SORBITAN PALMITATE

CAS No.: 26266-57-9
EC No.: 247-568-8

Synonyms:
SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; Sorbitan palmitate; Sorbitan, monopalmitate; SORBITAN MONOPALMITATE; 2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl hexadecanoate; 26266-57-9; [2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl] hexadecanoate; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; SORBITAN, MONOHEXADECANOATE; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70; Nissan nonion PP40; Rheodol SP-P 10; Emsorb 2510; Nissan nonion PP 40R; Sorbitan, esters, monohexadecanoate; Sorbester P16; 1,4-Anhydro-D-glucitol, 6-hexadecanoate; D-Glucitol, 1,4-anhydro-, 6-hexadecanoate; Sorbitan palmitate, INN; DTXSID80860361; Sorbitan monopalmitate [USAN:BAN]; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; Sorbitan monopalmitate, BAN, USAN; Span #40 (Sorbitan monopalmitate); LMFA07011019; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; MFCD00080946; 3,6-Anhydro-1-O-hexadecanoylhexitol; E495; FT-0688117; Sorbitane Monopalmitate - Polysorbate 40 in-source fragment; Cetyl Palmitate; Sorbitan Palmitate; Sorbitan Olivate; 1,4-anhydro-D-glucitol, 6-hexadecanoate; arlacel 40; [2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] hexadecanoate; emasol P-10V; D-glucitol, 1,4-anhydro-, 6-hexadecanoate; glycomul P; kaopan SP-P-10; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; liposorb P; lonzest™ SMP; monemul - 40; nikkol SP-10V; rheodol SP-P10; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan, esters, monohexadecanoate; sorbitan, monohexadecanoate; sorbitan, monopalmitate; span 40; ARLACEL 40; SORBITANE MONOPALMITATE; SORBITAN MONOPALMITATE; SORBITAN PALMITATE; SPAN 40; SPAN NO 40; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SPAN(R) 40; SPAN(TM) 40; crill2; emsorb2510; EmulsifierS40; glycomulp; liposorbp; montane40; nikkolsp10; nissannonionpp40; nissannonionpp40r; nonionpp40; protachemsmp; rheodolsp-p10; Sorbitan palmitate;  Sorbitane Palmitate;  Sorbitan palmitate;  SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; Sorbitan palmitate;  Sorbitan palmitate; Sorbitane Palmitate; Sorbitan Palmitate; Sorbitan palmitate; SORBITAN MONOPALMITATE; Span 40; Sorbitan monohexadecanoate; Arlacel 40; Sorbitan palmitate; 26266-57-9; UNII-77K6Z421KU; Glycomul P; Liposorb P; SORBITAN, MONOHEXADECANOATE; Protachem SMP; Sorbitan palmitas; 77K6Z421KU; Crill 2; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70; Nissan nonion PP40; Rheodol SP-P 10; Emsorb 2510; Nissan nonion PP 40R; [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] hexadecanoate; Sorbitani palmitas; Palmitate de sorbitan; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; Sorbitan palmitate [INN]; Palmitato de sorbitano; Sorbitan, esters, monohexadecanoate; Sorbitani palmitas [INN-Latin]; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1,4-Anhydro-D-glucitol, 6-hexadecanoate; EINECS 247-568-8; Palmitate de sorbitan [INN-French]; Palmitato de sorbitano [INN-Spanish]; D-Glucitol, 1,4-anhydro-, 6-hexadecanoate; AI3-03901; DSSTox_CID_9335; EC 247-568-8; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; DSSTox_RID_78767; DSSTox_GSID_29335; CHEMBL3186294; DTXSID6029335; SCHEMBL13700731; DTXSID90873164; ZINC8214459; Span 40 (=Sorbitan Monopalmitate); Tox21_112783; 1,4-anhydro-6-O-palmitoyl-D-glucitol; 1,4-Anhydro-6-O-hexadecanoyl-D-glucitol; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; CAS-26266-57-9; S0061; (R)-2-((2R,3R,4S)-3,4-dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl palmitate; Sorbitan monopalmitate. (Compound usually contains also associated fatty acids.); 