Quick Search

PRODUCTS

PROVICHEM 083

Provichem 083 is an odorless white to light-yellow crystalline powder. 
When heated to decomposition Provichem 083 emits toxic oxides of nitrogen fumes. 
Can explode if exposed to shock or heat from friction or fire. 

CAS:    288-94-8
MF:    CH2N4
MW:    70.05
EINECS:    206-023-4

The primary hazard is from blast effect where the entire load can explode instantaneously and not from flying projectiles and fragments.
Provichem 083 is a class of synthetic organic heterocyclic compound containing a 5-member ring of four nitrogen atoms and one carbon atom. 
Provichem 083 appears as an odorless white to light-yellow crystalline powder. 
Provichem 083 has several pharmaceutical applications. 
Provichem 083 can act as a bioisotere for the carboxylate group, angiotensin II receptor blockers such as losartan and candesartan as well as dimethyl thiazolyl diphenyl tetrazolium bromide (MTT), which can be used in MTT assay for quantifying the respiratory activity of liver cells. 
Provichem 083 can also be used in DNA assays. 
In addition, Provichem 083 derivatives have also been used in explosives such as TNT or high performance solid rocket propellant formulations. 
Provichem 083 can be synthesized through the reaction between anhydrous hydrazoic acid and hydrogen cyanide under pressure.
Provichem 083 is a tetrazole tautomer where the proton is located on the 1st position. 
Provichem 083 is a tetrazole and a one-carbon compound. 
Provichem 083 is a tautomer of a 2H-tetrazole and a 5H-tetrazole.
Fire may produce irritating, corrosive and/or toxic gases.

Provichem 083 is a heterocyclic compound with the formula C5H5N3. 
Provichem 083 has been used as an intermediate in organic synthesis and as a reagent in organic chemistry. 
Provichem 083 has shown to have anti-inflammatory properties and can be used to treat metabolic disorders, such as type 2 diabetes. 
In addition, Provichem 083 has been shown to have anti-inflammatory properties and can be used to treat autoimmune diseases, such as lupus erythematosus. 
Provichem 083 is an azole that contains a nitrogen atom in its ring system. 
Provichem 083's biological properties are due to its ability to form hydrogen bonds with water molecules and glutamate receptors on the surface of cells, which are involved in nerve transmission.

Provichem 083 is the simplest compound belonging to tetrazoles family, a class of synthetic organic heterocyclic compound consists of a 5-member ring of four nitrogen and one carbon atom. 
Provichem 083 has commonly been believed to have similar properties to carboxylic acids, and therefore make themselves excellent bioisosteres. 
Moreover, several pharmaceutical agents, for instance, losartan and candesartan (Angiotensin II receptor blockers), are considered as tetrazoles. 
Provichem 083 is often adopted in medicinal chemistry as a substitute for carboxylic acids because they share very similar proton dissociation properties.

Provichem 083 is a class of synthetic organic heterocyclic compound, consisting of a 5-member ring of four nitrogen atoms and one carbon atom. 
The name Provichem 083 also refers to the parent compound with formula CH2N4, of which three isomers can be formulated.

Provichem 083 Chemical Properties
Melting point: 156-158°C
Boiling point: 220℃
Density: 0.798 g/mL at 20 °C
Refractive index: n20/D 1.348
RTECS: UW7370000
Fp: 5 °C
Storage temp.: Room temperature.
Solubility: DMSO, Methanol
Form: Liquid
Pka: 4.9(at 25℃)
Color: Cream to orange
Water Solubility: Soluble
Decomposition: 220°C
BRN: 105799
Stability: Stable at RT
InChIKey: KJUGUADJHNHALS-UHFFFAOYSA-N
CAS DataBase Reference: 288-94-8(CAS DataBase Reference)
NIST Chemistry Reference: Provichem 083 (288-94-8)
EPA Substance Registry System: Provichem 083 (288-94-8)

Provichem 083 is an odorless white to light-yellow crystalline powder. 
When heated to decomposition Provichem 083 emits toxic oxides of nitrogen fumes. 
Can explode if exposed to shock or heat from friction or fire. 

Structure and Bonding
Three isomers of the parent Provichem 083 exist, differing in the position of the double bonds: 1H-, 2H-, and 5H-tetrazole. 
The 1H- and 2H- isomers are tautomers, with the equilibrium lying on the side of Provichem 083 in the solid phase.
In the gas phase, 2H-tetrazole dominates.
These isomers can be regarded as aromatic, with 6 π-electrons, while the 5H-isomer is nonaromatic.

