PRODUCTS

PROPYL 4-HYDROXYBENZOATE

Propyl 4-hydroxybenzoate is a bacteriostatic and fungistatic agent used as a preservative in cosmetic products, food and drugs.
As a food additive, Propyl 4-hydroxybenzoate has the E number E216.
To increase the activity and reduce Propyl 4-hydroxybenzoate is dose Propyl 4-hydroxybenzoate is used in a mixture with other parabens and in combination with other types of preservatives.

CAS Number: 94-13-3
EC Number: 202-307-7
Chemical Formula: C10H12O3
Molecular Weight: 180.20

Synonyms: PROPYLPARABEN, Propyl 4-hydroxybenzoate, 94-13-3, Propylparaben, Propyl p-hydroxybenzoate, Nipasol, Nipazol, Propyl parahydroxybenzoate, 4-Hydroxybenzoic acid propyl ester, Propagin, Tegosept P, Nipagin P, n-Propyl 4-hydroxybenzoate, Propyl Butex, Betacide P, Propylparasept, Chemacide pk, Chemocide pk, N-Propyl p-hydroxybenzoate, Propyl Parasept, Aseptoform P, Propyl Chemosept, Protaben P, Propyl aseptoform, Nipasol P, Solbrol P, 4-Hydroxybenzoic acid, propyl ester, Paseptol, p-Hydroxypropyl benzoate, Preserval P, Betacine P, Bonomold OP, Nipasol M, p-Hydroxybenzoic acid propyl ester, p-Hydroxybenzoic propyl ester, Parasept, N-Propylparaben, Propyl-4-hydroxybenzoate, Propyl chemsept, Propyl-paraben, Benzoic acid, 4-hydroxy-, propyl ester, n-Propylparaben, FEMA No. 2951, Benzoic acid, p-hydroxy-, propyl ester, Paratexin p, Paraben p, Chemoside PK, Lexgard P, propyl para-hydroxybenzoate, Pulvis conservans, p-Hydroxybenzoic acid, propyl ester, Propylparaben e216, n-PROPYL-p-HYDROXYBENZOATE, NSC-8511, propyl 4-oxidanylbenzoate, NSC-23515, Z8IX2SC1OH, MLS002152934, DTXSID4022527, CHEBI:32063, 4-Hydroxybenzoic acid-propyl ester, NSC23515, p-Hydroxybenzoic acid n-propyl ester, NCGC00090965-03, NCGC00090965-04, SMR000112070, WLN: QR DVO3, Propyl parahydroxybenzoate;Propyl 4-hydroxybenzoate, DTXCID602527, Caswell No. 714, Propylparaben [USAN], Propyl 4-hydroxybenzoate, >=99%, Bayer D 206, FEMA Number 2951, Pulvis conservans (VAN), 4-Hydroxybenzoic acid-propyl ester 1000 microg/mL in Acetonitrile, CAS-94-13-3, HSDB 203, p-Oxybenzoesaurepropylester [German], EINECS 202-307-7, UNII-Z8IX2SC1OH, MFCD00002354, NSC 23515, p-Oxybenzoesaurepropylester, Propylparaben [USAN:NF], EPA Pesticide Chemical Code 061203, 4-Hydroxybenzoic acid-propyl ester D7 (propyl D7), BRN 1103245, AI3-01341, Propylester kyseliny p-hydroxybenzoove [Czech], 4-Hydroxybenzoic acid propylester, (Propylparaben), 36M, Propylparaben (NF), Propylester kyseliny p-hydroxybenzoove, Propylparaben-[d7], Propylparaben, USAN, Propylis hydroxybenzoas, 85403-59-4, Propyl 4-?Hydroxybenzoate, SCHEMBL977, PROPYLPARABEN [II], PROPYLPARABEN [MI], p-Oxybenzoesaeurepropylester, EC 202-307-7, PROPYLPARABEN [FCC], cid_7175, n-propyl-p-hydroxy-benzoate, PROPYLPARABEN [HSDB], PROPYLPARABEN [INCI], PROPYLPARABEN [VANDF], 4-10-00-00374 (Beilstein Handbook Reference), MLS002222346, MLS006011654, BIDD:ER0229, Propyl-4-Hydroxybenzoate,(S), Propylparaben [VANDF], PROPYLPARABEN [USP-RS], PROPYLPARABEN [WHO-DD], CHEMBL194014, Propyl parahydroxybenzoate (TN), BDBM70190, NSC8511, HMS2268K21, Propyl 4-hydroxybenzoate, BioXtra, PROPYL (4-HYDROXYBENZOATE), Propyl parahydroxybenzoate (JP17), HY-N2026, PROPYL PARA HYDROXY BENZOATE, ZINC1586788, Tox21_111048, Tox21_400012, BBL023754, s5405, STL294815, 