5050-91-9; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; Sorbitan palmitate; Sorbitan, monopalmitate; SORBITAN MONOPALMITATE; 2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl hexadecanoate; 26266-57-9; [2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl] hexadecanoate; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; SORBITAN, MONOHEXADECANOATE; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70; Nissan nonion PP40; Rheodol SP-P 10; Emsorb 2510; Nissan nonion PP 40R; Sorbitan, esters, monohexadecanoate; Sorbester P16; 1,4-Anhydro-D-glucitol, 6-hexadecanoate; D-Glucitol, 1,4-anhydro-, 6-hexadecanoate; Sorbitan palmitate, INN; DTXSID80860361; Sorbitan monopalmitate [USAN:BAN]; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; Sorbitan monopalmitate, BAN, USAN; Span #40 (Sorbitan monopalmitate); LMFA07011019; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; MFCD00080946; 3,6-Anhydro-1-O-hexadecanoylhexitol; E495; FT-0688117; Sorbitane Monopalmitate - Polysorbate 40 in-source fragment; Cetyl Palmitate; Sorbitan Palmitate; Sorbitan Olivate; 1,4-anhydro-D-glucitol, 6-hexadecanoate; arlacel 40; [2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] hexadecanoate; emasol P-10V; D-glucitol, 1,4-anhydro-, 6-hexadecanoate; glycomul P; kaopan SP-P-10; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; liposorb P; lonzest™ SMP; monemul - 40; nikkol SP-10V; rheodol SP-P10; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan, esters, monohexadecanoate; sorbitan, monohexadecanoate; sorbitan, monopalmitate; span 40; ARLACEL 40; SORBITANE MONOPALMITATE; SORBITAN MONOPALMITATE; SORBITAN PALMITATE; SPAN 40; SPAN NO 40; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SPAN(R) 40; SPAN(TM) 40; crill2; emsorb2510; EmulsifierS40; glycomulp; liposorbp; montane40; nikkolsp10; nissannonionpp40; nissannonionpp40r; nonionpp40; protachemsmp; rheodolsp-p10; Sorbitan palmitate;  Sorbitane Palmitate;  Sorbitan palmitate;  SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; Sorbitan palmitate;  Sorbitan palmitate; Sorbitane Palmitate; Sorbitan Palmitate; Sorbitan palmitate; SORBITAN MONOPALMITATE; Span 40; Sorbitan monohexadecanoate; Arlacel 40; Sorbitan palmitate; 26266-57-9; UNII-77K6Z421KU; Glycomul P; Liposorb P; SORBITAN, MONOHEXADECANOATE; Protachem SMP; Sorbitan palmitas; 77K6Z421KU; Crill 2; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70; Nissan nonion PP40; Rheodol SP-P 10; Emsorb 2510; Nissan nonion PP 40R; [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] hexadecanoate; Sorbitani palmitas; Palmitate de sorbitan; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; Sorbitan palmitate [INN]; Palmitato de sorbitano; Sorbitan, esters, monohexadecanoate; Sorbitani palmitas [INN-Latin]; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1,4-Anhydro-D-glucitol, 6-hexadecanoate; EINECS 247-568-8; Palmitate de sorbitan [INN-French]; Palmitato de sorbitano [INN-Spanish]; D-Glucitol, 1,4-anhydro-, 6-hexadecanoate; AI3-03901; DSSTox_CID_9335; EC 247-568-8; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; DSSTox_RID_78767; DSSTox_GSID_29335; CHEMBL3186294; DTXSID6029335; SCHEMBL13700731; DTXSID90873164; ZINC8214459; Span 40 (=Sorbitan Monopalmitate); Tox21_112783; 1,4-anhydro-6-O-palmitoyl-D-glucitol; 1,4-Anhydro-6-O-hexadecanoyl-D-glucitol; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı; CAS-26266-57-9; S0061; (R)-2-((2R,3R,4S)-3,4-dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl palmitate; Sorbitan monopalmitate. (Compound usually contains also associated fatty acids.); 5050-91-9; SORBITAN PALMITATE; SORBİTAN PALMİTATI; Sorbitan Palmitate; Sorbitan Palmitatı

