SODIUM PHOSPHATE LIQUID

Synonyms:
SODIUM PHOSPHATE LIQUID; Monosodium phosphate; 7558-80-7; Sodium dihydrogenorthophosphate; SODIUM DIHYDROGEN PHOSPHATE; PHOSPHATE DE SODIUM; Sodium phosphate monobasic; Sodium acid phosphate; Sodium phosphate, monobasic; Monosodium dihydrogen orthophosphate; sodium dihydrogenphosphate; Acid sodium phosphate; Monosodium monophosphate; Sodium phosphate monobasic anhydrous; Sodium primary phosphate; Monosodium orthophosphate; Sodium dihydrogen orthophosphate; Monobasic sodium phosphate; Monosorb XP-4; Phosphoric acid, sodium salt; Monosodium dihydrogen phosphate; Monosodium phosphate, anhydrous; Primary sodium phosphate; Phosphoric acid, monosodium sal; UNII-KH7I04HPUU; Sodium biphosphate anhydrous; Monosodium hydrogen phosphate; Sodium dihydrogen phosphate, anhydrous; Sodium phosphate (NaH2PO4); Sodium orthophosphate, primary; Sodium dihydrogen monophosphate; HSDB 738; Sodium phosphate (Na(H2PO4)); Sodium phosphate; sodyum fosfat; Sodium phosfate; Sodium phosfat; Sodium phosphat; Na3O4P; orthophosphate de trisodium; phosphate acide de sodium; phosphate trisodique anhydre; phosphate monoacide de sodium; phosphate de sodium dibasique; phosphate de sodium monobasique; Na2HPO4; hydrogénophosphate de sodium; phosphate de monosodium; H2NaO4P; Na3PO4; NaH2PO4; phosphate de trisodium anhydre; phosphate de sodium tribasique; phosphate de trisodium; E339; MONO SODYUM FOSFAT; Dİ SODYUM FOSFAT; SODIUM PHOSPHATE LIQUID; Monosodium phosphate; 7558-80-7; Sodium dihydrogenorthophosphate; SODIUM DIHYDROGEN PHOSPHATE; Sodium phosphate monobasic; Sodium acid phosphate; Sodium phosphate, monobasic; Monosodium dihydrogen orthophosphate; sodium dihydrogenphosphate; Acid sodium phosphate; Monosodium monophosphate; Sodium phosphate monobasic anhydrous; Sodium primary phosphate; Monosodium orthophosphate; Sodium dihydrogen orthophosphate; Monobasic sodium phosphate; Monosorb XP-4; Phosphoric acid, sodium salt; Monosodium dihydrogen phosphate; Monosodium phosphate, anhydrous; Primary sodium phosphate; Phosphoric acid, monosodium sal; UNII-KH7I04HPUU; Sodium biphosphate anhydrous; Monosodium hydrogen phosphate; Sodium dihydrogen phosphate, anhydrous; Sodium phosphate (NaH2PO4); Sodium orthophosphate, primary; Sodium dihydrogen monophosphate; HSDB 738; Sodium phosphate (Na(H2PO4)); Sodium phosphate; sodyum fosfat; Sodium phosfate; Sodium phosfat; Sodium phosphat; Na3O4P; orthophosphate de trisodium; hosphate; tri sodium phosphate; tsp; trisodium phosphate; sodium phosphate tribasic; Sodium Phosphate Tribasic Anhydrate; TSP anhydrate; tribasic sodium phosphate anhydrous; Sodium phosphate tri basic; Sodium phosphate tribasic; trisodium; phosphate; Trisodium orthophosphate , Sodium phosphate tribasic , Sodium orthophosphate;Sodium phosphate, tribasic; Trisodium orthophosphate; Trisodyum fosfat anhidrat; Trisodyum Fosfat Anhidrat; trısodıum fosfat susuz; tspa; trisodyum fosfat anhidrat; trisodyumfosfatandhidrat; trisodyum fosfat anhidrus; trısodyum fosfat anhıdrat; trisodyum fosfat anhidrat; tri sodyum fosfat anhidrat; trisodyum fosfatanhidrat; trisodium fosfat anhidrat; trisodyum fosfat anyhidrat; trisodyum fosfat susuz; trisodyum fosfat; trisodyumfosfatsusuz; susuz trisodyum fosfat; TRISODYUM FOSFAT SUSUZ; TRISODYUMFOSFAT ANHYDROUS; TSPA; TSP; trısodıum phosphate anhydrate; trisodiumphosphateanhydrate; tri sodium phosphate anhydrate; Trisodium