PRODUCTS

TRIPOTASSIUM CITRATE

EC / List no.: 212-755-5
CAS no.: 866-84-2
Mol. formula: C6H8O7.3K

Tripotassium citrate is the common tribasic potassium salt of citric acid, also known as potassium citrate.
Tripotassium Citrate is produced by complete neutralisation of citric acid with a high purity potassium source and subsequent crystallisation.

Tripotassium citrate is used in foods, beverages, and technical applications as buffering, sequestering or emulsifying agent.
Tripotassium Citrate usually replaces trisodium citrate whenever a low sodium content is desired.
In pharmaceuticals it is used as potassium source and as active ingredient to treat urinary duct stones.
When added to oral care products, tripotassium citrate is the active ingredient to reduce the sensitivity of the teeth.

Tripotassium citrate occurs as transparent crystals or a white, granular powder.
Tripotassium Citrate is an odourless substance with a cooling, salty taste.
Tripotassium Citrate is slightly deliquescent when exposed to moist air, freely soluble in water and almost insoluble in ethanol (96%).
In contrary to other potassium salts, it is less bitter and thus can be used at higher concentration levels.

Tripotassium citrate is a non-toxic, slightly alkaline salt with low reactivity.
Tripotassium Citrate is chemically stable if stored at ambient temperatures.
In its monohydrate form it is very hygroscopic and must be protected from exposure to humidity.
Care must be taken not to expose tripotassium citrate monohydrate to high pressure during transport and storage as this may result in caking.

The food-approved substance is safe and easy in handling.
Furthermore, tripotassium Citrate is one of the few fully biodegradable and non-toxic flame retardants.

Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid with the molecular formula K3C6H5O7.
Tripotassium Citrate is a white, hygroscopic crystalline powder.
Tripotassium Citrate is odorless with a saline taste.
Tripotassium Citrate contains 38.28% potassium by mass.
In the monohydrate form, it is highly hygroscopic and deliquescent.

As a food additive, Tripotassium Citrate is used to regulate acidity, and is known as E number E332.
Medicinally, it may be used to control kidney stones derived from uric acid or cystine.

Synthesis
Tripotassium Citrate can be synthesized by the neutralization of Citric acid which is achieved by the addition of Potassium bicarbonate, Potassium carbonate or Potassium hydroxide to it. The solution can then be filtered and the solvent can be evaporated till granulation.

Uses
Tripotassium Citrate is rapidly absorbed when given by mouth, and is excreted in the urine.
Since it is an alkaline salt, it is effective in reducing the pain and frequency of urination when these are caused by highly acidic urine.
Tripotassium Citrate is used for this purpose in dogs and cats, but is chiefly employed as a non-irritating diuretic.

Tripotassium Citrate is an effective way to treat/manage gout and arrhythmia, if the patient is hypokalemic.

Tripotassium Citrate is widely used to treat urinary calculi (kidney stones), and is often used by patients with cystinuria.
A study of 500 patients with recurrent stones found that it reduced the frequency of stones from 2 per year to 0.5 per year.

Tripotassium Citrate is also used as an alkalizing agent in the treatment of mild urinary tract infections, such as cystitis.

Tripotassium Citrate is also used in many soft drinks as a buffering agent.

Frequently used in an aqueous solution with other potassium salts, it is a wet chemical fire suppressant that is particularly useful against kitchen fires.
Its alkaline pH encourages saponification to insulate the fuel from oxidizing air, and the endothermic dehydration reaction absorbs heat energy to reduce temperatures.

Properties
Monohydrate
White granular powder
Cooling, salty taste profile, less bitter compared to other potassium salts
Odourless
Very soluble in water
Potassium content of 36%
Slightly alkaline salt with low reactivity
Hygroscopic
Chemically and microbiologically stable
Fully biodegradable
Allergen and GMO free

Main functions
Potassium fortification
pH adjuster
Buffering agent
Complexing/stabilising agent
Emulsifying salt
Chelating agent
Flavour enhancer
Synergist with antioxidants
Sequestering agent
Sodium replacement, sodium-free pH regulation
Systemic alkalizer in pharmaceuticals
Treatment of kidney stones and bladder infection
Reduce sensitivity to pain of teeth
Stabilises milk and soy products during heat treatment
Reduces sensitivity of teeth in oral care products
Fire protection
Controls the burning rate of cigarette paper

