PRODUCTS

1-CYCLOHEXYLAMINE

1-Cyclohexylamine is an organic compound, belonging to the aliphatic amine class.
1-Cyclohexylamine is a colorless liquid, although, like many amines, samples are often colored due to contaminants.
1-Cyclohexylamine has a fishy odor and is miscible with water.
Like other amines, it is a weak base, compared to strong bases such as NaOH, but it is a stronger base than its aromatic analog, aniline.

IUPAC name: Cyclohexanamine
CAS Number: 108-91-8
EC Number: 203-629-0
Chemical formula: C6H13N

1-Cyclohexylamine is a useful intermediate in the production of many other organic compounds (e.g. cyclamate)

Preparation of 1-Cyclohexylamine:
1-Cyclohexylamine is produced by two routes, the main one being the complete hydrogenation of aniline using some cobalt- or nickel-based catalysts:

C6H5NH2 + 3 H2 → C6H11NH2
1-Cyclohexylamine is also prepared by alkylation of ammonia using cyclohexanol.

1-Cyclohexylamine is used as an intermediate in synthesis of other organic compounds.
1-Cyclohexylamine is the precursor to sulfenamide-based reagents used as accelerators for vulcanization.
1-Cyclohexylamine is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators).
The amine itself is an effective corrosion inhibitor. The herbicide hexazinone and the anesthetic hexylcaine are derived from 1-Cyclohexylamine.
1-Cyclohexylamine has been used as a flushing aid in the printing ink industry.

Toxicity of 1-Cyclohexylamine:
1-Cyclohexylamine has a low acute toxicity with LD50 (rat; p.o.) = 0.71 ml/kg Like other amines, it is corrosive.

1-Cyclohexylamine is listed as an extremely hazardous substance as defined by Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act.
The National Institute for Occupational Safety and Health has suggested workers not be exposed to a recommended exposure limit of over 10 ppm (40 mg/m3) over an eight-hour workshift.

1-Cyclohexylamine appears as a clear colorless to yellow liquid with an odor of ammonia.
Flash point 90 °F.
Irritates the eyes and respiratory system.
Skin contact may cause burns.
Less dense than water.
Vapors heavier than air.
Toxic oxides of nitrogen produced during combustion.

1-Cyclohexylamine is a primary aliphatic amine consisting of cyclohexane carrying an amino substituent.
1-Cyclohexylamine has a role as a human xenobiotic metabolite and a mouse metabolite.
1-Cyclohexylamine is a conjugate base of a cyclohexylammonium.

1-Cyclohexylamine is a natural product found in Zanthoxylum asiaticum and Phaseolus vulgaris with data available.

Aplications of 1-Cyclohexylamine:
Agriculture,
Catalysis and Chemicals Processing,
Chemical synthesis,
Dyestuffs, pigments and optical brighteners,
Food industry and auxiliaries,
Hardener and crosslinking agents for polymers,
Industrial Water Treatment,
Lubricants and oils,
Manufacturing of diabetics,
Manufacturing of herbicides and pesticides,
Manufacturing of insecticides / acaricides,
Manufacturing of pharmaceutical agents,
Manufacturing of sweeteners,
Manufacturing of textile dyestuffs,
Petroleum,
Polymer auxiliaries,
Polymers, Polymerisation initiator,
Specialities, Stabilizers for explosives.

Widespread uses by professional workers
1-Cyclohexylamine is used in the following products: water treatment chemicals, pH regulators and water treatment products, laboratory chemicals and metal working fluids.
1-Cyclohexylamine is used in the following areas: municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and offshore mining.
1-Cyclohexylamine is used for the manufacture of: Release to the environment of 1-Cyclohexylamine can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.
Other release to the environment of 1-Cyclohexylamine is likely to occur from: indoor use as processing aid, outdoor use as processing aid and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).

Formulation or re-packing of 1-Cyclohexylamine:
1-Cyclohexylamine is used in the following products: pH regulators and water treatment products and water treatment chemicals.
Release to the environment of 1-Cyclohexylamine can occur from industrial use: formulation of mixtures.

