ADVANTAME

Advantame is used in tabletop sweeteners for hot and cold beverages.
Advantame is used as a sweetener in beverages, including soft drinks and fruit juices.
Advantame is utilized in baked goods and confectioneries to enhance sweetness.

CAS Number: 714229-20-6 (monohydrate) 
245650-17-3 (anhydrous) 
EC Number: 429-450-3 (commonly assigned in regulatory inventories)
MDL Number: MFCD28144745
Molecular Formula: C₂₄H₃₀N₂O₇
Molecular Weight: 476.51 g/mol

SYNONYMS:
Advantame, E969, N-[N-(3-(3-hydroxy-4-methoxyphenyl)propyl]-L-aspartyl-L-phenylalanine 1-methyl ester, aspartame-vanillin derivative sweetener, IUPAC name: Methyl N-[3-(3-Hydroxy-4-methoxyphenyl)propyl]aspartylphenylalaninate, Systematic IUPAC name: (3S)-3-{[3-(3-Hydroxy-4-methoxyphenyl)propyl]amino}-4-{[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino}-4-oxobutanoic acid, N-[N-[3-(3-Hydroxy-4-methoxyphenyl)propyl]-α-L-aspartyl]-L-phenylalanine 1-methyl ester, Advantame, 714229-20-6, UNII-3ZA6810AWX, Advantame monohydrate, 3ZA6810AWX, (S)-3-((3-(3-Hydroxy-4-methoxyphenyl)propyl)amino)-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid hydrate, MFCD28144745, L-Phenylalanine, N-(3-(3-hydroxy-4-methoxyphenyl)propyl)-l-alpha-aspartyl-, 2-methyl ester, hydrate (1:1), L-Phenylalanine, N-(3-(3-hydroxy-4-methoxyphenyl)propyl)-l-alpha-aspartyl-, 2-methyl ester, monohydrate, Phenylalanine, N-(3-(3-hydroxy-4-methoxyphenyl)propyl)-alpha-aspartyl-, 2-methyl ester, monohydrate, advantame hydrate, ADVANTAME [USP-RS], INS NO.969, MSK5115W, orb1941610, orb3025945, SCHEMBL2156362, FEMA NO. 4716, DTXSID00991787, INS-969, C24H32N2O8, EX-A8009, HY-122351A, DA-50248, E969, CS-0835016, E-969, NS00127040, G90455, Q27258250, (3S)-4-[[(2S)-1-methoxy-1-oxidanylidene-3-phenyl-propan-2-yl]amino]-3-[3-(4-methoxy-3-oxidanyl-phenyl)propylamino]-4-oxidanylidene-butanoic acid;hydrate, 4-Hydroxy-3-{[3-(3-hydroxy-4-methoxyphenyl)propyl]amino}-4-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)imino]butanoic acid--water (1/1), L-PHENYLALANINE, N-(3-(3-HYDROXY-4-METHOXYPHENYL)PROPYL)-L-.ALPHA.-ASPARTYL-, 2-METHYL ESTER, HYDRATE (1:1), L-PHENYLALANINE, N-(3-(3-HYDROXY-4-METHOXYPHENYL)PROPYL)-L-.ALPHA.-ASPARTYL-, 2-METHYL ESTER, MONOHYDRATE, Methyl N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-alpha-aspartyl-L-phenylalaninate--water (1/1), N-(N-(3-(3-HYDROXY-4-METHOXYPHENYL) PROPYL)-L-.ALPHA.-ASPARTYL)-L-PHENYLALANINE-1-METHYL ESTER, MONOHYDRATE, PHENYLALANINE, N-(3-(3-HYDROXY-4-METHOXYPHENYL)PROPYL)-.ALPHA.-ASPARTYL-, 2-METHYL ESTER, MONOHYDRATE, aminosweet, (3R)-4-[[(1S)-1- benzyl-2-methoxy-2-oxo-ethyl]amino]-3-[3-(3-hydroxy-4-methoxy-phenyl)propylamino]-4-oxo-butanoic acid hydrate, N-[N-[3-(3- hydroxy-4-methoxyphenyl)propyl-alpha-L-phenylalanine methyl ester, monohydrate, N-[N-[3-(3- hydroxy-4-methoxyphenyl)propyl-alpha-laevo-phenylalanine methyl ester monohydrate, (N-[N-[3-(3- hydroxy-4-methoxyphenyl)propyl]-L-a-aspartyl]-L-phenylalanine 1-methyl ester) monohydrate, (R)-3-[3-(3- hydroxy-4-methoxyphenyl)propylamino]-4-[(S)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino]-4-oxobutanoic acid hydrate, (S)-3-[[3-(3-Hydroxy-4-methoxyphenyl)propyl]amino]-4-[[(S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid monohydrate, Methyl N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl-L-phenylalaninate monohydrate, N-[N-[3-(3-Hydroxy-4-methoxyphenyl)propyl]-α-L-aspartyl]-L-phenylalanine 1-methyl ester monohydrate

