VIVAPHARM PVP/VA

VIVAPHARM PVP/VA is a water-soluble, film-forming polymer that provides excellent binding, solubilizing, and stabilization properties in solid and liquid formulations.
VIVAPHARM PVP/VA is the ultimate tablet binder for all processing technologies.
VIVAPHARM PVP/VA features a spherical particle structure that provides excellent flowability, supporting uniform die filling and consistent tablet weight.

CAS Number: 25086-89-9
EC Number: 607-384-8

Synonyms: Copovidone, Poly(vinylpyrrolidone-co-vinyl acetate), PVP/VA Copolymer, VP/VA Copolymer, Vinylpyrrolidone–Vinyl Acetate Copolymer, Povidone/Vinyl Acetate Copolymer, 1-Vinyl-2-pyrrolidone/Vinyl Acetate Copolymer, Poly(1-vinyl-2-pyrrolidone-co-vinyl acetate), Vinylpyrrolidone–Vinyl Acetate Resin, VP/VA Resin, Copolyvidone, Vinylpyrrolidone Vinyl Acetate Polymer, PVP VA, VP-VA Polymer, Polyvinylpyrrolidone/Vinyl Acetate Copolymer

VIVAPHARM PVP/VA is a vinylpyrrolidone–vinyl acetate copolymer (copovidone) widely used as a pharmaceutical excipient.
VIVAPHARM PVP/VA is a water-soluble, film-forming polymer that provides excellent binding, solubilizing, and stabilization properties in solid and liquid formulations.
Due to its balanced hydrophilic–lipophilic structure, VIVAPHARM PVP/VA enhances drug dissolution and improves tablet mechanical strength while maintaining rapid disintegration.

VIVAPHARM PVP/VA is a 6:4 linear random copolymer of N-vinylpyrrolidone and vinyl acetate.
The vinyl acetate component of VIVAPHARM PVP/VA reduces the hydrophilicity and glass transition temperature (Tg) compared to povidone homopolymers of similar molecular weight.
As a result, VIVAPHARM PVP/VA is the ultimate tablet binder that extends its excellent adhesive property in wet granulation, as well as in dry granulation and direct compression.

Due to its spherical, hollow particle morphology and high plasticity, VIVAPHARM PVP/VA performs exceptionally well as a binder for direct compression.
In addition, a lower Tg makes VIVAPHARM PVP/VA an ideal polymer matrix for solid dispersions/solutions via hot melt extrusion, which enhances the dissolution of poorly soluble drug actives.
Due to its nonionic property, VIVAPHARM PVP/VA does not bear any risk of interaction with ionic APIs.

The objective of drug formulation is to develop a product that delivers therapeutic effectiveness in terms of the correct dosage and required bioavailability, while also ensuring that the final product is robust and disintegrates according to its drug release requirement.
Given the properties of an active pharmaceutical ingredient (API), formulators are often challenged with selecting the correct excipient and the appropriate technology to achieve a powder mix that has good compatibility and flow characteristics.

VIVAPHARM PVP/VA is the ultimate tablet binder for all processing technologies.
VIVAPHARM PVP/VA is a 6:4 linear random copolymer of N-vinylpyrrolidone and vinyl acetate.

The vinyl acetate component in VIVAPHARM PVP/VA reduces the hydrophilicity and glass transition temperature (Tg) compared to Povidone homopolymers of similar molecular weight.
As a result, VIVAPHARM PVP/VA is the ultimate tablet binder that extends its excellent adhesive property in wet granulation, as well as in dry granulation and direct compression.

Benefits and Applications of VIVAPHARM PVP/VA:
VIVAPHARM PVP/VA features a spherical particle structure that provides excellent flowability, supporting uniform die filling and consistent tablet weight.
VIVAPHARM PVP/VA's hollow particle morphology increases surface area, which enhances interparticle bonding and improves compressibility during tableting.

In direct compression systems, VIVAPHARM PVP/VA functions as an effective binder at typical use levels of 2–10% and demonstrates synergistic performance when combined with direct compression binder-fillers such as PROSOLV SMCC, VIVAPUR, and EMCOMPRESS.