Uses at industrial sites of 1-Cyclohexylamine:
1-Cyclohexylamine is used in the following products: water treatment chemicals, pH regulators and water treatment products, laboratory chemicals and metal working fluids.
1-Cyclohexylamine has an industrial use resulting in manufacture of another substance (use of intermediates).
1-Cyclohexylamine is used in the following areas: municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and offshore mining.
1-Cyclohexylamine is used for the manufacture of: and chemicals.
Release to the environment of 1-Cyclohexylamine can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release and as processing aid.

XLogP3: 1.5
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 0

Exact Mass: 99.104799419
Monoisotopic Mass: 99.104799419
Topological Polar Surface Area: 26 Å²
Heavy Atom Count: 7

Complexity: 46.1
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

1-Cyclohexylamine showed dose dependent kinetics after administration of single oral doses of 35, 200, or 500 mg/kg in rats, with a reduction in plasma clearance from 37 to 24 ml/min/kg, an increase in apparent half-life from 11.8 to 12 hr, and an increased area under the testicular concentration vs time curve.
Saturation of 1-Cyclohexylamine uptake by rat renal cortical slices in vitro and of renal tubular secretion in vivo occurred at concentrations and doses comparable to the oral dose studies.

1-Cyclohexylamine clearance from a 10 mg/kg infusion was 2.58 + or - 1.13 ml/min and from a 200 mg/kg infusion, 2.49 + or - 1.65 ml/min. The 1-Cyclohexylamine to inulin clearance ratios were 2 at a dose of 10 mg/kg and 1.23 at a dose of 200 mg/kg.
During chronic dietary administration the concentrations of 1-Cyclohexylamine in the plasma and testes showed a pronounced diurnal variation in rats, reaching a peak concentration at the end of the dark cycle at 6 AM (6.3 + or - 1.5 ug/ml in plasma an 45.7 + or - 3.4 ug/g in testes.

The lowest concentrations of 1-Cyclohexylamine were at 9 PM (1.5 + of - 0.5 ug/ml in plasma and 10.9 + or - 3.6 ug/g in testes). The steady state plasma clearance was 33 ml/min/kg.
The concentrations of 1-Cyclohexylamine in the plasma and testes of rats showed a nonlinear relationship to dietary intake.
Elevated concentrations were found at intake greater than 200 mg/kg/day.

After oral admin (0.2 g/kg) to rabbits, 1-Cyclohexylamine gave rise to unchanged 1-Cyclohexylamine & N-hydroxy1-Cyclohexylamine in the urine.
When C14-labeled 1-Cyclohexylamine was admin, 68% of the radioactivity was recovered in the urine after 60 hr.
A small amount (0.5%) was eliminated in the breath & 45% of the admin dose was shown to be excreted in the urine as unconjugated 1-Cyclohexylamine, 0.2% as N-hydroxy1-Cyclohexylamine in conjugated form, & 2.5% as cyclohexanone oxime.
The authors postulated the latter metabolite to be an artifact formed form the glucuronide of N-hydroxy1-Cyclohexylamine during the hydrolysis procedure.

The metabolites identified indicated that in rats, the metabolism of 1-Cyclohexylamine was mainly through hydroxylation of the cyclohexane ring, in man by deamination & in guinea pigs & rabbits by ring hydroxylation & deamination.
The metabolites to 1-Cyclohexylamine were excreted in both free & conjugated forms.

Most of the 1-Cyclohexylamine given by gavage or intraperitoneal injection to rats and guinea pigs was excreted unchanged, and only 4-5% was metabolized within 24 hours.
In rabbits, 30% was metabolized.
1-Cyclohexylamine has been reported to be metabolized further to cyclohexanone and then to cyclohexanol in guinea pigs, rabbits and rats.
A number of hydroxylated products of 1-Cyclohexylamine have been reported in these species, which were excreted in part as glucuronides.

