Quick Search

PRODUCTS

TRICAPRYLIN

TRICAPRYLIN

CAS NO.: 538-23-8
EC /LIST NO.: 208-686-5

Tricaprylin is a triester of glycerin and caprylic acid. 
Tricaprylin is used as a fragrance ingredient, solvent, and primarily as an emollient in a variety of personal care products, including makeup, creams and lotions, deodorants, sunscreens, hair conditioners, and skin cleansers. 
Tricaprylin is an ingredient of Axona, a prescription medical food intended for the clinical dietary management of the metabolic processes associated with mild to moderate Alzheimer’s disease. 
Axona provides a simple and safe method to induce hyperketonemia, thus providing an alternative energy substrate to glucose in the brain of patients with AD. 
After oral administration of Axona, Tricaprylin in Axona is processed by enzymes in the gut, and the resulting medium-chain fatty acids (MCFAs) are absorbed into the blood supply leading to the liver. 
The MCFAs rapidly pass directly to the liver, where they undergo oxidation to form ketones.
Since the liver does not use ketones, they are released into the circulation to be used by nonliver tissues. 
Some ketones can cross the blood-brain barrier and are then taken up by brain cells. 
While glucose is the brain’s chief energy source, ketones normally serve as the "backup" energy source. 
Ketones the body produces after Axona is consumed, act as an alternative energy source for brain cells that have lost their ability to use glucose (sugar) as a result of Alzheimer’s disease.

Tricaprylin is classified as a glyceryl triester, and is a relatively pure fat which differs only slightly from the fats and oils found in nature, most often in animal and vegetable fats, and oils such as tallow, palm-nut and coconut oils (CosmeticsInfo.org). 
Tricaprylin is used as a fragrance ingredient, solvent, and primarily as an emollient in a variety of personal care products, including makeup, creams and lotions, deodorants, sunscreens, hair conditioners, and skin cleansers. 
Historically, Tricaprylin has been used as a synthetic vehicle to test the carcinogenicity of other chemicals. 
According to a study published in the International Journal of Toxicology entitled "Final report on the safety assessment of … tricaprylin," glyceryl triesters are found in concentrations ranging from a few tenths of a percent to 46%. 
Also known as triglycerides, all of the glyceryl triesters, including Tricaprylin, are metabolized into free fatty acids when ingested, and are then absorbed in the intestines and further metabolized. 
When applied topically, they are not absorbed or metabolized, although they can enhance penetration of other ingredients.

Tricaprylin is used as a fragrance ingredient, solvent, and primarily as an emollient in a variety of personal care products, including makeup, creams and lotions, deodorants, sunscreens, hair conditioners, and skin cleansers.

Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.

Tricaprylin is an organic chemical compound of the triester of glycerin and caprylic acid. 
Tricaprylin belongs to the group of triglycerides.

Tricaprylin is a Triester of glycerin and caprylic acid Tricaprylin uses and applications include: 
Emollient, lubricant, spreading agent, penetrant for cosmetics and pharmaceuticals; carrier for essential oils, flavors; vehicle for vitamins, medicinals, nutritional products; production of dietary foods

Suggested storage of Tricaprylin: 
Store in a tightly closed container; refrigerate

Tricaprylin is used in pharmaceutical preparations as a neutral carrier, absorption promoter, and solubilizer for active drugs. 
Tricaprylin has been used as an oily phase to prepare water-in-oil-in-water multiple emulsions for incorporating water-soluble drugs such as cefadroxil, cephradine, 4-aminoantipyrine, and antipyrine, and also for obtaining stable microcapsules.
Tricaprylin acts as a vehicle for topical creams and lotions, and cosmetic preparations. 
Tricaprylin is used as a penetration-enhancing lipid base with excellent emollient and skin-smoothing properties. 
Owing to its non-greasy components and low viscosity, it has very good spreadability. 
In spite of being skin-permeable, tricaprylin does not obstruct natural skin respiration, and hence it is used in baby oils, massage oils, and face masks. 
Tricaprylin is an excellent dispersant, and acts as a solubilizer, wetting agent and binder in color cosmetics. 
Being readily miscible with natural oils and surfactants, tricaprylin is used as the fat component in two-phase foam baths. 
Tricaprylin is used in sunscreen creams and oils because of its compatibility with organic and inorganic filter agents. 
Tricaprylin is also used as a fixative for perfumes/fragrances.