Phosphate Anhydrate; trı sodıum phosphate anhydrate; trisodium phosphate anhidrate; 3sodium phosphate anhydrate; trisodium fosphate anhydrate; trisodyum phosphate anhydrate; trisodium phosphateanhydrate; phosphate acide de sodium; phosphate trisodique anhydre; phosphate monoacide de sodium; phosphate de sodium dibasique; phosphate de sodium monobasique; Na2HPO4; hydrogénophosphate de sodium; phosphate de monosodium; H2NaO4P; Na3PO4; NaH2PO4; phosphate de trisodium anhydre; phosphate de sodium tribasique; phosphate de trisodium; E339; MONO SODYUM FOSFAT; Dİ SODYUM FOSFAT; SODIUM PHOSPHATE LIQUID; Monosodium Phosphate; 7558-80-7; Sodium Dihydrogenorthophosphate; SODIUM DIHYDROGEN PHOSPHATE; Sodium Phosphate Monobasic; Sodium Acid Phosphate; Sodium Phosphate, Monobasic; Monosodium Dihydrogen Orthophosphate; Sodium Dihydrogenphosphate; Acid Sodium Phosphate; Monosodium Monophosphate; Sodium Phosphate Monobasic Anhydrous; Sodium Primary Phosphate; Monosodium Orthophosphate; Sodium Dihydrogen Orthophosphate; Monobasic Sodium Phosphate; Monosorb XP-4; Phosphoric Acid, Sodium Salt; Monosodium Dihydrogen Phosphate; Monosodium Phosphate, Anhydrous; Primary Sodium Phosphate; Phosphoric Acid, Monosodium Sal; UNII-KH7I04HPUU; Sodium Biphosphate Anhydrous; Monosodium Hydrogen Phosphate; Sodium Dihydrogen Phosphate, Anhydrous; Sodium Phosphate (Nah2po4); Sodium Orthophosphate, Primary; Sodium Dihydrogen Monophosphate; HSDB 738; Sodium Phosphate (Na(H2PO4)); Sodium Phosphate; Sodyum Fosfat; Sodium Phosfate; Sodium Phosfat; Sodium Phosphat; Na3O4P; Orthophosphate De Trisodium; Phosphate Acide De Sodium; Phosphate Trisodique Anhydre; Phosphate Monoacide De Sodium; Phosphate De Sodium Dibasique; Phosphate De Sodium Monobasique; Na2HPO4; Hydrogénophosphate De Sodium; Phosphate De Monosodium; H2nao4p; Na3PO4; Nah2po4; Phosphate De Trisodium Anhydre; Phosphate De Sodium Tribasique; Phosphate De Trisodium; E339; MONO SODYUM FOSFAT; Dİ SODYUM FOSFAT; SODIUM PHOSPHATE LIQUID; Monosodium phosphate; 7558-80-7; SODİUM DİHYDROGENORTHOPHOSPHATE; SODIUM DIHYDROGEN PHOSPHATE; SODİUM PHOSPHATE MONOBASİC; SODİUM ACİD PHOSPHATE; SODİUM PHOSPHATE, MONOBASİC; MONOSODİUM DİHYDROGEN ORTHOPHOSPHATE; SODİUM DİHYDROGENPHOSPHATE; ACİD SODİUM PHOSPHATE; MONOSODİUM MONOPHOSPHATE; SODİUM PHOSPHATE MONOBASİC ANHYDROUS; SODİUM PRİMARY PHOSPHATE; MONOSODİUM ORTHOPHOSPHATE; SODİUM DİHYDROGEN ORTHOPHOSPHATE; MONOBASİC SODİUM PHOSPHATE; MONOSORB XP-4; PHOSPHORİC ACİD, SODİUM SALT; MONOSODİUM DİHYDROGEN PHOSPHATE; MONOSODİUM PHOSPHATE, ANHYDROUS; PRİMARY SODİUM PHOSPHATE; PHOSPHORİC ACİD, MONOSODİUM SAL; UNII-KH7I04HPUU; SODİUM BİPHOSPHATE ANHYDROUS; MONOSODİUM HYDROGEN PHOSPHATE; SODİUM DİHYDROGEN PHOSPHATE, ANHYDROUS; SODİUM PHOSPHATE (NAH2PO4); SODİUM ORTHOPHOSPHATE, PRİMARY; SODİUM DİHYDROGEN MONOPHOSPHATE; HSDB 738; SODİUM PHOSPHATE (NA(H2PO4)); SODİUM PHOSPHATE; SODYUM FOSFAT; SODİUM PHOSFATE; SODİUM PHOSFAT; SODİUM PHOSPHAT; NA3O4P; ORTHOPHOSPHATE DE TRİSODİUM; PHOSPHATE ACİDE DE SODİUM; PHOSPHATE TRİSODİQUE ANHYDRE; PHOSPHATE MONOACİDE DE SODİUM; PHOSPHATE DE SODİUM DİBASİQUE; PHOSPHATE DE SODİUM MONOBASİQUE; NA2HPO4; HYDROGÉNOPHOSPHATE DE SODİUM; PHOSPHATE DE MONOSODİUM; H2NAO4P; NA3PO4; NAH2PO4; PHOSPHATE DE TRİSODİUM ANHYDRE; PHOSPHATE DE SODİUM TRİBASİQUE; PHOSPHATE DE TRİSODİUM; E339; MONO SODYUM FOSFAT; Dİ SODYUM FOSFAT; SODYUM FOSFAT; SODİUM FOSFAT; SODYUM PHOSFAT

