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EC / List no.: 231-679-3
CAS no.: 7681-82-5
Mol. formula: INa
Sodium iodide (chemical formula NaI) is an ionic compound formed from the chemical reaction of sodium metal and iodine.
Under standard conditions, it is a white, water-soluble solid comprising a 1:1 mix of sodium cations (Na+) and iodide anions (I−) in a crystal lattice.
Sodium iodide is used mainly as a nutritional supplement and in organic chemistry.
Sodium iodide is produced industrially as the salt formed when acidic iodides react with sodium hydroxide.
Sodium iodide is a chaotropic salt.
Sodium iodide is usually available in various concentration.
Special packaging information is available on demand.
Sodium iodide is an inorganic salt. Mixture of chlorotrimethylsilane/sodium iodide in acetonitrile is a useful reagent for the cleavage of esters, lactones, carbamates and ethers.
Uses:
Food supplement
Sodium iodide, as well as potassium iodide, is commonly used to treat and prevent iodine deficiency. Iodized table salt contains 10 ppm iodide.
Organic synthesis
Sodium iodide is used for conversion of alkyl chlorides into alkyl iodides.
This method, the Finkelstein reaction, relies on the insolubility of sodium chloride in acetone to drive the reaction:
R–Cl + NaI → R–I + NaCl
Nuclear medicine
Some radioactive iodide salts of sodium, including Na125I and Na131I, have radiopharmaceutical uses, such as in the treatment of thyroid cancer and hyperthyroidism or as radioactive tracer in imaging.
Thallium-doped NaI(Tl) scintillators
Sodium iodide activated with thallium, NaI(Tl), when subjected to ionizing radiation, emits photons (i.e., scintillate) and is used in scintillation detectors, traditionally in nuclear medicine, geophysics, nuclear physics, and environmental measurements.
NaI(Tl) is the most widely used scintillation material.
The crystals are usually coupled with a photomultiplier tube, in a hermetically sealed assembly, as sodium iodide is hygroscopic.
Fine-tuning of some parameters (i.e., radiation hardness, afterglow, transparency) can be achieved by varying the conditions of the crystal growth.
Crystals with a higher level of doping are used in X-ray detectors with high spectrometric quality.
Sodium iodide can be used both as single crystals and as polycrystals for this purpose.
The wavelength of maximum emission is 415 nm.
Stability
Iodides (including sodium iodide) are detectably oxidized by atmospheric oxygen (O2) to molecular iodine (I2).
I2 and I− complex to form the triiodide complex, which has a yellow color, unlike the white color of sodium iodide.
Water accelerates the oxidation process, and iodide can also produce I2 by photooxidation, therefore for maximum stability sodium iodide should be stored under dark, low temperature, low humidity conditions.
Chemical Properties
Sodium iodide is colorless cubic crystal or white crystalline powder.
Sodium iodide is odorless with salty taste bitter.
Sodium iodide is easily soluble in water, soluble in methanol, ethanol, acetone, glycerol, liquid ammonia and liquid sulfur dioxide.
The aqueous solution was slightly alkaline.
White or almost white, crystalline powder or colourless crystals, hygroscopic.
Sodium iodide, white solid, soluble, formed by reaction of sodium carbonate or hydroxide and hydriodic acid, and then evaporating. Used in photography, in medicine and as a source of iodide.
Physical properties
White crystalline deliquescent powder or granules;
saline and slight bitter taste;
absorbs moisture from air;
slowly turns brown on exposure to air due to iodine evolved;
density 3.67g/cm3;
melts at 660°C;
vaporizes at 1,304°C;
vapor pressure 1 torr at 767°C and 5 torr at 857°C; very soluble in water, 178.7 g/100 mL at 20°C and 294 g/100 mL at 70°C; soluble in ethanol and acetone.
Uses:
Used as iodometric reagent
Sodium iodide is widely used for halide exchange (Finkelstein reaction), for example in the conversion of an alkyl chloride, allyl chloride and arylmethyl chloride into their respective iodides, which are precursors for pharmaceutical and fine chemical products.
