SACCHARIN and ITS K SALTS

Saccharin and its K salts are commonly used where improved water solubility and sodium reduction are important formulation objectives.
Saccharin and its K salts are extensively used in sugar-free, reduced-calorie, and diabetic-friendly products.
Saccharin and its K salts are commonly incorporated into soft drinks, flavored beverages, powdered drink mixes, chewing gum, confectionery products, desserts, jams, jellies, canned fruits, dairy products, bakery items, and tabletop sweeteners.

Saccharin
CAS Number: 81-07-2
EC Number: 201-321-0
Molecular Formula: C7H5NO3S
Molecular Weight: 183.18 g/mol

Saccharin K salts (Potassium Saccharin)
CAS Number: 55589-62-3
EC Number: 259-715-3
Molecular Formula: C7H4KNO3S
Molecular Weight: 221.27 g/mol

SYNONYMS:
Saccharin Synonyms
Saccharin, Benzoic Sulfimide, o-Sulfobenzimide, Benzosulfimide, Saccharine, Insoluble Saccharin, 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, E954, INS 954, Saccharin, Benzoic Sulfimide, o-Sulfobenzimide, 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, Benzosulfimide, Saccharine, Insoluble Saccharin, E954, INS 954, 1H-1λ6,2-Benzothiazole-1,1,3(2H)-trione, ortho-benzoic sulfimide, ortho sulphobenzimide, saccharin, 81-07-2, o-Benzoic sulfimide, o-Sulfobenzimide, Saccharine, Saccharimide, Benzosulfimide, Garantose, o-Benzosulfimide, Benzoic sulfimide, Benzosulphimide, Saccharinol, Saccharinose, Saccharin insoluble, Hermesetas, Saccharol, Glucid, Gluside, Saccharin acid, 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, Benzoic sulphimide, Benzosulfinide, Kandiset, Sacarina, Sucrette, Zaharina, Sykose, Saxin, o-Benzoyl sulfimide, Sucre edulcor, Benzo-2-sulphimide, o-Benzoic sulphimide, Benzoylsulfonic Imide, o-Benzosulphimide, o-Sulfobenzoic acid imide, Insoluble saccharin, 550 Saccharine, Natreen, Sacharin, o-Benzoyl sulphimide, 2-Sulphobenzoic imide, Benzoic acid sulfimide, Anhydro-o-sulfaminebenzoic acid, 2,3-Dihydro-3-oxobenzisosulfonazole, 1,1-dioxo-1,2-benzothiazol-3-one, 1,2-Dihydro-2-ketobenzisosulfonazole, 3-Benzisothiazolinone 1,1-dioxide, Saccharinum, 2,3-Dihydro-3-oxobenzisosulphonazole, 1,2-Dihydro-2-ketobenzisosulphonazole, 1,2-Benzisothiazolin-3-one 1,1-dioxide, 3-Hydroxybenzisothiazole-S,S-dioxide, 1,2-Benzisothiazolin-3-one, 1,1-dioxide, NSC-5349, FST467XS7D, DTXSID5021251, INS NO.954(I), 1,1-Dioxo-1,2-benzisothiazol-3(2H)-one, INS-954(I), E-954(I), DTXCID401251, CHEBI:32111, Calcium, Saccharin, 2,3-dihydro-1$l^{6},2-benzothiazole-1,1,3-trione, 2,3-dihydro-1$l^(6),2-benzothiazole-1,1,3-trione, RefChem:6208, 201-321-0, 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, Sweeta, Benzo[d]isothiazol-3(2H)-one 1,1-dioxide, 3-Hydroxybenzisothiazole S,S-dioxide, 2-Sulfobenzoic acid imide, Rcra waste number U202, Saccharin, insoluble, Syncal, o-Benzoic acid sulfimide, Benzo-sulphinide, Cristallose, Soluble saccharin, 1,2-Benzothiazol-3(2H)-one 1,1-dioxide, MFCD00005866, Saccharin, sodium salt, 2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 1,1-Dioxide-1,2-benzisothiazolin-3-one, CHEMBL310671, 1,1-Dioxo-1,2-dihydro-benzo[d]isothiazol-3-one, 1,1-Diox-1,2-benzisothiazol-3-one, NCGC00094918-03, 1,1-Dioxo-1,2-dihydro-1lambda6-benzo[d]isothiazol-3-one, E954, Saccharin, soluble, 1,2-Benzisothiazoline-3-one 1,1-dioxide, 1,1-Dioxide-1,2-benzisothiazol-3(2H)-one, Sacharin [Czech], Benzosulfimide, O-, Saccharin [USAN], Sulfobenzimide, O-, 2,3-Dihydro-1,2-benzoisothiazol-3-one-1,1-dioxide, 1,1-Dioxo-1,2-dihydro-1lambda6-benzo[d]-isothiazol-3-one, Sodium 1,2 benzisothiazolin-3-one 1,1-dioxide, CAS-81-07-2, Saccharin [NF], NSC5731, 2-hydrobenzo[d]isothiazole-1,1,3-trione, LSA, HSDB 669, NSC 5349, NSC 5731, EINECS 201-321-0, RCRA waste