formation of polyesters and polyurethanes, and Propanediol (Trimethylene glycol) is no exception.

Propanediol (Trimethylene glycol)’s high reactivity leads to its use as a primary diol, its use in chain extension reactions for the formation of polyurethanes, and as an intermediate in the formation of polyester polyols.
Propanediol (Trimethylene glycol) has many household and manufacturing uses.

Propanediol (Trimethylene glycol) is found in a variety of products, from skin cream to printer ink to auto antifreeze.
Cosmetic companies use Propanediol (Trimethylene glycol) because it’s effective — and low cost — as a moisturizer.
Propanediol (Trimethylene glycol) can help your skin quickly absorb other ingredients in your product of choice.

Propanediol (Trimethylene glycol) can also help dilute other active ingredients.
According to the Environmental Working Group (EWG), you’ll find Propanediol (Trimethylene glycol) most often in facial moisturizers, serums, and face masks.

But you can also find Propanediol (Trimethylene glycol) in other personal care products, including: antiperspirant, hair color, eyeliner, foundation.
Propanediol (Trimethylene glycol) is a common ingredient in cosmetic products and personal care products.

Propanediol (Trimethylene glycol) can be lotions, serum, cleaning products and other skin treatments.
Propanediol (Trimethylene glycol) is a chemical similar to propylene glycol, but it should be a safe alternative after research.
Propanediol (Trimethylene glycol) is approved for use in cosmetics, in the United States, Canada and Europe.

The manufacturers of cosmetics use Propanediol (Trimethylene glycol) because it is effective and cheaply as moisturizing element in the products.
Propanediol (Trimethylene glycol) helps your skin absorb other ingredients in a given product.

Propanediol (Trimethylene glycol) is often found in moisturizer, serums and face masks.
But you can also find Propanediol (Trimethylene glycol) in hair color, eyeliner, foundation.
Propanediol (Trimethylene glycol) is mainly used as a building block in the production of polymers such as polytrimethylene terephthalate.

Propanediol (Trimethylene glycol) can be formulated into a variety of industrial products including composites, adhesives, laminates, coatings, moldings, aliphatic polyesters, and copolyesters.
Propanediol (Trimethylene glycol) is also a common solvent.

Propanediol (Trimethylene glycol) is used as an antifreeze and as a component in wood paint.
Uses, Applications & Markets: Key applications of Propanediol (Trimethylene glycol): Antifreeze & Coolant, Food & Beverage, Industrial Chemicals, Lubricant & Grease, Metal Working, Organic Intermediates, Personal Care & Cosmetics, Solvents & Degreasers, and Textile Auxiliaries.

Propanediol (Trimethylene glycol) has good viscosity and hygroscopicity, and is non-toxic, widely used as hygroscopicity agent, antifreeze agent, lubricant and solvent in food and cosmetics industry.
Propanediol (Trimethylene glycol) is an excellent solvent for condiments and pigments in the food industry, and a solvent, softener and excipient for making all kinds of ointments and ointments.

Propanediol (Trimethylene glycol) can also be used as moisturizer, mildew, food processing equipment lubricants and food labeling humor solvent, propylene glycol aqueous solution or effective antifreeze agent.
Propanediol (Trimethylene glycol) is used as the raw material of non-saturated alkyd resin, plasticizer, dehydration, surface active agent, solidification agent, and cohesive agent.

Propanediol (Trimethylene glycol) is also used in paint industry, pesticide industry etc.
Propanediol (Trimethylene glycol) is mainly used as a building block in the production of polymers such as polytrimethylene terephthalate.
Propanediol (Trimethylene glycol) can be formulated into a variety of industrial products including composites, adhesives, laminates, coatings, moldings, aliphatic polyesters, and copolyesters.

Propanediol (Trimethylene glycol) is also a common solvent.
Propanediol (Trimethylene glycol) is used as an antifreeze and as a component in wood paint.
Propanediol (Trimethylene glycol) is used as a building block in the production of polymers such as polytrimethylene terephthalate.

