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PTSA 70 %= P-TOLUENE SULFONIC ACID
CAS: 104-15-4
MF: C7H8O3S
MW: 172.2 g/mol
EINECS: 203-180-0
DESCRIPTION:
p-toluene sulfonic acid (Its molecular structural formula is p-CH3C6H4SO3H, also known as TsOH, English name is p-toluene sulfonic acid) referred to as PTS, is a non-oxidizing organic acid, white needle or powder crystals, soluble in water, alcohols, ethers and other polar solvents.
Easy deliquescence, easy to make wood, cotton fabric dehydration and carbonization, insoluble in benzene and toluene. generating p-cresol when alkali fusion.
Commonly, p-toluenesulfonic acid-monohydrate (TsOHH2O) or tetrahydrate (TsOH4H2O) is preferred.
Preparation of methyl p-cresol acid in industry is by using concentrated sulfuric acid on the toluene sulfonation of p-toluenesulfonic acid.
The preparated p-toluenesulfonic acid often contains benzene sulfonic acid and sulfuric acid impurities, can be purified in recrystallization of concentrated hydrochloric acid, azeotropic drying.
p-toluene sulfonic acid is widely used as catalyst agent in the synthesis of pharmaceuticals, pesticides, polymerization stabilizer and organic synthesis (esters, etc.), paint intermediates and resin curing agent. And it is also the commonly used acid catalyst in organic synthesis.
It is neutralized with sodium hydroxide and then obtains sodium p-toluene sulfonate, and react with phosphorus pentachloride, can obtains p-toluenesulfonyl chloride.
The latter used in the nucleophilic substitution reaction, also used as alcohol hydroxyl protective group.
p-CH3C6H4SO3Na + PCl5 →p-CH3C6H4SO2Cl.
The use of p-toluenesulfonic acid also catalyzes the protection of dihydrofuran on the alcohol, carboxylic acid esterification, transesterification reaction, making the aldehyde generate acetal.
PTSA 70 % is Colorless monoclinic sheet or columnar crystals.
PTSA 70 % is Soluble in ethanol and ether, slightly soluble in water and hot benzene.
p-Toluene sulfonic acid (PTSA) or tosylic acid (TsOH) is an organic compound with the formula CH3C6H4SO3H.
PTSA 70 % is a white solid that is soluble in water, alcohols, and other polar organic solvents.
The 4-CH3C6H4SO2- group is known as tosyl group and is often abbreviated as Ts or Tos.
Most often, TsOH refers to the monohydrate, TsOH.H2O.
TsOH is a strong organic acid, about a million times stronger than benzoic acid.
PTSA 70 % is one of the few strong acids that is solid and, hence, conveniently weighed.
Also, unlike some strong mineral acids (especially nitric acid, sulfuric acid, and per chloric acid), TsOH is non - oxidizing.
PTSA 70 % is an arenesulfonic acid that is benzenesulfonic acid in which the hydrogen at position 4 is replaced by a methyl group.
PTSA 70 % is used as a catalyst in various esterification reactions like biodiesel production. Additionally it is used as a hardener in urea - formaldehyde, melamine-formaldehyde and phenol - formaldehyde resins.
CAS: 104-15-4
MF: C7H8O3S
MW: 172.2 g/mol
EINECS: 203-180-0
Reactions of PTSA 70 %:
p-Toluene sulfonic acid may be converted to p-toluene sulfonic anhydride by heating with phosphorus pentoxide.
When TsOH is heated with acid and water, a hydrolysis reaction takes place and toluene is formed:
CH3C6H4SO3H + H2O → C6H5CH3 + H2SO4
This reaction is general for aryl sulfonic acids, but the rate at which it occurs depends upon the structure of the acid, the temperature and the nature of the catalyzing acid.
For example p- TsOH is unaffected by cold concentrated hydrochloric acid, but hydrolyzes when heated to 186°C in concentrated phosphoric acid.
Preparation and handling:
TsOH is prepared on an industrial scale by the sulfonation of toluene.
It hydrates readily.
Common impurities include benzene sulfonic acid and sulfuric acid.
Impurities can be removed by recrystallization from its concentrated aqueous solution followed by azeotropic drying with toluene.