SORBITAN PALMITATE

Abstract
The invention discloses an application of sorbitan palmitate. The sorbitan palmitate is applied to an acid copper plating process to replace one or two of a wetting agent, a leveling agent and a brightening agent used in a traditional process. Traditional additives in the acid copper plating process are subjected to structure-activity analysis, so that sorbitan palmitate molecules, additive molecules with multiple performance, are sought out, the sorbitan palmitate molecules have the characteristics of the three traditional additives simultaneously but do not belong to any one of the wetting agent, the leveling agent and the brightening agent as proved through electrochemical analysis and electroplating experiments. The novel additive molecules can replace components, with higher costs or unstable relative performance, in a traditional bright copper plating system or can constitute a two-agent bright copper plating system, so that use and maintenance costs of a customer can be effectively reduced, the development of a non-dye system bright copper plating process is promoted, and wider potential space is developed for establishment of a new theory mode of the process.

Why is it used in cosmetics and personal care products?
Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate and Sorbitan Trioleate function as surfactant - emulsifying agents.

Scientific Facts: 
The sorbitan esters are produced by reacting the polyol, sorbitol, with a fatty acids (stearic acid, lauric acid, oleic acid, palmitic acid). Both sobitol and the fatty acids are naturally occurring and are used in cosmetic products.

Safety Information: 
The Food and Drug Administration (FDA) allows Sorbitan Stearate to be added to food as a multipurpose food additive. Sorbitan Stearate is also on FDA's list of and flavoring substances and adjuvants that may be added to food. The safety of Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate and Sorbitan Trioleate has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The CIR Expert Panel evaluated scientific data and concluded that these ingredients were safe as a cosmetic ingredient under present conditions of concentration and use.

More safety Information: 
CIR Review: The CIR Expert Panel noted that as a class, the Sorbitan esters, including Sorbitan Stearate, are generally mild skin irritants but nonsensitizers. Sorbitan Stearate is not a photosensitizer. Sorbitan Stearate and Sorbitan Laurate were negative in carcinongenicity studies. Based on the available information, the CIR Expert Panel concluded that Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate, and Sorbitan Trioleate were safe as cosmetic ingredients.

Multipurpose Additives 
Flavoring Agents and Related Substances 
When made from plants Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate and Sorbitan Trioleate may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Regulation of the European Union. Ingredients of animal origin must comply with the European Union animal by-products regulations.

The Joint FAO/WHO Expert Committee on Food Additives has established an Acceptable Daily Intake of 0-25 mg/kg body weight for the sum of Sorbitan esters of lauric, oleic, palmitic, and stearic acid. 

More scientific Information: 
The Sorbitan esters are the fatty-acid esters of hexitol anhydrides derived from sorbitol. Esterification with a fatty acid derivatives normally yields the ester at the terminal (primary) alcohol group (e.g., Sorbitan Oleate). Sorbitan esters are water insoluble. The sorbitan derivatives as a class are excellent emulsifiers.

Sorbitan monopalmitate
Sorbitan monopalmitate
Names
Other names
Sorbitan palmitate; Span 40; E495
Identifiers
CAS Number    
26266-57-9 check
Infobox references
Sorbitan monopalmitate (SMP) is a food additive, permitted by the EU. It is entry E495 in the E number list of permitted food additives. It is also known under the trade name Span 40.

Synopsis
Sorbitan monopalmitate has been known since at least 1959.

Around 2000, SMP was permitted by the EU in bakery products, icings, marmalades, simulations of milk and cream, beverage whiteners, liquid concentrates of fruit and herbs, sorbets, emulsified sauces, food supplements and chewing gum amongst others.

SMP is a polysorbate that is derived from the mixture of partial esters of sorbitol treated with palmitic acid. SMP is a lipophilic surfactant. It may be found in combination with polysorbates. It is used to modify crystallisation of fats. It is insoluble in water. Up to 25 mg/kg bodyweight can be processed by humans. SMP is metabolized to sorbitol and palmitic acid, without any apparent side effects. The use of animal fats, like pork, in the production of SMP is possible.