no. U202, UNII-FST467XS7D, Glycophenol, Neosaccharin, AI3-38107, SR-01000389315, ulfonylurea TP3, Saccharin CRS, Benzo-2-sulfiide, O-Benzoylsulfimide, 2-Sulfobenzoicimide, M07 (saccharin), O-Sulfobenzoic imide, Sweeta (TN), o-sulphobenzoic imide, 2-Sulfobenzoic imide, Oxasulfuron metabolite, Saccharin (Standard), Saccharin M.P. RS, Spectrum_000213, Saccharin, >=98%, Saccharin, >=99%, SACCHARIN [FCC], SACCHARIN [JAN], SACCHARIN [II], SACCHARIN [MI], SACCHARIN [HSDB], SACCHARIN [IARC], Saccharin (JP15/NF), Saccharin (JP17/NF), Spectrum2_001432, Spectrum3_001475, Spectrum4_000449, Spectrum5_001181, SACCHARIN [VANDF], 1,2-benzisothiazol-3(2H)-one-1,1-dioxide, SACCHARINUM [HPUS], SACCHARIN [MART.], WLN: T56 BSWMVJ, EC 201-321-0, SACCHARIN [USP-RS], SACCHARIN [WHO-DD], SCHEMBL3816, Saccharin, puriss., 98%, NCIOpen2_005140, NCIOpen2_005180, Saccharin (IN-00581), BSPBio_003029, KBioGR_000838, KBioSS_000693, DivK1c_000164, SCHEMBL574097, SPECTRUM1501171, SPBio_001564, GTPL5432, orb1310197, SCHEMBL4562664, SCHEMBL5907951, SCHEMBL7361433, SCHEMBL8810914, SACCHARIN [EP MONOGRAPH], SCHEMBL29358404, BDBM29278, HMS500I06, HY-Y0272R, KBio1_000164, KBio2_000693, KBio2_003261, KBio2_005829, KBio3_002529, MSK5104, NSC5349, 2q38, NINDS_000164, HMS1921N03, HMS2092J09, HMS5083B10, Pharmakon1600-01501171, HY-Y0272, LBC47901, PXB46617, STR03759, 3-Benzisothiazolinone 1, 1-dioxide, Tox21_111358, Tox21_201880, Tox21_302950, BBL015343, CCG-39011, EBC-03311, NSC757878, s4819, SBB027246, STK803263, 2, 3-Dihydro-3-oxobenzisosulfonazole, 2,3-Dihydro-3-oxo-Benzisosulfonazole, AKOS000120481, AKOS017272711, Saccharin (only persons who manufacture are subject, no supplier notification), Tox21_111358_1, 1, 2-Dihydro-2-ketobenzisosulfonazole, DB12418, FS27775, NSC-757878, IDI1_000164, 1.2-benzoisothiazole-3-on-1.1-dioxide, Benzisosulfonazole, 2,3-dihydro-3-oxo-, NCGC00094918-01, NCGC00094918-02, NCGC00094918-04, NCGC00094918-05, NCGC00094918-06, NCGC00094918-07, NCGC00094918-09, NCGC00256329-01, NCGC00259429-01, ST073992, 1,2-benzisothiazoline-3-one-1,1-dioxide, 1.2 -benzoisothiazole-3-on 1.1-dioxide, SBI-0051671.P002, 1, 2-Benzisothiazolin-3-one 1,1-dioxide, 1,2-benzisothiazol-3(2H)-one,1,1-dioxide, B0004, CS-0013120, NS00007781, T0889, 1,2-Benzisothiazol-3(2H) one 1,1-dioxide, EN300-18624, D01085, D70140, 1, 2-Benzisothiazol-3(2H)-one, 1,1-dioxide, 3-keto-2H,3H-1,2-benzisothiazole 1,1-dioxide, AB00052233-04, AB00052233_05, 2,3-dihydro-1??,2-benzothiazole-1,1,3-trione, F055150, Q191381, 1,1-Dioxido-3-oxo-2,3-dihydrobenzo[d]isothiazole, 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, 9CI, 1H-1lambda~6~,2-Benzothiazole-1,1,3(2H)-trione, 2,3-dihydro-1,2-benzisothiazol-3-one-1,1-dioxide, 2,3-dihydro-3-oxo-1,2-benzisothiazol-1,1-dioxide, doi:10.14272/CVHZOJJKTDOEJC-UHFFFAOYSA-N.1, SR-01000389315-2, 03AC8EC2-D02A-464C-A7C3-7CABD643CC1E, 2,3-dihydro-1lambda6,2-benzothiazole-1,1,3-trione, BRD-K46493214-001-03-4, BRD-K46493214-001-06-7, 1, 2-Benzisothiazolin-3-one, 1,1-dioxide, sodium salt, 1, 2-Benzothiazol-3(2H)-one 1,1-dioxide sodium salt, F0001-2092, Z256708526, 1, 2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt, 1,1-dioxo-1,2-dihydro-1lambda6-benzo[d]isothiazol-3-one, Saccharin, European Pharmacopoeia (EP) Reference Standard, Saccharin, United States Pharmacopeia (USP) Reference Standard, Saccharin, Pharmaceutical Secondary Standard; Certified Reference Material, InChI=1/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9, Mettler-Toledo Calibration substance ME 51143091, Saccharin, traceable to primary standards (LGC), saccharine saccharimide benzosulfimide o-sulfobenzoic acid imide benzoic sulphimide o-benzosulfimide benzoic acid sulfimide benzoic sulfimide benzosulphimide o-sulfobenzimide

