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Acesulfame potassium is approved for use in food as a sweetener.
Acesulfame potassium is included in the ingredient list on the food label as acesulfame K, acesulfame potassium, or Ace-K.
Acesulfame potassium is regulates as a food additive.
CAS Number: 55589-62-3
Molecular Formula: C4H4KNO4S
Molecular Weight: 201.24
EINECS Number: 259-715-3
Synonyms: Acesulfame potassium, 55589-62-3, Acesulfame K, potassium 6-methyl-4-oxo-4H-1,2,3-oxathiazin-3-ide 2,2-dioxide, 6-Methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide potassium salt, Acesulfame (potassium), Acesulfame-K, Potassium acesulfame, Otizon, Acesulfame-potassium, Potassium acesulfamate, potassium;6-methyl-2,2-dioxo-1-oxa-2lambda6-thia-3-azanidacyclohex-5-en-4-one, Acesulfame potassium salt, DTXSID1030606, Sunett d, E 950, NCGC00090729-01, DTXCID9010606, Acesulfame potassium (NF), INS NO.950, INS-950, Potassium 6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide, CAS-55589-62-3, 1,2,3-Oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt, NSC-760104, E950, E-950, Acesulfamepotassium, MFCD00043833, 761 - Sweeteners, MLS006010910, Acesulfame potassium 1000 microg/mL in Acetonitrile, CHEMBL1351474, HY-D0195R, Acesulfame K, analytical standard, 517 - Dilutable/Ready to drink, CHEBI:184415, Acesulfame (potassium) (Standard), HMS3264B22, HY-D0195, Tox21_111001, Tox21_202423, Tox21_303370, 516 - Carbonated Drink (degassed), AKOS016015051, AKOS025310719, 1ST5101, CCG-213614, NCGC00090729-02, NCGC00257361-01, NCGC00259972-01, AS-12294, DA-70485, SMR001595518, A1490, Acesulfame K, for food analysis, >=99.0%, CS-0010111, D08836, Acesulfame potassium, European Pharmacopoeia (EP) Reference Standard, Acesulfame potassium, United States Pharmacopeia (USP) Reference Standard, Acesulfame K, Pharmaceutical Secondary Standard; Certified Reference Material, 6-METHYL-1,2,3-OXATHIAZIN-4(3H)-ONE 2,2-DIOXIDE POTASSIUM SALT;ACESULFAME K;ACESULFAME POTASSIUM SALT;ACESULFAME POTASSIUM(AK);ACESULPHAME-K;POTASSIUMACESULFAMEK;ASPARTAMEACESULPHAMESALT;ACESULPHAMEPOTASSIUM
Acesulfame potassium for use in specific food and beverage categories in 1988 and in 2003 approved it as a general-purpose sweetener and flavor enhancer in food, except in meat and poultry, under certain conditions of use.
It is widely used in the food industry, such as mouthwash and soft drinks.
However, some researches have found that it does harm to the liver and nervous system.
Acesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste.
Acesulfame potassium, is a sweetener that resembles saccharin in structure and taste profile.
Acesulfame potassium, the first of many sweet compounds belonging to the dihydrooxathiazinone dioxide class, was discovered accidentally in 1967.
From these many sweet compounds, acesulfame was chosen for commercialization.
To improve water solubility, the potassium salt was made.
Acesulfame potassium was approved for dry product use in the United States in 1988 and in Canada in October, 1994.
In 2003, acesulfame-K was approved as a general purposes sweetener by the FDA.
Acesulfame potassium, commonly referred to as Acesulfame K or Ace-K, is a non-nutritive artificial sweetener widely used in a variety of food and beverage products.
It is approximately 200 times sweeter than sucrose, or table sugar, and provides a sweet taste without adding calories, making it a popular choice for sugar-free and reduced-calorie products.
Due to its intense sweetness, only small amounts are needed to achieve the desired sweetness level in foods and drinks.
Chemically, Acesulfame potassium is known by its formula C₄H₄KNO₄S, and it has a molecular weight of about 201.24 g/mol.
Its structure allows it to remain stable under a wide range of pH levels and at high temperatures, which is why it is commonly used in products that require long shelf lives or involve cooking and baking processes.