Essential’s Cetyl Palmitate, Sorbitan Palmitate, Sorbitan Olivate (OLIWAX® LC) is a cutting-edge oil-in water emulsion stabilizing agent and liquid crystal promoter lamellar liquid that actually reorganizes emulsion structure on a microscopic level, improving product performance, texture and feel. The distinct lamellar liquid crystal structure is remarkably similar to the skin’s own natural lipid structure, creating an excellent delivery system that provides superior hydrating effects due to the high water content of the liquid crystalline structure that forms when in contact with the skin. Though providing intense moisturization and skin softening abilities, it leaves a uniquely modern, light, non-greasy feel and finish that is without tackiness or whitening effect.

Excellent for use as a stabilizing wax for oil-in-water systems, or as viscosity enhancer, or as an effective support system to boost the efficiency of sun care formulations (those using physical sun filters), due to the lamellar phase in the emulsion.

Also perfect for use in such products as skin/body care crenes, lotions, moisturizers, serums, day/night/eye creams, sensitive skin products, sun care products and after-sun care products. Also effective for use in color cosmetic products such as foundations (fluid oil-in-water), make-up removers, lipsticks, and lip balms.

MARKET INTRODUCTION

Sorbitan is a mixture of isomeric organic compounds that are derived from the dehydration of sorbitol and is an intermediate in the conversion of sorbitol to isosorbide. Sorbitan esters are nonionic surfactants used as emulsifying agents in the preparation of emulsions, creams, and ointments for pharmaceutical and cosmetic use. Sorbitan palmitate is a surfactant and emulsifier that is made from palm oil and sorbitol (natural sugar alcohol). It is biodegradable, non-toxic and a non-irritant.

MARKET DYNAMICS

The sorbitan palmitate market has witnessed a significant growth owing to factors such as growth of chemical industry. Moreover, to provide economic factors, technology trends, and market trends that influence the global Sorbitan Palmitate market. However, less consumer knowledge related to sorbitan palmitate is projected to hamper the overall growth of the sorbitan palmitate market.

MARKET SCOPE

The "Global Sorbitan Palmitate Market Analysis to 2027" is a specialized and in-depth study of the chemicals and materials industry with a special focus on the global market trend analysis. The report aims to provide an overview of the sorbitan palmitate market with detailed market segmentation type, application, and geography. The global sorbitan palmitate market is expected to witness high growth during the forecast period. The report provides key statistics on the market status of the leading sorbitan palmitate market players and offers key trends and opportunities in the market.

MARKET SEGMENTATION

The global sorbitan palmitate market is segmented on the basis of product and application. On the basis of product, the global sorbitan palmitate market is divided into cosmetic grade and food grade. On the basis of application, the global sorbitan palmitate market is divided into cosmetic, food, and medicine.

Introduction
In 1985, the Cosmetic Ingredient Review (CIR) Expert Panel (Panel) published a safety assessment of 7 sorbitan esters; based on the data presented in that assessment, the panel concluded that sorbitan stearate, sorbitan laurate, sorbitan sesquioleate, sorbitan oleate, sorbitan tristearate, sorbitan palmitate, and sorbitan trioleate were safe as cosmetic ingredients under [then] present conditions of concentration and use. In 2002, the Panel considered the safety of an additional 10 sorbitan fatty acid esters and, based on new data as well as data from the 1985 review, concluded that the sorbitan fatty acid esters were safe for use in cosmetic ingredients under the [then] present practices of use.

The sorbitan esters have many uses in the eye area; the highest concentration of use reported for eye products is 7.7% sorbitan olivate in mascara. Some sorbitan esters are reported to be used in baby products (eg, 0.99% sorbitan stearate in baby lotions, oils, and creams), in products applied to the mucous membranes, or in products that could possibly be ingested (eg, 5.3% sorbitan palmitate in lipsticks).

Sorbitan laurate and sorbitan palmitate are used as emulsifiers in niosomes (nonionic surfactant-based vesicles). Niosomes are microscopic vesicles composed of nonionic surface active agent bilayers, and the intended use of these vesicles is as a drug delivery system.

Subchronic dermal studies of 2% sorbitan palmitate and 4% sorbitan palmitate were negative for any systemic toxicity. No systemic toxicity was observed with dermal application of 5% sorbitan trioleate for 93 days.

The original safety assessments of the sorbitan esters included data that indicated that this group of ingredients was relatively nontoxic upon ingestion of a single dose.