Saccharin K salts (Potassium Saccharin) Synonyms
Potassium Saccharin, Potassium Benzosulfimide, Potassium o-Sulfobenzimide, Potassium Saccharinate, Potassium Salt of Saccharin, Potassium 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, E954iii, INS 954iii, saccharin potassium, Potassium saccharate, Potassium saccharin, 10332-51-1, Saccharin, potassium salt, K2BEG3J28N, 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, potassium salt, potassium saccharinate, 1,2-Benzisothiazolin-3-one, 1,1-dioxide, potassium salt, INS NO.954(III), INS-954(III), SACCHARIN POTASSIUM SALT, DTXSID90890654, 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, potassium salt (1:1), E-954(III), SACCHARIN POTASSIUM [MART.], SACCHARIN POTASSIUM (MART.), RefChem:884311, Potassium Saccharin Monohydrate, DTXCID401030957, Potassium Salt of 1,2-Benzisothiazole-3(2h)-One-1,1-Dioxide Monohydrate, potassium;1,1-dioxo-1,2-benzothiazol-2-id-3-one, potassium;1,1-dioxo-1,2-benzothiazol-3-olate, UNII-K2BEG3J28N, AKOS000277807, Q27281856, Potassium 1,1,3-trioxo-1,3-dihydro-1lambda~6~,2-benzothiazol-2-ide, Potassium salt of 1,2-benzisothiazole-3(2H)-one-1,1-dioxide, monohydrate, 3-oxo-2,3-dihydrobenzo[d]isothiazol-1,1-dioxide monohydrate, 2,3-dihydro-3-oxobenziso-sulfonazole monohydrate; potassium, o-benzosulfimide, 1,2-benzisothiazol-3(2H)-one, 1,1-dioxide, potassium salt (1:1), potassium 1,1-dioxo-1,2-benzothiazol-2-id-3-one, potassium saccharate, saccharin potassium salt

Saccharin and its K salts are white crystals or a white, crystalline powder, odourless or with a faint, aromatic odour
Saccharin and its K salts are synthetic high-intensity sweeteners widely used in food, beverage, pharmaceutical, and personal care industries.
Saccharin itself is an intensely sweet sulfonamide compound, while potassium saccharin is the potassium salt form designed to improve water solubility and formulation compatibility in industrial applications.

