VIVAPHARM PVP/VA

VIVAPHARM PVP/VA is a pharmaceutical-grade vinylpyrrolidone/vinyl acetate copolymer used as a binder, film former, and solubilizing aid in solid dosage forms, and VIVAPHARM PVP/VA is valued for strong binding, good tablet hardness development, and broad compatibility with many actives and excipients.
VIVAPHARM PVP/VA is widely used in tablets, granules, and film coating systems, and VIVAPHARM PVP/VA performance depends on copolymer ratio, molecular weight, particle size, moisture content, and the chosen granulation and drying process.
VIVAPHARM PVP/VA is typically supplied as a white to off-white free-flowing powder, and VIVAPHARM PVP/VA dissolves readily in water and many alcohol/water mixtures, supporting flexible processing and robust manufacturing.

CAS Number: 25086-89-9 (PVP/VA copolymer; commonly associated)
EC Number: 607-265-0 (polymer; commonly associated)
Molecular Formula: Copolymer (vinylpyrrolidone/vinyl acetate; variable)
Molecular Weight: Copolymer (variable; grade dependent)

Synonyms: VIVAPHARM PVP/VA, VP/VA Copolymer, PVP/VA Copolymer, Vinylpyrrolidone/Vinyl Acetate Copolymer, Povidone/VA Copolymer, Copolymer of 1-Vinyl-2-pyrrolidone and Vinyl Acetate, PVP VA Binder, Pharmaceutical VP/VA, VP/VA Binder Polymer, PVP/VA Film Former, PVP/VA Tablet Binder, VP/VA Pharmaceutical Grade, VIVAPHARM PVP/VA, Vivapharm PVP/VA, PVP/VA Copolymer, Polyvinylpyrrolidone Vinyl Acetate Copolymer, Vinylpyrrolidone Vinyl Acetate Copolymer, VP/VA Copolymer, PVP-VA Copolymer, Povidone Vinyl Acetate Copolymer, Copolyvidone, Copovidone, Kollidon VA 64, Plasdone S-630, PVP/VA 64, VP/VA 64, Vinylpyrrolidone-Vinyl Acetate 64 Copolymer, N-Vinyl-2-pyrrolidone Vinyl Acetate Copolymer, 1-Vinyl-2-pyrrolidone Vinyl Acetate Copolymer, Poly(1-vinyl-2-pyrrolidone-co-vinyl acetate), Poly(N-vinylpyrrolidone-co-vinyl acetate), Polyvinylpyrrolidone-co-vinyl Acetate, PVP/VA Resin, PVP/VA Polymer, PVP/VA Binder, PVP/VA Film Former, PVP/VA Stabilizer, PVP/VA Matrix Former, PVP/VA Pharmaceutical Excipient, Copovidone Excipient, Copovidone Binder, Copovidone Film Former, Copovidone Solubilizer, Copovidone Granulation Binder, Tablet Binder PVP/VA, Pharmaceutical Grade PVP/VA, VIVAPHARM Copovidone, VIVAPHARM PVP/VA 64, VIVAPHARM PVP/VA Copolymer, VIVAPHARM VP/VA Copolymer

APPLICATIONS

VIVAPHARM PVP/VA is used as a binder in wet granulation to improve granule strength and produce robust compressible granules.
VIVAPHARM PVP/VA is incorporated into tablet formulations to improve tablet hardness and reduce friability in compatible designs.
VIVAPHARM PVP/VA is used in direct compression blends in selected applications to improve binding and reduce capping or lamination.

VIVAPHARM PVP/VA is used in film coating systems to form clear, flexible films that protect tablets and improve appearance.
VIVAPHARM PVP/VA is incorporated into immediate-release coating formulations to improve film integrity and reduce cracking.
VIVAPHARM PVP/VA is used in taste-masking coatings in selected applications to improve mouthfeel and reduce bitterness perception.

VIVAPHARM PVP/VA is used as a solubilizing aid in solid dispersions to improve dissolution of poorly soluble actives.
VIVAPHARM PVP/VA is incorporated into amorphous solid dispersions to stabilize amorphous APIs and improve bioavailability in compatible systems.
VIVAPHARM PVP/VA is used in spray-dried dispersions in selected applications where polymer selection supports stable processing and storage.

VIVAPHARM PVP/VA is used in granulation liquids as an aqueous or hydroalcoholic binder solution to support controlled granule growth.
VIVAPHARM PVP/VA is incorporated into pelletization and extrusion-spheronization processes in selected formulations to improve pellet integrity.
VIVAPHARM PVP/VA is valued because VIVAPHARM PVP/VA provides reliable binding, film formation, and solubilization support across multiple solid oral dosage technologies.

VIVAPHARM PVP/VA is used as a pharmaceutical binder in tablet formulations.
VIVAPHARM PVP/VA helps improve cohesion during tablet granulation.
VIVAPHARM PVP/VA is used in wet granulation processes.
VIVAPHARM PVP/VA supports formation of strong and uniform granules.