SODİUM PHOSPHATE LİQUİD

Chemical and Physical Properties    HelpNew Window
3.1Computed Properties    HelpNew Window
Property Name of Sodium phosphate    Property Value    Reference
Molecular Weight of Sodium phosphate    119.977 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
Hydrogen Bond Donor Count of Sodium phosphate    2    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Hydrogen Bond Acceptor Count of Sodium phosphate    4    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Rotatable Bond Count of Sodium phosphate    0    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Exact Mass of Sodium phosphate    119.95884 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
Monoisotopic Mass of Sodium phosphate    119.95884 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
Topological Polar Surface Area of Sodium phosphate    80.6 Ų    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Heavy Atom Count of Sodium phosphate    6    Computed by PubChem
Formal Charge of Sodium phosphate    0    Computed by PubChem
Complexity of Sodium phosphate    61.9    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Isotope Atom Count of Sodium phosphate    0    Computed by PubChem
Defined Atom Stereocenter Count of Sodium phosphate    0    Computed by PubChem
Undefined Atom Stereocenter Count of Sodium phosphate    0    Computed by PubChem
Defined Bond Stereocenter Count of Sodium phosphate    0    Computed by PubChem
Undefined Bond Stereocenter Count of Sodium phosphate    0    Computed by PubChem
Covalently-Bonded Unit Count of Sodium phosphate    2    Computed by PubChem
Compound of Sodium phosphate Is Canonicalized    Yes

Sodium phosphates
Sodium dihydrogen phosphate
Sodium hydrogen phosphate

Overview

Sodium phosphate is an umbrella term that refers to multiple combinations of sodium (salt) and phosphate (an inorganic, salt-forming chemical). Food-grade sodium phosphate is recognized by the U.S. Food and Drug Administration (FDA) as safe for consumption. It is often used as an additive in processed food manufacturing. It’s also an ingredient in many household products and medications. For some people, sodium phosphate may be used to prepare the bowel prior to colonoscopy.