They are used to ehnance the efficiency of the formation of Wittig adducts from less reactive chlorides and bromides.
Appropriate prepartions find use as a nutrient supplement.
Sodium iodide is used as the precursor to the control agent in ab initio emulsion polymerization.
Sodium iodide finds use in the determination of dissolved oxygen in the modified Winkler method, synthesis of the fluorescent dye coppersensor-1 (CS1) for imaging labile copper pools in biological samples, and the cleavage of esters, lactones, carbamates and ethers in combination with chlorotrimethylsilane.
Production method
Eight iron iodide method: based on the mass ratio of iodine method: iron = 3.3: 1, first add the washed iron powder to the reactor; then add water with the mass ratio of the added water amount over iron being 7: 1.
Successively add iodine tablet. Owing to the large amount of heating generated during the reaction between iodine and iron, we should use chilled water to cool outside of the reactor to a temperature below 65 ℃.
After addition of iodine tablet, the solution turns dark red-brown.
When the solution exhibits light green, add the second batch of iodine; after further removal of the iron powder by filtration, add iodine for reaction to generate eight iron iodide.
Sodium bicarbonate solution was added to the vessel, add slowly with stirring of eight iron iodide for reaction and there will be carbon dioxide gas released at this time.
The reaction solution was allowed to stand; the supernatant was aspirated and concentrated by evaporation to 70~72°
Bé, filter upon hot, cool and crystallize, centrifuge, separate, and dry to obtain the finished product of sodium iodide.
Fe + I2 → FeI2
3FeI2 + I2 → Fe3I8
Fe3I8 + 8NaHCO3 → 8NaI + Fe3O4 + 4H2O + 8CO2 ↑
Reduction method of iron powder: take 100% to 103% the theoretical amount of caustic soda, add water into 10% solution and heat in the reactor to 60~80 ℃.
Add quantitatively of iodine with several times, maintain the temperature of 80~90 ℃ and react upon stirring for about 1h with the reaction liquid being brown and the Ph range of 6 to 7 while there is white crystals of sodium iodide being precipitated out.
The reaction solution was cooled to below 30 ℃.
Add 2 times the theoretical amount of iron powder to reduce the sodium iodate to sodium iodide.
At the beginning, the reaction is relative fierce.
When the reaction is eased, heat to boiling and continue the stirring for reaction of 1~2h, then use 10% caustic soda solution for adjustment the Ph to 8; boil for 30min, after cooling, standing for filtration; evaporate and concentrate the colorless filtrate so that the crystal is precipitated out; further filter upon hot, dry to obtain the finished product of sodium iodide.
3I2 + 6NaOH → 5NaI + NaIO3 + 3H2O
NaIO3 + 3Fe + 3H2O → NaI + 3Fe (OH) 2
Outline
Sodium iodide is a white solid obtained through the reaction between sodium carbonate with hydroiodic acid and further evaporation of the solution.
There are anhydrous, dihydrate and pentahydrate compound.
Sodium iodide is the raw material for the manufacturing of iodine, for being used in medicine and photography.
The acidic solution of sodium iodide, due to the generation of hydroiodic acid, displays reductive capability.
Anhydrous compound has its chemical formula be NaI and the molecular weight of 149.89.
Sodium iodide is colorless cubic crystal or white granular substance with salty taste and slightly bitter.
Sodium iodide has a melting point of 651 ℃, boiling point of 1304 ℃, the relative density of 3.665 (4 ℃), 3.607 (25 ℃) and the refractive index of 1.7745.
Sodium iodide is easily soluble in water (0 ℃: 159.7,20 ℃: 179.3,25 ℃: 184, 30 ℃: 190, 40 ℃: 205,50 ℃: 227,60 ℃: 257,80 ℃: 296,100 ℃:302) , ethanol (25 ℃:43.3), methanol (10 ℃:65.0,25 ℃: 78.0,40 ℃: 80.7,60 ℃:79,4), acetone (20 ℃:30.0, 80 ℃:21.8), ammonia and pyridine.
Sodium iodide is also soluble in glycerol.