Saccharin is approximately 300–500 times sweeter than sucrose and contributes virtually no calories.
Saccharin and its K salts are especially useful in sugar-free and reduced-calorie products because it dissolves readily in water and provide stable sweetness in beverages, processed foods, and pharmaceutical formulations.

Saccharin and its K salts are commonly blended with cyclamate, aspartame, sucralose, acesulfame potassium, and steviol glycosides to improve sweetness quality and reduce metallic or bitter aftertastes.
Saccharin and its K salts are particularly valued in formulations where sodium reduction is important.

USES and APPLICATIONS of SACCHARIN and ITS K SALTS:
Saccharin and its K salts are commonly used where improved water solubility and sodium reduction are important formulation objectives.
Saccharin and its K salts remain highly valuable in beverage systems and pharmaceutical liquids because of their rapid dissolution and stable sweetness profile.
Saccharin and its K salts continue to be widely utilized in industrial sugar-reduction technologies because they combine cost efficiency, strong sweetness intensity, processing stability, and long-term shelf performance.

Saccharin and its K salts are extensively used in sugar-free, reduced-calorie, and diabetic-friendly products.
Saccharin and its K salts are commonly incorporated into soft drinks, flavored beverages, powdered drink mixes, chewing gum, confectionery products, desserts, jams, jellies, canned fruits, dairy products, bakery items, and tabletop sweeteners.

In pharmaceutical applications, Saccharin and its K salts is used in syrups, oral suspensions, chewable tablets, nutraceuticals, vitamin products, and medicinal formulations to improve taste and mask bitterness.
Its excellent solubility makes it particularly useful in liquid dosage forms.

Saccharin and its K salts are also applied in oral care and personal care products such as toothpaste, mouthwash, breath fresheners, dental gels, lip products, and cosmetic formulations because they provide sweetness without contributing to dental caries.
Industrial manufacturers frequently combine potassium saccharin with cyclamate, sucralose, acesulfame potassium, or aspartame to improve sweetness quality, reduce formulation costs, and maintain stable sweetness in processed foods and beverages.

CHARACTERISTICS of SACCHARIN and ITS K SALTS:
Saccharin and its K salts are characterized by very high sweetening power, excellent shelf stability, and low caloric contribution.
Saccharin and its K salts are especially valued because they offer improved water solubility compared with the acid form, making them suitable for beverages, syrups, and liquid formulations.
Saccharin and its K salts demonstrate excellent chemical and thermal stability, allowing use in processed foods, acidic beverages, baked products, and pharmaceutical formulations.
Saccharin and its K salts' sweetness remains stable during long-term storage and industrial processing.

One important characteristic is Saccharin and its K salts' synergistic interaction with cyclamate, sucralose, aspartame, and acesulfame potassium.
These combinations help produce sweetness profiles closer to sucrose while reducing metallic or bitter aftertastes.
Saccharin and its K salts are also advantageous in sodium-reduced products because they replace sodium-containing sweetener salts while maintaining sweetness functionality.

PHYSICAL and CHEMICAL PROPERTIES of SACCHARIN and ITS K SALTS:
Saccharin and its K salts appear as white crystalline solids with intense sweetness and little or no odor.
Saccharin and its K salts exhibit significantly improved water solubility compared with insoluble saccharin, making it more suitable for beverage systems and liquid pharmaceutical formulations.

Chemically, Saccharin and its K salts belong to the sulfonamide class and contain aromatic benzene structures linked to sulfonimide functional groups.
Potassium saccharin exists as an ionic salt that readily dissociates in water, enhancing sweetness distribution in aqueous systems.
Saccharin and its K salts exhibit good thermal stability and remain functional during baking, pasteurization, sterilization, and long-term storage.