Uses in food
Sodium phosphate can be found in fast food, deli meat, processed meat, canned tuna, baked goods, and other manufactured foods.Sodium phosphate serves a variety of functions:

Sodium phosphate thickens food. Sodium phosphate stabilizes the texture of processed foods, such as mashed potato mixes.
Sodium phosphate cures meat and meat products. Sodium phosphate helps to keep deli meats and bacon moist, avoiding spoilage.
Sodium phosphate is a leavening agent. It helps dough rise in commercially prepared cakes and breads and in cake mixes.
Sodium phosphate is an emulsifying agent. Sodium phosphate acts as a stabilizer to keep oil and water mixed together in certain types of food, such as processed cheese.
Sodium phosphate balances pH levels in processed food. It stabilizes the balance between acidity and alkalinity, extending shelf life and improving taste.
Is Sodium phosphate safe to consume?
Food-grade sodium phosphate is categorized by the FDA as GRAS, which means “generally recognized as safe.” This may be because the amount of sodium phosphate added to processed food, is relatively low.

One study Trusted Source found that sodium phosphate, when used as a food additive, can impact health differently than naturally occurring phosphate. This is because it’s absorbed differently by the body. According to the abstract, high levels of phosphate may elevate mortality rates for the general public, as well as for those with kidney disease and cardiovascular disease. Researchers linked high phosphate levels to accelerated aging and vascular damage. The researchers recommended that people eat foods with naturally occurring phosphates, rather than those with added sodium phosphate.

Some athletes take sodium phosphate as a supplement to enhance performance. However, a study, reported in the International Journal of Sport Nutrition and Exercise MetabolismTrusted Source, found that supplementation with sodium phosphate did not improve aerobic ability in athletes.

Side effects from an overdose of sodium phosphate may include:

vomiting
headache
reduced urine output
bloating
abdominal pain
dizziness
irregular heartbeat
seizure

Trisodium phosphate
Sodium phosphate is a generic term for a variety of salts of sodium (Na+) and phosphate (PO43−). Phosphate also forms families or condensed anions including di-, tri-, tetra-, and polyphosphates. Most of these salts are known in both anhydrous (water-free) and hydrated forms. The hydrates are more common than the anhydrous forms.[1]

Uses
Sodium phosphates have many applications in food and for water treatment. For example, sodium phosphates are often used as emulsifiers (as in processed cheese),[2] thickening agents, and leavening agents for baked goods. They are also used to control pH of processed foods.[3] They are also used in medicine for constipation and to prepare the bowel for medical procedures. Moreover, they are used in detergents for softening water, and as an efficient anti rust solution.

Adverse effects
Sodium phosphates are popular in commerce in part because they are inexpensive and because they are nontoxic at normal levels of consumption.[4] However, oral sodium phosphates when taken at high doses for bowel preparation for colonoscopy may in some individuals carry a risk of kidney injury under the form of phosphate nephropathy. There are several oral phosphate formulations which are prepared extemporaneously. Oral phosphate prep drugs have been withdrawn in the United States, although evidence of causality is equivocal.[5] Since safe and effective replacements for phosphate purgatives are available, several medical authorities have recommended general disuse of oral phosphates.[6]

Monophosphates
Three families of sodium monophosphates are common, those derived from orthophosphate (PO43−), hydrogen phosphate (HPO42−), and dihydrogenphosphate (H2PO4−). Some of the most well known salts are shown in the table.

name    formula    CAS registry number
monosodium phosphate (anhydrous)    NaH2PO4    7558-80-7
monosodium phosphate (monohydrate)    NaH2PO4(H2O)    10049-21-5
monosodium phosphate (dihydrate)    NaH2PO4(H2O)2    13472-35-0
disodium phosphate (anhydrous)    Na2HPO4    7558-79-4
disodium phosphate (dihydrate)    HNa2PO4(H2O)2    10028-24-7
disodium phosphate (heptahydrate)    HNa2PO4(H2O)7    7782-85-6
disodium phosphate (octahydrate)    HNa2PO4(H2O)8    
disodium phosphate (dodecahydrate)    HNa2PO4(H2O)12    10039-32-4
trisodium phosphate (anhydrous, hexagonal)    Na3PO4    
trisodium phosphate (anhydrous, cubic)    Na3PO4    7601-54-9
trisodium phosphate (hemihydrate)    Na3PO4(H2O)0.5    
trisodium phosphate (hexahydrate)    Na3PO4(H2O)6    
trisodium phosphate (octahydrate)    Na3PO4(H2O)8    
trisodium phosphate (dodecahydrate)    Na3PO4(H2O)12    10101-89-0
Di- and polyphosphates
In addition to these phosphates, sodium forms a number of useful salts with pyrophosphates (also called diphosphates), triphosphates and high polymers. Of these salts, those of the diphosphates are particularly common commercially.