Sodium iodide has strong hygroscopicity with gradually absorbing moisture in the air to reach the moisture content being 5%.
Sodium iodide can turn to brown color due to release of iodine upon oxidation by air.
The aqueous solution was slightly alkaline and also has the same change.
You can supply a slight amount of alkaline to maintain its stability.
The pH of the aqueous solution is 8-9.5.
Sodium iodide should be stored sealed and free of light.
Its crystal is dihydrate sodium iodide with the chemical formula being NaI•2H2O and the molecular weight being 185.92.
Sodium iodide is colorless crystal with deliquescence and is easily soluble in water, ethanol and glycerol.
Sodium iodide will loss crystal water at temperature above 65 ℃.
Its melting point is 752 ℃.
Sodium iodide has reduction capability.
In air or aqueous solution, it is easily oxidized by oxygen in the air with its iodine being precipitated out and turning black color.
Sodium iodide should be stored sealed and free of light.
The transition temperature of pentahydrate, dihydrate and anhydrous is as below:
NaI•5H2O---(-13.5 ℃)---NaI • 2H2O---(65 ℃)---NaI
Sodium iodide can be used as determination agent and measurement of palladium, platinum and thallium, etc through trace analysis measurement.
The co-solvent of iodine (sodium iodide can form complex with iodine in an aqueous solution and can increase the iodine solubility), it can also be used as the raw materials of pharmaceuticals, photographic emulsion and single crystal.
Drug properties and Applications
Sodium iodide can be used for cystography, retrograde urography, cholangiography via T-tube and fistula angiography of other parts.
Urography: 6.25% 100ml.
Cystography: 6.25% 150ml.
Retrograde pyelography: 12.5% 5~7ml.
T-tube cholangiography: 12.5% 10~30ml.
Fistula angiography: determine the injection site and dose according the state of the illness.
Description
Information not available
Appearance
Sodium iodide occurs as crystals or as a crystalline powder that turn yellow on exposure to air due to the formation of iodine.
Solubility
Sodium iodide is soluble in water and in many organic solvents such as aliphatic alcohols or benzyl alcohol and glycerin.
Uses:
Sodium iodide is used as a raw material for the pharmaceutical industry and in the photographic industry, it is also used as a raw material for zootechnical application.
Classification
Request safety data sheet (SDS) and refer to points 4, 5, 6, 8, 10,13, 14, 15. Technical specifications are provided on request according to the application.
Safety
Request safety data sheet (SDS) and refer to points 4, 5, 6, 7, 8, 10, 13.
Specifications
Technical specifications are provided on request according to the application: sodium iodide is stored in original packing and under conditions mentioned on the safety data sheet (SDS).
Use and Manufacturing
Industry Uses
Corrosion inhibitors and anti-scaling agents
Intermediates
Organic chemical manufacturing
Photosensitive chemicals
Processing aids, not otherwise listed
Surface active agents
crystals for ionizing radiation detection
Consumer Uses
Chemical manufacturing
Cleaning and furnishing care products
Non-TSCA use
General Manufacturing Information
Industry Processing Sectors
All other basic inorganic chemical manufacturing
All other basic organic chemical manufacturing
Electrical equipment, appliance, and component manufacturing
Oil and gas drilling, extraction, and support activities
Pharmaceutical and medicine manufacturing
Soap, cleaning compound, and toilet preparation manufacturing
other measuring and controlling device manufacturing
Precaution and Taboo
X-ray contrast agent is a drug which can take the properties of easily penetrating or not easily penetrating of X-ray as contrast so that the checked part can be developed.
The current clinically used contrast agents are divided into two categories including negative contrast agent (its developing density is lower than human soft tissue) and positive contrast agent (developing density is higher than human soft tissue). Negative contrast agents include air, carbon dioxide and oxygen.
Positive contrast agents, except barium sulfate, are almost all organic iodide and iodine compounds. Sodium iodide was first used in the urinary system angiography.
The iodine-carbon bond of the organic iodine compound is quite stable and is not easily to form iodide with almost no physiological effects on the human body.
