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An amine combining a primary, secondary, and ter- tiary amine in one molecule.
2-piperazin-1-ylethylamine appears as a colorless liquid with a faint fishlike odor.
Flash point 199 °F. Corrosive to tissue. Toxic oxides of nitrogen are produced by combustion.
CAS: 140-31-8
MF: C6H15N3
MW: 129.2
EINECS: 205-411-0
Synonyms
LABOTEST-BB LTBB000498;AMINOETHYLPIPERAZINE;AKOS BBS-00004342;AEP;2-(1-PIPERAZINYL)ETHYLAMINE;1-piperazineethanamine;2-PIPERAZINOETHYLAMINE;2-PIPERAZIN-1-YL-ETHYLAMINE
2-piperazin-1-ylethylamine is a derivative of piperazine.
2-piperazin-1-ylethylamine contains three nitrogen atoms; one primary, one secondary and one tertiary.
2-piperazin-1-ylethylamine is a corrosive organic liquid and can cause second or third degree burns.
2-piperazin-1-ylethylamine can also cause pulmonary edema as a result of inhalation.
2-piperazin-1-ylethylamine is REACH and TSCA registered.
2-piperazin-1-ylethylamine is a chemical compound that can be used as an environmentally friendly catalyst for the degradation of ethylene diamine and other amines.
2-piperazin-1-ylethylamine has been shown to be stable under alkaline conditions, and its fluorescence probe has been used to monitor the progress of the reaction.
2-piperazin-1-ylethylamine is a coordination complex with nitrogen atoms at the corners of a square and two amines at opposite corners of the square.
The amine groups are coordinated to metal ions in a geometry that is determined by the atomic number of the metal ion.
Disulfide bonds form between two cysteine residues on adjacent chains.
Glycol ethers can also form disulfide bonds with 2-piperazin-1-ylethylamine, forming glycol ether-NAPE complexes.
Antibodies have been shown to bind to glycol ether-2-piperazin-1-ylethylamine complexes, suggesting that these complexes may play a role in antibody response, although experimental solubility data have not yet confirmed this
2-piperazin-1-ylethylamine is a cyclic ethyleneamine, it is a single-component product that is clear and colorless and has an ammonia-like odor.
2-piperazin-1-ylethylamine's molecular formula is C6H15N3.
2-piperazin-1-ylethylamine Chemical Properties
Melting point: -19 °C
Boiling point: 218-222 °C(lit.)
Density: 0.985 g/mL at 25 °C(lit.)
Vapor density: 4.4 (vs air)
Vapor pressure: 0.05 mm Hg ( 20 °C)
Refractive index: n20/D 1.500
Fp: 200 °F
Storage temp.: Store below +30°C.
Solubility: >1000g/l
Form: Liquid
pka: 10.11±0.10(Predicted)
Color: Clear colorless to slightly yellow
PH: 12 (100g/l, H2O, 20℃)
Explosive limit: 2.1-10.5%(V)
Water Solubility: soluble
Sensitive: Air Sensitive
BRN: 104363
Stability:: Stable. Flammable. Incompatible with acids, acid anhydrides, acid chlorides, strong oxidizing agents, chloroformates.
LogP: -1.48 at 20℃
CAS DataBase Reference: 140-31-8(CAS DataBase Reference)
NIST Chemistry Reference: 2-piperazin-1-ylethylamine(140-31-8)
EPA Substance Registry System: 2-piperazin-1-ylethylamine (140-31-8)
2-piperazin-1-ylethylamine is a combustible and corrosive aliphatic amine.
2-piperazin-1-ylethylamine is a colorless to light yellow viscous liquid.
Uses
2-piperazin-1-ylethylamine is utilized in a variety of reactions for studying corrosion inhibition, biological activity and metal ligand effects on catalysis.
2-piperazin-1-ylethylamine is used for epoxy curing, surface activation, and as an asphalt additive.
2-piperazin-1-ylethylamine is used in lube oil and fuel additives, mineral processing aids, polyamide resins, urethane chemicals, wet strength resins.
Uses include inhibition of corrosion, surface activation, and as an asphalt additive.
As AEP is alkaline and carbon dioxide is weakly acidic, 2-piperazin-1-ylethylamine has been researched as a carbon dioxide sequestrant.
2-piperazin-1-ylethylamine is part of ongoing research in Carbon capture and storage.
Preparation
He synthesis of N-(2-aminoethyl) piperazine from PZ and MEA in the presence of CO2 was conducted using a method similar to that of thermal degradation experiments.
7 m PZ/2 m MEA with 0.3 mol CO2 /mol alkalinity was placed in ?-inch OD 316 stainless steel thermal cylinders , which were then sealed and placed in a convection oven held at 150 °C.
Cylinders were removed periodically and samples were analyzed using ion chromatography.
Production
2-piperazin-1-ylethylamine is reacted with ammonia as a main method of production.
This process produces various ethylene amines which can then be purified by distillation.
These include ethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, other higher homologues and aminoethyl piperazine.
2-piperazin-1-ylethylamine is also manufactured by reacting ethylenediamine or ethanolamine/ammonia mixtures over a catalyst.
Reactivity Profile
2-piperazin-1-ylethylamine neutralizes acids to form salts plus water in exothermic reactions.
May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.