name    formula    CAS Registry number
monosodium diphosphate (anhydrous)    NaH3P2O7    
disodium diphosphate (anhydrous)    Na2H2P2O7    7758-16-9
disodium diphosphate (hexahydrate)    Na2H2P2O7(H2O)6    
trisodium diphosphate (anhydrous)    Na3HP2O7    
trisodium diphosphate (monohydrate)    Na3HP2O7(H2O)    
trisodium diphosphate (nonahydrate)    Na3HP2O7(H2O)9    
tetrasodium diphosphate (anhydrous)    Na4P2O7    7722-88-5
tetrasodium diphosphate (decahydrate)    Na4P2O7(H2O)10    13472-36-1
Beyond the diphosphates, sodium salts are known triphosphates, e.g. sodium triphosphate and tetraphosphates. The cyclic polyphosphates, called metaphosphates, include the trimer sodium trimetaphosphate and the tetramer, Na3P3O9 and Na4P4O12, respectively.

Polymeric sodium phosphates are formed upon heating mixtures of NaH2PO4 and Na2HPO4, which induces a condensation reaction. The specific polyphosphate generated depends on the details of the heating and annealling. One derivative is the glassy (i.e., amorphous) Graham's salt. It is a linear polyphosphate the average formula NaO(NaPO3)Na2. Crystalline high molecular weight polyphosphates include Kurrol's salt and Maddrell's salt (CAS#10361-03-2). These species have the formula [NaPO3]n[NaPO3(OH)]2 where n can be as great as 2000. In terms of their structures, these polymers consist of PO3− "monomers", with the chains are terminated by protonated phosphates.[1][7]

Sodium Phosphates Oral Solution
Generic Name: Sodium Phosphates Oral Solution (SOW dee um FOS fates)

Do not let anyone else take your medication. Your prescription is probably not refillable, since you will not need more sodium phosphate after your colonoscopy.

Sodium phosphate has also been sold as a nonprescription laxative to relieve constipation. Many nonprescription oral sodium phosphate products are no longer sold in the United States, but some may still be available. If you are taking oral sodium phosphate for constipation, it is important that you take it exactly as directed on the package label. Do not take more of the medication than directed on the label for each dose, and do not take more than one dose in 24 hours even if you do not have a bowel movement after you take the medication. Do not give nonprescription oral sodium phosphate to a child 5 years of age or younger unless the child's doctor tells you that you can. Taking too much nonprescription sodium phosphate may cause serious damage to the heart or kidneys or death.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

What side effects can this medication cause?
Sodium phosphate may cause side effects. Tell your doctor if either of these symptoms is severe or do not go away:
stomach pain
nausea
bloating
Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
irregular heartbeat
vomiting
fainting
seizures
rash
hives
itching
swelling of the eyes, face, lips, tongue, mouth or throat
burning or tingling of the lips, tongue, or mouth
throat tightness
difficulty breathing or swallowing
Sodium phosphate may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA)

Sodium dihydrogenphosphate is a sodium phosphate.

ChEBI
Sodium phosphate is a saline laxative that is thought to work by increasing fluid in the small intestine. It usually results in a bowel movement after 30 minutes to 6 hours.

Application: Trisodium Phosphate has uses in the food industry including emulsifying agent, buffer, and brine constituent, example include: processed cheeses,dairy products .
Used as a water softening agent, cleaning agent in electroplating, color fixer in fabric dyeing and flux in enamel ware
manufacturing and so on.
 