Advantame is the result of a persistent search for a sugar-like high-intensity sweetener – far from chemists who lick their fingers and accidentally discover sweeteners, which history is otherwise full of.
Advantame is formed from aspartame and vanillin, which in turn are chemically produced ingredients.
Advantame is undeniably a high-intensity sweetener; it is 20,000 times sweeter than sugar.

By comparison, aspartame is 100 times sweeter than sugar.
Advantame is at least as stable as aspartame, and more stable during heating.
Advantame also has a longer sweet aftertaste.

Advantame is not dangerous for humans according to the studies that have been done.
Advantame is an N-substituted derivative of aspartame.
Advantame is a high-intensity, low calorie sweetener.

Advantame can interact with plasma protein.
Advantame is a high-intensity sweetener that is derived from the natural plant extract, Stevia rebaudiana.
Advantame has been shown to be safe for use in humans and animals at doses up to 200 times the typical amount of aspartame.

Advantame is about 200 times sweeter than aspartame, but it does not have any unpleasant aftertaste.
Advantame has no calories or carbohydrates and does not affect blood sugar levels.
Advantame (E969) is a high-intensity, zero-calorie sweetener that is 20,000 times sweeter than sugar and approximately 100 times sweeter than aspartame.

This N-substituted derivative of aspartame, made from aspartame and vanillin, provides a clean, sweet taste without added calories.
Advantame is recognized for its exceptional quality and purity as a food-grade ingredient, offering stability under heat and varying pH conditions.
Advantame (N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-La-aspartyl]-L-phenylalanine-1-methyl ester) is a high-intensity sweetener that is 20,000 times sweeter than sucrose.

Advantame is a high-potency sweetener that offers a remarkable alternative to traditional sugar and artificial sweeteners.
With its unique structure, Advantame is approximately 20,000 times sweeter than sucrose, making it an ideal choice for food and beverage formulations where reduced caloric content is desired without sacrificing taste.
Advantame is particularly beneficial in the production of low-calorie and sugar-free products, including soft drinks, baked goods, and confectioneries.

Advantame's stability under heat and varying pH conditions allows for versatile applications in both cooking and baking, providing manufacturers with the flexibility to innovate while meeting consumer demands for healthier options.
In addition to its sweetness, Advantame is recognized for its clean taste profile, which does not leave any bitter aftertaste commonly associated with other sweeteners.

This makes Advantame an attractive ingredient for formulators aiming to enhance flavor without compromising on quality.
Researchers and industry professionals can leverage Advantame's properties to create products that cater to health-conscious consumers, thereby expanding market opportunities in the growing low-calorie segment.
Advantame is a high intensity, non-caloric sweetener, which is derived from aspartame.

