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Pyridine-2,6-dicarboxylic acid (dipicolinic acid) contains two carboxylic groups on each side of the pyridine ring.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) could be complex and bind with metals under certain conditions.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid), metal complexes, drugs, and CPs based on PDCA were developed for applications related to gas storage, separation, catalysis, magnetism, and sensing.
CAS Number: 499-83-2
Molecular Formula: C7H5NO4
Molecular Weight: 167.12
EINECS: 207-894-3
Synonyms: 2,6-Pyridinedicarboxylic acid, 499-83-2, PYRIDINE-2,6-DICARBOXYLIC ACID, Dipicolinic acid, 2,6-Dipicolinic acid, Dipicolinate, 2,6-Dicarboxypyridine, 2,6-pyridinedicarboxylate, MFCD00006299, UE81S5CQ0G, CHEMBL284104, DTXSID7022043, CHEBI:46837, NSC-176, 2,6-Pyridinedicarboxylic acid, 99%, NSC 176, EINECS 207-894-3, UNII-UE81S5CQ0G, 2,6-pyridine dicarboxylic acid, pyridine-2, pydcH2, 4ih3, pyridine carboxylate, 6d, 2,6-pyridinedicarboxylic acid (dipicolinic acid), Oprea1_533632, SCHEMBL34595, 2,6-DIPICLINIC ACID, MLS000080748, 6-CARBOXYPICOLINIC ACID, DTXCID602043, IFLab1_001781, NSC176, Dipicolinic acid, Beauveria sp., BDBM26116, 2,6-DI-CARBOXY-PYRIDINE, Pyridinedicarboxylic acid-(2,6), HMS1417A21, HMS2231H20, HY-Y1024, Tox21_301129, AC-704, BBL012080, CCG-44216, CL0252, STK092939, PYRIDINE-2,6-DICARBOXYLICACID, AKOS000112829, AM82010, DB04267, PS-8736, NCGC00071864-02, NCGC00255028-01, CAS-499-83-2, SMR000034075, SY001460, DB-015930, A7431, CS-0016012, EU-0033484, NS00013573, P0554, EN300-18133, Q417164, 2,6-Pyridinedicarboxylic acid-2,6-dipicolinic acid, SR-01000600024-2, W-105996, L-042,134, Z57202012, B63A70CE-B9AB-4EA2-834A-6C7634226BB0, F0451-0137, 2,6-Pyridinedicarboxylic acid, for ion chromatography, >=99.5% (T), InChI=1/C7H5NO4/c9-6(10)4-2-1-3-5(8-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) in methanol, ethanol, n-propanol, isopropanol, THF, 1,4-dioxane, acetic acid, formic acid, acetonitrile, ethyl acetate, and toluene.
They found that PDCA solubility was the highest in methanol but the lowest in acetonitrile.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a pyridinedicarboxylic acid carrying two carboxy groups at positions 2 and 6.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) has a role as a bacterial metabolite.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a conjugate acid of a dipicolinate(1-).
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a chemical compound which plays a role in the heat resistance of bacterial endospores.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is also used to prepare dipicolinato ligated lanthanide and transition metal complexes for ion chromatography.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) composes 5% to 15% of the dry weight of Bacillus subtilis spores.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) has been implicated as responsible for the heat resistance of the endospore, although mutants resistant to heat but lacking dipicolinic acid have been isolated, suggesting other mechanisms contributing to heat resistance are at work.
Two genera of bacterial pathogens are known to produce endospores: the aerobic Bacillus and anaerobic Clostridium.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) forms a complex with calcium ions within the endospore core.
This complex binds free water molecules, causing dehydration of the spore.
As a result, the heat resistance of macromolecules within the core increases.
The calcium-dipicolinic acid complex also functions to protect DNA from heat denaturation by inserting itself between the nucleobases, thereby increasing the stability of DNA.
A new polymorph of anhydrous Pyridine-2,6-dicarboxylic acid (dipicolinic acid) in which salt formation is favoured over carboxylic acid dimerisation is reported, together with the solid-state architectures of a novel dipicolinic acid dihydrate and a monohydrate structure of the 4-chloro analogue.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid), also known as 2,6-dicarboxypyridine or 2,6-dipicolinic acid, belongs to the class of organic compounds known as pyridinecarboxylic acids.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid)s are compounds containing a pyridine ring bearing a carboxylic acid group.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a secondary metabolite.
Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules.
In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites.
Based on a literature review very few articles have been published on Pyridine-2,6-dicarboxylic acid (dipicolinic acid).
Pyridine-2,6-dicarboxylic acid (dipicolinic acid), commonly known as dipicolinic acid, is an organic compound with the formula C7H5NO4.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a derivative of pyridine with carboxylic acid groups at the 2 and 6 positions.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid), also known as 2,6-dipicolinic acid or 2,6-dicarboxypyridine, belongs to the class of organic compounds known as pyridinecarboxylic acids.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid)s are compounds containing a pyridine ring bearing a carboxylic acid group.
Based on a literature review very few articles have been published on Pyridine-2,6-dicarboxylic acid (dipicolinic acid).
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a chemical compound which composes 5% to 15% of the dry weight of bacterial spores.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) forms a complex with calcium ions within the endospore core.
This complex binds free water molecules, causing dehydration of the spore.
As a result, the heat resistance of macromolecules within the core increases.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a chemical compound which plays a role in the heat resistance of bacterial endospores.
It is also used to prepare dipicolinato ligated lanthanide and transition metal complexes for ion chromatography.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a major component of bacterial endospores, comprising 5-15% of the spore dry weight, and is important for spore stability and resistance properties.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) and its derivatives are introduced as a new sensitizer system for enzyme-amplified lanthanide luminescence (EALL), a detection scheme for bioassays, which combines enzymatic amplification with time-resolved luminescence measurements of lanthanide chelates.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a chemical reagent that is used in the pharmaceutical industry for manufacturing anti-inflammatory drugs.
It is also used as a precursor to synthesize pyridyl-based ligands, which have applications in catalysis and material science.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) has a purity of 98% and comes in a 25g package. Proper safety precautions should be taken when handling this substance as it can cause skin irritation and eye damage upon contact.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) should be stored in a cool, dry place away from sources of ignition or heat.
The environmental impact of this product has not been reported.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) was released from the autoclaved killing of thermobacterium stearophilus spores.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) induces the accumulation of chitosan-stabilized gold nanoparticles, causing the color of the solution to change from red to blue.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is an organic compound with CAS 499-83-2 and chemical formula C7H5NO4.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a white or light yellow crystalline powder with a slight irritating odor.
Soluble in organic solvents such as water, ethanol, and ether, slightly soluble in benzene, chloroform, etc.
Stable at room temperature, but easily decomposes at high temperatures.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is an important intermediate in drug synthesis with a wide range of applications.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) can be used to synthesize 2,6-diacetylpyridine, 2,6-diamino-4-chloropyridine, and can also be used for the next step of synthesizing metal ligand compounds, functional materials, and pharmaceutical intermediates.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) naturally exists in bacterial spores, but its content is low and cannot meet the demand, making extraction difficult.
The first synthetic literature report was in 1935, in which Alvin W. Singer and s. m. mcelvain oxidized Pyridine-2,6-dicarboxylic acid (dipicolinic acid) in water with potassium permanganate in a yield of 64%.
In industry, Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is usually prepared by oxidation method.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is released from the spores of thermophilic fatty acid bacteria killed by high-pressure sterilization; It induces the aggregation of chitosan stabilized gold nanoparticles and changes the color of the solution from red to blue.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) also referred to as Pyridine-2,6-dicarboxylic acid (PDC), is a pyridinedicarboxylic acid carrying two carboxy groups at positions 2 and 6.
It’s mot common application is to prepare dipicolinato ligated complexes for use in ion chromatography.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) 5% to 15% of the dry weight of bacterial spores.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) has been implicated as responsible for the heat resistance of the endospore, although mutants resistant to heat but lacking dipicolinic acid have been isolated, suggesting other mechanisms contributing to heat resistance are at work.
Two genera of bacterial pathogens are known to produce endospores: the aerobic Bacillus and anaerobic Clostridium.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) forms a complex with calcium ions within the endospore core.
