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SymWhite 377, also known by its chemical name 4-(1-phenylethyl)benzene-1,3-diol or Phenylethyl Resorcinol, is a synthetic compound widely used in the cosmetic and skincare industry.
SymWhite 377 is known for its skin-brightening properties and is commonly included in formulations aimed at reducing hyperpigmentation, age spots, and uneven skin tone.
SymWhite 377 acts as a skin brightening-, lightening and anti-oxidant active.
CAS Number: 85-27-8
Molecular Formula: C14H14O2
Molecular Weight: 214.26
EINECS Number: 480-070-0
Synonyms: 4-(1-phenylethyl)benzene-1,3-diol, 85-27-8, Phenylethyl resorcinol, 4-(alpha-Methylbenzyl)resorcinol, 1,3-Benzenediol, 4-(1-phenylethyl)-, 4-(1-phenylethyl)-1,3-Benzenediol, Symwhite 377, (+/-)-Phenylethyl resorcinol, G37UFG162O, MFCD21648466, UNII-G37UFG162O, Phenylethyl resorcinol, (+/-), 4-(alpha-Methylbenzyl)resorcinol; 4-(1-Phenylethyl)benzene-1,3-diol; 4-(1-Phenylethyl)resorcin; 4-(1-Phenylethyl)resorcinol; 4-(alpha-Methylbenzyl)resorcinol, 2,4-dihydroxydiphenylethane, 1,3-Benzenediol, 4-(1-phenylethyl)-, (+/-), 4-(1-phenylethyl)resorcinol, SCHEMBL369337, CHEMBL3961037, PQSXNIMHIHYFEE-UHFFFAOYSA-N, BDBM240731, DTXSID501005319, AMY14169, BCP08432, BBL102852, STL556660, AKOS017343138, DB14120, DS-8462, PHENYLETHYL RESORCINOL, (+/-)-, DA-17621, SY056470, HY-125809, CS-0099447, M2754, NS00022840, D78256, EN300-7418385, A863626, AU-004/43508421, Q27278684, US9422261, 4-(1- phenylethyl) benzene-1,3- diol, 1,3-BENZENEDIOL, 4-(1-PHENYLETHYL)-, (+/-)-, 4-((c) paragraph sign-Methylbenzyl)resorcinol pound>>4-(alpha-Methylbenzyl)resorcinol pound>>1,3-Benzenediol, 4-(1-phenylethyl)-.
SymWhite 377 is one of the most potent non-toxic tyrosinase inhibitors naturally occurring in pine-tree.
SymWhite 377 outperforms kojic acid, a benchmark reference in skin lightening.
It protects against discoloration and uneven skin tone caused by UV and visible light exposure.
SymWhite 377 is suitable for a wide range of cosmetic applications.
SymWhite 377 helps to reduce the appearance of darker facial and underarm hair.
It promotes a more even-looking skin for a radiant complexion.
SymWhite 377 is a white crystalline solid used as a highly efficient skin lightener.
This antioxidant is nature-inspired, derived from a powerful molecule that exists naturally in Pine tree and is safe to the skin.
SymWhite 377 use in a wide range of cosmetic applications to brighten the skin tone treat uneven skin tone as well as diminish the appearance of dark facial & armpit hair.
SymWhite 377 is a white crystalline solid used as a highly efficient skin lightener.
This antioxidant is nature-inspired and safe to the skin.
SymWhite 377 is used in a wide range of cosmetic applications to brighten the skin, treat uneven skin tone, as well as diminish the appearance of dark facial & armpit hair.
Enriched SymWhite 377 serum with lightweight texture and low molecular weight, easily penetrates the skin and effectively brightens the dark spots on the skin.
SymWhite 377 reduces melanin production, protects against free radical damage, and helps to reduce the dark spots within 14 days.
This serum is also enriched with Niacinamide and Tranexamic Acid that significantly reducing the stubborn dark spots, and redness, and locking the moisture into the skin.
Stably formulated and not irritating the skin, brighten the uneven skin tone for a young-looking skin look.
SymWhite 377 is a nature-identical extract inspired by a potent, multifunctional substance from Pine trees.
SymWhite 377 is a strong antioxidant that also has benefits in skin brightening, promoting an even complexion.
SymWhite 377 is comparable to kojic acid but without skin irritation and associated side effects.
SymWhite 377 is one of the highest tyrosinase inhibitors, which is 22 times higher than kojic acid.
It also has excellent antioxidant activity against environmental oxidative stress.
A clinical study with Asian subjects proved that 0.5% SymWhite 377 is a more effective solution for brighter skin than 1.0 % kojic acid.
SymWhite 377 is effective against hyperpigmentation caused by harmful UV rays.
It promotes a radiant complexion.