Orally administration cyclamate appears to be readily absorbed by rabbits but less readily by guinea pigs, rats and humans.
All of these species convert cyclamate to 1-Cyclohexylamine, via the action of gastrointestinal microflora on unabsorbed cyclamate.
The metabolism of 1-Cyclohexylamine to other products differs somewhat in humans and other species, although most 1-Cyclohexylamine is rapidly excreted unchanged in the urine.
In rats, it is metabolized mainly by hydroxylation of the cyclohexane ring; in humans, it is metabolized by deamination; and in guinea pigs and rabbits, it is metabolized by ring hydroxylation and deamination.

Mice were fed 1-Cyclohexylamine (as the hydrochloride) at a constant intake of 400 mg/kg/day for 13 weeks.
Food intake and body weight gain were not affected.
The metabolism of (14)C labeled 1-Cyclohexylamine administered as a single oral dose (2 uCi per mouse) was not significantly different among animals chronically fed 1-Cyclohexylamine for 0, 3, 7, or 13 weeks.
The major metabolite produced was 3-aminocyclohexanol; total metabolism was less than 2%. ... Concentrations of 1-Cyclohexylamine in plasma (ug/ml) after 3 weeks feeding were 0.20; after 7 weeks 0.18; and after 13 weeks, 4.51 + or - 2.94. Concentrations of the chemical in testes (ug/g wet weight) varied from 6.81 + or - 5.21 at 3 weeks to 4.51 + or - 2.94 at 13 weeks. /1-Cyclohexylamine hydrochloride/

Wistar and DA rats were fed 1-Cyclohexylamine (as the hydrochloride) at constant intake of 400 mg/kg/day for 13 weeks.
The metabolism of (14)C-labeled 1-Cyclohexylamine administered as a single oral dose (8 uCi per rat) was similar for both strains of rat, with no consistent effect due to age or prolonged feeding with 1-Cyclohexylamine.
However, there was reduced elimination of (14)C in the treated Wistar and DA rats compared to that in the controls during the first 6 hr after dosing; the difference was statistically significant at 3 weeks in both strains and at 13 weeks in the DA strain.

The major metabolites produced were 3- and 4-aminocyclohexanols; at 13 weeks the total metabolism was 17% to 18% for the Wistar rats, 4% to 6% in the DA rats.
After 13 weeks, testicular atrophy was demonstrated in both strains of rat fed 1-Cyclohexylamine; DA rats appeared more sensitive to testicular toxicity than the Wistar rats.
Concentrations of 1-Cyclohexylamine and its metabolites in plasma and in testicular tissue were higher in Wistar rats than in DA rats.

1-Cyclohexylamine can be formed to a variable extent by microbial biotransformation of cyclamate in the gastrointestinal tract of all species studied; after absorption, it is further metabolized to several compounds that are excreted in the urine.

Biological Half-Life of 1-Cyclohexylamine
1-Cyclohexylamine showed dose dependent kinetics after administration of single oral doses of 35, 200 or 500 mg/kg in mice, with a reduction in plasma clearance from 61 to 53 ml/min/kg, an increase in apparent half-life from 1.4 to 3.5 hr, and an increased area under the testicular concentration vs time curve.
During chronic dietary administration the concentrations of 1-Cyclohexylamine in the plasma and testes showed little diurna variation. The steady state plasma clearance was 65 ml/min/kg.
The concentrations of 1-Cyclohexylamine in the plasma and testes of the mice showed a linear relationship to dietary intake, even at the highest intake, about 900 mg/kg/day.

1-Cyclohexylamine is produced by two routes, the main one being hydrogenation of aniline using cobalt or nickel catalysts:
1-Cyclohexylamine is a useful intermediate in the production of many other organic compounds.
1-Cyclohexylamine is also prepared by alkylation of ammonia using cyclohexanol.
1-Cyclohexylamine is used as an intermediate in synthesis of other organic compounds.
1-Cyclohexylamine is the precursor to sulfenamide-based reagents used as accelerators for vulcanization.