Physical properties:white crystals or granules, freely soluble in water, insoluble in alcohol.

Items standard request Test result

Assay (as Na3PO4) ,% 97.0Min    98.3
P2O5, %    40.5-43.5    41.0
pH ( 1% solution )    11.5-12.5    11.7
Arsenic ( As ),mg/kg    1.0Max    0.6
Fluoride ( F ),mg/kg    50.0Max    8.0
Cadmium (Cd) ,mg/kg    1.0Max    0.02
Mercury (Hg),mg/kg    1.0Max    0.02
Lead ( Pb ),mg/kg    4.0Max    0.6
Water insoluble,% 0.2Max    0.02
 

Inhalation    Cough. Sore throat. Burning sensation. Shortness of breath. Use local exhaust or breathing protection. Fresh air, rest. Half-upright position. Refer immediately for medical attention.
 

Skin    Skin burns. Pain. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention .

Eyes    Redness. Pain. Severe deep burns. Wear face shield or eye protection in combination with breathing protection. Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

Ingestion    Cough. Sore throat. Abdominal pain. Burning sensation. Shock or collapse. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Rest. Refer immediately for medical attention.

Application: In the food industry,tribasic sodium phosphate plays a role of quality improvement. It is for food processing of emulsifier, quality improver, nutritional supplements, and increase in food bottles (tank) detergent. trisodium phosphate approved as a food additive in the EU and other countries.
Trisodium phosphate (TSP) is the inorganic compound with the chemical formula Na3PO4. It is a white, granular or crystalline solid, highly soluble in water, producing an alkaline solution. TSP is used as a cleaning agent, builder, lubricant, food additive, stain remover, and degreaser.[7]
 

The item of commerce is often partially hydrated and may range from anhydrous Na3PO4 to the dodecahydrate Na3PO4 • 12H2O. Most often found in white powder form, it can also be called trisodium orthophosphate or simply sodium phosphate.

Uses
Cleaning
Trisodium phosphate was at one time extensively used in formulations for a variety of consumer-grade soaps and detergents, and the most common use for trisodium phosphate has been in cleaning agents. The pH of a 1% solution is 12 (i.e., very basic), and the solution is sufficiently alkaline to saponify grease and oils. In combination with surfactants, TSP is an excellent agent for cleaning everything from laundry to concrete driveways. This versatility and low manufacturing price made TSP the basis for a plethora of cleaning products sold in the mid-20th century. TSP is still sold and used as a cleaning agent, but since the late 1960s, its use has diminished in the United States and many other parts of the world because, like many phosphate-based cleaners, it is known to cause extensive eutrophication of lakes and rivers once it enters a water system.[8] Substitutes are generally not as effective.[9]
 

TSP is commonly used after cleaning a surface with mineral spirits to remove hydrocarbon residues and may be used with household chlorine bleach in the same solution without hazardous reactions.[citation needed] This mixture is particularly effective for removing mildew, but is less effective at removing mold.[citation needed]

Although it is still the active ingredient in some toilet bowl-cleaning tablets, TSP is generally not recommended for cleaning bathrooms because it can stain metal fixtures and can damage grout.[10]

Chlorinated trisodium phosphate
With the formula {displaystyle {ce {Na3PO4.1/4NaOCl.11H2O}}} {displaystyle {ce {Na3PO4.1/4NaOCl.11H2O}}} the material called chlorinated trisodium phosphate is used as a disinfectant and bleach, like sodium hypochlorite. It is prepared using NaOCl in place of some of the base to neutralize phosphoric acid.[7]
 

Flux
In the U.S., trisodium phosphate is an approved flux for use in hard soldering joints in medical-grade copper plumbing. The flux is applied as a concentrated water solution and dissolves copper oxides at the temperature used in copper brazing. Residues are water soluble and can be rinsed out before plumbing is put into service.
 

TSP is used as an ingredient in fluxes designed to deoxygenate nonferrous metals for casting. It can be used in ceramic production to lower the flow point of glazes.