Saccharin and its K salts also demonstrate broad pH stability, allowing use in acidic and neutral products.
Although highly stable, Saccharin and its K salts may produce slight metallic or bitter notes at elevated concentrations.
For this reason, manufacturers frequently blend them with other sweeteners to optimize taste quality.

BENEFITS of SACCHARIN and ITS K SALTS:
Extremely high sweetness intensity
Virtually zero calories
Excellent water solubility for liquid systems
Stable during thermal processing
Stable in acidic beverages
Long shelf life
Suitable for diabetic-friendly products
Non-cariogenic
Useful for sodium-reduced formulations
Efficient bitterness masking in pharmaceuticals
Economical sweetening agent
Compatible with other sweeteners
Requires very low usage concentrations
Good industrial processing stability

PHYSICAL and CHEMICAL PROPERTIES of SACCHARIN and ITS K SALTS:
Saccharin
CAS Number: 81-07-2
EC Number: 201-321-0
Molecular Formula: C7H5NO3S
Molecular Weight: 183.18 g/mol
Appearance: White crystalline powder or crystals
Odor: Odorless
Taste: Intensely sweet with slight metallic or bitter aftertaste at high concentrations
Sweetness Intensity: Approximately 300–500 times sweeter than sucrose
Physical State: Solid
Solubility in Water: Slightly soluble
Solubility in Alcohol: Slightly soluble
Melting Point: Approximately 226–230°C with decomposition
Density: Approximately 0.83 g/cm³
Hygroscopicity: Low
Thermal Stability: Good
pH Stability: Stable over broad pH ranges
Volatility: Non-volatile
Chemical Class: Sulfonamide derivative
Functional Groups:
Sulfonimide group
Aromatic benzene ring
Acidity: Weak acidic compound
pKa: Approximately 1.6–2.2
Reactivity: Low under normal conditions
Oxidation Stability: Good
Hydrolysis Stability: Stable under standard food-processing conditions
Flammability: Non-flammable

Saccharin K salts (Potassium Saccharin)
CAS Number: 55589-62-3
EC Number: 259-715-3
Molecular Formula: C7H4KNO3S
Molecular Weight: 221.27 g/mol
Appearance: White crystalline powder or granules
Odor: Odorless
Taste: Strong sweet taste
Sweetness Intensity: Approximately 300–500 times sweeter than sucrose

Physical State: Solid
Solubility in Water: Highly soluble
Solubility in Alcohol: Slightly soluble
Hygroscopicity: Low to moderate
Thermal Stability: Excellent stability during processing
Shelf Stability: Good long-term stability
Bulk Density: Variable according to commercial grade
Volatility: Non-volatile

Chemical Class: Potassium salt of saccharin
Ionic Character: Potassium salt
Chemical Stability: Stable under normal storage and processing conditions
Compatibility: Compatible with many food ingredients and sweetener systems
Synergistic Sweetening: Commonly blended with cyclamates and other sweeteners
Thermal Resistance: Stable during pasteurization and baking
Reactivity: Low chemical reactivity

Oxidation Stability: Good resistance to oxidation
Water Dissociation: Readily dissociates in aqueous systems
FDA UNII: K2BEG3J28N
Molecular Weight: 221.27678000
Formula: C7 H4 K N O3 S
Appearance: white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No

Melting Point: 226.00 to 230.00 °C. @ 760.00 mm Hg
Soluble in: water, alcohol, very slightly
Insoluble in: alcohol
Molecular Weight: 221.28 g/mol
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 0

Exact Mass: 220.95489565 Da
Monoisotopic Mass: 220.95489565 Da
Topological Polar Surface Area: 60.6 Ų
Heavy Atom Count: 13
Formal Charge: 0
Complexity: 308

Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

FIRST AID MEASURES of SACCHARIN and ITS K SALTS:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of SACCHARIN and ITS K SALTS:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of SACCHARIN and ITS K SALTS:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of SACCHARIN and ITS K SALTS:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of SACCHARIN and ITS K SALTS:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of SACCHARIN and ITS K SALTS:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available