Applications

Industrial Applications
Agrochemicals, Fertilisers
Construction
Metal Surface Treatment
Paper
Fire protection
Beverages
Alcoholic Beverages
Carbonated Soft Drinks
Instant Drinks, Syrups
Juice Drinks
Plant-based
RTD Tea and Coffee
Sports and Energy Drinks
Waters

Food
Baby Food, Infant Formula
Bakery
Cereals, Snacks
Confectionery
Dairy
Dairy Alternatives
Desserts, Ice Cream
Flavours
Fruit Preparations, Sweet Spreads
Fruits, Vegetables
Meat Alternatives
Meat, Seafood
Plant-based Products
Ready Meals, Instant Food
Sauces, Dressings, Seasonings
Table Top Products

Pharma
Buffering agent
Chelating agent
Mineral source

Healthcare
Clinical Nutrition
OTC, Food Supplements
Pharmaceutical Products

Personal Care
Colour Cosmetics
Deodorants
Hair Care
Oral Care
Skin Care
Soap and Bath Products

Cleaners & Detergents
Dish Washing
Industrial Cleaners
Laundry Care

Feed & Pet Food
Feed
Pet Food

Tripotassium citrate is used in the following products: fertilisers, biocides (e.g. disinfectants, pest control products), laboratory chemicals, adhesives and sealants, adsorbents, air care products, coating products, fillers, putties, plasters, modelling clay, inks and toners, pH regulators and water treatment products, perfumes and fragrances, photo-chemicals, polishes and waxes, textile treatment products and dyes, washing & cleaning products, water softeners, water treatment chemicals and cosmetics and personal care products.
Other release to the environment of Tripotassium citrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

Release to the environment of Tripotassium citrate can occur from industrial use: in the production of articles.

Tripotassium citrate can be found in products with material based on: paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper), stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), wood (e.g. floors, furniture, toys), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys) and leather (e.g. gloves, shoes, purses, furniture).
Tripotassium citrate is intended to be released from scented: paper products.

Tripotassium citrate is used in the following products: laboratory chemicals, fertilisers, biocides (e.g. disinfectants, pest control products), adsorbents, air care products, coating products, fillers, putties, plasters, modelling clay, inks and toners, perfumes and fragrances, photo-chemicals, polishes and waxes, textile treatment products and dyes, washing & cleaning products, water softeners, water treatment chemicals and cosmetics and personal care products.
Tripotassium citrate is used in the following areas: health services, building & construction work, agriculture, forestry and fishing, formulation of mixtures and/or re-packaging and mining.
Tripotassium citrate is used for the manufacture of: machinery and vehicles and furniture.
Release to the environment of Tripotassium citrate can occur from industrial use: formulation of mixtures, in processing aids at industrial sites and in the production of articles.
Other release to the environment of Tripotassium citrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

Tripotassium citrate is used in the following products: fertilisers, air care products, polishes and waxes, washing & cleaning products, biocides (e.g. disinfectants, pest control products), laboratory chemicals, perfumes and fragrances, water softeners and water treatment chemicals.
Release to the environment of Tripotassium citrate can occur from industrial use: formulation of mixtures, in processing aids at industrial sites, manufacturing of the substance and formulation in materials.

Tripotassium citrate is used in the following products: pH regulators and water treatment products, polishes and waxes, washing & cleaning products and water treatment chemicals.
Tripotassium citrate is used in the following areas: mining, health services, building & construction work and formulation of mixtures and/or re-packaging.
Tripotassium citrate is used for the manufacture of: machinery and vehicles, chemicals, electrical, electronic and optical equipment, metals, fabricated metal products and textile, leather or fur.
Release to the environment of Tripotassium citrate can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as processing aid and formulation of mixtures.
Other release to the environment of Tripotassium citrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

Release to the environment of Tripotassium citrate can occur from industrial use: manufacturing of the substance, formulation of mixtures, formulation in materials and in processing aids at industrial sites.

