SODIUM CITRATE DIHYDRATE

SODIUM CITRATE DIHYDRATE

Sodium Citrate, Dihydrate, a conjugate base of a weak acid, can perform as a biological buffering agent because it resists changes in pH. 
Citric acid is one of a series of compounds responsible for the physiological oxidation of fats, carbohydrates and proteins to carbon dioxide and water. 
Sodium Citrate, Dihydrate is often used to prepare sodium citrate buffer for antigen retrieval of tissue samples. 
The citrate solution is designed to break protein cross-links; thus, unmasking antigens and epitopes in formalin-fixed and paraffin embedded tissue sections, resulting in enhancing staining intensity of antibodies. 
Citrate has anticoagulant activity and as a calcium chelator, it forms complexes that disrupt the tendency of blood to clot.

CAS Number: 6132-04-3

IUPAC Name: trisodium;2-hydroxypropane-1,2,3-tricarboxylate;dihydrate

Molecular Formula: C6H9Na3O9
Molecular Weight: 294.10 g/mol

Usage :
• For antigen retrieval, prepare a solution of 10 mM sodium citrate buffer, pH 6.0.
Physical State :Solid
Solubility :Soluble in water (29.4 g/l at 20° C). Insoluble in ethanol.
Storage :Store at room temperature
Melting Point :>300° C (lit.)
Boiling Point :309.6° C at 760 mmHg (Predicted)
Density :1.76 g/cm3

Sodium citrate dihydrate is a white powder that is used as a buffering, sequestering, or emulsifying agent in foods, beverages, and various other industrial applications. 
Sodium citrate dihydrate can also be used in detergent formulations due to its rapid biodegradability characteristics.

Sodium citrate dihydrate is the sodium salt of citric acid. 
Sodium citrate dihydrate is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. 
Like citric acid, it has a sour taste. 
From the medical point of view, Sodium citrate dihydrate is used as alkalinizing agent. 
Sodium citrate dihydrate works by neutralizing excess acid in the blood and urine. 
Sodium citrate dihydrate has been indicated for the treatment of metabolic acidosis.

Sodium Citrate Dihydrate, also known as Trisodium Citrate Dihydrate, Sodium Citrate Tribasic Dihydrate, Citric Acid Trisodium Salt Dihydrate, and Sodium Citrate Tribasic Dihydrate, has the chemical formula C6H9Na3O9 or C6H5Na3O7-2H2O. 
Sodium citrate dihydrate is dihydrate of Sodium Citrate and appears as colorless or white crystals or crystalline powder. 
Sodium citrate dihydrate is soluble in Water and insoluble in Alcohol at ambient conditions. 
Sodium Citrate is commonly available as three different salts of Sodium namely Monosodium Citrate, Disodium Citrate, and Trisodium Citrate. 

Properties:

- Dihydrate
- White
- Granular crystals or crystalline powder
- Typical, practically odourless
- Pleasantly salty
- Freely soluble in water
- Practically insoluble in ethanol (96 %)
- Non-toxic
- Low reactive
- Chemically and microbiologically stable
- Fully biodegradable

Main functions:

- pH regulator
- Chelating agent
- Buffering agent
- Flavour enhancer
- Stabiliser
- Emulsifying agent

Applications:

Common Uses

- Food preservative
- Emulsifying agent

Commercial/Industrial Applications

- Pharmaceuticals
- Cosmetics
- Food Additive

Food:

- Baby Food, Infant Formula
- Bakery
- Cereals, Snacks
- Confectionery
- Dairy
- Dairy Alternatives
- Desserts, Ice Cream
- Flavours
- Fruit Preparations, Sweet Spreads
- Fruits, Vegetables
- Meat Alternatives
- Meat, Seafood
- Plant-based Products
- Ready Meals, Instant Food
- Sauces, Dressings, Seasonings

Beverages:

- Alcoholic Beverages
- Carbonated Soft Drinks
- Instant Drinks, Syrups
- Juice Drinks
- Plant-based
- RTD Tea and Coffee
- Sports and Energy Drinks
- Waters

Healthcare: 

- Clinical Nutrition
- Medical Devices
- OTC, Food Supplements
- Pharmaceutical Products

Personal Care: 

- Colour Cosmetics
- Fragrances
- Hair Care
- Oral Care
- Skin Care
- Soap and Bath Products

Cleaners & Detergents:

- Dish Washing
- Industrial Cleaners
- Laundry Care
- Surface Care
- A detergent tab splashing in water
- More about Cleaners & Detergents

Industrial Applications:

- Adhesives, Sealants
- Agrochemicals, Fertilisers
- Construction
- Fine Chemicals
- Inks, Paints, Coatings
- Oil Drilling
- Paper
- Plastics, Polymers
- Textile, Leather

Sodium citrate dehydrate (Trisodium citrate dihydrate) is a natural product with oral activity that can be found in citrus fruits. 
Sodium citrate dehydrate can inhibit the proliferation of tumor cells and induce apoptosis. 
Sodium citrate dehydrate has antibacterial, anti-tumor and antioxidant activities.

Sodium citrate dihydrate is a tribasic salt of citric acid. 
Sodium citrate dihydrate is produced by complete neutralisation of citric acid with high purity sodium hydroxide or carbonate and subsequent crystallisation. 
Sodium citrate dihydrate is widely used in foods, beverages and various technical applications mainly as buffering, sequestering or emulsifying agent.

Sodium citrate dihydrate occurs as white, granular crystals or as white, crystalline powder with a pleasant, salty taste. 
Sodium citrate dihydrate is slightly deliquescent in moist air, freely soluble in water and practically insoluble in ethanol (96 %).

Sodium citrate dihydrate is a non-toxic, neutral salt with low reactivity. 
Sodium citrate dihydrate is chemically stable if stored at ambient temperatures. 
Sodium citrate dihydrate is fully biodegradable and can be disposed of with regular waste or sewage.

SYNONYMS:

Sodium citrate (dihydrate)
Sodium citrate dihydrate, for molecular biology
Sodium citrate dihydrate, meets USP testing specifications
Sodium citrate dihydrate, United States Pharmacopeia (USP) Reference Standard
HY-B1610E
HY-B1610H
HY-B1610I
HY-B1610
CS-0013545
CS-0926157
CS-0926158
CS-0926159