Painting enhancement
TSP is still in common use for the cleaning, degreasing, and deglossing of walls prior to painting. TSP breaks the gloss of oil-based paints and opens the pores of latex-based paint, providing a surface better suited for the adhesion of the subsequent layer.[11][unreliable source?]
 

Food additive
Sodium phosphates including monosodium phosphate, disodium phosphate, and trisodium phosphate are approved as food additives in the EU. They are commonly used as acidity regulators and have the collective E number E339.[12] The United States Food and Drug Administration lists sodium phosphates as generally recognized as safe.[13][14]
 

Exercise performance enhancement
Trisodium phosphate has gained a following as a nutritional supplement that can improve certain parameters of exercise performance.[15] The basis of this belief is the fact that phosphate is required for the energy-producing Krebs cycle central to aerobic metabolism. Phosphates are available from a number of other sources that are much milder than TSP. While TSP is not toxic per se, it is severely irritating to gastric mucosa unless used as part of a buffered solution.
 

Regulation
In the Western world, phosphate usage has declined owing to ecological problems with the damage to lakes and rivers through eutrophication.
 

TSP substitutes
See also: Cleaning products and the environment
By the end of the 20th century, many products that formerly contained TSP were manufactured with TSP substitutes, which consist mainly of sodium carbonate along with various admixtures of nonionic surfactants and a limited percentage of sodium phosphates.
 

Products sold as TSP substitutes, containing soda ash and zeolites, are promoted as direct substitutes. However, sodium carbonate is not as strongly basic as trisodium phosphate, making it less effective in demanding applications. Zeolites, which are clay based, are added to laundry detergents as water softening agents and are essentially non-polluting; however, zeolites do not dissolve and can deposit a fine, powdery residue in the wash tub. Cleaning products labeled as TSP may contain other ingredients, with perhaps less than 50% trisodium phosphate.[16]

Trisodium phosphate is produced by neutralization of phosphoric acid using sodium hydroxide, often with sodium carbonate. Carbonate can only produce disodium phosphate:

Na2CO3 + H3PO4 › Na2HPO4 + CO2 + H2O
Na2HPO4 + NaOH › Na3PO4 + H2O
 

Sodium Phosphate is an inorganic compound used as a laxative, dietary supplement and for electrolyte-replacement purposes. Phosphate, a predominant intracellular anion, plays an important role in energy storage, osteoblastic and osteoclastic activities, regulating serum calcium concentrations, and numerous cellular phosphate-transfer reactions. Sodium phosphate increases fluidity of the intestinal contents by retention of water by osmotic forces, thereby indirectly inducing intestinal smooth muscle constriction. Sodium phosphate is also used in the renal excretion of hydrogen ions while promoting the reabsorption of sodium ions.
Bionecessity    HelpNew Window
Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions. /Phosphate/
 

Use Classification
Food additives
 

Food Improvement Agents
For trisodium phosphate (USEPA/OPP Pesticide Code: 076406) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./
 

National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Trisodium Phosphate (7601-54-9). Available from, as of March 17, 2009: http://npirspublic.ceris.purdue.edu/ppis/

The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

USEPA/OPP; Status of Pesticides in Registration, Reregistration and Special Review p.319 (Spring, 1998) EPA 738-R-98-002

from HSDB
Important ingredient in soap powders, detergents, and cleaning agents ... also used as a water softener to remove polyvalent metals and in the manufacture of paper and leather. Products for removing or preventing boiler scale often contain trisodium phosphate, as do those for removing insectide residues from fruit and inhibiting mold.

The ability of trisodium phosphate to break fats and greases into water-soluble glycerin and soap makes it extremely useful in scouring powders. When combined with abrasives and chlorine-generating bleaches, trisodium phosphate removes cooking grease and stains.

In photographic developers; clarifying sugar; removing boiler scale, softening water; manufacture of paper; laundering; tanning leather; in detergent mixture.

Dispersant (easy-cooking cereals); emulsifier (cheese); abrasive metal cleaner ingredient; builder (industrial cleaning formulations); metal phosphatising reagent; softening/conditioning agent (boiler water treatment).