1-Cyclohexylamine is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators).
The amine itself is an effective corrosion inhibitor.
Some sweeteners are derived from this amine, notably cyclamate. The herbicide hexazinone is derived from 1-Cyclohexylamine.
1-Cyclohexylamine 1-Cyclohexylamine is an organic compound, belonging to the aliphatic amine class.

1-Cyclohexylamine is a colorless liquid, although like many amines, samples are often colored due to contaminants.
1-Cyclohexylamine has a fishy odor and is miscible with water.
Like other amines, it is a weak base, compared to strong bases such as NaOH, but it is a stronger base than its aromatic analog, aniline.
1-Cyclohexylamine is flammable, with flash point at 28.6 °C.
1-Cyclohexylamine is toxic by both ingestion and inhalation; the inhalation itself may be fatal.

1-Cyclohexylamine readily absorbs through skin, which it irritates.
1-Cyclohexylamine is corrosive.
1-Cyclohexylamine is listed as an extremely hazardous substance as defined by Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act.
1-Cyclohexylamine has been used as a flushing aid in the printing ink industry.
1-Cyclohexylamine In regards to occupational exposures, the National Institute for Occupational Safety and Health has suggested workers not be exposed to a recommended exposure limit of over 10 ppm (40 mg/m) over an eight-hour workshift.

1-Cyclohexylamine is a food contaminant arising from its use as a boiler water additive 1-Cyclohexylamine, also called hexahydroaniline, 1-aminocyclohexane, or aminohexahydrobenzene, is an organic chemical, an amine derived from cyclohexane.
1-Cyclohexylamine is a clear to yellowish liquid with fishy odor, with melting point of 17.7 ¬∞C and boiling point 134.5 ¬∞C, miscible with water.
Like other amines, it is of mildly alkaline nature, compared to strong bases such as NaOH, but it is a stronger base than its aromatic sister compound aniline, which differs only in that its ring is aromatic.

1-Cyclohexylamine is flammable, with flash point at 28.6 ¬∞C. Explosive mixtures with air can be formed above 26 ¬∞C. It is toxic by both ingestion and inhalation; the inhalation itself may be fatal.
1-Cyclohexylamine readily absorbs through skin, which it irritates.
1-Cyclohexylamine is corrosive.
1-Cyclohexylamine is listed as an extremely hazardous substance as defined by Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act.

Belongs to the class of organic compounds known as 1-Cyclohexylamines.
These are organic compounds containing a 1-Cyclohexylamine moiety, which consist of a cyclohexane ring attached to an amine group.

1-Cyclohexylamine is used in the manufacturing of chemical intermediates, insecticide intermediates, rubber accelerators, water treatment chemicals and corrosion inhibitors.
1-Cyclohexylamine is a primary aliphatic amine consisting of cyclohexane carrying an amino substituent.

1-Cyclohexylamine is a colorless organic liquid having a substituent of an amine group.
1-Cyclohexylamine is used in low-pressure boilers where the condensate works for a longer period of time.

1-Cyclohexylamine is used especially for the industrial water treatment, for the production of cure accelerator, for the manufacturing of synthetic sweeteners and in a rubber industry for 1-Cyclohexylamineion of vulcanisation accelerators.
1-Cyclohexylamine is typically used as an intermediate in synthesis for different herbicides, antioxidants and pharmaceuticals.

1-Cyclohexylamine is a colorless organic liquid having a substituent of an amine group.
1-Cyclohexylamine is used in low-pressure boilers where the condensate works for a longer period of time.

1-Cyclohexylamine can remain along with condensate steam at various steam pressures which cannot be done with other neutralizing amines.
1-Cyclohexylamine is a metabolite of cyclamate and has been found to be useful in production of other organic compounds.

On the basis of end user demands and desires, industrial 1-Cyclohexylamine can be utilized for various respective applications for various respective industries like agriculture, rubber, food, oil, pharma, petroleum and textile industries.