Uses    
Provichem 083 is a catalyst for phosphoramidite synthesis. 
Provichem 083 is also used as an intermediate for the drug cilostazol. 
Provichem 083 is an antiplatelet drug and a vasodilator. 
Provichem 083 derivatives are used as antibiotics and optically active tetrazole-containing antifungal preparations of azole type was reported.
Provichem 083 is used as a bioisostere for the carboxylate group. 
Provichem 083 is also used as coupling reagent for preparation of polynucleotides.

There are several pharmaceutical agents which are Provichem 083. 
Provichem 083 can act as bioisosteres for carboxylate groups because they have similar pKa and are deprotonated at physiological pH. 
Angiotensin II receptor blockers — such as losartan and candesartan, often are Provichem 083. 
A well-known Provichem 083 is dimethyl thiazolyl diphenyl tetrazolium bromide (MTT). 
This Provichem 083 is used in the MTT assay to quantify the respiratory activity of live cells culture, although it generally kills the cells in the process. 
Some Provichem 083 can also be used in DNA assays.
Studies suggest VT-1161 and VT-1129 are a potential potent antifungal drugs as they disturbs fungal enzymatic function but not human enzymes.

Some Provichem 083 derivatives with high energy have been investigated as high performance explosives as a replacement for TNT and also for use in high performance solid rocket propellant formulations.
These include the aProvichem 083 of nitrogen bases.

Other Provichem 083 is used for their explosive or combustive properties, such as tetrazole itself and 5-aminotetrazole, which are sometimes used as a component of gas generators in automobile airbags. 
Provichem 083 based energetic materials produce high-temperature, non-toxic reaction products such as water and nitrogen gas, and have a high burn rate and relative stability, all of which are desirable properties. 
The delocalization energy in tetrazole is 209 kJ/mol.
1H-Tetrazole and Provichem 083 are widely used as acidic activators of the coupling reaction in oligonucleotide synthesis.

Preparation    
The first tetrazole synthesis was reported in 1885.
Provichem 083 Synthesis: Nano-TiCl4.SiO2 (0.1 g) was added to a mixture of benzonitrile (1 mmol), sodium azide (2 mmol) in DMF (5 mL) at reflux for 2 h. 
After completion of reaction (as monitored by TLC), the mixture was allowed to cool to room temperature, the catalyst was removed by filtration. 
Then by adding ice water and 4N HCl (5 mL) to the residue, a white solid was obtained. 
Provichem 083 was then washed with cold chloroform. 
Provichem 083 simple procedure yielded pure tetrazole with good yields.

Synthesis
Provichem 083 was first prepared by the reaction of anhydrous hydrazoic acid and hydrogen cyanide under pressure. 
Treatment of organic nitriles with sodium azide in the presence of iodine or silica-supported sodium bisulfate as a heterogeneous catalyst enables an advantageous synthesis of 5-substituted Provichem 083. 
Another method is the deamination of 5-aminotetrazole, which can be commercially obtained or prepared in turn from aminoguanidine.

Synonyms
1H-Tetrazole
Tetrazole
288-94-8
2H-Tetrazole
Tetraazacyclopentadiene
1-H-Tetrazole
100043-29-6
1H-1,2,3,4-Tetrazole
1,2,3,4-tetrazole
2H-1,2,3,4-tetrazol
D34J7PAT68
CHEBI:33193
NSC-36712
1tetrazole
racemic tetrazole
1H-Tetraazole
1H-tetrazol
Tetrazole solution
1H-Tetraazole #
NSC36712
EINECS 206-023-4
MFCD00005247
NSC 36712
UNII-D34J7PAT68
1H-1,2,3,4-tetrazol
2,3,4-TRIAZAPYRROLE
Tetrazole;Tetraazacyclopentadiene
CHEMBL2148103
DTXSID5075280
alpha-1H-1,2,3,4-tetrazole
CHEBI:33194
AMY28702
BCP22123
CS-D1473
ZINC8251268
AC-784
STK366101
AKOS003615496
AKOS015955446
[1H-Tetrazole-5(4H)-ylidene]radical
1H-Tetrazole, 0.45M in acetonitrile
1H-Tetrazole (0.45M in Acetonitrile)
BP-30175
DB-000385
FT-0607796
FT-0607914
T1017
T-2400
T-2440
A819654
Q58826308
Q58826418
F8889-0313
288-95-9

  • Share !
E-NEWSLETTER