CHEMICAL BEHAVIOR of PROPANEDIOL (TRIMETHYLENE GLYCOL):
Typical alcohol reactivity.
Propanediol (Trimethylene glycol) condenses with carboxylic acids to form esters.
Propanediol (Trimethylene glycol) reacts with isocyanates to yield urethanes and with acid chlorides to yield esters.
Propanediol (Trimethylene glycol) has two primary hydroxyl groups of equivalent reactivity (unlike 1,2-propanediol).

MARKETS of PROPANEDIOL (TRIMETHYLENE GLYCOL):
*Coatings, Adhesives, Solvents, Elastomers
*Cosmetic / Personal Care
*Food & Beverage
*Industrial Chemicals

BENEFITS of PROPANEDIOL (TRIMETHYLENE GLYCOL):
The key benefit of Propanediol (Trimethylene glycol) is its flexibility – making it an important part of many industrial processes.
Propanediol (Trimethylene glycol) can be formulated for use in composites, adhesives, laminates, moldings, coatings, copolyesters, solvents, or aliphatic polyesters.

Propanediol (Trimethylene glycol) is a popular ingredient used in cosmetic and skin care products.
Propanediol (Trimethylene glycol) is a colorless and odorless liquid that is very effective and is a low-cost ingredient.

Propanediol (Trimethylene glycol) is a humectant as well as an emollient which means that apart from adding moisture to the skin, it also reduces moisture loss from the skin.
Additionally, Propanediol (Trimethylene glycol) is an excellent solvent and dissolves all the other ingredients in a formulation.

PRODUCTION & REACTIVITY of PROPANEDIOL (TRIMETHYLENE GLYCOL):
*Synthesis:
Hydrolysis of acrolein to 3-hydroxypropanal, then hydrogenation (~45 % yield).
Hydroformylation of ethylene oxide followed by hydrogenation (up to ~92 % yield, but less economical).

WHAT IS PROPANEDIOL (TRIMETHYLENE GLYCOL) USED FOR?
Propanediol (Trimethylene glycol) is widely used in products such as cleansers, toners, eyeliners, and foundations.
Propanediol (Trimethylene glycol) leaves the skin radiant and glowing without any negative effects.

In skin care, Propanediol (Trimethylene glycol) is known for softening and soothing the skin.
Propanediol (Trimethylene glycol) acts as an emollient and retains moisture on the skin - making it healthy and supple and promoting anti-aging properties.

Further, Propanediol (Trimethylene glycol) also prevents water loss by forming a protective barrier on the skin.
For hair care, Propanediol (Trimethylene glycol) is known to deeply hydrate the scalp and makes hair softer and smoother.
Propanediol (Trimethylene glycol) is a great conditioner and also promotes product absorption in formulations.

ORIGIN of PROPANEDIOL (TRIMETHYLENE GLYCOL):
Propanediol (Trimethylene glycol) can be made either naturally or synthetically.
Propanediol (Trimethylene glycol) is extracted from either corn sugar or corn glucose.
Further, in the lab, Propanediol (Trimethylene glycol) is made synthetically from petroleum.
Propanediol (Trimethylene glycol) is very expensive to produce but is found safer than other petroleum-derived glycols such as propylene glycol.

WHAT DOES PROPANEDIOL (TRIMETHYLENE GLYCOL) DO IN A FORMULATION?
*EMOLLIENT
*HUMECTANT
*MOISTURISING
*SOLVENT
*SOOTHING
*VISCOSITY CONTROLLING

Propanediol (Trimethylene glycol) is generally a natural ingredient, but it is also sometimes made from petroleum which is not preferred.
Propanediol (Trimethylene glycol) is a safe ingredient for skin and hair when used in small concentrations.
A patch test, however, is recommended.
Additionally, Propanediol (Trimethylene glycol) has deep cleansing abilities and does not clog pores, making it a non-comedogenic ingredient.