This stability ensures that the sweetener retains its potency and effectiveness even in processed or cooked foods.
Acesulfame potassium, also known as acesulfame K (K is the symbol for potassium) or Ace K, is a synthetic calorie-free sugar substitute (artificial sweetener) often marketed under the trade names Sunett and Sweet One.
In the European Union, it is known under the E number (additive code) E950.
Acesulfame potassium was discovered accidentally in 1967 by German chemist Karl Clauss at Hoechst AG (now Nutrinova).
Acesulfame potassium is the potassium salt of 6-methyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide.
Acesulfame potassium is a white crystalline powder.
Acesulfame potassium is 200 times sweeter than sucrose (common sugar), as sweet as aspartame, about two-thirds as sweet as saccharin, and one-third as sweet as sucralose.
Like saccharin, it has a slightly bitter aftertaste, especially at high concentrations.
Acesulfame potassium is often blended with other sweeteners (usually sucralose or aspartame).
These blends are reputed to give a more sucrose-like taste whereby each sweetener masks the other's aftertaste, or exhibits a synergistic effect by which the blend is sweeter than its components.
Acesulfame potassium has a smaller particle size than sucrose, allowing for its mixtures with other sweeteners to be more uniform.
Unlike aspartame, Acesulfame potassium is stable under heat, even under moderately acidic or basic conditions, allowing it to be used as a food additive in baking, or in products that require a long shelf life.
Although acesulfame potassium has a stable shelf life, it can eventually degrade to acetoacetamide, which is toxic in high doses.
In carbonated drinks, it is almost always used in conjunction with another sweetener, such as aspartame or sucralose.
Acesulfame potassium is also used as a sweetener in protein shakes and pharmaceutical products, especially chewable and liquid medications, where it can make the active ingredients more palatable.
The acceptable daily intake of acesulfame potassium is listed as 15 mg/kg/day.
Acesulfame potassium, also known as Acesulfame K or Ace-K, is a calorie-free artificial sweetener commonly used in food and beverages.
Acesulfame potassium is about 200 times sweeter than sucrose (table sugar) and is often used in combination with other sweeteners to provide a sugar-like taste while reducing overall calorie content.
Acesulfame potassium provides sweet taste quickly after it is consumed.
Eventually, it is completely absorbed into our blood from the gut, filtered out by our kidneys, and rapidly excreted unchanged in urine—all within about 24 hours.
Small amounts of acesulfame potassium can also be excreted in the breast milk of lactating women.
Acesulfame potassium is a highly versatile artificial sweetener that manufacturers use in a wide range of foods and drinks.
Acesulfame potassium is an artificial sweetener also known as Ace-K.
The use of artificial sweeteners has been controversial given some of their potential health risks.
But some of these sugar substitutes offer a good way to cut back on the sweet stuff, and they have some health benefits, too.
Provides a sweet taste with a slight aftertaste, often used with other sweeteners like aspartame or sucralose to balance flavors.
Highly stable under heat and over a wide range of pH conditions, making it suitable for use in baking and products with long shelf lives.
One of the key advantages of Acesulfame potassium is its ability to blend well with other sweeteners, such as aspartame, sucralose, or saccharin, to create a more sugar-like taste and to help mask any aftertaste that might occur when these sweeteners are used individually.
This characteristic is particularly beneficial in carbonated soft drinks, where it helps to provide a pleasant, balanced sweetness.
Acesulfame potassium is not metabolized by the body and does not provide any calories, which is why it is favored in the creation of diet beverages, sugar-free chewing gum, low-calorie desserts, and a variety of other reduced-calorie food items.
Additionally, it does not contribute to tooth decay and has no impact on blood glucose levels, making it suitable for people with diabetes.
Melting point: 229-232°C (dec.)
Boiling point: 210℃[at 101 325 Pa]
Density (solid): 1.81 g/cm3; d (bulk) 1.1-1.3 kg/dm3
vapor pressure: 0.291Pa at 25℃
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).
form: Solid
color: White crystalline solid
Odor: odorless with sweet taste
Odor Type: odorless
Water Solubility: almost transparency
Merck: 14,37
BRN: 3637857
LogP: -2.35 at 23℃
Acesulfame potassium is synthesized from acetoacetic acid tertbutyl ester and fluorosulfonyl isocyanate.