SymWhite 377 is very safe to use on the skin.
SymWhite 377 is effective in inhibiting the activity of tyrosinase, an enzyme involved in the production of melanin.
This helps in reducing dark spots and brightening the skin.
SymWhite 377 also has antioxidant properties, which help protect the skin from damage caused by free radicals and environmental stressors, thereby promoting a more youthful appearance.
SymWhite 377 is stable and compatible with various cosmetic formulations, including creams, serums, and lotions.
SymWhite 377 is typically used at concentrations ranging from 0.1% to 0.5% in cosmetic products, depending on the formulation and desired effect.
SymWhite 377 is considered safe for use in cosmetics at recommended concentrations, with minimal risk of irritation or sensitivity for most skin types.
Melting point: 78-79℃
Boiling point: 244°C/12mmHg(lit.)
Density: 1.171
vapor pressure: 0Pa at 20℃
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 9.77±0.40(Predicted)
color: Light Beige to Pale Brown
Water Solubility: 3.85g/L at 20℃
InChI: InChI=1S/C14H14O2/c1-10(11-5-3-2-4-6-11)13-8-7-12(15)9-14(13)16/h2-10,15-16H,1H3
InChIKey: PQSXNIMHIHYFEE-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(C(C2=CC=CC=C2)C)C(O)=C1
LogP: 2.11 at 22℃
SymWhite 377 is 4-(1-Phenylethyl)-1,3-benzenediol.
This excellent skin brightening ingredient is one of the most potent tyrosinase inhibitors ever reported.
SymWhite 377 promotes an even-toned, radiant complexion while brightening and balancing skin's natural tone.
SymWhite 377 is a skin-lightening ingredient derived from pine bark.
It helps brighten skin tone, reduce dark spots, and improve overall complexion.
Safe and effective, SymWhite 377’s commonly used in skincare products.
SymWhite 377 primarily works by inhibiting tyrosinase, the key enzyme involved in the synthesis of melanin, which is responsible for skin pigmentation.
By blocking this enzyme, SymWhite 377 reduces the formation of melanin, leading to a lighter skin appearance and a reduction in hyperpigmented areas such as dark spots and age spots.
Regular use of products containing SymWhite 377 can help in achieving a more uniform skin tone by diminishing the appearance of hyperpigmented areas.
SymWhite 377 is effective in lightening dark spots caused by various factors, including sun exposure, aging, and post-inflammatory hyperpigmentation (PIH), such as that from acne scars.
By inhibiting tyrosinase, SymWhite 377 not only reduces existing pigmentation but also helps prevent new dark spots from forming.
It enhances the overall radiance and brightness of the skin, giving it a more youthful and healthy appearance.
SymWhite 377 is commonly found in products like serums, moisturizers, creams, and masks.
SymWhite 377 is especially popular in brightening serums and spot treatments that target hyperpigmentation.
Some formulations incorporate SymWhite 377 to complement UV protection with skin-brightening effects, as UV exposure can exacerbate pigmentation issues.
SymWhite 377 has been tested for skin compatibility and is generally well-tolerated, making it suitable for most skin types, including sensitive skin.
Unlike some other brightening agents, such as hydroquinone, SymWhite 377 has a lower risk of causing irritation or sensitivity, making it a favorable option for prolonged use.
SymWhite 377 is stable under various pH conditions and does not readily degrade, which ensures its efficacy and shelf-life in cosmetic formulations.
SymWhite 377 is approved for use in cosmetic products in many regions, including Europe and Asia.
It is important for formulators and consumers to follow the recommended usage concentrations to ensure both safety and effectiveness.
While hydroquinone is a potent skin-lightening agent, it is associated with a higher risk of irritation and has regulatory restrictions in some countries.
SymWhite 377 offers a milder alternative with fewer side effects.
Like SymWhite 377, arbutin is another melanin-inhibiting agent but can be less effective at lower concentrations.
SymWhite 377 tends to be more potent at similar concentrations.
SymWhite 377 can be used in conjunction with other antioxidants like Vitamin C for a synergistic effect, enhancing overall skin-brightening and anti-aging benefits.
For best results, products containing SymWhite 377 should be used consistently, ideally as part of a broader skincare regimen that includes sun protection, as UV exposure can negate its effects.
Applying these products in the morning and evening can maximize their benefits.
Uses Of SymWhite 377:
SymWhite 377 is an novel active ingredient of highly efficient skin lightening agents.
SymWhite 377 is widely used in creams, serums, and lotions formulated to brighten the skin.
It helps reduce the appearance of dark spots, hyperpigmentation, and uneven skin tone, providing a more radiant complexion.
SymWhite 377 is effective in targeted treatments for areas with concentrated pigmentation, such as age spots, melasma, or post-inflammatory hyperpigmentation from acne.