4-Hydroxybenzoic acid, n-propyl ester, AKOS008948099, component of Heb-Cort MC (Salt/Mix), PROPYL HYDROXYBENZOATE [MART.], CCG-266432, DB14177, DS-3427, PROPYL HYDROXYBENZOATE [WHO-IP], PROPYL P-HYDROXYBENZOATE [FHFI], PROPYL PARAHYDROXYBENZOATE [JAN], NCGC00090965-01, NCGC00090965-02, NCGC00090965-05, NCGC00090965-06, NCGC00090965-07, AC-34533, E216, CS-0018518, FT-0618698, H0219, P1955, PROPYLIS HYDROXYBENZOAS [WHO-IP LATIN], D01422, PROPYL PARAHYDROXYBENZOATE [EP IMPURITY], EN300-7419478, PROPYL PARAHYDROXYBENZOATE [EP MONOGRAPH], A844839, Propyl 4-hydroxybenzoate, p.a., 99.0-100.5%, Propyl Parahydroxybenzoate 0.01 mg/ml in Methanol, Propyl Parahydroxybenzoate 1.0 mg/ml in Methanol, Q511627, 4-Arm PEG-OMs, 95%, average M.W. 20,000, Q-201635, Propyl 4-hydroxybenzoate, SAJ first grade, >=98.0%, Propyl 4-hydroxybenzoate, tested according to Ph.Eur., Propyl 4-hydroxybenzoate, Vetec(TM) reagent grade, 98%, METHYL PARAHYDROXYBENZOATE IMPURITY C [EP IMPURITY], Propylparaben, certified reference material, TraceCERT(R), Propylparaben, United States Pharmacopeia (USP) Reference Standard, Propyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard, Propylparaben, Pharmaceutical Secondary Standard; Certified Reference Material, Propylparaben [NF] [USAN] [Wiki], 202-307-7 [EINECS], 4-10-00-00374 [Beilstein], 4-Hydroxybenzoate de propyle [French] [ACD/IUPAC Name], 4-Hydroxybenzoic acid n-propyl ester, 4-hydroxybenzoic acid propyl ester, 4-Hydroxybenzoic acid, n-propyl ester, 94-13-3 [RN], Benzoic acid, 4-hydroxy-, propyl ester [ACD/Index Name], Benzoic acid, p-hydroxy-, propyl ester, DH2800000, Mekkings P [Trade name], MFCD00002354 [MDL number], Nipasol M [Trade name], n-propyl 4-hydroxybenzoate, n-Propyl p-hydroxybenzoate, n-Propylparaben, N-Propyl-p-hydroxybenzoate, p-Hydroxybenzoic acid n-propyl ester, p-Hydroxybenzoic acid, propyl ester, p-Oxybenzoesaurepropylester [German], Propyl 4-hydroxybenzoate [ACD/IUPAC Name], Propyl chemosept [Trade name], Propylparaben, Propyl parahydroxybenzoate [JP15], PROPYL PARASEPT [Trade name], propyl p-hydroxybenzoate, Propyl-4-hydroxybenzoate, Propyl-4-hydroxybenzoat [German] [ACD/IUPAC Name], Propylester kyseliny p-hydroxybenzoove [Czech], Propylis parahydroxybenzoas, Solbrol P [Trade name], Z8IX2SC1OH, 1219802-67-1 [RN], 1246820-92-7 [RN], 4-Hydroxy-benzoic acid propyl ester, 4-Hydroxybenzoic acid propylester, 4-hydroxybenzoic acid, propyl ester, 4-Hydroxybenzoic acid-propyl ester, Aseptoform P, Bayer D 206, Benzoic acid, 4-(aminomethyl)- (9CI), Bonomold OP, Chemocide pk, DS-3427, Lexgard P, Nipagin P, NIPASEPT, Nipasol, Nipasol P, Nipazol, n-Propyl 4-Hydroxybenzoate--d4, n-Propylparaben, N-Propyl-4-hydroxybenzoate, n-Propyl-p-hydroxy-benzoate, Parasept, Paseptol, PEPH, P-HYDROXY PROPYL BENZOATE, p-hydroxybenzoic acid propyl ester, p-Hydroxybenzoic propyl ester, p-Hydroxypropyl benzoate, p-Oxybenzoesaeurepropylester, Preserval P, Propagin, propilparabeno [Portuguese], Propyl aseptoform, Propyl butex, PROPYL PARA HYDROXY BENZOATE, Propyl Parahydroxybenzoate 0.01 mg/ml in Methanol, Propyl Parahydroxybenzoate 1.0 mg/ml in Methanol, Propyl-4-hydroxybenzoate, Propyl-d7 Paraben, Propyl-paraben, Propylparasept, Propyl-p-Hydroxybenzoate, Protaben P, QR DVO3 [WLN], Tegosept P, UNII:Z8IX2SC1OH, UNII-Z8IX2SC1OH