X-ray contrast agent, after absorption and appropriate concentration in certain organs or tissues, reaching a certain concentration, can absorb X-ray for radiography.
They can be divided into two categories including water-soluble and oil-soluble.
According to different chemical types, the former can be divided into phthalocyanine, organic acids, sulfonic acids and pyridine ketones; the latter is mainly iodized oil.
Ideal contrast agent should have the following requirements: clear developing, non-toxic, no adverse reactions, easily absorbed and excreted, stable physical and chemical properties and can be subject to long-term storage without corrosion, easy to use, easy for manufacturing and inexpensive.
Preparation
Sodium iodide is prepared by adding hydriodic acid or an acidic iodide solution to a solution of sodium hydroxide or sodium carbonate, followed by evaporation and crystallization: NaOH + HI → NaI + H2O
The solution is filtered to remove any impurities prior to its evaporation and crystallization.
Definition
sodium iodide: A white crystallinesolid, NaI, very soluble in water andsoluble in both ethanol and ethanoicacid.
Sodium iodide is known in both the anhydrousform (cubic; r.d. 3.67; m.p.661°C; b.p. 1304°C) and as the dihydrate(monoclinic; r.d. 2.45).
Sodium iodide is preparedby the reaction of hydrogeniodide with sodium carbonate orsodium hydroxide in solution.
Likepotassium iodide, sodium iodide inaqueous solution dissolves iodine toform a brown solution containingthe I3- ion.
Sodium iodide finds applications inphotography and is also used in medicineas an expectorant and in the administrationof radioactive iodine for studies of thyroid function and fortreatment of diseases of the thyroid.
Purification Methods
Crystallise NaI from water/ethanol solution and dry it for 12hours under vacuum, at 70o.
Alternatively, dissolve it in acetone, filter it and cool it to -20o; the resulting yellow crystals are filtered off and heated in a vacuum oven at 70o for 6hours to remove acetone.
The NaI is then crystallised from very dilute NaOH, dried under vacuum, and stored in a vacuum desiccator [Verdin Trans Faraday Soc 57 484 1961].
General description
Sodium iodide (NaI) is a water soluble ionic compound that consists of an equivalent addition of sodium as a cation (Na+) and iodide as an anion (I-) in crystal space.
Sodium iodide is industrially prepared by reacting acidic iodides with sodium hydroxide (NaOH) to form NaI salts.
Sodium iodide is a less toxic compound than iodine and can be stored and handled easily.
Application
NaI can be used as a precursor in the preparation of controlling agents for emulsion polymerization.
Sodium iodide can also be used as an inorganic salt in the development of liquid electrolytes for the fabrication of dye sensitized solar cells (DSSCs).
Sodium iodide is a metal iodide salt with a Na(+) counterion.
Sodium iodide is an inorganic sodium salt and an iodide salt.
Sodium iodide is a water-soluble ionic compound with a crystal lattice.
Sodium iodide is a source of iodine and can be administered as a supplement for total parenteral nutrition but is more commonly used in veterinary medicine.
Radiolabelled compound, [DB09293], is used as a diagnostic tool to evaluate thyroid function and morphology.
Sodium iodide is a water-soluble ionic compound with a crystal lattice.
Sodium iodide is a source of iodine and can be administered as a supplement for total parenteral nutrition 2 but is more commonly used in veterinary medicine.
Radiolabelled compound, Iodide I-131, is used as a diagnostic tool to evaluate thyroid function and morphology.
Pharmacodynamics
When intravenously administered for total parental nutrition, sodium iodide prevents the depletion of endogenous stores of iodine and subsequent deficiency symptoms 2.
Sodium iodide is used to prevent or treat iodine deficiency.
The body needs iodine for normal growth and health. For patients who are unable to get enough iodine in their regular diet or who have a need for more iodine, sodium iodide may be necessary.
Iodine is needed so that your thyroid gland can function properly.
Iodine deficiency in the United States is rare because iodine is added to table salt.
Most people get enough salt from the foods they eat, without adding salt to their meals.
Iodine deficiency is a problem in other areas of the world.
Lack of iodine may lead to thyroid problems, mental problems, hearing loss, and goiter.