The resulting compound is transformed to fluorosulfonyl acetoacetic acid amide, which is then cyclized in the presence of potassium hydroxide to form the oxathiazinone dioxide ring system.
Because of the strong acidity of this compound, the potassium salt is produced directly.
An alternative synthesis route for acesulfame potassium starts with the reaction between diketene and amidosulfonic acid.
In the presence of dehydrating agents, and after neutralization with potassium hydroxide, acesulfame potassium is formed.
Acesulfame potassium of dimethylethylamine were added drop-wise, with cooling, to 80 g (0.825 mol) of sulfamic acid suspended in 500 ml of glacial acetic acid.
When dissolution was complete, 80 ml (1.038 mol) of diketene were added, while cooling at 25°-35°C.
After 16 hours, the mixture was evaporated and the residue was stirred with acetone, whereupon crystallization of dimethylethylammonium acetoacetamide-N-sulfonate took place.
12.7 g (50 mmol) of dimethylethylammonium acetoacetamide-N-sulfonate in 110 ml of methylene chloride were added drop-wise to 8 ml (200 mmol) of liquid SO3 in 100 ml of CH2Cl2 at -30°C, stirring vigorously, within 60 minutes.
30 minutes later, 50 ml of ethyl acetate and 50 g of ice were added to the solution.
The organic phase was separated off, and the aqueous phase was extracted twice more with ethyl acetate.
The combined organic phases were dried over sodium sulfate, evaporated and the residue was dissolved in methanol.
On neutralization of the solution with methanolic KOH, the potassium salt of 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide precipitated out.
Yield: 7.3 g (73%). The product was detected by thinlayer chromatography; the structure of it was confirmed with IR spectrum.
In rats, Acesulfame potassium (AceK) consumption from in-utero to post-weaning stages accelerated puberty onset, accompanied by increased brain gonadotropin-releasing hormone (GnRH) expression.
Intracerebroventricular AceK injection also induced early puberty onset in rats.
In N44 hypothalamic neuron cells, AceK treatment increased reactive oxygen species production, which led to protein kinase A (PKA) activation and increased GnRH expression.
Included in the FDA Inactive Ingredients Database for oral and sublingual preparations.
Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Accepted for use in Europe as a food additive.
Acesulfame potassium is also accepted for use in certain food products in the USA and several countries in Central and South America, the Middle East, Africa, Asia, and Australia.
Acesulfame potassium provides a sweet taste with no caloric value.
There is no high-quality evidence that using acesulfame potassium as a sweetener affects body weight or body mass index (BMI).
Acesulfame potassium was developed after the accidental discovery of a similar compound (5,6-dimethyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide) in 1967 by Karl Clauss and Harald Jensen at Hoechst AG.
After accidentally dipping his fingers into the chemicals with which he was working, Clauss licked them to pick up a piece of paper.
Clauss is the inventor listed on a United States patent issued in 1975 to the assignee Hoechst Aktiengesellschaft for one process of manufacturing acesulfame potassium.
Subsequent research showed a number of compounds with the same basic ring structure had different levels of sweetness.
6-methyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide had particularly favourable taste characteristics and was relatively easy to synthesize, so it was singled out for further research, and received its generic name (acesulfame-K) from the World Health Organization in 1978.
Acesulfame potassium first received approval for table top use in the United States in 1988.
Acesulfame potassium is a no-calorie sweetener that is used in foods and beverages to provide sweetness without the added calories contained in sugars.
While some types of sweeteners are considered no-calorie (e.g., acesulfame potassium, monk fruit sweeteners, stevia sweeteners and sucralose) and others are low-calorie (e.g., aspartame), this category of ingredients is often collectively referred to as artificial sweeteners, high-intensity sweeteners, low-calorie sweeteners, low- and no-calorie sweeteners, nonnutritive sweeteners or sugar substitutes.
Originally developed by German researchers in 1967, acesulfame potassium was first approved for use in Europe in 1983.
Today, it is often used in combination with other low- and no-calorie sweeteners, such as aspartame and sucralose, to provide a more sugar-like taste than acesulfame potassium provides on its own.
Like other low- and no-calorie sweeteners, acesulfame potassium is intensely sweet.
