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Thioglycerin is a reagent used in fluorescence, spectroscopy, and microbiology techniques.
Varying the concentration of Thioglycerin in the preparation of CdSe/CdS core-shell ultrasmall quantum dots (CS-USQDs) allows a precise way to control the size of the shell, with shell size increasing with increased concentration.
Thioglycerin is used as a capping agent in the synthesis of nanocrystals analyzed via Raman and UV/Vis spectroscopy.
CAS: 96-27-5
MF: C3H8O2S
MW: 108.16
EINECS: 202-495-0
Synonyms
ALPHA-THIOGLYCEROL;ALPHA-MONOTHIOGLYCEROL;A-MONOTHIOGLYCEROL;3-MERCAPTO-1,2-PROPANDIOL;3-MERCAPTO-1,2-PROPANEDIOL;1,2-Propanediol, 3-mercapto-;1-Mercapto-2,3-propanediol;1-Mercaptoglycerol
Biologically, Thioglycerin stimulates porphyrin synthesis and increases glutamyl-tRNA reductase activity in E. coli grown in an aerobic environment.
Thioglycerin was previously a component in hair permanents used to produce waves or curls.
A thiol that is glycerol in which one of the primary hydroxy groups is replaced by a thiol group.
Thioglycerin stimulates the synthesis of porphyrin in aerobically growing Escherichia coli.
Thioglycerin is an inhibitor of glycerol kinase activity in vitro and in situ.
3-Mercaptopropane-1,2-diol, also known as Thioglycerin, is a chemical compound and thiol that is used as a matrix in fast atom bombardment mass spectrometry and liquid secondary ion mass spectrometry.
Thioglycerin, also known as 1,2,3-propanetriol thiol or glycerol thiol, is a colorless, viscous liquid with a slightly sweet odor.
Thioglycerin is a thiol derivative of glycerol, characterized by the presence of a sulfhydryl (-SH) group, which imparts distinct chemical properties.
Thioglycerin is soluble in water and organic solvents, making it versatile in various applications.
Thioglycerin exhibits reducing properties, allowing it to participate in redox reactions, and can form disulfide bonds with other thiol-containing compounds.
Thioglycerin is often used in biochemical and pharmaceutical applications, including as a reducing agent, stabilizer, and in the synthesis of thiol-containing compounds.
Additionally, Thioglycerin has applications in the cosmetic industry due to its moisturizing properties.
However, Thioglycerin should be handled with care, as thiols can have strong odors and may be toxic in high concentrations.
Overall, Thioglycerin is a valuable compound in both industrial and laboratory settings, owing to its unique chemical characteristics and reactivity.
Thioglycerin Chemical Properties
Melting point: <25 °C
Boiling point: 118 °C5 mm Hg(lit.)
density: 1.25 g/mL at 25 °C(lit.)
vapor pressure: <1 hPa (20 °C)
refractive index: n20/D 1.527(lit.)
Fp: >230 °F
storage temp.: 2-8°C
solubility: absolute ethanol: 1 mL/mL
form: liquid
pka: pK1:9.43 (25°C,μ=0.5)
color: Clear colorless to yellow
Odor: Stench odour
PH: 3.5-7.0
biological source: synthetic (organic)
Water Solubility: slightly soluble
Sensitive: Air Sensitive & Hygroscopic
Merck: 14,9335
BRN: 1732046
Stability: Air Sensitive, Hygroscopic
Cosmetics IngredientsFunctions: DEPILATORY KERATOLYTIC HAIR WAVING OR STRAIGHTENING REDUCING
InChI: 1S/C3H8O2S/c4-1-3(5)2-6/h3-6H,1-2H2
InChIKey: PJUIMOJAAPLTRJ-UHFFFAOYSA-N
LogP: -0.84 at 20℃
CAS DataBase Reference: 96-27-5(CAS DataBase Reference)
NIST Chemistry Reference: Thioglycerin (96-27-5)
EPA Substance Registry System: Thioglycerin(96-27-5)
Monothioglycerol occurs as a colorless or pale-yellow colored, viscous, hygroscopic liquid with a slight odor of sulfide.
Uses
Thioglycerin generally used as a size-regulating capping agent for nanocrystals.
Thioglycerin is also used in bacteriology experiments to induce the synthesis of porphyrin compounds in aerobically growing Escherichia coli.
Also used to study the pH-sensitive photoluminescence of aqueous thiol-capped CdTe nanocrystals.
Thioglycerin is used to develop and test thiol functionalized copolymers.
Thioglycerin is used as a post-modification agent in the generation of non-standard peptide foldamers.
Potential substitute for 2-mercaptoethanol, probe for the study of lymphocyte activation.
Thioglycerin can be used as antioxidant preservative; reagent in analytical chemistry, cell culture research.
Matrix substrate in fast atom bombardment mass spectrometry.
Thioglycerin has been used in a study to assess the manipulation of aqueous growth of CdTe nanocrystals.
Thioglycerin has also been used in a study that investigated the effect of surface attachment on ligand binding
Thioglycerin is a thiol that is glycerol in which one of the primary hydroxy groups is replaced by a thiol group.
Thioglycerin has a role as a vulnerary and a reducing agent.
Thioglycerin is a thiol and a member of propane-1,2-diols.
Pharmaceutical Applications
Thioglycerin is used as an antioxidant in pharmaceutical formulations, mainly in parenteral preparations.
Thioglycerin is reported to have some antimicrobial activity.
Thioglycerin is also widely used in cosmetic formulations such as depilating agents.
Therapeutically, monothioglycerol has been used in a 0.02% w/w aqueous solution to stimulate wound healing, and as a 0.1% w/w jelly in atrophic rhinitis.
Production Methods
Thioglycerin is prepared by heating an ethanolic solution of 3- chloro-1,2-propanediol with potassium bisulfide.