This complex binds free water molecules, causing dehydration of the spore.
As a result, the heat resistance of macromolecules within the core increases.
The calcium-dipicolinic acid complex also functions to protect DNA from heat denaturation by inserting itself between the nucleobases, thereby increasing the stability of DNA.
The high concentration of Pyridine-2,6-dicarboxylic acid (dipicolinic acid) in and specificity to bacterial endospores has long made it a prime target in analytical methods for the detection and measurement of bacterial endospores.
A particularly important development in this area was the demonstration by Rosen et al. of an assay for DPA based on photoluminescence in the presence of terbium, although this phenomenon was first investigated for using DPA in an assay for terbium by Barela and Sherry.
Extensive subsequent work by numerous scientists has elaborated on and further developed this approach.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a pyridinedicarboxylic acid carrying two carboxyl groups at positions 2 and 6.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) has a role as a bacterial metabolite.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a conjugate acid of a dipicolinate.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid)s are interesting oxido pincer ligands with an O,N,O donor set.
They are derived from the potentially O,N,O tridentate binding Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a frequently used ligand and coordinates are usually in a deprotonated tridentate mode.
The coordinates use the N donor atom and the two carboxylate O donor functions, including the possibility of bridging.
In contrast to this, the pydic ester ligands are neutral and have three options of tris-chelate O,N,O binding, which gives rise to three different isomers Ocarbonyl–M–Ocarbonyl (CC isomer), Ocarbonyl–M–Oalkoxy (CA isomer), and Oalkoxy–M–Oalkoxy (AA isomer)while a bridging mode observed frequently for pydic2− is less probable.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used for transition metal ions, organic peroxides.
Also be used as enzyme inhibitor in biochemistry.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used as a bifunctional monomer and a pharmaceutical intermediate.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid), also known as 2,6-dipicolinic acid or 2,6-dicarboxypyridine, belongs to the class of organic compounds known as pyridinecarboxylic acids.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid)s are compounds containing a pyridine ring bearing a carboxylic acid group.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is an extremely weak basic (essentially neutral) compound (based on its pKa).
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in the preparation of dipicolinato ligated lanthanide and transition metal complexes.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) acts as a chelating agent for chromium, zinc, manganese, copper, iron and molybdenum.
Its calcium-dipcolinic acid complex is used to protect deoxyribonucleic acid (DNA) from heat denaturation which enhances the DNA stability.
It plays an important role as a marker for the effectiveness of sterilization.
Melting point: 248-250 °C (dec.)(lit.)
Boiling point: 295.67°C (rough estimate)
Density 1.5216: (rough estimate)
vapor pressure: <0.01 hPa (20 °C)
refractive index: 1.6280 (estimate)
Flash point: 188 °C
storage temp.: Store below +30°C.
solubility: H2O: 1%, clear
pka: 2.16(at 25℃)
form: Crystalline Powder
color: White
PH: 2.0 (5g/l, H2O, 20℃)
Water Solubility: 5 g/L (20 ºC)
BRN: 131629
InChIKey: WJJMNDUMQPNECX-UHFFFAOYSA-N
LogP: 0.3 at 25℃ and pH1.8
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in the preparation of dipicolinate ligated lanthanide and transition metal complexes.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) acts as a chelating agent for chromium, zinc, manganese, copper, iron and molybdenum.
Its calcium-dipcolinic acid complex is used to protect deoxyribonucleic acid (DNA) from heat denaturation which enhances the DNA stability.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) plays an important role as a marker for the effectiveness of sterilization.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a chemical compound that causes the heat resistance of the endospore.
The bacteria anaerobic Clostridium and aerobic Bacillus are known to produce endospores.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is also used to prepare lanthanide and transition metal complexes for ion chromatography.
Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is released from the autoclave killing of Geobacillus stearothermophilus spores used in biological indicators; It induces
the aggregation of chitosan stabilized gold nanoparticles, causing the solution to change colors varying from red to blue.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a disubstituted pyridine derivative containing two carboxylic acid groups.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is commonly found in bacterial spores, as it confers heat resistance to the endospore.
It is a powerful complexation agent and has several uses in biochemistry and transition metal chemistry.