ALTERNATIVES of PROPANEDIOL (TRIMETHYLENE GLYCOL):
*PROPYLENE GLYCOL

PRODUCTION of PROPANEDIOL (TRIMETHYLENE GLYCOL):
Propanediol (Trimethylene glycol), trimethylene glycol, HOCH2CH2CH2OH, is produced on a much smaller scale than its isomer, propylene glycol.
In spite of some interesting areas of application of Propanediol (Trimethylene glycol), total production remains relatively small.
The difficulties of manufacturing Propanediol (Trimethylene glycol) result in a poorly competitive price structure relative to other diols.

CHEMICAL PROPERTIES of PROPANEDIOL (TRIMETHYLENE GLYCOL):
Propanediol (Trimethylene glycol) is a clear, colorless, odorless liquid that is miscible with water, alcohols, ethers, and formamide.
Propanediol (Trimethylene glycol) is sparingly soluble in benzene and chloroform.
The chemical properties of Propanediol (Trimethylene glycol) are typical of alcohols.

Like 1,2-Propanediol (Trimethylene glycol), Propanediol (Trimethylene glycol) condenses with carboxylic acids at elevated temperature to yield esters.
Propanediol (Trimethylene glycol) also reacts with isocyanates and acid chlorides to yield urethanes and esters, respectively.
Unlike 1,2-Propanediol (Trimethylene glycol), Propanediol (Trimethylene glycol) has two primary hydroxyl groups with equivalent reactivity.

PRODUCTION of PROPANEDIOL (TRIMETHYLENE GLYCOL):
Propanediol (Trimethylene glycol) is prepared by a two-step process involving the hydrolysis of acrolein to 3-hydroxypropanal followed by hydrogenation : synthesis of Propanediol (Trimethylene glycol)

Hydrolysis is carried out under weakly acidic conditions in water containing initially ca. 20 % acrolein.
Higher concentrations of acrolein tend to lead to greater amounts of undesired byproducts as a result of reaction between acrolein and hydroxypropanal.

3-Hydroxypropanal can be hydrogenated in the aqueous phase directly; however, the preferred technique is to extract the aldehyde into an organic solvent – particularly 2-methylpropanol – and then hydrogenate the aldehyde to yield the diol.
Hydrogenation is conducted with Raney nickel under pressure in the aqueous phase and with nickel-supported catalysts at 2 – 4 MPa and 110 – 150 ◦C in the organic phase.

The diol is subsequently separated from solvent and water by distillation.
The yield of desired product by this route is relatively low – approximately 45 %.

Alternative techniques for synthesizing the diol have appeared in the patent literature.
Hydroformylation of ethylene oxide followed by hydrogenation yields Propanediol (Trimethylene glycol) in good yield (92 %), but a high catalyst concentration and a very large excess of solvent render the process uneconomical.

More recently, hydroformylation of ethylene oxide directly to Propanediol (Trimethylene glycol) with a rhodium – phosphine catalyst system has been disclosed.
The reaction of ethylene with formaldehyde and carboxylic acids has also not been commericialized because of low selectivity.

OCCURRENCE of PROPANEDIOL (TRIMETHYLENE GLYCOL):
Propanediol (Trimethylene glycol) has been reported in Arabidopsis thaliana, Solanum lycopersicum, and Vitis vinifera.
Propanediol (Trimethylene glycol) is a metabolite found in or produced by Saccharomyces cerevisiae.

PRODUCTION of PROPANEDIOL (TRIMETHYLENE GLYCOL):
Propanediol (Trimethylene glycol) is mainly produced by the hydration of acrolein.
An alternative route involves the hydroformylation of ethylene oxide to form 3-hydroxypropionaldehyde.
The aldehyde is subsequently hydrogenated to give Propanediol (Trimethylene glycol).
Biotechnological routes are also known.

PROPERTIES of PROPANEDIOL (TRIMETHYLENE GLYCOL):
Propanediol (Trimethylene glycol) is the simplest member of the class of propane-1,3-diols, consisting of propane in which one hydrogen from each methyl group is substituted by a hydroxy group.

A colourless, viscous, water-miscible liquid with a high (210℃) boiling point, Propanediol (Trimethylene glycol) is used in the synthesis of certain polymers and as a solvent and antifreeze.
Propanediol (Trimethylene glycol) has a role as a protic solvent and a metabolite.