Acesulfame potassium is about 200 times sweeter than sucrose (table sugar), so only small amounts are used to match the sweetness provided by sugar.
Acesulfame potassium retains its sweetness at a wide range of temperatures and in many food-processing conditions, which allows it to be used as an ingredient in a variety of food products, including baked goods, beverages, candies, chocolates, dairy products, desserts, and more.
When acesulfame potassium is used as an ingredient in a packaged food or beverage, it will appear in the ingredient list for that product as either Ace-K, acesulfame K, or acesulfame potassium.
Helps reduce calorie intake, making it popular in "diet" or "light" products.
Non-Glycemic: Does not affect blood sugar levels, suitable for people with diabetes.
Heat Stability: Suitable for cooking and baking without losing sweetness.
The safety of Acesulfame potassium has been thoroughly evaluated by numerous health and regulatory organizations, including the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA).
These organizations have concluded that Acesulfame potassium is safe for human consumption when used within the established acceptable daily intake levels.
Extensive studies, including long-term animal studies, have shown no evidence of carcinogenic or toxic effects, supporting its continued use in the food supply.
Uses Of Acesulfame potassium:
Acesulfame-K is the potassium salt of 6-methyl-l,2,3-oxathiazin-4(3H)- one-2,2-dioxide.
This sweetener was discovered in Germany and was first approved by the FDA in 1988 for use as a nonnutritive sweetener.
The complex chemical name of this substance led to the creation of the trademark common name, acesulfame-K, which is based on its following relationships to acetocetic acid and sulfanic acid, and to its potassium salt nature.
Acesulfame potassium is 200 times as sweet as sugar and is not metabolized and is thus noncaloric.
Acesulfame potassium is exceptionally stable at elevated temperatures encountered in baking, and it is also stable in acidic products, such as carbonated soft drinks.
Acesulfame potassium has a synergistic effect when mixed with other low-calorie sweetners, such as aspartame.
Common applications of acesulfame-K are table uses, chewing gums, beverages, foods, bakery products, confectionary, oral hygiene products, and pharmaceuticals.
Acesulfame potassium is used as an intense sweetening agent in cosmetics, foods, beverage products, table-top sweeteners, vitamin and pharmaceutical preparations, including powder mixes, tablets, and liquid products.
It is widely used as a sugar substitute in compounded formulations,and as a toothpaste sweetener.
The approximate sweetening power is 180–200 times that of sucrose, similar to aspartame, about one-third as sweet as sucralose, one-half as sweet as sodium saccharin, and about 4-5 times sweeter than sodium cyclamate.
It enhances flavor systems and can be used to mask some unpleasant taste characteristics.
Acesulfame potassium is widely used in the human diet and excreted by the kidneys.
Acesulfame potassium thus has been used by researchers as a marker to estimate to what degree swimming pools are contaminated by urine.
Other names for acesulfame K are Acesulfame potassium, potassium salt of 6-methyl-1,2,3-oxothiazin-4(3H)-one-2,3-dioxide, and potassium 6-methyl-1,2,3-oxathiazine-4(3H)-one-3-ate-2,2-dioxide.
Found in products like soft drinks, baked goods, dairy products, and confectionery.
Acesulfame potassium sometimes used to mask the taste of certain medications.
Available as a sugar substitute for home use.
Acesulfame potassium is commonly used in diet sodas and other carbonated beverages to provide sweetness without adding calories.
Due to its heat stability, Acesulfame potassium is used in low-calorie and sugar-free baked products like cookies, cakes, and pastries, where it maintains sweetness even after baking.
Found in sugar-free or low-calorie dairy items such as yogurt, ice cream, and puddings.
Used in sugar-free candies, chewing gum, and chocolate to provide a sweet flavor without sugar.
Acesulfame potassium included in low-calorie or reduced-sugar jams and preserves to retain sweetness.
Added to sugar-free or reduced-calorie sauces, salad dressings, and condiments.
Used to mask the bitter taste of certain liquid medications, chewable tablets, and oral suspensions.
Added to protein shakes, vitamins, and electrolyte solutions to improve flavor without adding sugar.
Available in powdered or tablet form for consumers to use as a sugar substitute in tea, coffee, and other beverages or for sprinkling on food.