1-Cyclohexylamine Market size has foreseen dynamic growth owing to 1-Cyclohexylamine increased usage as a corrosion inhibitor for boiler water treatment plants and low corrosion inhibitor in oil field production where high alkalinity is preferred.
1-Cyclohexylamine is also used in manufacturing of several synthetic chemicals which include acid gas absorbents, dry cleaning soaps, emulsifying agents, plasticizers and insecticides.

1-Cyclohexylamine is also used in rubber industry for manufacturing of vulcanization accelerators.
Moreover, increasing use in making synthetic sweeteners and for industrial water treatments will further augment the industry growth.
Some other amines, especially morpholine is replacing 1-Cyclohexylamine demand in water boiler treatment may act as a restraint for industrial 1-Cyclohexylamine market over the forecasted period of time.

1-Cyclohexylamine generally is found from wood plant of toddalia asiatica.
1-Cyclohexylamine is a strong base and a flammable liquid.

1-Cyclohexylamine is manufactured by the catalyst hydrogenation of aniline at high pressure and temperature by the reduction of nitrocyclohexane or by the ammonolysis of cyclohexanol.
1-Cyclohexylamine is colourless or yellowish colour liquid with odour of ammonia or fish.
1-Cyclohexylamine is also referred as Hexahydroaniline, Aminohexahydrobenzene, Aminocyclohexane and Cyclohexanamine.

1-Cyclohexylamine has a melting and boiling plant at 17.7 ºC and 134.5 ºC respectively.
Like all other amines 1-Cyclohexylamine has a weak base when compared to other strong bases including NaOH and has a stronger base than aniline, which differs only in than 1-Cyclohexylamine ring in aromatic.

1-Cyclohexylamine also has some health hazardous effects including toxic and caustic.
1-Cyclohexylamine also cause irritation in eyes and also there is possible risk of impaired fertility.

On the basis of 1-Cyclohexylamine application, industrial 1-Cyclohexylamine market can be segmented into artificial sweeteners, corrosion inhibitors, accelerators in rubber industry, water treatment industry.
1-Cyclohexylamine is also used in manufacturing several synthetic chemicals, including acid gas absorbents, dry cleaning soaps, dyes, emulsifying agents, plasticizers and insecticides.

Among these, water treatment industry hold a major share in application segment.
Upsurge in use of rubber in various end uses is likely to drive 1-Cyclohexylamine market over the estimated years.

Industrial 1-Cyclohexylamine market can be divided on the basis of end user industry into agriculture, chemical, dyes & pigments, rubber, food, oil, pharmaceutical, petroleum and textile industries.
Amongst, chemical synthesis and rubber industry holds a maximum portion in end user industry segment and is considered to remain the same during the forecasted years.

North America industrial 1-Cyclohexylamine market will witness significant growth due to presence of substantial number of industries in the region.
Rising research & development activities in the region will provide positive outlook to the industry growth.

Upsurge in chemical and pharmaceutical industries will be the key reasons for propelling the future growth.
Boom in shale gas & oil in the U.S. may have a positive effect on the industry market.

Europe industrial 1-Cyclohexylamine market is the second biggest market and the region will observe the same strong trend over the estimated years.
Rise in automotive industries has raised the demand for tyres, thereby impelling the industry demand.
Propagating textile and chemical sector in the region will further enhance the market.

Asia Pacific industrial 1-Cyclohexylamine market is the fastest growing region owing to rapid industrialization & urbanization and expanding textile & pharmaceutical industries.
Increasing number of water treatment plants owing to growing population will boost the industry demand.
Also, upsurge in chemical activities in various countries in the region will support the market.

1-Cyclohexylamine is an organic compound, belonging to the aliphatic amine class.
1-Cyclohexylamine is a colorless liquid, although, like many amines, samples are often colored due to contaminants.