The aldehyde is subsequently hydrogenated to give Propanediol (Trimethylene glycol).
Biotechnological routes are also known.
Two other routes involve bioprocessing by certain micro-organisms:

Conversion from glucose effected by a genetically modified strain of E. coli by DuPont Tate & Lyle BioProducts (See: bioseparation of Propanediol (Trimethylene glycol)).
An estimated 120,000 tons were produced in 2007".

According to DuPont, the Bio-PDO process uses 40% less energy than conventional processes,
Because of DuPont and Tate & Lyle's success in developing a renewable Bio-PDO process, the American Chemical Society awarded the Bio-PDO research teams the "2007 Heroes of Chemistry" award.

Conversion from glycerol (a by-product of biodiesel production) using Clostridium diolis bacteria and Enterobacteriaceae.
Trimethylene Glycol, also known as Propanediol (Trimethylene glycol), is a versatile diol gaining prominence as a sustainable and bio-based chemical.

Propanediol (Trimethylene glycol) is a crucial monomer in the production of high-performance polymers, particularly poly(trimethylene terephthalate) (PTT) for fibers and engineering plastics.
Propanediol (Trimethylene glycol) also functions as an effective solvent for various resins and organic compounds.

As a humectant, Propanediol (Trimethylene glycol) helps retain moisture in cosmetics and personal care products, and finds applications in antifreeze formulations and cleaning agents.

Propanediol (Trimethylene glycol) is intended solely for professional manufacturing, laboratories and industrial/commercial applications.
Propanediol (Trimethylene glycol) is not for personal use.

PHYSICAL and CHEMICAL PROPERTIES of PROPANEDIOL (TRIMETHYLENE GLYCOL):
CAS Number: 504-63-2
EC (EINECS) Number: 207-997-3
IUPAC Name: Propane-1,3-diol
Chemical Name: 1,3-Propanediol (PDO), also known as Trimethylene Glycol
Molecular Formula: C₃H₈O₂
Molecular Weight: 76.10 g/mol
Appearance: Colorless, viscous/lucid liquid; almost odorless
Boiling Point: 211-217 °C
Melting Point: -27 °C
pH: 4.5-7.0

Solubility: Miscible in water
Density / Specific Gravity: ~1.053–1.06 g/cm³ at ~20 °C
Appearance: colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 1.05300 to 1.05600 @ 20.00 °C
Pounds per Gallon - (est.): 8.772 to 8.797
Refractive Index: 1.43800 to 1.44100 @ 20.00 °C
Boiling Point: 214.00 to 215.00 °C @ 760.00 mm Hg
Vapor Pressure: 0.034000 mmHg @ 25.00 °C (est)

Flash Point: 175.00 °F. TCC (79.44 °C)
logP (o/w): -1.040 (est)
Soluble in: alcohol
water, 1e+006 mg/L @ 25 °C (est)
Melting Point: approx. –26 °C
Boiling Point: ~214–215 °C
Refractive Index: ~1.44
Vapor Pressure: ~0.034 mmHg (~4.5 Pa) at 25 °C
Log P (Octanol-Water Partition): ~ –1.04 to –1.09 (hydrophilic)
Solubility: Miscible with water, alcohols, ethers, formamide;
sparingly soluble in benzene and chloroform
Flash Point: ~79.4 °C (TCC)

Auto-ignition Temperature: ~400 °C
Enthalpies: ΔHf° ≈ –476 to –486 kJ/mol; ΔHc° ≈ –1838 to –1848 kJ/mol
Molecular Formula / Molecular Weight: C3H8O2 = 76.10
Physical State (20 °C): Liquid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15 °C)
CAS RN: 504-63-2
Reaxys Registry Number: 969155
PubChem Substance ID: 87574671
SDBS (AIST Spectral DB): 2951
Merck Index (14): 9714

MDL Number: MFCD00002949
CAS / EC: 504-63-2 / 207-997-3
Formula / M.W.: C₃H₈O₂ / 76.10 g/mol
Physical Aspects: Colorless viscous liquid, odorless,
density ~1.05 g/cm³,
melting –26 °C, boiling ~214-215 °C,
refractive index ~1.44, flash point ~79 °C
Solubility: Fully miscible with water, alcohols, ethers;
sparingly in benzene/chloroform

