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Sorbitan Monopalmitate (E495) is a food additive, permitted by the EU.
Sorbitan Monopalmitate (E495) is entry E495 in the E number list of permitted food additives.
Sorbitan Monopalmitate (E495) is also known under the trade name Span 40.
CAS: 26266-57-9
MF: C22H42O6
MW: 402.57
EINECS: 247-568-8
Synonyms
ARLACEL 40;SORBITANMONOPALMITATE,NF;Sorbitanpalmitat;SORBITAN PALMITATE;SORBITAN MONOPALMITATE;SORBITANE MONOPALMITATE;SPAN(TM) 40;SPAN NO 40;Sorbitan palmitat;SORBITAN MONOPALMITATE;26266-57-9;2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl hexadecanoate;Glycomul P;Liposorb P;Protachem SMP;Sorbitan palmitas;SORBITAN, MONOHEXADECANOATE;Crill 2;Montane 40;Nikkol SP10;Nonion PP40;Sorgen 70;Nissan nonion PP40;Rheodol SP-P 10;Sorbitan, monopalmitate;Emsorb 2510;Nissan nonion PP 40;Sorbester P16;Sorbitan palmitate, INN;DTXSID80860361;(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl hexadecanoate;CHEBI:170910;[2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl] hexadecanoate;Sorbitan monopalmitate [USAN:BAN];Sorbitan monopalmitate, BAN, USAN;Span #40 (Sorbitan monopalmitate);LMFA07011019;MFCD00080946;3,6-Anhydro-1-O-hexadecanoylhexitol;E495;NS00014101
Sorbitan Monopalmitate (E495) is a fatty acid ester.
Sorbitan Monopalmitate (E495) has been known since at least 1959.
Around 2000, Sorbitan Monopalmitate (E495) was permitted by the EU in bakery products, icings, marmalades, simulations of milk and cream, beverage whiteners, liquid concentrates of fruit and herbs, sorbets, emulsified sauces, food supplements and chewing gum amongst others.
Sorbitan Monopalmitate (E495) is used for niosomes particle preparation.
Sorbitan Monopalmitate (E495) can be used as an excipient, such as nonionic surfactants, emulsifiers.
Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients.
Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations.
Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.
Sorbitan Monopalmitate (E495) is a polysorbate that is derived from the mixture of partial esters of sorbitol treated with palmitic acid.
Sorbitan Monopalmitate (E495) is a lipophilic surfactant.
Sorbitan Monopalmitate (E495) may be found in combination with polysorbates.
Sorbitan Monopalmitate (E495) is used to modify crystallisation of fats.
Sorbitan Monopalmitate (E495) is insoluble in water.
Up to 25 mg/kg bodyweight can be processed by humans.
Sorbitan Monopalmitate (E495) is metabolized to sorbitol and palmitic acid, without any apparent side effects.
The use of animal fats, like pork, in the production of Sorbitan Monopalmitate (E495) is possible.
Sorbitan Monopalmitate (E495) Chemical Properties
Melting point: 46-47 °C(lit.)
Boiling point: 444.68°C (rough estimate)
Density: 1.0412 (rough estimate)
Refractive index: 1.4593 (estimate)
Fp: >230 °F
Storage temp.: Inert atmosphere,Room Temperature
Solubility: Practically insoluble in water, soluble in fatty oils, slightly soluble in alcohol.
Form: Solid
Color: White flakes
Water Solubility: Insoluble in water
Hydrophilic-Lipophilic Balance (HLB): 6.7
InChIKey: DOCCLKYMPJSXGB-VCDGYCQFSA-N
LogP: 5.404 (est)
CAS DataBase Reference: 26266-57-9(CAS DataBase Reference)
EPA Substance Registry System: Sorbitan Monopalmitate (E495)(26266-57-9)
Uses
Sorbitan Monopalmitate (E495) is a nonionic, mid-range HLB surfactant suggested for use as a w/o or an o/w emulsifier for cosmetic formulations, household products and textile chemicals.
Sorbitan Monopalmitate (E495) is an emulsifier with moisture-binding abilities.
Sorbitan Monopalmitate (E495) also serves as a solubilizer of essential oils in water.
Sorbitan Monopalmitate (E495) is derived from sorbitol.