Propyl 4-hydroxybenzoate, the n-propyl ester of p-hydroxybenzoic acid, occurs as a natural substance found in many plants and some insects, although Propyl 4-hydroxybenzoate is manufactured synthetically for use in cosmetics, pharmaceuticals, and foods.
Propyl 4-hydroxybenzoate is a member of the class of parabens.

Propyl 4-hydroxybenzoate is a preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos, and bath products.
As a food additive, Propyl 4-hydroxybenzoate has the E number E216.

Sodium propyl p-hydroxybenzoate, the sodium salt of Propyl 4-hydroxybenzoate, a compound with formula Na(C3H7(C6H4COO)O), is also used similarly as a food additive and as an anti-fungal preservation agent.
Propyl 4-hydroxybenzoate is E number is E217.

In 2010 the European Union Scientific Committee on Consumer Safety stated that Propyl 4-hydroxybenzoate considered the use of butylparaben and Propyl 4-hydroxybenzoate as preservatives in finished cosmetic products as safe to the consumer, as long as the sum of their concentrations does not exceed 0.19%.

Propyl 4-hydroxybenzoate is a chemical allergen capable of producing immunologically mediated hypersensitivity reactions.
Chemically Propyl 4-hydroxybenzoate is an ester of p-hydroxybenzoic acid.

Propyl 4-hydroxybenzoate is in the paraben family of preservatives used by the food, pharmaceutical, and personal care product industries.
Parabens mimic estrogen and can act as potential hormone (endocrine) system disruptors.

Propyl 4-hydroxybenzoate is a type of paraben having the chemical formula C10H12O3.
The molar mass of Propyl 4-hydroxybenzoate is 180.2 g/mol.

The density of Propyl 4-hydroxybenzoate is 1.06 g/cm3, and Propyl 4-hydroxybenzoate is melting point can range from 96 to 99 degrees Celsius.
Propyl 4-hydroxybenzoate is the n-propyl ester of p-hydroxybenzoic acid.
Propyl 4-hydroxybenzoate occurs naturally in plants and some insects.

However, Propyl 4-hydroxybenzoate can be manufactured synthetically to be used in the cosmetic industry, pharmaceutical industry, and food industry.
This is because Propyl 4-hydroxybenzoate can act as a preservative for various products.

The Propyl 4-hydroxybenzoate compound has anti-fungal and antimicrobial properties and can be used in a variety of water-based cosmetics and personal-care products due to this property.
Moreover, we can use Propyl 4-hydroxybenzoate as a food additive, and Propyl 4-hydroxybenzoate has the E number E216.
In addition, Propyl 4-hydroxybenzoate is a standardized chemical allergen, and Propyl 4-hydroxybenzoate is important in allergenic testing.

Propyl 4-hydroxybenzoate, the n-propyl ester of p-hydroxybenzoic acid, occurs as a natural substance found in many plants and some insects, although Propyl 4-hydroxybenzoate is manufactured synthetically for use in cosmetics, pharmaceuticals and foods.
Propyl 4-hydroxybenzoate is one of the most commonly used preservatives in cosmetics since Propyl 4-hydroxybenzoate is stable in most pH levels.

Propyl 4-hydroxybenzoate is a paraben, which is a group of controversial preservatives that also includes butylparaben, isobutylparaben, methylparaben, and ethylparaben.
All of these were at one time the most widely used group of preservatives used in cosmetics.

Parabens were so popular because of their gentle, non-sensitizing, and highly effective profile in comparison to other preservatives but also because they were derived naturally from plants, a rare phenomenon for a preservative.
Parabens are found in plants in the form of p-hydroxybenzoic acid (PHBA), a chemical that breaks down to become parabens for a plants own protection.

Over the past 10 years parabens have become criticized and condemned for use in cosmetics due to their alleged relation to health concerns affecting women and men.
The research about parabens is conflicting and polarizing.