Toluene sulfonic acid finds use in organic synthesis as an "organic - soluble" acid catalyst.
Examples of uses :
• Acetalization of an aldehyde.
• Esterification of carboxylic acids.
• Trans esterification of an ester.
Tosylate esters Tosylate esters are used as alkylating agents because the tosyl group is electron-with drawing, which makes the tosylate anion a good leaving group.
The tosyl group is also a protecting group for alcohols and amines, prepared by combining the alcohol with 4- toluenesulfonyl chloride, usually in an aprotic solvent, often pyridine, the basicity of which activates the reaction.
Toluenesulfonate esters undergo nucleophilic attack or elimination.
Reduction of tosylate esters gives the hydrocarbon.
Thus, tosylation followed by reduction allows for the deoxygenation of alcohols.
Application Areas of PTSA 70%:
In esterification reactions: As a dehydration catalyst.
Foundry: A hardening agent of furan resin which is used in sand casting.
Resin Systems: Hardener in urea-formaldehyde, melamine-formaldehyde and phenol-formaldehyde resins.
Also PTSA 70%:is used as an intermediate of dye chemistry and specialized plasticizers
CAS: 104-15-4
MF: C7H8O3S
MW: 172.2 g/mol
EINECS: 203-180-0
Chemical Properties of PTSA 70%
Melting point : 106~107℃
Boiling point: 116 °C
Density: 1.07
refractive index: 1.3825-1.3845
Fp : 41 °C
storage temp. :Inert atmosphere,Room Temperature
pka: -0.43±0.50(Predicted)
form : Solution
color : Clear colorless to light yellow
Water Solubility : soluble
CAS DataBase Reference: 104-15-4(CAS DataBase Reference)
NIST Chemistry Reference:P-toluene sulfonic acid(104-15-4)
Content (as C7H8O3S • H2O)% :≥ 90-93.0 96.0 97.0 98.0
Free acid (H2SO4): ≤% 3.0 0.7 0.5 0.1
Moisture (excluding crystal water): ≤% 4.0 3.5 2.5 1.5
Iron (in Fe ++): ≤ ppm 50 30 30 10
Ignition residue: ≤%/0.2 0.2 0.02
Melting point (°C)// 102-105EPA Substance Registry System: 4-Methylbenzenesulfonic acid (104-15-4)
Physical state: Liquid. Paste.
Colour : Brownish.
Melting point/freezing point
30 °C. Remarks:+/- 1 C.
Boiling point or initial boiling point and boiling range
223.4 °C. Remarks:+/- 1.0%.
Flash point: Ca. 127 °C.
Auto-ignition temperature:> 465 °C. Atm. press.:Ca. 1 atm.
Kinematic viscosity:
kinematic viscosity (in mm²/s) = Ca. 13.91. Temperature:50.0°C. Remarks:+/- 0.5%.
Solubility:
In water: Ca. 1 154 g/L. Temperature:20 °C. pH:Ca. 0. Remarks:Solubility is average of three samples for each of three days.
Partition coefficient n-octanol/water:
log Pow = -0.96. Temperature:50 °C.
Vapour pressure:
Ca. 3.3 kPa. Temperature:Ca. 35 °C. Remarks:+/- 1.5%; and 12.6 kPa at 50 C.
Density and/or relative density: 1.345
Appearance: Pinky brown coloured crystal solid
P.T.S.A. Content: Min. 84.0 %
Free Sulphuric Acid: Max. 5.0 %
Free Toluene Content: 1.5 %
Iron Content: Max. 30 ppm
Isomeric Composition: para-isomer 88-90 %
ortho-isomer 8-10 %
meta-isomer, approx. 2
CAS: 104-15-4
MF: C7H8O3S
MW: 172.2 g/mol
EINECS: 203-180-0
SAFETY INFORMATION ABOUT PTSA 70%:
First-aid measures:
Description of necessary first-aid measures
If inhaled:
Fresh air, rest. Half-upright position.
Artificial respiration may be needed.
Refer immediately for medical attention.
Following skin contact:
Remove contaminated clothes.
Rinse skin with plenty of water or shower.
Refer immediately for medical attention.
