PRODUCTS

TETRACOSAHEXAENOIC ACID

TETRACOSAHEXAENOIC ACID = NISINIC ACID

CAS Number: 81247-23-6 / 68378-49-4
Molecular Formula: C24H36O2

Any C24 straight-chain fatty acid containing six C=C double bonds.
Tetracosahexaenoic acid has role metabolite tetracosahexaenoic acid is a long-chain fatty acid.
Tetracosahexaenoic acid is a polyunsaturated fatty acid tetracosahexaenoic acid is a straight-chain fatty acid.
Tetracosahexaenoic acid is conjugate acid of tetracosahexaenoate.
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
Any intermediate or product resulting from metabolism.

The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
Tetracosahexaenoic acid, also known as C24:6N-3 or C24:6omega-3, belongs to the class of organic compounds known as very long-chain fatty acids.
These are fatty acids with an aliphatic tail that contains at least 22 carbon atoms.
Tetracosahexaenoic acid belongs to the class of organic compounds known as very long-chain fatty acids.

Tetracosahexaenoic acid (C24:6n-3, THA, 3) is an essential biosynthetic precursor in mammals of docosahexaenoic acid (C22:6n-3, DHA, 1), the end-product of the metabolism of n-3 fatty acids.
Tetracosahexaenoic acid is present in commercially valuable fishes, such as flathead flounder.
Tricosahexaenoic acid (C23:6n-3, TrHA, 2), an odd-numbered-chain fatty acid, has been identified from marine organisms such as the dinoflagellate, Amphidinium carterae.
To date, few studies have examined Tetracosahexaenoic acid and TrHA 2 due to difficulties in detecting and identifying these compounds, so their chemical and biological properties remain poorly characterized.

Only one methodology for the chemical synthesis of Tetracosahexaenoic acid has been presented, and no method for the synthesis of TrHA 2 has been reported.
6,9,12,15,18,21-Tetracosahexaenoic acid (24∶6n−3) was isolated from a brittle star, Ophiura sarsi Lutken, at>95% purity to evaluate its physiological functions.
6(Z),9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosahexaenoic acid is a very long chain polyunsaturated fatty acid (VLCPUFA) that has been found in tunny, herring, cod-liver, pilot whale, sardine, and squalus-suclii-liver oils, bovine retina, and as a component of triglycerides and cholesterol esters in mouse and rat testis.

Naturally occurring very long chain fatty acids (fatty acids with more than 22 carbon atoms) include the main families: saturated, monounsaturated, methylene-interrupted and non methylene interrupted polyunsaturated fatty acids (VLCPUFA), and hydroxy acids.
There is a growing interest in one of these families, methylene-interrupted VLCPUFA, especially due to their involvement in the biosynthesis of docosahexaenoic acid in mammals.
Allegedly the best known representative of this family is Tetracosahexaenoic acid, 24:6n-3.

Elevated levels of these acids were found in mammalian reproductive organs and retina, but Tetracosahexaenoic acid is likely that virtually all mammalian cells contain these acids.
Dietary sources of Tetracosahexaenoic and related acids include marine fish and a number of Omega-3 food supplements.
Tetracosahexaenoic acid is a very long chain polyunsaturated omega-3 fatty acid, similar to docosahexaenoic acid (DHA).
The lipid name is 24:6 (n-3) and the chemical name is all-cis-6,9,12,15,18,21-tetracosahexaenoic acid.
Tetracosahexaenoic acid is not well studied, but polyunsaturated fatty acids even longer than DHA, nisinic acid included, may hold scientific promise.