Some research indicates they are safe as used in cosmetics and are preferred over other preservatives to keep a formula stable.
These studies also showed parabens did not have any effect when compared to natural hormones in the body.

However, other research has concluded they are indeed problematic: Some studies determined a 100% concentration of parabens caused skin samples (meaning not intact skin on a person) to break down.
However, these studies don’t apply to the tiny amount (1% or less) of parabens typically used in cosmetics.
In low amounts, parabens were not shown to harm skin; in fact, they offer a benefit due to their ability to thwart the growth of mold, fungi, and harmful pathogens.

Other studies casting parabens in a negative light were based on force-feeding them to rats, a practice that is not only cruel but unrelated to what happens when parabens are applied to skin.
There are studies indicating absorption of parabens through skin associated with application of skin care products, but those studies did not take into consideration that parabens are still used as food-grade preservatives or found naturally in plants and that could have been the source not the cosmetics.

Propyl 4-hydroxybenzoate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
Propyl 4-hydroxybenzoate is used by consumers, by professional workers (widespread uses) and in formulation or re-packing.

Propyl 4-hydroxybenzoate is a preservative used in skincare and cosmetic formulations.

Propyl 4-hydroxybenzoate is classed as a paraben, a group of preservatives with slightly different functions and anti-microbial activity based on their size.
Other common parabens include methylparaben, butylparaben, isobutylparaben, and ethylparaben.

Propyl 4-hydroxybenzoate is used to extend the shelf-life of a product life by preventing microbial contamination.
Microbial contamination can occur from exposure to bacteria and molds in the air and general use of Propyl 4-hydroxybenzoate from your hands.

Preservatives like parabens are designed to reduce the likelihood that bacteria and molds can grow in your product.
This is important for ensuring the safety of a product.

Propyl 4-hydroxybenzoate naturally occurs in some fruit and vegetable products, such as barley, flaxseed, and grapes.
Parabens are found in plants in the form of p-hydroxybenzoic acid (PHBA), a chemical that breaks down to become parabens to protect the plant.

The parabens used in cosmetics are identical to those found in nature.
If parabens are absorbed through the skin, the human body can quickly metabolize them to PHBA and eliminate them.

Parabens have up until recently been the most widely used group of preservatives in skincare and cosmetic products.
Parabens were so popular because of their gentle, non-sensitizing, and highly effective in comparison to other preservatives.
However, the use of parabens is now controversial due to their alleged relation to health concerns.

Propyl 4-hydroxybenzoate is an antimicrobial preservative used in cosmetics and personal care.
Parabens are the most commonly used preservatives in personal care products.

They are non-irritating, have low toxicity levels, and are active against a wide spectrum of fungi and bacteria at low concentrations.
In addition to meeting the NF standards of USP, our Propyl 4-hydroxybenzoate also complies with BP and PhEur requirements.
Propyl 4-hydroxybenzoate is recommended for toothpaste, mascara, eyeliner, lipstick, and eyeshadow.

Propyl 4-hydroxybenzoate, also known as propyl chemosept or propyl parasept, belongs to the class of organic compounds known as p-hydroxybenzoic acid alkyl esters.
These are aromatic compounds containing a benzoic acid, which is esterified with an alkyl group and para-substituted with a hydroxyl group.

Propyl 4-hydroxybenzoate is a sweet, burnt, and hawthorn tasting compound.
Propyl 4-hydroxybenzoate is a potentially toxic compound.
Propyl 4-hydroxybenzoate is an antimicrobial agent, preservative, flavouring agent.

Propyl 4-hydroxybenzoate is the benzoate ester that is the propyl ester of 4-hydroxybenzoic acid.
Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products.

Propyl 4-hydroxybenzoate is also used as a food additive.
Propyl 4-hydroxybenzoate has a role as an antifungal agent and an antimicrobial agent.

Propyl 4-hydroxybenzoate is a benzoate ester, a member of phenols and a paraben.
Propyl 4-hydroxybenzoate is functionally related to a propan-1-ol and a 4-hydroxybenzoic acid.

Propyl 4-hydroxybenzoate is an antimicrobial agent, preservative, flavouring agent.
Propyl 4-hydroxybenzoate belongs to the family of Hydroxybenzoic Acid Derivatives.
These are compounds containing an hydroxybenzoic acid (or a derivative), which is a benzene ring bearing a carboxylic acid.

Propyl 4-hydroxybenzoate is a Standardized Chemical Allergen.
The physiologic effect of Propyl 4-hydroxybenzoate is by means of Increased Histamine Release, and Cell-mediated Immunity.