Tricaprylin is classified as a stable compound. 
Tricaprylin has high stability against oxidation and is not heat sensitive. Even in hot climates cooling is not necessary. 
However, exposure to high temperatures near the flash point (246℃) should be avoided. 
Owing to its very low water content, Tricaprylin is not sensitive to hydrolytic and microbial splitting. 
Although polymerization of tricaprylin will not occur, it is reported to decompose into carbon monoxide and carbon dioxide.
Tricaprylin should be stored in well-closed containers, protected from light, in a dry place at ambient temperature. 
High-density polyethylene, polypropylene, metal (aluminum), and glass are suitable for packaging. 
Some plastics, especially those containing plasticizers, can become brittle or expand in the presence of tricaprylin. 
Polystyrene and polyvinyl chloride are not suitable for its storage. 
Tricaprylin has a high tendency to migrate, and therefore care should be taken when selecting seal-closure elastomer material.

Tricaprylin is used as a fragrance ingredient, solvent, and primarily as an emollient in a variety of personal care products, including makeup, creams and lotions, deodorants, sunscreens, hair conditioners, and skin cleansers. 
Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.

Tricaprylin can be analyzed by this reverse phase (RP) HPLC method with simple conditions. 
The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. 
For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. 
Smaller 3 µm particles columns available for fast UPLC applications. 
This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. 
Tricaprylin also suitable for pharmacokinetics.

Tricaprylin is classified as a stable compound. 
Tricaprylin has high stability against oxidation and is not heat sensitive. 
Even in hot climates cooling is not necessary. 
However, exposure to high temperatures near the flash point (2468C) should be avoided. 
Owing to its very low water content, it is not sensitive to hydrolytic and microbial splitting. 
Although polymerization of tricaprylin will not occur, it is reported to decompose into carbon monoxide and carbon dioxide.
Tricaprylin should be stored in well-closed containers, protected from light, in a dry place at ambient temperature. 
High-density polyethylene, polypropylene, metal (aluminum), and glass are suitable for packaging. 
Some plastics, especially those containing plasticizers, can become brittle or expand in the presence of tricaprylin. 
Polystyrene and polyvinyl chloride are not suitable for its storage. 
Tricaprylin has a high tendency to migrate, and therefore care should be taken when selecting seal-closure elastomer material.

Tricaprylin is approved as an additive for cosmetic articles with the INCI name of the same name on the list of ingredients; 
Here it fulfills the function of a skin-caring, fragrant or odor-marking substance.

In the USA in particular, tricaprylin is offered as a nutritional supplement for patients suffering from Alzheimer's disease. 
The benefit is said to be that medium-chain triglycerides, such as glyceryl tricaprylate, are broken down by the metabolism into ketones, which represent an alternative source of energy for the brain. 
The concept behind it is based on the assumption that the sick person's brain can only partially access glucose as a normal supplier of energy; here the preparation should have a beneficial effect.

Physical properties

mp :9-10 °C
bp :233 °C1 mm Hg(lit.)
density :0.956 g/mL at 20 °C(lit.)
refractive index :n 20/D  1.448
Fp :225 °C
Storage temp. :2-8°C
Safety Information
Safety Statements : 23-24/25
WGK Germany -
RTECS : YJ7700000

Appearance : Colorless - pale yellow, clear liquid
Boiling Point : about 230 degrees C
Flash Point : 210 degrees C (Cleveland open test)
Density    : 0.950 - 0.960g/ml (20 degrees C)
Refractive Index : 1.445 - 1.450 (20 degrees C/D)

IUPAC NAME:

1,3-bis(octanoyloxy)propan-2-yl octanoate
 
2,3-di(octanoyloxy)propyl octanoate
 
ester of triglycerol and caprylic acid 
  
Glycerol trioctanoate

SYNONYMS:

1,2,3-Propanetriol trioctanoate
1,2,3-Propanetriyl trioctanoate   
1,2,3-Propantriyltrioctanoat
1,2,3-Propantriyl-trioctanoat  
1,2,3-Tricapryloylglycerol
1,2,3-Tri-n-Octanoylglycerol
1,2,3-Trioctanoyl Glycerol
1,2,3-Trioctanoylglycerol
1717202
208-686-5  
 

  • Share !
E-NEWSLETTER