VIVAPHARM PVP/VA is used in direct compression tablet formulations.
VIVAPHARM PVP/VA helps improve compactibility and tablet integrity.
VIVAPHARM PVP/VA is used in film coating formulations.
VIVAPHARM PVP/VA supports smooth and uniform coating formation on tablets.

VIVAPHARM PVP/VA is used as a film-forming polymer in pharmaceutical coatings.
VIVAPHARM PVP/VA helps improve the appearance and handling strength of coated dosage forms.
VIVAPHARM PVP/VA is used in immediate-release tablets.
VIVAPHARM PVP/VA supports rapid disintegration and drug release when properly formulated.

VIVAPHARM PVP/VA is used in oral solid dosage forms.
VIVAPHARM PVP/VA helps stabilize active pharmaceutical ingredients in compatible systems.
VIVAPHARM PVP/VA is used in capsule formulations.
VIVAPHARM PVP/VA can improve powder binding and formulation consistency.

VIVAPHARM PVP/VA is used in granules and sachet formulations.
VIVAPHARM PVP/VA supports improved particle binding and flow behavior.
VIVAPHARM PVP/VA is used in pellet coating applications.
VIVAPHARM PVP/VA helps create flexible polymer films on multiparticulate systems.

VIVAPHARM PVP/VA is used in solid dispersion formulations.
VIVAPHARM PVP/VA can improve dispersion of poorly water-soluble active ingredients.
VIVAPHARM PVP/VA is used in solubility-enhancement studies.
VIVAPHARM PVP/VA supports amorphous drug stabilization in selected formulations.

VIVAPHARM PVP/VA is used in hot-melt extrusion research.
VIVAPHARM PVP/VA can act as a polymeric carrier in compatible extrusion systems.
VIVAPHARM PVP/VA is used in spray-dried pharmaceutical dispersions.
VIVAPHARM PVP/VA helps form uniform polymer-drug matrices.

VIVAPHARM PVP/VA is used in oral films.
VIVAPHARM PVP/VA provides film-forming and mechanical strength properties.
VIVAPHARM PVP/VA is used in buccal and sublingual dosage-form development.
VIVAPHARM PVP/VA supports flexible films and controlled polymer performance.

VIVAPHARM PVP/VA is used in taste-masking formulations.
VIVAPHARM PVP/VA helps create polymer barriers around unpleasant-tasting ingredients.
VIVAPHARM PVP/VA is used in pharmaceutical layering processes.
VIVAPHARM PVP/VA supports adhesion of active layers onto inert cores.

VIVAPHARM PVP/VA is used in nutraceutical tablet formulations.
VIVAPHARM PVP/VA improves binding of vitamins, minerals, and botanical ingredients.
VIVAPHARM PVP/VA is used in dietary supplement granulation.
VIVAPHARM PVP/VA supports uniform granule formation and dose consistency.

VIVAPHARM PVP/VA is used in veterinary dosage forms.
VIVAPHARM PVP/VA helps improve tablet strength and processing behavior.
VIVAPHARM PVP/VA is used in cosmetic formulations.
VIVAPHARM PVP/VA acts as a film former in selected personal care products.

VIVAPHARM PVP/VA is used in hair styling formulations.
VIVAPHARM PVP/VA helps provide hold, flexibility, and film durability.
VIVAPHARM PVP/VA is used in hair sprays and styling gels.
VIVAPHARM PVP/VA supports clear films and good styling performance.

VIVAPHARM PVP/VA is used in topical formulation development.
VIVAPHARM PVP/VA can improve film formation and ingredient distribution on the skin.
VIVAPHARM PVP/VA is used in adhesive and coating research.
VIVAPHARM PVP/VA supports polymer systems requiring water-soluble film-forming behavior.

DESCRIPTION

VIVAPHARM PVP/VA is a copolymer of vinylpyrrolidone and vinyl acetate, and VIVAPHARM PVP/VA combines the hydrophilicity and adhesion of VP with the film flexibility and reduced hygroscopicity contribution of VA.
VIVAPHARM PVP/VA forms strong interparticle bridges during drying, and this behavior explains its effectiveness as a tablet binder and granulation aid.
VIVAPHARM PVP/VA can improve API dispersion and wettability, and this supports improved dissolution for selected poorly soluble actives when used in solid dispersion approaches.

VIVAPHARM PVP/VA is typically less hygroscopic than pure PVP grades, but moisture control is still important because water content affects flow, granulation behavior, and compression performance.
VIVAPHARM PVP/VA is compatible with many excipients and APIs, but polymer-API interactions can influence stability in amorphous dispersions, so compatibility studies are required for each product.
VIVAPHARM PVP/VA should be used according to applicable pharmaceutical regulations and good manufacturing practices, including compendial testing where required.