1-Cyclohexylamine has a fishy odor and is miscible with water.
Like other amines, 1-Cyclohexylamine is a weak base, compared to strong bases such as NaOH, but 1-Cyclohexylamine is a stronger base than 1-Cyclohexylamine aromatic analog, aniline.

Uses of 1-Cyclohexylamine:
In organic synthesis, manufacture of insecticides, plasticizers, corrosion inhibitors, rubber chemicals, dyestuffs, emulsifying agents, dry-cleaning soaps, acid gas absorbents.

1-Cyclohexylamine is used in the manufactureof a number of products, including plasticizers, drycleaning soaps, insecticides, andemulsifying agents.
1-Cyclohexylamine is also used as a corrosion inhibitor and in organic synthesis.

Production of rubber processing chemicals.
Corrosion inhibitor in boiler feed water.

Production of insecticides, plasticizers, and dry cleaning soaps.
A metabolite of the sweetener cyclamate

1-Cyclohexylamine can be used as the vulcanization accelerator of rubber; and also used as the raw material of synthetic fibers, dyes, and gaseous-phase corrosion inhibitor.
1-Cyclohexylamine can be used for the manufacture of dyes, softener VS and drugs such as Antiradon, thio-TEPA and solaziquone.

1-Cyclohexylamine can also be used in medicine, pesticides.
1-Cyclohexylamine is the intermediate of herbicides “Hexazinone” as well as the intermediate of rubber accelerators, oil additives, and corrosion inhibitors.

1-Cyclohexylamine can be used for the preparation of cyclohexanol, cyclohexanone, caprolactam, cellulose acetate and nylon 6 and the like.
1-Cyclohexylamine itself is a solvent and can be used in resins, paints, fat, and paraffin oils.

1-Cyclohexylamine can also be used for making desulfurization agent, rubber antioxidant, vulcanization accelerator, chemical auxiliaries of plastics and textile, the treatment agent of boiler feed water, metal corrosion inhibitors, emulsifiers, preservatives, anti-static agents, latex coagulants, oil additives , fungicides, pesticides and dye intermediates.
The sulfonate salt of 1-Cyclohexylamine can be used as artificial sweeteners for being applied to foods, beverages and pharmaceuticals.

1-Cyclohexylamine can be used in organic synthesis, plastic synthesis, also used as a preservative and acid gas absorbent.
1-Cyclohexylamine can be used for the production of water treatment chemicals, artificial sweeteners, and the intermediate of rubber processing chemicals and agrochemicals.
1-Cyclohexylamine can be used as acidic gas absorbent for organic synthesis.

Industrial uses of 1-Cyclohexylamine:
The primary use of 1-Cyclohexylamine is as a corrosion inhibitor in boiler water treatment and in oil field applications.
1-Cyclohexylamine is also a chemical intermediate for rubber processing chemicals, dyes, cyclamate artificial sweeteners and herbicides and a processing agent for nylon fiber production.
Windholz et al (1983) reports 1-Cyclohexylamine use in the manufacture of insecticides, plasticizers, emulsifying agents, dry-cleaning soaps, and acid gas absorbents.

Applications of 1-Cyclohexylamine:
1-Cyclohexylamine is used as an intermediate in synthesis of other organic compounds.
1-Cyclohexylamine is the precursor to sulfenamide-based reagents used as accelerators for vulcanization.

1-Cyclohexylamine is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators).
The amine itself is an effective corrosion inhibitor.

Some sweeteners are derived from this amine, notably cyclamate.
The herbicide hexazinone and the anesthetic hexylcaine are derived from 1-Cyclohexylamine

Applications Areas of 1-Cyclohexylamine:
1-Cyclohexylamine is used especially for the industrial water treatment, for the production of cure accelerator, for the manufacturing of synthetic sweeteners and in a rubber industry for 1-Cyclohexylamineion of vulcanisation accelerators.