Incorporated into low-calorie or diet-friendly meals to maintain sweetness in various dishes.
Acesulfame potassium is used in sugar-free or low-calorie snack bars, chips, and other packaged foods.
Found in sugar-free toothpaste, mouthwashes, and chewing gum to provide a pleasant taste without contributing to tooth decay.
Included in meal replacement drinks and diet shakes to enhance flavor while keeping calorie content low.
Acesulfame potassium is used in dietary supplements aimed at weight management to improve taste without adding calories.
Included in sugar-free or low-calorie sports drinks to provide sweetness while keeping the calorie count low.
Sometimes added to specialized infant formulas for specific medical needs, although use in this category is less common.
Acesulfame potassium is a key ingredient in sugar-free sodas, diet colas, and energy drinks, where it helps reduce calorie content while providing a taste similar to sugary beverages.
Used extensively in gelatin desserts, sugar-free custards, and mousse to offer a sweet taste without adding calories.
Found in low-calorie ice creams, frozen yogurts, and popsicles, helping maintain sweetness after freezing.
Included in sugar-reduced cereals and breakfast bars to enhance sweetness while lowering the sugar content.
Due to its stability at high temperatures, it’s used in baking recipes that require a sweetener that won't break down or lose its sweetness during baking.
Popular in the production of sugar-free hard candies, gummy bears, and lollipops to provide sweetness without contributing to the overall calorie count.
Often combined with other sweeteners to provide long-lasting sweetness in sugar-free gum.
Acesulfame potassium is used in combination with other sweeteners to create low-sugar or sugar-free chocolate products.
Acesulfame potassium helps mask the unpleasant tastes of active pharmaceutical ingredients in cough syrups, antacids, and liquid medications.
Enhances the flavor profile of chewable vitamins, supplements, and lozenges.
Found in oral rehydration salts and electrolyte drinks, improving taste while keeping sugar content low.
Acesulfame potassium is extensively used in diet shakes, meal replacement bars, and weight loss supplements to maintain a sweet taste while minimizing calorie content.
Acesulfame potassium is used in protein supplements and shakes to enhance flavor, making them more palatable for regular consumption.
Included in formulas designed for individuals with specific dietary needs, such as diabetic-friendly nutritional drinks.
Found in sugar-free toothpaste and mouthwash, offering a pleasant, sweet taste while maintaining oral health.
Used in breath mints to provide sweetness without contributing to tooth decay.
In ready-to-eat meals, sauces, soups, and canned goods, Acesulfame potassium enhances sweetness while reducing sugar content, catering to the demand for healthier food options.
Common in sugar-free or reduced-sugar snack foods like chips, popcorn, and trail mixes, providing a sweet flavor without the addition of sugar.
Acesulfame potassium is used in products specifically formulated for people with diabetes, allowing them to enjoy sweet flavors without raising blood sugar levels.
Occasionally included in pediatric and infant formulas designed for specific medical or dietary needs, providing sweetness without sugar.
Used in light or low-calorie alcoholic beverages, including cocktails, wine coolers, and flavored alcoholic drinks, to provide sweetness while minimizing calories.
Storage Of Acesulfame potassium:
Acesulfame potassium possesses good stability.
In the bulk form it shows no sign of decomposition at ambient temperature over many years.
In aqueous solutions (pH 3.0–3.5 at 208℃) no reduction in sweetness was observed over a period of approximately 2 years.
Stability at elevated temperatures is good, although some decomposition was noted following storage at 408℃ for several months.
Sterilization and pasteurization do not affect the taste of acesulfame potassium.
The bulk material should be stored in a well-closed container in a cool, dry place and protected from light.
Safety Profile Of Acesulfame potassium:
When heated to decompositionemits toxic fumes of SOx.
Acesulfame potassium is widely used in beverages, cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material.
Pharmacokinetic studies have shown that acesulfame potassium is not metabolized and is rapidly excreted unchanged in the urine.
Long-term feeding studies in rats and dogs showed no evidence to suggest acesulfame potassium is mutagenic or carcinogenic.
Acesulfame potassium is approved for use by major regulatory bodies like the FDA (Food and Drug Administration) and EFSA (European Food Safety Authority).
It has been extensively studied for safety and is considered safe for human consumption within established daily intake limits.