Propyl 4-hydroxybenzoate (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria.
Propyl 4-hydroxybenzoate is prevalently used in cosmetics, pharmaceuticals, and foods.

Propyl 4-hydroxybenzoate disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways.
Propyl 4-hydroxybenzoate also decreases sperm number and motile activity in rats.

Uses of Propyl 4-Hydroxybenzoate:
Propyl 4-hydroxybenzoate has antifungal and antimicrobial properties and is typically used in a variety of water-based cosmetics and personal-care products.
Propyl 4-hydroxybenzoate is also used as a food additive, and is designated with E number E216.
Propyl 4-hydroxybenzoate is also a Standardized Chemical Allergen and is used in allergenic testing.

Propyl 4-hydroxybenzoate is used as antimicrobial preservatives in pharmaceuticals, foods, cosmetics, and shampoos.
The parabens (methyl, ethyl, propyl, and butyl) were the most widely used preservatives in cosmetics (0.1% to 0.8%) until their sensitizing potential was recognized.

Widespread uses by professional workers:
Propyl 4-hydroxybenzoate is used in the following products: cosmetics and personal care products.
Other release to the environment of Propyl 4-hydroxybenzoate is likely to occur from: indoor use as processing aid.

Industry Uses:
Not Known or Reasonably Ascertainable

Consumer Uses:
Propyl 4-hydroxybenzoate is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Other release to the environment of Propyl 4-hydroxybenzoate is likely to occur from: indoor use as processing aid.

Other Consumer Uses:
Laboratory chemicals

Properties of Propyl 4-Hydroxybenzoate:
Propyl 4-hydroxybenzoate is a fine white powder with a peculiar odor somewhat reminiscent of algae.
The purity is at least 98% and Propyl 4-hydroxybenzoate has a reasonably long shelf life.

Propyl 4-hydroxybenzoate is a widely used preservative in cosmetics, due to a combination of pleasant properties:
Propyl 4-hydroxybenzoate is very active against fungi and Gram positive bacteria
Propyl 4-hydroxybenzoate is, especially for a preservative, little harmful to the health of humans, animals and plants

Propyl 4-hydroxybenzoate usually breaks down easily and quickly in the environment
Propyl 4-hydroxybenzoate occurs naturally in various plants and animals and could therefore be called “natural”

Propyl 4-hydroxybenzoate is active in a fairly wide pH range, a pH of 5-6 is ideal, but 3-8 is also possible in many cases
Propyl 4-hydroxybenzoate has been used as a preservative in food, medicine and cosmetics for a century and is very well researched

Parabens do not always go well with highly ethoxylated substances such as polysorbate 20 and polysorbate 80 and to a lesser extent proylparaben becomes completely or partially inactive with, for example, lecithin and proteinaceous substances such as hyaluronic acid.
Furthermore, Propyl 4-hydroxybenzoate may work well against fungi, but Propyl 4-hydroxybenzoate does not or hardly work against Gram-negative bacteria in particular.
Thus, an additional preservative is usually required.

Although rare, hypersensitivity to benzoic acid and related substances such as parabens does occur.
In that case, also do not use sodium benzoate, benzoic acid and benzoin tincture.
Incidentally, this hypersensitivity mainly affects damaged skin, a reaction is unusual on intact skin.

Paraben madness:
A disadvantage of a completely different nature is the fact that parabens received a lot bad press in recent decades.
In addition to many nonsense stories, there is also a more serious concern.

Parabens were found to have the potential to disrupt hormones in laboratory research.
For this reason, a lot of additional research has been done.

For the time being, Propyl 4-hydroxybenzoate seems that Propyl 4-hydroxybenzoate does not act as a hormone disruptor in mammals, but not all studies have yet been completed.
Because parabens have been used in food and cosmetics for more than a century, we know that there is no obvious great danger in the use of this group of substances, but Propyl 4-hydroxybenzoate would be nice if we could also exclude the possible hormone disruption completely.

Manufacturing Methods of Propyl 4-Hydroxybenzoate:
Produced by esterifying p-hydroxybenzoic acid with n-propanol, using an acid catalyst such as sulfuric acid and an excess of propanol.
Propyl 4-hydroxybenzoates are heated in a glass-lined reactor under reflux.

The acid is then neutralized with caustic soda and Propyl 4-hydroxybenzoate is crystallized by cooling.
The crystallized product is centrifuged, washed, dried under vacuum, milled and blended, all in corrosion-resistant equipment to avoid metallic contamination.