The applications of potassium citrate (or tripotassium citrate) mainly derive from its alkaline properties.
Tripotassium Citrate is used to treat kidney stones composed of uric acid and cysteine, as well as other renal failures caused by excess acidity, including in veterinary applications.
As an additive to soft drinks and other edibles, it also functions as an acid buffer, less bitter than other potassium salts, and with less sodium than trisodium citrate.
An additional use of Tripotassium Citrate is to supplement potassium in patients with hypokalemia, preventing and treating gout and arrhythmia.

Prevention of urinary calculi drug
Tripotassium Citrate is the drug which is most commonly used to prevent calculus.
Tripotassium Citrate was found that in the urine pH value and citric acid value and have a very close relationship with the formation urinary tract calculus.
In an acidic urine (pH <5.5), the uric acid solubility is very low, so it is likely to cause uric acid calculus; while in alkaline urine (pH> 7), it is easy to form calcium or magnesium phosphate calculus.
63% of urinary calculus patients are below normal urine citrate, and Tripotassium Citrate can provide a lot of citric acid to enhance the urine pH value.
So for uric acid calculus.
Tripotassium Citrate has a very significant therapeutic effect to low calcium citrate calculus disease and tubular poisoning calcium calculus disease.
But Tripotassium Citrate will raise the concentration of potassium and lower the concentration of ammonium ion in urinary, which is because not only complements the citric acid, but also supplements of potassium.
Since potassium metabolism is very quickly in the body, there is no change in blood potassium concentration.
Tripotassium Citrate has little effect on the body.
The daily amount of total urine, oxalate, phosphate, sodium, magnesium, sulfate and uric acid and other aspects test from patients with uric acid calculus, it is found that it is not affected by taking potassium citrate.

Chemical properties
Colorless crystals or white crystalline powder, odorless, cool and salty, slight deliquescence, soluble in water and glycerin, insoluble in ethanol.
Colorless or white crystals or powder; cooling, saline taste; odorless; deliquescent.
Soluble in water and glycerol; almost insoluble in alcohol.

Tripotassium Citrate is a potassium salt of citric acid with the molecular formula C6H5K3O7.
Tripotassium Citrate is a white, slightly hygroscopic crystalline powder.
Tripotassium Citrate is odorless with a saline taste.
As a food additive, Tripotassium Citrate is used to regulate acidity and is known as E number E332.
Medicinally, it may be used to control kidney stones derived from either uric acid or cystine.

Uses
As a preservative, stabilizing and pH buffering agents and others. China provides for various types of food, according to production needs to use appropriately.
Used in the food, pharmaceutical and other industries, as buffering agents, chelating agents, flavoring agents, stabilizers, antioxidants, emulsifying salts.
Tripotassium Citrate is it acts as a buffer, maintaining product pH constant, a pH adjuster and a product stabilizer. This is a potassium salt.
For use as an electrolyte replenisher and in the treatment of hypokalemia.
Tripotassium Citrate is rapidly absorbed when given by mouth and is excreted in the urine.
Since it is an alkaline salt it is effective in reducing the pain and frequency of urination when these are caused by highly acidic urine.
Tripotassium Citrate is used for this purpose in dogs and cats, but is chiefly employed as a non-irritating diuretic.
Tripotassium Citrate is an effective way to treat/manage gout and arrhythmia, if the patient is hypokalemic.
Tripotassium Citrate is widely used to treat urinary calculi (kidney stones) and is often used by patients with cystinuria .

Production methods
Citric acid and potassium hydroxide or potassium bicarbonate derived products.
C6H8O7 + 3KHCO3 → CaH5K3O7 · H2O + 3CO2 ↑ + 2H2O
Tripotassium Citrate is produced by adding potassium bicarbonate or potassium carbonate to a solution of citric acid until effervescence ceases, filtering the solution and evaporating to granulation.

Industrial uses
Tripotassium Citrate is used in the United Kingdom as an over-the-counter drug for the relief from discomfort experienced in mild urinary-tract infections by increasing the urinary pH.
Tripotassium Citrate should be not given to men if they experience pain in the kidney area (risk of kidney stones) or if blood or pus is present in the urine.
Also, patients with raised blood pressure or diabetes should avoid taking Tripotassium Citrate without consultation with their general practitioner (GP).
Caution is generally advised to patients with renal impairment, cardiac problems and the elderly.