Reactivity: Typical primary diol; reactive with acids, isocyanates, acid chlorides
Chemical formula: CH2(CH2OH)2
Molar mass: 76.095 g·mol−1
Appearance: Colourless liquid
Density: 1.0597 g cm−3
Melting point: −27 °C; −17 °F; 246 K
Boiling point: 211 to 217 °C; 412 to 422 °F; 484 to 490 K
Solubility in water: Miscible
log P: −1.093
Vapor pressure: 4.5 Pa
Refractive index (nD): 1.440

Thermochemistry
Std enthalpy of formation (ΔfH⦵298): −485.9–−475.7 kJ mol−1
Std enthalpy of combustion (ΔcH⦵298): −1848.1–−1837.9 kJ mol−1
Molecular Weight: 76.09 g/mol
XLogP3: -1
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 2
Exact Mass: 76.052429494 Da
Monoisotopic Mass: 76.052429494 Da
Topological Polar Surface Area: 40.5 Å²

Heavy Atom Count: 5
Formal Charge: 0
Complexity: 12.4
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Linear Formula: HO(CH2)3OH
CAS Number: 504-63-2
Molecular Weight: 76.09
MDL number: MFCD00002949
UNSPSC Code: 12352104
EC Index Number: 207-997-3
NACRES: NA.22
Physical state: liquid
Color: colorless
Odor: No data available
Melting Freezing point/point/freezing point range: -24,6 °C

Initial boiling point and boiling range: 208,9 °C at 989,91585 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: > 99 °C
Autoignition temperature: 342 °C at 1.021,24 hPa
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: 44,923 mm2/s at 24 °C
Viscosity, dynamic: No data available

Water solubility: 1.000 g/l at 21 °C - OECD Test Guideline 105 - completely soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: < 0,1 hPa at 20 °C
Density: 1,05 g/cm3 at 20 °C
Relative density: 1,05 at 25 °C
Relative vapor density:
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none

Other safety information: Surface tension 74,16 mN/m at 21 °C
CAS: 504-63-2
Density: 1.0520 g/mL
Flash Point: 140°C
Assay Percent Range: 97.5% min. (GC)
Molecular Formula: C3H8O2
Linear Formula: HO(CH2)3OH
Fieser: 13,268
Merck Index: 15,9885
Solubility Information: Solubility in water: 100 g/L water.

Other solubilities: soluble in ethanol, diethyl ether, slightly soluble in benzene
SMILES: OCCCO
Molecular Weight (g/mol): 76.10
Viscosity: 52.7 mPa.s (20°C)
Formula Weight: 76.09
Physical Form: Oily Liquid
Melting Point: -32.0°C
Boiling Point: 214.0°C
Infrared Spectrum: Authentic

Refractive Index: 1.4380 to 1.4400
MDL Number: MFCD00002949
Beilstein: 01,475
Specific Gravity: 1.052
InChI Key: YPFDHNVEDLHUCE-UHFFFAOYSA-N
IUPAC Name: propane-1,3-diol
PubChem CID: 10442
ChEBI: CHEBI:16109
Percent Purity: 98%
Chemical Name or Material: 1,3-Propanediol

Appearance: Colorless to pale yellow liquid
Boiling point: 214 °C
Density: 1.053 g/cm³
Flash Point: 79 °C
Melting point: −27 °C
Molecular Weight: 76.09
Odor: Odorless
Purity: 98%
Refractive index: 1.440

FIRST AID MEASURES of PROPANEDIOL (TRIMETHYLENE GLYCOL):
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of PROPANEDIOL (TRIMETHYLENE GLYCOL):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of PROPANEDIOL (TRIMETHYLENE GLYCOL):
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of PROPANEDIOL (TRIMETHYLENE GLYCOL):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of PROPANEDIOL (TRIMETHYLENE GLYCOL):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of PROPANEDIOL (TRIMETHYLENE GLYCOL):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available