Propyl 4-hydroxybenzoate is produced by the n-propanol esterification of p-hydroxybenzoic acid in the presence of sulfuric acid, with subsequent distillation.

Parabens are prepared by esterifying PHBA parahydroxybenzoic acid with the corresponding alcohol in the presence of an acid catalyst, such as sulfuric acid, and an excess of the specific alcohol.
The acid is then neutralized with caustic soda, and Propyl 4-hydroxybenzoate is crystallized by cooling, centrifuged, washed, dried under vacuum, milled, and blended.

Clinical Laboratory Methods of Propyl 4-Hydroxybenzoate:
Bisphenol A (BPA), benzophenones and parabens are commonly used in the production of polycarbonate plastics, as UV-filters and as antimicrobial preservatives, respectively, and they are thought to exhibit endocrine disrupting properties.
Exposure to these compounds remains poorly characterized in developing countries, despite the fact that certain behaviors related to westernization have the potential to influence exposure.

The aim of this pilot study was to measure urinary concentrations of BPA, six different benzophenones and four parabens in 34 Tunisian women.
In addition, we identified some socio-demographic and dietary predictors of exposure to these compounds.

Chemical analyses were carried out by dispersive liquid-liquid microextraction (DLLME) and ultra-high performance liquid chromatography with tandem mass spectrometry detection (UHPLC-MS/MS).
Detection frequencies of methylparaben (MP), ethylparaben (EP) and Propyl 4-hydroxybenzoate (PP) ranged between 67.6 and 94.1%. Butylparaben (BP) was found in 38.2% of the analyzed samples; BPA in 64.7%; and benzophenone-1 (BP-1) and benzophenone-3 (BP-3) were detected in 91.2 and 64.7% of the analyzed samples, respectively.

Urinary geometric mean concentrations of MP, EP, PP, and BP were 30.1, 1.4, 2.0 and 0.5 ng/L, respectively.
Geometric mean concentrations of BPA, BP-1, and BP-3 were 0.4, 1.3 and 1.1 ng/L, respectively.

Our results suggest that Tunisian women are widely exposed to BPA, parabens and some benzophenones.
Further studies on the general Tunisian population are needed in order to assess the levels of exposure to these compounds and to identify sources of exposure and population groups at higher risk.

Parabens are the most widely used preservative and are considered to be relatively safe compounds.
However, studies have demonstrated that they may have estrogenic activity, and there is ongoing debate regarding the safety and potential cancer risk of using products containing these compounds. In the present work, liquid chromatography-tandem mass spectrometry was applied to determine methylparaben and Propyl 4-hydroxybenzoateconcentrations in serum, and the results were correlated with lipstick application.

Samples were analyzed using liquid-liquid extraction, followed by liquid chromatography-tandem mass spectrometry.
The validation results demonstrated the linearity of the method over a range of 1-20 ng/mL, in addition to the method's precision and accuracy.
A statistically significant difference was demonstrated between serum parabens in women who used lipstick containing these substances compared with those not using this cosmetic (p = 0.0005 and 0.0016, respectively), and a strong association was observed between serum parabens and lipstick use (Spearman correlation = 0.7202).

Two rugged liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for the determination of Propyl 4-hydroxybenzoate, Propyl 4-hydroxybenzoate is major metabolite, p-hydroxybenzoic acid (pHBA), and their sulfate conjugates have been developed and validated in citric acid-treated rat plasma.
To prevent Propyl 4-hydroxybenzoate being hydrolyzed to pHBA ex vivo, rat plasma was first treated with citric acid; then collected and processed at a reduced temperature (ice bath).

Stable isotope labeled internal standards, d4-Propyl 4-hydroxybenzoate, (13)C6-pHBA, and the d4-labeled internal standards of their sulfate conjugates were used in the methods.
The analytes were extracted from the matrix using protein precipitation, followed by chromatographic separation on a Waters ACQUITY UPLC HSS T3 column.

Quantification using negative ion electrospray was performed on a Sciex API 4000 mass spectrometer.
The analytical ranges were established from 2.00 to 200 ng/mL for Propyl 4-hydroxybenzoate, 50.0-5000 ng/mL for pHBA, 50.0-10,000 ng/mL for the sulfate conjugate of Propyl 4-hydroxybenzoate (SPP) and 200-40,000 ng/mL for the sulfate conjugate of pHBA (SHBA).

Inter- and intra-run precision for the quality control samples were less than 5.3% and 4.4% for all analytes; and the overall accuracy was within +/-5.7% of the nominal values.
The validated bioanalytical methods demonstrated excellent sensitivity, specificity, accuracy and precision and were successfully applied to a rat toxicology study under the regulations of Good Laboratory Practices (GLP).
Strategies have been developed and applied toward overcoming the challenges related to analyte stability, and environmental and endogenous background.