Water softeners, boiler-water compounds, detergent, metal cleaner, textiles, manufacture of paper, laundering, tanning, sugar purification, photographic developers, paint removers, industrial cleaners, dietary supplement, buffer, emulsifier, food additive.

Metal extraction; refining and processing of metals. Paper, pulp, and board industry. Textile processing industry. Bleaching agents. Cleaning/washing agents and disinfectants. Complexing agents. Cosmetics. Fillers. Food/foodstuff additives. Laboratory chemicals. pH regulating agents. Pharmaceuticals. Photochemicals. Softeners.

The effects of dipping treatments (15 min) in potable water or in solutions (wt/vol) of 12% trisodium phosphate (TSP), 1,200 ppm acidified sodium chlorite (ASC), 2% citric acid (CA), and 220 ppm peroxyacids (PA) on inoculated pathogenic bacteria (Listeria monocytogenes, Staphylococcus aureus, Bacillus cereus, Salmonella Enteritidis, Escherichia coli, and Yersinia enterocolitica) and skin pH were investigated throughout storage of chicken legs (days 0, 1, 3, and 5) at 3 +/- 1 deg C. All chemical solutions reduced microbial populations (P<0.001) as compared with the control (untreated) samples...

Industry Uses 
Agricultural chemicals (non-pesticidal)
Corrosion inhibitors and anti-scaling agents
Finishing agents
Industrial Detergent
Intermediates
Oxidizing/reducing agents
Plating agents and surface treating agents
Processing aids, not otherwise listed
Solvents (for cleaning and degreasing)
Surface active agents
Viscosity adjustors
Cleaning additive
 

Consumer Uses 
Agricultural products (non-pesticidal)
Automotive care products
Building/construction materials not covered elsewhere
Cleaning and furnishing care products
Fabric, textile, and leather products not covered elsewhere
Laundry and dishwashing products
Metal products not covered elsewhere
Non-TSCA use
Water treatment products
 

Methods of Manufacturing 
Sodium monophosphates are usually produced by neutralization of phosphoric acid with soda ash or caustic soda. The latter is predominantly used in Germany, while in the United States, the less expensive soda ash prevails. The basicity of sodium carbonate is insufficient for the formation of trisodium phosphate, so that caustic soda must be used in this step. The phosphates crystallize from the solutions as hydrates and are separated by centrifugation. Anhydrous salts are obtained by dehydration in rotary dryers or directly from the solutions by spray drying or in rotary kilns. Both thermal phosphoric acid and the cheaper wet phosphoric acid are used as starting materials. The very pure thermal phosphoric acid is generally used in the production of food-grade phosphates. /Sodium monophosphates/

Trisodium phosphate is mainly produced as the dodecahydrate by complete neutralization of phosphoric acid with caustic soda or soda ash and subsequent crystallization. Since neutralization with soda ash does not proceed beyond the stage of the disodium salt, caustic soda must be added to complete the reaction. Frequently, mother liquors of mono- or disodium phosphate production or crystalline disodium phosphates are used as starting materials. In another process, trisodium phosphate is obtained by digestion of the phosphate-rich neutralization sludges, which accumulate in the purification of wet phosphoric acid by precipitation, with caustic soda and with addition of water glass

By mixing soda ash and phosphoric acid in proper proportions to form disodium phosphate and then adding caustic soda.

Sodium hydroxide & monazite (Ce, La, Th)PO4 (salt formation/separation; byproduct of thorium dioxide/rare earth oxide, hydrate production).
 

General Manufacturing Information
Industry Processing Sectors
Agriculture, forestry, fishing and hunting
All other chemical product and preparation manufacturing
Cyclic crude and intermediate manufacturing
Food, beverage, and tobacco product manufacturing
Machinery manufacturing
Nonmetallic mineral product manufacturing (includes clay, glass, cement, concrete, lime, gypsum, and other nonmetallic mineral product manufacturing.
Oil and gas drilling, extraction, and support activities
Primary metal manufacturing
Services
Fire Hazard 
Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.,

Skin, Eye, and Respiratory Irritations 
Acute exposures to trisodium phosphate may cause irritation of the respiratory system with subsequent coughing and pain.