Preparation of 1-Cyclohexylamine:
1-Cyclohexylamine is produced by two routes, the main one being the complete hydrogenation of aniline using some cobalt- or nickel-based catalysts:
C6H5NH2 + 3 H2 → C6H11NH2

1-Cyclohexylamine is also prepared by alkylation of ammonia using cyclohexanol.
1-Cyclohexylamine is a useful intermediate in the production of many other organic compounds (e.g cyclamate)

Production method of 1-Cyclohexylamine:
1-Cyclohexylamine is derived from the catalyzed hydrogenation of aniline.
The process can be divided into normal pressure method and reduced pressure method.
In addition, other routes such as the catalytic aminolysis of either cyclohexane or cyclohexanol, the reduction of nitro cyclohexane, and the catalyzed aminolysis of cyclohexanone can also be applied for produce 1-Cyclohexylamine.

The preparation method is using aniline as raw materials and going through catalytic hydrogenation.
Mix the aniline vapor and hydrogen gas and pour into the catalytic reactor.
Carry out the hydrogenation reaction at 130 to 170 ℃ in the presence of a cobalt catalyst with the finished product obtained after cooling and further distillation.

Reactivity Profile of 1-Cyclohexylamine:
1-Cyclohexylamine neutralizes acids in exothermic reactions to form salts plus water.
May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Chemical Properties of 1-Cyclohexylamine:
1-Cyclohexylamine is colorless liquid with an unpleasant odor.
1-Cyclohexylamine is miscible with various kinds of organic solvents.

1-Cyclohexylamine is a derivative of ammonia in which one of the hydrogen atoms has been replaced with a six-carbon, saturated ring.
1-Cyclohexylamine is a very strong base and forms salts with all acids, including carbon dioxide which 1-Cyclohexylamine rapidly absorbs from the air.

1-Cyclohexylamine undergoes the usual reaction of aliphatic amines with carbon disulfide to form dithiocarbamates.
1-Cyclohexylamine reacts with long-chain fatty acids to form soaps (Carswell and Morrill 1937).

With nitrous acid, 1-Cyclohexylamine forms cyclohexanol with the release of nitrogen (Schweizer 1978).
1-Cyclohexylamine reacts with organic compounds containing an active halogen atom, acid anhydrides, and alkylene oxides to replace one or both hydrogens on the nitrogen atom.

1-Cyclohexylamine attacks all copper alloys and lead.
When hot, 1-Cyclohexylamine attacks aluminum very slowly.

Other names:
108-91-8
Aminocyclohexane
Hexahydroaniline
Hexahydrobenzenamine
Aminohexahydrobenzene
Cyclohexyl amine
1-1-Cyclohexylamine
1-Aminocyclohexane
Aniline, hexahydro-
Benzenamine, hexahydro-
Aminocylcohexane
cyclohexyl-amine
1-AMINO-CYCLOHEXANE
CCRIS 3645
HSDB 918
cyclohexaneamine
UNII-I6GH4W7AEG
1-Cyclohexylamine.HCl
I6GH4W7AEG
157973-60-9
CHEBI:15773
MFCD00001486
CAS-108-91-8
HAI
EINECS 203-629-0
UN2357
BRN 0471175
cylohexylamine
cyclohexylarnine
cyclo-hexylamine
AI3-15323
cyclohexane-amine
n-1-Cyclohexylamine
cyclohexanyl amine
Hexahydro-Aniline
mono1-Cyclohexylamine
4-1-Cyclohexylamine
1-Cyclohexylamine,(S)
Hexahydro-Benzenamine
Cyclohexanamine, 9CI
CyNH2
bmse000451
EC 203-629-0
BIDD:ER0290
GTPL5507
CHEMBL1794762
DTXSID1023996
BDBM81970
BCP30928
Tox21_202380
Tox21_300038
STK387114
ZINC12358775
AKOS000119083
UN 2357
VS-0326
NCGC00247889-01
NCGC00247889-02
NCGC00253922-01
NCGC00259929-01
AM802905
BP-21278
CAS_108-91-8
NCI60_004907
FT-0624217
EN300-16958
C00571
J-002206
J-520164
Q1147539
F2190-0381