Action Mechanism of Propyl 4-Hydroxybenzoate:
The mechanism of Propyl 4-hydroxybenzoate may be linked to mitochondrial failure dependent on induction of membrane permeability transition accompanied by the mitochondrial depolarization and depletion of cellular ATP through uncoupling of oxidative phosphorylation.

Handling and Storage of Propyl 4-Hydroxybenzoate:

Handling:
Avoid contact with eyes, skin, and clothing.
Avoid generating and breathing dust.

Use only in well-ventilated areas or under local exhaust.
Wear appropriate PPE (gloves, goggles, lab coat).
Wash hands thoroughly after handling and before eating or drinking.

Storage:
Store in tightly closed containers in a cool, dry, well-ventilated place.
Protect from heat, direct sunlight, and moisture.
Keep away from strong oxidizers and strong bases (which can hydrolyze esters).

Stability and Reactivity of Propyl 4-Hydroxybenzoate:

Stability:
Stable under normal temperatures and pressures.

Reactivity:
Hydrolyzes in strong alkaline conditions to p-hydroxybenzoic acid and propanol; may react with strong oxidizing agents.

Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, and irritating fumes on thermal decomposition/combustion.

Incompatibilities:
Strong oxidizers; strong bases/alkalis; strong acids (prolonged contact); powerful acylation/alkylation reagents.

First Aid Measures of Propyl 4-Hydroxybenzoate:

Inhalation:
Move person to fresh air.
If symptoms (cough, irritation) persist, seek medical attention.

Skin Contact:
Wash with soap and plenty of water.
Remove contaminated clothing.
Get medical advice if irritation develops.

Eye Contact:
Rinse cautiously with water for at least 15 minutes, lifting eyelids occasionally.
Remove contact lenses if present and easy.
Seek medical attention if irritation persists.

Ingestion:
Rinse mouth with water.
Do not induce vomiting.

Give water if conscious.
Seek medical advice if unwell.

Firefighting Measures of Propyl 4-Hydroxybenzoate:

Extinguishing Media:
Dry chemical, CO₂, foam; water spray/fog to cool containers (avoid high-pressure jets).

Specific Hazards:
Combustible solid; dust may form explosive mixtures with air if dispersed.
Thermal decomposition may produce irritating/toxic fumes.

Protective Equipment:
Firefighters wear SCBA and full protective gear.
Prevent contaminated runoff from entering drains/waterways.

Accidental Release Measures of Propyl 4-Hydroxybenzoate:

Personal Precautions:
Avoid dust formation.
Provide adequate ventilation.

Wear gloves, goggles, and protective clothing; use a respirator if airborne dust may exceed limits.
Remove ignition sources.

Spill Cleanup:
Sweep or vacuum with HEPA filtration to avoid dust generation.
Collect into labeled containers for disposal.
Wash spill area with water and mild detergent.

Environmental Precautions:
Prevent entry into drains and surface waters in bulk releases.

Exposure Controls / Personal Protective Equipment of Propyl 4-Hydroxybenzoate:

Engineering Controls:
Use local exhaust or general ventilation to keep airborne dust below nuisance/occupational limits.
Provide eyewash and safety shower where handling powders.

Respiratory Protection:
Not normally required with adequate ventilation; use a NIOSH-approved particulate respirator if dust is generated.

Hand Protection:
Chemical-resistant gloves (nitrile or neoprene).

Eye/Face Protection:
Safety goggles; add face shield if large quantities/dust clouds present.

Skin/Body Protection:
Lab coat or protective clothing to minimize skin contact.

Hygiene Measures:
Do not eat, drink, or smoke when handling.
Wash hands and exposed skin after use; launder contaminated clothing before reuse.