Following eye contact:
Rinse with plenty of water for several minutes (remove contact lenses if easily possible).
Refer immediately for medical attention.
Following ingestion
Rinse mouth.
Do NOT induce vomiting.
Refer immediately for medical attention.
Fire-fighting measures:
Suitable extinguishing media:
Use dry chemical, carbon dioxide or alcohol-resistant foam.
Specific hazards arising from the chemical
Combustible.
Gives off irritating or toxic fumes (or gases) in a fire.
Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
In case of fire: keep drums, etc., cool by spraying with water.
Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: complete protective clothing including self-contained breathing apparatus. Sweep spilled substance into covered dry, plastic containers.
If appropriate, moisten first to prevent dusting.
Carefully collect remainder.
Then store and dispose of according to local regulations.
Environmental precautions:
Prevent further spillage or leakage if it is safe to do so.
Do not let the chemical enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Collect and arrange disposal.
Keep the chemical in suitable and closed containers for disposal.
Remove all sources of ignition.
Use spark-proof tools and explosion-proof equipment.
Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Handling and storage:
Precautions for safe handling:
NO open flames.
Handling in a well ventilated place.
Wear suitable protective clothing.
Avoid contact with skin and eyes.
Avoid formation of dust and aerosols.
Use non-sparking tools.
Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Dry.
Separated from strong bases and food and feedstuffs.
Exposure controls/personal protection:
Appropriate engineering controls
Ensure adequate ventilation.
Handle in accordance with good industrial hygiene and safety practice.
Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection:
Wear face shield or eye protection in combination with breathing protection.
Skin protection:
Protective gloves.
Protective clothing.
Respiratory protection:
Use local exhaust.
Use breathing protection.
Disposal considerations:
Disposal methods:
Product:
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing.
Do not contaminate water, foodstuffs, feed or seed by storage or disposal.
Do not discharge to sewer systems.
Contaminated packaging:
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill.
Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
CAS: 104-15-4
MF: C7H8O3S
MW: 172.2 g/mol
EINECS: 203-180-0
SYNONYMS OF PTSA 70%:
TL65
TL65LS
PARATOLUENE SULPHONIC ACID
p-tolylsulfonicacid
PTSA 70
toluene-4-sulphonic
Toluene-p-sulfonate
toluenesulfonicacid,liquid,withmorethan5%freesulfuricacid
toluenesulfonicacid,solid,withmorethan5%freesulfuricacid
Tosylic acid
Tsa-hp
Tsa-mh
toluene-p-sulfonic acid
paraToluene Sulfonic Acid Monohydrate, C99 Grade
p-Toluenesulfonic acid, 12% in acetic acid, pure
PARA-TOLUENESULPHONATE
TOLUENESULPHONICACID
4-Toluolsulfonsure
PTSA
Manro PTSA Crystals
toluene sulfonic acid, solid, <= 5% free H2-SO4
acidep-toluenesulfonique
Ar-Toluenesulfonic acid
Benzenesulfonic acid, 4-methyl-
Benzenesulfonic acid, methyl-
Benzenesulfonicacid,4-methyl-
Cyclophil P T S A
cyzac4040
Eltesol
Eltesol TSX
k-cure1040
Kyselina p-toluenesulfonova
Kyselina p-toluensulfonova
kyselinap-toluenesulfonova(czech)
kyselinap-toluensulfonova
Manro PTSA
Manro ptsa 65 E
Manro ptsa 65 H
Manro ptsa 65 ls
manroptsa65e
manroptsa65h
manroptsa65ls
Methylbenzenesulfonic acid
p-Methylbenzenesulfonic acid
p-Methylbenzenesulfonicacid
p-Methylphenylsulfonic acid
p-methylphenylsulfonicacid
p-Toluene sulfonic acid monohydrate BP
p-Toluenesulfonate
p-toluenesulfonic
p-Toluolenesulfonic acid
p-Tolylsulfonic acid
4-TOLUENESULFONIC ACID
4-METHYLBENZENESULFONIC ACID
Nacure 1040
p-Toluenesulfonic acid (anhydrous)
p-Toluenesulfonic acid,pure,12% in acetic acid
p-toluenesulphonic acid (containing a maximum of 5 % H2SO4)