ALTERNATIVE PARENTS of TETRACOSAHEXAENOIC ACID:
-Unsaturated fatty acids
-Straight chain fatty acids
-Monocarboxylic acids and derivatives
-Carboxylic acids
-Organic oxides
-Hydrocarbon derivatives
-Carbonyl compounds

SUBSTITUENTS of TETRACOSAHEXAENOIC ACID:
-Very long-chain fatty acid
-Unsaturated fatty acid
-Straight chain fatty acid
-Monocarboxylic acid or derivatives
-Carboxylic acid derivative
-Carboxylic acid
-Organic oxygen compound
-Organic oxide
-Hydrocarbon derivative
-Organooxygen compound
-Carbonyl group
-Aliphatic acyclic compound

PHYSICAL and CHEMICAL PROPERTIES of TETRACOSAHEXAENOIC ACID:
Molecular Weight: 356.
Average mass: 356.541 Da
Monoisotopic mass: 356.271515 Da
XLogP3-AA: 9.1
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Exact Mass: 356.271530387
Monoisotopic Mass: 356.271530387

Topological Polar Surface Are: 37.3 Å²
Heavy Atom Count: 26
Formal Charge: 0
Complexity: 490
Density: 0.9±0.1 g/cm3
Boiling Point: 525.7±19.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.0 mmHg at 25°C
Enthalpy of Vaporization: 87.5±6.0 kJ/mol

Flash Point: 402.3±12.4 °C
Index of Refraction: 1.516
Molar Refractivity: 115.1±0.3 cm3
#H bond acceptors: 2
#H bond donors: 1
#Freely Rotating Bonds: 16
Physical States: [ ] Gas [ X ] Liquid [ ] Solid
Melting Point: No data.
Boiling Point: No data.

Flash Pt: 14.00 C Method Used: Closed Cup
Explosive Limits: LEL: 3.3% at 25.0 C UEL: 19.0% at 25.0 C
Vapor Pressure (vs. Air or mm Hg): 43 MM_HG at 20.0 C
Vapor Density (vs. Air = 1): No data.
Evaporation Rate: No data.
pH: No data.
Appearance and Odor: A solution in ethanol
Flammability (solid, gas): No data available

Specific Gravity (Water = 1): No data.
Solubility in Water: No data.
Octanol/Water Partition Coefficient: No data.
Decomposition Temperature: No data.
Autoignition Pt: 363.00 C
Viscosity: No data.
Percent Volatile: No data.

FIRST AID MEASURES of TETRACOSAHEXAENOIC ACID:
-Description of First Aid Measures:
*In Case of Inhalation:
Remove to fresh air.

*In Case of Skin Contact:
Remove contaminated clothing.
Wash clothing before reuse.

*In Case of Ingestion:
Get medical attention.

FIRE FIGHTING MEASURES of TETRACOSAHEXAENOIC ACID:
-Suitable Extinguishing Media:
Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray.
Use water spray to cool fire-exposed containers.

EXPOSURE CONTROLS/PERSONAL PROTECTION of TETRACOSAHEXAENOIC ACID:
-Exposure Controls:
-Personal protection equipment:
*Eye Protection:
Safety glasses
Protective Gloves
*Other Protective Clothing:
Lab coat
*Work/Hygienic/Maintenance Practices:
Do not take internally.
Eyewash and a safety shower.
Wash thoroughly after handling.

HANDLING AND STORAGE of TETRACOSAHEXAENOIC ACID:
-Precautions To Be Taken in Storing:
Keep container tightly closed.
Store in accordance with information listed on the product insert.

STABILITY and REACTIVITY of TETRACOSAHEXAENOIC ACID:
Reactivity: No data available
Stability: Stable
Stability Note(s): Stable if stored in accordance with information listed on the product insert.
Polymerization: Will not occur

SYNONYMS:
(2E,4E,6E,8E,10E,12E)-tetracosa-2,4,6,8,10,12-hexaenoic acid
6,9,12,15,18,21-Tetracosahexaenoic acid
2E,4E,6E,8E,10E,12E-tetracosahexaenoic acid
C24:6n-12,14,16,18,20,22
tetracosahexaenoate
(2E,4E,6E,8E,10E,12E)-2,4,6,8,10,12-Tetracosahexaenoic acid
2,4,6,8,10,12-Tetracosahexaenoic acid, (2E,4E,6E,8E,10E,12E)-
tetracosahexaenoic acid