Tripotassium Citrate is the potassium salt form of citrate with alkalinizing property.
Following absorption, Tripotassium Citrate causes increased plasma bicarbonate concentration, thereby raising blood and urinary pH.
A simultaneous decrease in calcium ion activity occurs as a result of increasing calcium complex formation with dissociated anions.
Levels of urinary citrate are increased due to modification of the renal handling of citrate.
By promoting excretion of free bicarbonate ion and by increasing urinary pH in addition to an increased ionization of uric acid to more soluble urate ions, this agent exerts the alkalizing and anti-urolithic effect.

Tripotassium Citrate (anhydrous) is the anhydrous form of the tripotassium salt of citric acid. Tripotassium Citrate has a role as a diuretic.
Tripotassium Citrate contains a citrate(3-).

Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid.
Tripotassium Citrate is a white, hygroscopic crystalline powder.
Tripotassium Citrate is odorless with a saline taste.
Tripotassium Citrate contains 38.3% potassium by mass.
In the monohydrate form it is highly hygroscopic and deliquescent.
Tripotassium Citrate is used to treat a kidney stone condition called renal tubular acidosis.
Tripotassium Citrate is indicated also for the management of Hypocitraturic calcium oxalate nephrolithiasis.

Pharmacology

Tripotassium Citrate induces changes in the urine which renders urine less susceptible to the formation of crystals and stones from salts e.g. calcium oxalate, calcium phosphate and uric acid.
Increased citrate levels in the urine will make complexation with calcium which decrease the calcium ion activity and decrease the chance for the formation of calcium phosphate crystals.
Citrate also inhibits the spontaneous nucleation of calcium oxalate and calcium phosphate.

Use and Manufacturing

Household & Commercial/Institutional Products
• Auto Products
• Commercial / Institutional
• Inside the Home

Uses
• Related to products specifically designed for children (e.g. toys, children's cosmetics, etc)
• Related to all forms of cleaning/washing, including cleaning products used in the home, laundry detergents, soaps, de-greasers, spot removers, etc.
• Detergents with wide variety of applications
• Drug product, or related to the manufacturing of drugs
• Fire prevention materials, or additives/coatings to prevent flammability in paints, textiles, plastics, etc
• Pharmaceutical related
• Includes antifoaming agents, coagulating agents, dispersion agents, emulsifiers, flotation agents, foaming agents, viscosity adjustors, etc
• Includes spices, extracts, colorings, flavors, etc added to food for human consumption
• Related to the farming of meats (including cattle, poultry, swine), and the manufacturing of meat for human consumption
• Includes food packaging, paper plates, cutlery, small appliances such as roasters, etc.; does not include facilities that manufacture food
• Chemicals in cigarettes, or tobacco related products, or related to the manufacturing of tobacco products
• Related to metals - manufacturing of metals, casting of metals, production of metals, surface treatment of metals, etc
• Plastic products, industry for plastics, manufacturing of plastics, plastic additives
• Rubber products (e.g. tires) and their manufacture
• Related to the manufcturing of pulp or paper products, or paper products in general
• Inert ingredients in a pesticide
• Related to the process of printing (newspapers, books media, etc), printing inks, toners, etc
• Related to photography, film, photographic equipment, photographic laboraties, photochemicals, and developing of photographs
• Accelerators, activators, oxidation agents, reducing agents, etc

Industry Uses
• Surface active agents

Consumer Uses
• Cleaning and furnishing care products

Tripotassium Citrate is the common tribasic potassium salt of citric acid, also known as potassium citrate.
Tripotassium Citrate is produced by complete neutralisation of citric acid with a high purity potassium source and subsequent crystallisation.
Tripotassium Citrate is used in foods, beverages and technical applications as buffering, sequestering or emulsifying agent.
Tripotassium Citrate usually replaces trisodium citrate whenever a low sodium content is desired.
In pharmaceuticals it is used as potassium source and as active ingredient to treat urinary duct stones.
When added to oral care products, tripotassium citrate is the active ingredient to reduce the sensitivity of the teeth.
Applications: food, beverages, personal care, cleaners & detergents, industrial applications, healthcare, feed & pet food.

