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PVP/VA 64 is a 6:4 linear random copolymer of N-vinylpyrrolidone and vinyl acetate.
The vinyl acetate component of PVP/VA 64 reduces the hydrophilicity and glass transition temperature (T g ) compared to povidone homopolymers of similar molecular weight.
As a result, PVP/VA 64 is the ultimate tablet binder that extends its excellent adhesive property in wet granulation, as well as in dry granulation and direct compression.
CAS: 25086-89-9
MF: C10H15NO3
MW: 197.23
EINECS: 200-001-8
Synonyms:
ceticacid,ethenylester,polymerwith1-ethenyl-2-pyrrolidinone;aceticacidethenylester,polymerwith1-ethenyl-2-pyrrolidinone;aceticacidethenylestercopolymerwith1-ethenyl-2-pyrrolidinone;aceticacidvinylester,polymerwith1-vinyl-2-pyrrolidinone;gantrons860;i535;i635;i735
Due to its spherical, hollow particle morphology and high plasticity, PVP/VA 64 performs exceptionally well as a binder for direct compression.
In addition, a lower T g makes PVP/VA 64 an ideal polymer matrix for solid dispersions/solutions via hot melt extrusion, which enhances the dissolution of poorly soluble drug actives.
PVP/VA 64 is a film-forming polymer that provides excellent hold and styling properties.
PVP/VA 64 is a white or slightly yellowish, free-flowing powder with a faint characteristic odour and practically no taste.
PVP/VA 64 readily dissolves in all hydrophilic solvents.
Solutions of more than 10 % concentration can be prepared in water, ethanol, isopropanol, methylene chloride, glycerol and propylene glycol.
PVP/VA 64 is less soluble in ether, cyclic, aliphatic and alicyclic hydrocarbons.
PVP/VA 64, identified by CAS number 25086-89-9, is a synthetic polymer that combines the properties of vinyl acetate and vinylpyrrolidone.
PVP/VA 64 is known for its excellent film-forming abilities, making it useful in various applications, particularly in the cosmetic and pharmaceutical industries.
PVP/VA 64 exhibits good adhesion, flexibility, and resistance to water, which enhances its utility in formulations such as hair sprays, coatings, and adhesives.
The copolymer is also characterized by its ability to provide a smooth texture and improve the stability of emulsions.
Additionally, PVP/VA 64 is non-toxic and biocompatible, making it suitable for use in personal care products.
The copolymer can be processed in various forms, including powders and solutions, and is often used to enhance the performance of other ingredients in formulations.
Overall, PVP/VA 64 is valued for its versatility and effectiveness in enhancing product performance across multiple applications.
PVP/VA 64 Chemical Properties
density: 1.27 g/mL at 25 °C(lit.)
Tg: 108
refractive index: 1.4300 to 1.4380
Fp: 72 °F
solubility: Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
form: powder
color: White
Stability: Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
Major Application: pharmaceutical (small molecule)
Cosmetics Ingredients Functions BINDING
FILM FORMING
HAIR FIXING
InChI: InChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
InChIKey: FYUWIEKAVLOHSE-UHFFFAOYSA-N
LogP: 0.370 (est)
EPA Substance Registry System: PVP/VA 64 (25086-89-9)
PVP/VA 64 is a white to yellowish-white amorphous powder.
PVP/VA 64 is typically spray-dried with a relatively fine particle size.
PVP/VA 64 has a slight odor and a faint taste.
Uses
PVP/VA 64 is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches.