VIVAPHARM PVP/VA should be stored in tightly closed containers in a cool, dry place to prevent moisture pickup and maintain consistent flow.
VIVAPHARM PVP/VA should be handled with dust control practices during bulk powder transfer to minimize airborne particulates.
VIVAPHARM PVP/VA should be protected from contamination and stored under controlled conditions appropriate for pharmaceutical excipients.

VIVAPHARM PVP/VA is a pharmaceutical-grade copolymer of vinylpyrrolidone and vinyl acetate.
VIVAPHARM PVP/VA is commonly known as PVP/VA copolymer.
VIVAPHARM PVP/VA is valued for its binding and film-forming properties.
VIVAPHARM PVP/VA is typically supplied as a white to off-white powder or granules.

VIVAPHARM PVP/VA is soluble or dispersible in suitable aqueous and hydroalcoholic systems.
VIVAPHARM PVP/VA combines the hydrophilic character of vinylpyrrolidone with the film flexibility of vinyl acetate.
VIVAPHARM PVP/VA provides good adhesion in tablet and coating formulations.
VIVAPHARM PVP/VA can form clear and flexible polymer films.

VIVAPHARM PVP/VA is used where a balance of binding strength and film flexibility is required.
VIVAPHARM PVP/VA can improve granule strength and reduce tablet friability.
VIVAPHARM PVP/VA can support uniform coating layers on solid dosage forms.
VIVAPHARM PVP/VA can help stabilize amorphous active ingredients in selected systems.

VIVAPHARM PVP/VA performance depends on molecular weight, copolymer ratio, viscosity, and formulation design.
VIVAPHARM PVP/VA performance also depends on solvent system, processing method, and active ingredient compatibility.
VIVAPHARM PVP/VA may be used with fillers, disintegrants, plasticizers, pigments, and other excipients.
VIVAPHARM PVP/VA is selected when reliable pharmaceutical polymer performance is needed.

VIVAPHARM PVP/VA should be stored in tightly closed containers.
VIVAPHARM PVP/VA should be protected from moisture, heat, and contamination.
VIVAPHARM PVP/VA should be handled under appropriate pharmaceutical manufacturing conditions.
VIVAPHARM PVP/VA should be used according to supplier specifications and regulatory requirements.

VIVAPHARM PVP/VA quality may be defined by viscosity, residual monomers, water content, appearance, and compendial compliance.
VIVAPHARM PVP/VA is important in tablets, granules, coatings, solid dispersions, and film-based dosage forms.
VIVAPHARM PVP/VA is valued for combining binder efficiency, film formation, and formulation compatibility.
VIVAPHARM PVP/VA supports consistent manufacturing of pharmaceutical and nutraceutical products.

PROPERTIES

Common Name: VIVAPHARM PVP/VA
Chemical Type: Pharmaceutical excipient; binder; film former; solubilizing polymer
Appearance: White to off-white free-flowing powder
Odor: Odorless
Solubility: Soluble in water; soluble in many alcohol/water mixtures; limited solubility in some organic solvents
Glass Transition Temperature: Grade dependent; important for solid dispersion stability
Hygroscopicity: Moderate; generally lower than PVP homopolymer, grade dependent
Viscosity: Grade dependent; affects binder solution performance
Particle Size: Grade dependent; affects flow and blending
Stability: Stable under normal dry storage; moisture sensitive
Storage Temperature: 15–25°C, tightly closed, dry
Shelf Life: Typically 24–48 months in original sealed packaging (supplier dependent)

FIRST AID

Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory irritation persists.
Avoid breathing dust during powder handling.

Skin Contact:
Wash with soap and water after contact.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops or persists.

Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.

Ingestion:
Rinse mouth with water.
Seek medical attention if discomfort occurs.
Never give anything by mouth to an unconscious person.

Note to Physicians:
Treat symptomatically.
No specific antidote is required.
Provide supportive care as needed.

HANDLING AND STORAGE

Handling:
Use appropriate PPE including gloves and safety glasses for bulk handling.
Avoid generating dust and avoid inhalation of fine powder.
Use clean, dry, GMP-compliant equipment and controlled handling for pharmaceutical manufacturing.

Ventilation:
Use general ventilation for normal handling.
Use local exhaust where dust may be generated during powder transfer.
Minimize airborne particulate accumulation in enclosed areas.

Storage:
Store in tightly closed containers in a cool, dry place.
Protect from moisture to maintain flow and prevent caking.
Keep containers properly labeled and protected from contamination.

Spill and Leak Procedures:
Sweep up spilled powder and avoid dust generation.
Collect into suitable containers for reuse or disposal according to GMP procedures.
Clean residues with water if needed and dry the area to prevent slip hazards.

Handling Precautions:
Control moisture exposure because VIVAPHARM PVP/VA properties and processing behavior depend on water content.
Optimize binder solution concentration because viscosity and granulation performance depend on polymer grade and solids level.
Rotate stock using FIFO practices and follow GMP documentation to maintain consistent excipient quality.