This certified eluent concentrate for ion chromatography is traceable by potentiometric titration to NIST Standard Reference Material.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is certified in accordance with ISO Guide 31.
All details about exact content, uncertainty, traceability and expiry date are described in the certificate.
The high concentration of Pyridine-2,6-dicarboxylic acid (dipicolinic acid) in and specificity to bacterial endospores has long made it a prime target in analytical methods for the detection and measurement of bacterial endospores.
A particularly important development in this area was the demonstration by Rosen et al. of an assay for DPA based on photoluminescence in the presence of terbium, although this phenomenon was first investigated for using Pyridine-2,6-dicarboxylic acid (dipicolinic acid) in an assay for terbium by Barela and Sherry.
Simple substituted pyridines vary significantly in environmental fate characteristics, such as volatility, adsorption, and biodegradation.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is among the least volatile, least adsorbed by soil, and most rapidly degraded of the simple pyridines.
A number of studies have confirmed Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is biodegradable in aerobic and anaerobic environments, which is consistent with the widespread occurrence of the compound in nature.
With a high solubility (5g/liter) and limited sorption (estimated Koc = 1.86), utilization of Pyridine-2,6-dicarboxylic acid (dipicolinic acid) as a growth substrate by microorganisms is not limited by bioavailability in nature.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a major component of bacterial endospores, comprising 5-15% of the spore dry weight, and is important for spore stability and resistance properties.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) and its derivatives are introduced as a new sensitizer system for enzyme-amplified lanthanide luminescence (EALL), a detection scheme for bioassays, which combines enzymatic amplification with time-resolved luminescence measurements of lanthanide chelates.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid)s are good chelation agents.
There are multiple free electron pairs on the molecule, one on the lone nitrogen atom and two on oxygen atoms in the carboxylate groups, making it a tridentate ligand.
Numerous metals will complex to the dipicolinate ion, most notably chromium and the lanthanides.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a chemical compound with the molecular formula C7H5NO4.
It is a white crystalline solid that is soluble in water and ethanol.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is commonly used as a chelating agent and a precursor for the synthesis of metal complexes.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in the following products: cosmetics and personal care products, biocides (e.g. disinfectants, pest control
products) and washing & cleaning products.
Other release to the environment of this substance is likely to occur from: indoor use as processing aid.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in the following products: cosmetics and personal care products.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a significant component of bacterial endospores, constituting up to 10% of the dry weight of spores.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is often used as a biomarker for the presence of bacterial spores, including those of Bacillus and Clostridium species.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used as a ligand in coordination chemistry for the synthesis of metal complexes.
Intermediate in the synthesis of various organic compounds.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in some flame retardant formulations due to its ability to form char when burned, contributing to the material's fire resistance.
Employed in complexometric titrations as a chelating agent for metal ions.
The presence of dipicolinic acid in bacterial spores contributes to their resistance to heat and desiccation, which is a critical factor in the survival and persistence of spores in harsh environments.
Its ability to chelate metal ions makes it useful in various biochemical and industrial processes.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system.
Proper personal protective equipment (PPE) such as gloves, goggles, and masks should be used.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) should be stored in a cool, dry place, away from incompatible substances and moisture.
As an organic compound, dipicolinic acid is generally biodegradable, but its environmental impact is primarily related to its presence in bacterial spores rather than as a pollutant.
As a component of bacterial endospores, Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is crucial for studying spore-forming bacteria.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid)'s often extracted and quantified to assess spore viability and concentration.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used as a biomarker for detecting bacterial contamination, especially in food and medical industries.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) acts as a chelating agent, forming stable complexes with metal ions like calcium, magnesium, and transition metals.
These complexes are utilized in catalysis and materials science.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) serves as an intermediate in synthesizing various organic compounds, including pharmaceuticals, dyes, and agrochemicals.
Its ability to form complexes with metal ions makes it useful in titrations to determine metal ion concentrations.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) complexes can be analyzed using UV-Vis and fluorescence spectroscopy, providing insights into metal ion coordination and binding properties.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) contributes to the development of flame-retardant materials by promoting char formation and reducing flammability.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used as an additive in polymers to enhance their thermal stability and fire resistance.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) contributes to the heat resistance of bacterial spores, enabling them to survive extreme conditions.