For dry granulation processes, including roller compaction, VIVAPHARM PVP/VA can be successfully applied as a binder to improve granule strength and tablet integrity.
In wet granulation, VIVAPHARM PVP/VA's relatively low hygroscopicity allows processing of moisture-sensitive active pharmaceutical ingredients (APIs).

In hot melt extrusion, VIVAPHARM PVP/VA acts as a polymeric carrier matrix for solid dispersions or solid solutions, supported by its suitable glass transition temperature of approximately 105°C.
Additionally, VIVAPHARM PVP/VA can be used as a co-film former in film coating systems, contributing to mechanical strength and film flexibility.

Physical Properties of VIVAPHARM PVP/VA:
Soluble in water and a range of organic solvents
Less hygroscopic than povidone homopolymers of similar molecular weight
Free-flowing powder
Exhibits plastic deformation
Large surface area due to hollow, spherical particle morphology
Ideal glass transition temperature (Tg) for hot melt extrusion
Non-ionic copolymer

Stability and Reactivity of VIVAPHARM PVP/VA:

Chemical stability:
Stable under normal conditions of storage and handling.

Reactivity:
No hazardous reactions under recommended conditions of use.

Conditions to avoid:
Excessive heat.
Direct sunlight.

High humidity.
Strong oxidizing environments.

Incompatible materials:
Strong oxidizing agents.
Strong acids.

Hazardous decomposition products:
Thermal decomposition may produce carbon oxides (CO, CO₂).
Nitrogen-containing fumes.

Handling and Storage of VIVAPHARM PVP/VA:

Handling:
Avoid excessive dust formation and inhalation.
Follow good industrial hygiene practices.

Avoid contact with eyes.
Avoid prolonged skin exposure.

Storage:
Store in a cool, dry, well-ventilated area.
Keep containers tightly closed when not in use.
Protect from moisture.

Storage conditions:
Maintain in original packaging to prevent contamination and humidity uptake.

First Aid Measures of VIVAPHARM PVP/VA:

Inhalation:
Move the affected person to fresh air.
Seek medical attention if symptoms persist.

Skin contact:
Wash thoroughly with soap and water.

Eye contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do.

Ingestion:
Rinse mouth.
Seek medical advice if discomfort occurs.

Firefighting Measures of VIVAPHARM PVP/VA:

Suitable extinguishing media:
Water spray.
Foam.
Dry chemical powder.
Carbon dioxide (CO₂).

Specific hazards:
Combustion may generate carbon oxides.
Irritating fumes.

Protective equipment:
Firefighters should wear self-contained breathing apparatus.
Protective clothing.

Accidental Release Measures of VIVAPHARM PVP/VA:

Personal precautions:
Avoid generating airborne dust.
Use appropriate personal protective equipment.
Ensure adequate ventilation.

Environmental precautions:
Prevent large quantities from entering drains or waterways.

Methods for cleaning up:
Sweep or vacuum using suitable equipment.
Place in appropriate containers for disposal.
Avoid dust dispersion.

Exposure Controls / Personal Protection of VIVAPHARM PVP/VA:

Respiratory protection:
Dust mask recommended if airborne particles exceed occupational limits.

Hand protection:
Protective gloves recommended.

Eye protection:
Safety goggles advised during bulk handling.

Skin protection:
Standard protective work clothing.

Identifiers of VIVAPHARM PVP/VA:
Chemical Name: Vinylpyrrolidone–Vinyl Acetate Copolymer
Common Name: Copovidone
INCI Name: VP/VA Copolymer
CAS Number: 25086-89-9
EC Number: 607-384-8
Polymer Type: Synthetic water-soluble copolymer

Properties of VIVAPHARM PVP/VA:
Appearance: White to slightly off-white free-flowing powder
Particle Morphology: Spherical, partially hollow particles
Odor: Practically odorless
Solubility: Freely soluble in water and ethanol; soluble in isopropanol and other polar organic solvents