Identifiers of Propyl 4-Hydroxybenzoate:
CAS Number: 94-13-3
ChEBI: CHEBI:32063
ChEMBL: ChEMBL194014
ChemSpider: 6907
ECHA InfoCard: 100.002.098
EC Number: 202-307-7
E number: E216 (preservatives)
KEGG: D01422
PubChem CID: 7175
UNII: Z8IX2SC1OH
CompTox Dashboard (EPA): DTXSID4022527
InChI: InChI=1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3
Key: QELSKZZBTMNZEB-UHFFFAOYSA-N
InChI=1/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3
Key: QELSKZZBTMNZEB-UHFFFAOYAD
SMILES: O=C(OCCC)c1ccc(O)cc1

CAS number: 94-13-3
EC number: 202-307-7
Grade: Ph Eur,BP,JP,NF
Hill Formula: C₁₀H₁₂O₃
Molar Mass: 180.2 g/mol
HS Code: 2918 29 00

Linear Formula: HOC6H4CO2CH2CH2CH3
CAS Number: 94-13-3
Molecular Weight: 180.20
EC Number: 202-307-7

EC / List no.: 202-307-7
CAS no.: 94-13-3
Mol. formula: C10H12O3

Typical Properties of Propyl 4-Hydroxybenzoate:
Chemical formula: C10H12O3
Molar mass: 180.203 g·mol−1
Density: 1.0630 g/cm3
Melting point: 96 to 99 °C (205 to 210 °F; 369 to 372 K)

Density: 1.287 g/cm3 (20 °C)
Flash point: 180 °C
Ignition temperature: >600 °C
Melting Point: 96 - 97 °C
pH value: 6 - 7 (H₂O, 20 °C) (saturated solution)
Vapor pressure: 0.67 hPa (122 °C)
Bulk density: 350 kg/m3
Solubility: 0.4 g/l

Molecular Weight: 180.20
XLogP3: 3
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 4
Exact Mass: 180.078644241
Monoisotopic Mass: 180.078644241
Topological Polar Surface Area: 46.5 Å²
Heavy Atom Count: 13
Complexity: 160
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of Propyl 4-Hydroxybenzoate:
Assay (HPLC, Ph. Eur., JP): 98.0 - 102.0 %
Assay (HPLC, NF): 98.0 - 102.0 %
Identity (IR-spectrum): passes test
Identity (melting range): passes test
Appearance of solution (100 g/l, Ethanol 96 %): clear and not more intense in color than reference solution BY₆
Acidic substances: passes test
Melting range (lower value): ≥ 96 °C
Melting range (upper value): ≤ 99 °C
Heavy metals (as Pb): ≤ 10 ppm
Related substances (HPLC, Ph. Eur., JP): passes test
p-Hydroxybenzoic acid (Ph. Eur., JP): ≤ 0.5 %
Sum of all impurities (Ph. Eur., JP): ≤ 1.0 %
Largest unspecified impurity (Ph. Eur., JP): ≤ 0.5 %
Related substances (HPLC, NF): passes test
p-Hydroxybenzoic acid (NF): ≤ 0.5 %
Sum of all impurities (NF): ≤ 1.0 %
Largest unspecified impurity (NF): ≤ 0.5 %
1-Propylalcohol (HS-GC): ≤ 5000 ppm
Other residual solvents (ICH Q3C): excluded by manufactoring process
Sulfated ash: ≤ 0.1 %

Related Products of Propyl 4-Hydroxybenzoate:
1,1-Dimethoxybutane
(E)-6,6-Dimethyl-2-hept-1-en-4-yn-1-amine
2,2-dimethoxybutane
Dimethyl trans-3-Hexenedioate
Dimethyl Hydroxyaspartate, Mixture of Diastereomers

Related compounds of Propyl 4-Hydroxybenzoate:
Paraben
Butylparaben
Ethylparaben
Methylparaben

Names of Propyl 4-Hydroxybenzoate:

Regulatory process names:
4-hydroxybenzoic acid, propyl ester
Propyl 4-hydroxybenzoate
Propyl 4-hydroxybenzoate
propyl 4-hydroxybenzoate
Propylparaben

CAS names:
Benzoic acid
4-hydroxy-
propyl ester

IUPAC names:
4-Hydroxybenzoic acid, propylester
BENZOIC ACID, 4-HYDROXY-, PROPYL ESTER
hydroxybenzoate 4 propylique
Hydroxybenzoic acid propylester, 4-
p-Hydroxybenzoic acid, propyl ester
Propyl 4-Hydroxybenzoate
Propyl 4-hydroxybenzoate
propyl 4-hydroxybenzoate
Propylparaben
Propylparaben
Propylparaben
propyl-4-hydroxybenzoate
Propylparaben

Preferred IUPAC name:
Propyl 4-hydroxybenzoate

Trade names:
Faracide P
Microcare OHB
Paratexin P
Solbrol P

Other names:
4-Hydroxybenzoesäurepropylester
Propylparaben
Propyl p-hydroxybenzoate
Propyl parahydroxybenzoate
Nipasol
E216

Other identifiers:
58339-85-8
58339-85-8
59593-07-6
59593-07-6
94-13-3