These complexes stabilize the spore core, protecting DNA and essential proteins from heat and desiccation.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is biodegradable, breaking down into less harmful substances under environmental conditions.
Generally low, but care should be taken to prevent large releases into aquatic systems.
Avoid inhalation of dust and contact with skin and eyes.
Use appropriate Pyridine-2,6-dicarboxylic acid (dipicolinic acid) like gloves, safety goggles, and masks.
Store in a cool, dry place, tightly sealed to prevent moisture absorption and degradation.
Uses Of Pyridine-2,6-dicarboxylic acid (dipicolinic acid):
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in the preparation of dipicolinato ligated lanthanide and transition metal complexes.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) acts as a chelating agent for chromium, zinc, manganese, copper, iron and molybdenum.
Its calcium-dipcolinic acid complex is used to protect deoxyribonucleic acid (DNA) from heat denaturation which enhances the DNA stability.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) plays an important role as a marker for the effectiveness of sterilization.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is an amphoteric polar metabolite produced by many bacterial and fungal species.
Prior to its discovery as a microbial metabolite, dipicolinic acid had long been recognised as a chelating agent for many metal ions.
Wide distribution of dipicolinic acid among microbes makes it an important dereplication standard in discovery.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) reaches high concentrations (~10% w/w) in Bacillus endospores aiding heat resistance and is used in laboratories as a marker for the effectiveness of sterilisation.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is widely used in the pharmaceutical, chemical, and agricultural industries.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is commonly used as a chelating agent in metal complexation reactions.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is also used as a precursor for the synthesis of various organic compounds.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) plays a biological role in providing heat-resistance property to endospores produced by bacterial pathogens such as the aerobic Bacillus and anaerobic Clostridium. It accomplishes this by forming a complex with calcium ions in the endospore’s core. This complex binds to free water molecules, causing the spore to become dehydrated. Consequently, the thermal resistance of the macromolecules within the nucleus increases.
Additionally, it is used to produce complexes of lanthanide and transition metals for ion chromatography.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in the preparation of dipicolinato ligated lanthanide and transition metal complexes.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is calcium-dipcolinic acid complex is used to protect deoxyribonucleic acid (DNA) from heat denaturation which enhances the DNA stability.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is active in the metabolism of body.
For example, Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is is a constituent of the redox coenzymes nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate which are essential in energy metabolism in the living cell.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) act as chelating agents of elements such as chromium, zinc, manganese, copper, iron, and molybdenum in the body.
They are involved in Pyridine-2,6-dicarboxylic acid (dipicolinic acid), tryptophan, and alkaloids production, and for the quantitative detection of calcium.
This forms a complex with zinc, may facilitate the passage of zinc through the gastrointestinal wall and into the circulatory system.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) reacts with hemoglobin and myoglobin, which provide an application in meat processing to form brighter colour.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) acts to reduce plasma cholesterol, as a vasodilator and to treat pellagra.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used for the prophylaxis.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid)s and their derivatives can be studied for these effects.
They used as intermediate to produce pharmaceuticals and metal salts for the application of nutritional supplements. Quinolinic acid inhibits glucose synthesis.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) inhibits dopamine beta-hydroxylase activity.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid)s are very important in industrial field as well as in bio chemistry.
Nucleotide consist of either a nitrogenous heterocyclic base (purine or pyrimidine).
Three major pyrimidines in living systems are cytosine, thymine, and uracil.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid)s are biologically important components of nucleic acids (DNA, RNA) and coenzymes. Some pyridine system is active in the metabolism in the body.
Certain nitrogenous plant products also have pyridine class compounds.
They can be the parent compound of many drugs, including the barbiturates.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid)s are used as solvents and starting material for the synthesis of target compounds such as insecticides, herbicides, medicines, vitamins, food flavorings, feed additives, dyes, rubber chemicals, explosives, disinfectants, and adhesives.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is a key component of bacterial spores, constituting up to 10% of the dry weight of spores.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used as a biomarker to identify and quantify bacterial spores, particularly for species like Bacillus and Clostridium.