Tripotassium citrate monohydrate (TPC) is the common tribasic potassium salt of citric acid, also known as potassium citrate.
Tripotassium Citrate (TPC) is used in foods, beverages, personal care and technical applications as buffering, sequestering or emulsifying agent.
Tripotassium Citrate (TPC) usually replaces trisodium citrate whenever a low sodium content is desired.

Tripotassium citrate monohydrate is the common tribasic potassium salt of citric acid, also known as potassium citrate.
Tripotassium Citrate is produced by complete neutralization of citric acid with a high purity potassium source and subsequent crystallisation.
Tripotassium citrate is used in foods, beverages, and technical applications as buffering, sequestering or emulsifying agent.
Tripotassium Citrate usually replaces trisodium citrate whenever a low sodium content is desired. In pharmaceuticals it is used as potassium source and as active ingredient to treat urinary duct stones.
When added to oral care products, tripotassium citrate is the active ingredient to reduce the sensitivity of the teeth.

Tripotassium Citrate is used in the following products:

fertilisers
biocides (e.g. disinfectants, pest control products)
laboratory chemicals
adhesives and sealants
adsorbents
air care products
coating products
fillers
putties
plasters
modelling clay
inks and toners
pH regulators and water treatment products
perfumes and fragrances
photo-chemicals
polishes and waxes
textile treatment products and dyes
washing & cleaning products
water softeners
water treatment chemicals
cosmetics and personal care products.

Tripotassium Citrate is a white, granular powder with an odorless but cooling, salty taste.
Tripotassium Citrate is a non-toxic, slightly alkaline salt with low reactivity.
Contrary to other potassium salts, Tripotassium Citrate is less bitter and thus can be used at higher concentration levels.

One of the special salts produced by our partner Jungbunzlauer, Tripotassium Citrate can be used for mineral enrichment in food, beverages, nutraceutical and pharmaceutical products, due to its superior technological and nutritional properties.

IUPAC NAMES:

potassium 2-hydroxypropane-1,2,3-tricarboxylate
Potassium citrate
potassium citrates
tri potassium citrate
Tripotassium 2-hydroxypropane-1,2,3-tricarboxylate
tripotassium 2-hydroxypropane-1,2,3-tricarboxylate
Tripotassium 3-hydroxy-3-carboxylate-1,5-pentanedicarboxylate
Tripotassium citrate
tripotassium citrate
Tripotassium Citrate
Tripotassium citrate
Trisodium 2-hydroxypropane-1,2,3-tricarboxylate
Trisodium citrate

SYNONYMS
tripotassium 2-hydroxypropane-1,2,3-tricarboxylate
tripotassiuM citrate anhydrous
sdTripotassium Citrate
HYDROXY CITRIC ACID SYNTHETIC
2-Hydroxy-1,2,3-propanetricarboxylic acid tripotassium salt
SODIUM POTASSIUM
POTASSIUM CITRATE TRIBASIC SOLUTION
Tripotassium-2-hydroxypropane-1,2,3-tricarboxylateanhydrous
Tripotassiumcitrate:forfood,E332
1,2,3-Propanetricarboxylicacid,2-hydroxy-,tripotassiumsalt
2,3-propanetricarboxylicacid,2-hydroxy-tripotassiumsalt
kajos
Potassium citrate without water
Pharmaceutical Intermediates grade potassium citrate anhydrous CAS 866-84-2
Tripotassium citrate
Pharmaceutical Intermediates grade potassium citrate anhydrous
potassiuM 2-hydroxypropane-1,2,3-tricarboxylate
Potassium Citrate Anhydrous Powder
kaliksir
porekal
potassiumcitrateanhydrous
seltz-k
POTASSIUM CITRATE
Potassium citrate tribasic solution, 1M in water
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, potassium salt (1:3)
Potassium acid citrate
Potassium Citrate anhydrous o tripotassium citrate
Potassium Citrate USP/EP/BP