SymWhite 377 is included in anti-aging skincare products to help combat dullness and uneven skin tone that often accompany aging.
It enhances skin radiance and promotes a more youthful appearance.
SymWhite 377 is also used in face masks designed to brighten the complexion and reduce signs of aging, such as dark spots and uneven pigmentation.
SymWhite 377 is sometimes added to sunscreens and after-sun care products.
It helps prevent UV-induced pigmentation by inhibiting tyrosinase activity, which is often upregulated by UV exposure.
SymWhite 377 can be found in daily moisturizers designed for both day and night use.
These products aim to maintain an even skin tone and prevent pigmentation issues while keeping the skin hydrated.
SymWhite 377 is also used in products formulated to address specific skin conditions like melasma or solar lentigines (sun spots).
SymWhite 377 helps lighten these conditions by reducing melanin production in the affected areas.
SymWhite 377 is often formulated with other active ingredients such as niacinamide, Vitamin C, and retinoids to enhance overall skin benefits, including improving skin texture, reducing fine lines, and boosting overall skin radiance.
Some cosmetic formulations, like foundations, BB creams, and CC creams, may include SymWhite 377 to provide not just coverage but also long-term skin-brightening benefits.
Skincare products containing SymWhite 377 are sometimes recommended after skin treatments like chemical peels or laser therapy to minimize the risk of post-inflammatory hyperpigmentation and to promote even skin tone recovery.
SymWhite 377 is also used in men's skincare lines, particularly in aftershaves and moisturizers, to help address skin tone irregularities and maintain a brighter, clearer complexion.
SymWhite 377 can be found in body care formulations, targeting hyperpigmentation and uneven skin tone on areas such as the arms, legs, and chest.
SymWhite 377 is a key ingredient in products specifically marketed for skin whitening or lightening.
These products are popular in regions where lighter skin is culturally desirable, aiming to achieve an overall lighter complexion rather than just treating specific spots.
SymWhite 377 is less likely to cause irritation compared to some other skin-brightening agents, it is included in products formulated for sensitive skin.
SymWhite 377 provides effective brightening without the risk of adverse reactions, making it suitable for those with delicate skin.
SymWhite 377 is used in products designed to reduce post-inflammatory hyperpigmentation, which can occur after acne lesions heal.
By minimizing melanin production, it helps fade the dark spots left behind by acne, promoting a clearer complexion.
SymWhite 377 is also found in eye creams and serums that target dark circles and pigmentation around the eyes.
SymWhite 377 helps lighten these areas, reducing the appearance of tiredness and improving overall eye brightness.
SymWhite 377 is occasionally used in toners and facial mists designed for brightening the skin.
These products are meant to be used after cleansing and before moisturizing, helping to enhance the absorption of subsequent skincare products while providing a subtle brightening effect.
Some makeup primers incorporate SymWhite 377 to provide a brightening effect under makeup, helping to create a more even and luminous base for foundation and other cosmetics.
SymWhite 377 can be found in lip balms and treatments aimed at lightening dark lips or reducing pigmentation caused by external factors like sun exposure or smoking.
In some formulations, SymWhite 377 is combined with exfoliating acids (like AHAs and BHAs) to enhance the brightening effects while simultaneously improving skin texture and tone.
While less common, some innovative formulations may include SymWhite 377 in hair care products aimed at brightening the scalp and addressing pigmentation issues on the scalp or near the hairline.
Some all-in-one skincare solutions, designed to simplify routines, include SymWhite 377 to provide brightening benefits alongside hydration, anti-aging, and UV protection.
SymWhite 377 is used in cosmeceuticals, which are products that blend cosmetic and pharmaceutical properties.
These products are often recommended by dermatologists and skincare professionals for their efficacy in treating pigmentation disorders and improving overall skin tone.
Safety Profile Of SymWhite 377:
Although SymWhite 377 is less irritating than some other brightening agents, it can still cause skin irritation in some individuals, particularly at high concentrations or in sensitive skin types.
Symptoms may include redness, itching, or a burning sensation.
There is a potential risk of allergic reactions, though this is relatively rare.
Individuals with a history of allergies or sensitive skin should patch-test products containing SymWhite 377 before widespread use.
As a skin-brightening agent, SymWhite 377 may increase the skin’s sensitivity to sunlight.
This can lead to a higher risk of sunburn or sun damage if proper sun protection is not used.
SymWhite 377 is advisable to use sunscreen and limit sun exposure when using products containing SymWhite 377.
SymWhite 377 comes into contact with the eyes, it may cause irritation.
It is important to avoid direct contact with the eyes and to rinse thoroughly with water if accidental contact occurs.