Injectable sodium iodide is administered only by or under the supervision of a health care professional. Some multivitamin/mineral preparations that contain sodium iodide are available without your health care professional's prescription.
Sodium Iodide is generally immediately available in most volumes.
High purity, submicron and nanopowder forms may be considered. Hydrate or anhydrous forms may be purchased.
Iodide compounds are water soluble; however, iodide-rich solutions act as better dissolution agents for creating iodide solutions.
Iodides are often used in internal medicine.
Treating an iodide with manganese dioxide and sulfuric acid sublimes the iodine.
Formula: NaI
Formula Weight: 149.89
Form: Crystalline Powder
Melting point: 651°
Boiling Point: 1300-1304°
Density: 3.67
Refractive Index: 1.7745
Storage & Sensitivity: Hygroscopic. Ambient temperatures.
Solubility
Soluble in water, alcohol, glycerol and acetone.
Insoluble in ether.
Applications
Sodium iodide commonly is used to prevent iodine deficiency.
Used as analytical reagents, in the manufacture of disinfectants, antiseptics, deodorants and medicines.
They are used in baking ingredient conditioner and as animal feed.
Sodium iodide is used for conversion of an alkyl chlorides into an alkyl iodides, such as in the treatment of thyroid cancer and hyperthyroidism and in scintillation detectors, traditionally in nuclear medicine, geophysics, nuclear physics, and environmental measurements.
About Sodium iodide
Helpful information
Sodium iodide is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
Sodium iodide is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses
Sodium iodide is used in the following products: pH regulators and water treatment products and cosmetics and personal care products.
Other release to the environment of Sodium iodide is likely to occur from: indoor use as reactive substance and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).
Article service life
Other release to the environment of Sodium iodide is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).
Sodium iodide can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones) and plastic used for articles with intense direct dermal (skin) contact during normal use (e.g. handles, ball pens).
Widespread uses by professional workers
Sodium iodide is used in the following products: laboratory chemicals, pH regulators and water treatment products, biocides (e.g. disinfectants, pest control products), washing & cleaning products, polishes and waxes and water softeners.
Sodium iodide has an industrial use resulting in manufacture of another substance (use of intermediates).
Sodium iodide is used in the following areas: health services, scientific research and development and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.
Sodium iodide is used for the manufacture of: chemicals and textile, leather or fur.
Other release to the environment of Sodium iodide is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use as processing aid and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Formulation or re-packing
Sodium iodide is used in the following products: washing & cleaning products, polymers, biocides (e.g. disinfectants, pest control products), pharmaceuticals, polishes and waxes, water treatment chemicals and cosmetics and personal care products.
Release to the environment of Sodium iodide can occur from industrial use: formulation of mixtures and formulation in materials.
Uses at industrial sites
Sodium iodide is used in the following products: laboratory chemicals, biocides (e.g. disinfectants, pest control products), pH regulators and water treatment products, pharmaceuticals, washing & cleaning products, metal surface treatment products, metal working fluids, plant protection products and water treatment chemicals.
Sodium iodide has an industrial use resulting in manufacture of another substance (use of intermediates).
Sodium iodide is used in the following areas: health services, formulation of mixtures and/or re-packaging and agriculture, forestry and fishing.
Sodium iodide is used for the manufacture of: chemicals, fabricated metal products and metals.
Release to the environment of Sodium iodide can occur from industrial use: of substances in closed systems with minimal release, as processing aid, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and in processing aids at industrial sites.
Manufacture
Release to the environment of Sodium iodide can occur from industrial use: manufacturing of the substance.
Sodium Iodide is a crystalline salt commonly used in the Finkelstein reaction via an SN2 pathway, detection of radiation, and in the conversion of an alkyl chloride into an alkyl iodide.
When activated with thallium, Sodium Iodide can be subjected to ionizing radiation, emitting photons, which makes it essential in detecting gamma rays using scintillation detectors.
Biologically, Sodium Iodide is used in PCR, the Sodium Iodide symporter, and to produce chemokines, particularly CCL2, CXCL8, and CXC14 by stimulation of thyroid follicular cells.