Researchers study Pyridine-2,6-dicarboxylic acid (dipicolinic acid) to understand the mechanisms behind spore resistance to heat and desiccation.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) forms stable complexes with metal ions such as calcium, magnesium, and transition metals.
This property is utilized in the synthesis of coordination compounds.
The metal complexes of Pyridine-2,6-dicarboxylic acid (dipicolinic acid) are used as catalysts in various organic reactions, enhancing reaction rates and selectivity.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used as a chelating agent in complexometric titrations to determine metal ion concentrations in solutions.
Metal-dipicolinate complexes can be analyzed using UV-Vis and fluorescence spectroscopy, providing insights into the coordination and binding properties of metal ions.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in the formulation of flame retardants.
It promotes char formation and reduces flammability in materials like plastics, textiles, and coatings.
Incorporated into polymers to enhance their thermal stability and fire resistance, making them safer for use in construction, electronics, and automotive industries.
5. Pharmaceuticals and Agrochemicals
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals.
Its chemical structure allows it to participate in the formation of more complex molecules.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in research and development of new drugs due to its ability to form stable complexes with metal ions, which can influence the pharmacokinetics and pharmacodynamics of therapeutic agents.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in the synthesis of MOFs, which are materials with high surface areas and porosity.
These materials are used for gas storage, separation, and catalysis.
Utilized in the development of advanced composite materials with enhanced mechanical and thermal properties.
Due to its organic nature, Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in developing biodegradable materials that break down into non-toxic components, reducing environmental impact.
WUsed in water treatment processes to chelate and remove heavy metals from contaminated water sources.
Ongoing research focuses on developing sensitive methods to detect Pyridine-2,6-dicarboxylic acid (dipicolinic acid) in clinical and environmental samples, which is crucial for monitoring bacterial contamination.
Explored in the creation of nanoparticles and nanostructured materials for use in medical diagnostics, drug delivery, and environmental sensing.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in educational settings to demonstrate principles of coordination chemistry, metal chelation, and complexometric titrations.
Employed as a standard in various analytical techniques to ensure accuracy and reliability of results.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is crucial for understanding how bacterial spores survive extreme conditions.
Studies focus on its role in protecting spore DNA and proteins from heat and desiccation.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used to investigate the germination process of bacterial spores, which is essential for developing methods to control harmful spore-forming bacteria in medical and food industries.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid)'s strong affinity for metal ions is exploited to design new chelating agents for industrial and environmental applications.
Synthetic complexes of Pyridine-2,6-dicarboxylic acid (dipicolinic acid) are used to mimic the active sites of metalloenzymes, aiding in the study of enzymatic mechanisms and the development of enzyme inhibitors.
Utilized in methods to detect and quantify trace amounts of metal ions in environmental and biological samples, improving the accuracy of pollution monitoring and medical diagnostics.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is used in chromatographic methods to separate and analyze complex mixtures of metal ions.
Research is ongoing to use Pyridine-2,6-dicarboxylic acid (dipicolinic acid) in developing non-toxic, environmentally friendly flame retardants for consumer products.
Added to intumescent coatings, dipicolinic acid helps these coatings expand and form a protective char layer when exposed to heat, providing improved fire resistance.
Safety Profile Of Pyridine-2,6-dicarboxylic acid (dipicolinic acid):
Direct contact with Pyridine-2,6-dicarboxylic acid (dipicolinic acid) may cause skin irritation, especially in individuals with sensitive skin or prolonged exposure.
Contact with the eyes can lead to irritation, redness, and discomfort.
Immediate flushing with water is necessary if eye contact occurs.
Inhalation of dust or vapors may irritate the respiratory tract, causing coughing, sore throat, or difficulty breathing.
Swallowing dipicolinic acid may cause nausea, vomiting, abdominal pain, and diarrhea.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) is essential to seek medical attention if ingestion occurs, and avoid inducing vomiting unless directed by medical professionals.
While dipicolinic acid is biodegradable, large quantities can potentially impact aquatic ecosystems.
Pyridine-2,6-dicarboxylic acid (dipicolinic acid) should be prevented from entering waterways or soil in concentrated forms.