IUPAC NAMES:
Natriumiodid
sodio ioduro
Sodio Yoduro
sodium iodde
Sodium Iodide
Sodium iodide
sodium iodide
Sodium Iodide
Sodium iodide
Sodium iodide (NaI)
Sodium iodideNaI
sodium;iodide
SYNONYMS:
sodium iodide
7681-82-5
Ioduril
Sodium iodide (NaI)
sodiumiodide
Sodium monoiodide
Soiodin
sodium;iodide
Jodid sodny
UNII-F5WR8N145C
MFCD00003532
F5WR8N145C
CHEMBL1644695
CHEBI:33167
Iodure de sodium
NSC-77388
Natriumjodid
Natrii iodidum
Sodium iodide, ultra dry
Sodium iodide (Na131I)
Jodid sodny [Czech]
Caswell No. 777
Natriumjodid [German]
HSDB 750
EINECS 231-679-3
NSC 77388
EPA Pesticide Chemical Code 075702
Sodium iodide [USP:JAN]
sodium-iodide
sodium iodide-
Sodium iodide solution
Sodium iodide, anhydrous
Sodium iodide, ACS grade
EC 231-679-3
sodium iodine-131(1-)
Sodium iodide (JP17/USP)
Sodium iodide, Trace metals grade
SODIUM IODIDE
UV-VIS STANDARD 3
UV-VIS STANDARD 3: SODIUM IODIDE
Anayodin
Hydriodic acid sodium salt
ioduredesodium
Ioduril
Jodid sodny
jodidsodny
natriiiodidum
Natriumjodid
Sodium iodide (NaI)
Sodium iodine
Sodium monoiodide
sodiumiodide(nai)
Sodiumiodide,anhydrous
sodiumiodide[nai]
sodiumiodine
sodiummonoiodide
Soiodin
Sodium iodide 99+%
SodiumiodideanhydrousHO
SODIUM IODIDE USP
SODIUM IODIDE, 99.99+% METALS BASIS
SODIUM IODIDE REAGENTPLUS(TM) >=99%
SODIUM IODIDE, REAGENTPLUS, >=99%
SODIUM IODIDE 99.5% A.C.S. REAGENT
SODIUM IODIDE, ANHYDROUS, 99.999%
SODIUM IODIDE, 99.999% METALS BASIS
Sodium iodide 1 M Solution
SODIUM IODIDE EXTRA PURE, DAB, PH. EUR., B. P., PH. FRANC., U. S. P.
SodiumIodideSodiumIodideBp/Usp/Ep/Ar/Lr/Acs
SodiumIodideExtraPure
SodiumIodideAnhydrous99+%
SodiumIodideGr
Sodiumiodidehydrate,Puratronic,99.999%(metalsbasis)
Sodiumiodide,min.99.0-100.5%,EP,BP,USP,
Sodiumiodide,ultradry,99.99%(metalsbasis)
Sodium iodide, anhydrous, pure, 99+%
Sodium iodide, extra pure, 99.999%
SODIUM IODIDE REAGENT (ACS)
SODIUM IODIDE, 1% STRAY LIGHT FILTER
SODIUM IODIDE, SOLUTION, 0.10 M
Sodiumiodide,anhydrous,99%(H2O<1%)
sodium iodide, acs
sodium iodide, ultra dry
SODIUMIODIDE,GRANULAR,REAGENT
Sodium Indide
Sodium Iodide (Metals Basis)
Sodium iodide 1 M solution,Additive Screening Solution 18/Fluka kit no 78374, Sodium iodide solution
Sodium iodide, extra pure, Ph Eur, USP, BP
Sodium iodide, reagent grade, ACS
"Sodium iodide, anhydrous/ 99.9%"
Sodium iodide, extra pure, (trace metal basis), 99.999%
Sodium iodide solution
SODIUM IODIDE FOR ANALYSIS EMSURE
SODIUM IODIDE 99.99 SUPRAPUR 500 G
SODIUM IODIDE 99.99 SUPRAPUR 100 G