Advantame is a non-caloric artificial sweetener and aspartame analog by Ajinomoto.
By mass, Advantame is about 20,000 times sweeter than sucrose and about 110 times sweeter than aspartame.
Advantame has no notable off-flavors when compared to sucrose and tastes sweet a bit longer than aspartame and is chemically more stable.

Advantame can be blended with many other natural and artificial sweeteners.
In 2013, Advantame was approved for use in foods within EU with the E number E969.
In 2014, FDA approved advantame as a non-nutritive sweetener and flavor enhancer within United States in foods generally, except meat and poultry.

Advantame is a junior among the artificial sweeteners.
Advantame is a high-intensity, non-nutritive artificial sweetener derived structurally from aspartame and vanillin.
Advantame belongs to the dipeptide methyl ester class and is considered one of the most potent sweeteners ever developed, with sweetness intensity estimated to be approximately 20,000–37,000 times greater than sucrose.

Advantame is a next-generation artificial sweetener developed to overcome limitations of earlier sweeteners such as aspartame, particularly instability at high temperatures and limited sweetness potency.
Advantame is synthesized from aspartame and vanillin derivatives, resulting in a highly stable, intensely sweet compound.
Because of Advantame's extremely high sweetness intensity, only trace amounts are required in food formulations.

Advantame is an ultra-high-intensity sweetener with excellent thermal and chemical stability, low caloric contribution, and strong sweetness receptor affinity.
Its structural derivation from aspartame enhances both its stability and sweetness potency, making Advantame suitable for modern food systems requiring sugar reduction without compromising taste quality.

Advantame is an ultra-high-intensity, non-caloric artificial sweetener derived from aspartame and vanillin, approximately 20,000 times sweeter than sucrose.
Approved by the FDA and in other regions, Advantame is used in beverages, dairy, and baked goods due to its stability under high heat, clean taste, and ability to enhance flavors.

USES and APPLICATIONS of ADVANTAME:
Beverages : Advantame is commonly used in carbonated drinks and other beverages.
Tabletop Sweeteners : Advantame is used in tabletop sweeteners for hot and cold beverages.
Advantame is used as a sweetener in beverages, including soft drinks and fruit juices.

Advantame is incorporated in dairy products such as yogurt and ice cream.
Advantame is utilized in baked goods and confectioneries to enhance sweetness.
Advantame is applied in chewing gums and candies.

Advantame is suitable for use in tabletop sweeteners and sugar substitutes.
Advantame is ideal for keto-friendly products.
Advantame is safe for individuals with phenylketonuria (PKU).

Advantame can be used in a large number of foods to replace sugar and high-calorie sweeteners.
Advantame can be used in a variety of foods and beverages, including baked goods, dairy products, frozen desserts, soft drinks, gelatins and puddings, jams and jellies, chewing gum, confections and frosting.
Advantame is a super-sweet, zero-calorie sweetener that’s 20,000 times sweeter than sugar and about 100 times sweeter than aspartame.

Advantame’s made from a mix of aspartame and vanillin, giving it a clean, delicious sweetness without any extra calories.
Advantame is one of the latest high-intensity sweeteners approved for general use.
What makes Advantame special is that it’s heat and pH-stable, meaning it can hold up in cooking and baking.

Whether you’re making baked goods, drinks, or other food items, Advantame’ll keep its sweetness even in high heat—up to 240°C (464°F).
Plus, Advantame’s keto-friendly and safe for people with PKU (phenylketonuria).
So if you’re looking for a way to sweeten your foods without the sugar or calories, Advantame is a great option to try.

Advantame is the sweetest sweetener ever developed and can be used as a sweetener and flavor enhancer in various foods.
Advantame is used as a food additive, feed additive, fertilizer additive, in cosmetics, raw materials, etc.
Advantame is widely used in food and beverage industry.

Advantame can be used as a table top sweetener and in certain bubblegums, flavored drinks, milk products, jams and confectionery among other things.
Advantame is primarily used as a high-intensity sweetener in the food and beverage industry.
Advantame is suitable for sugar-free, low-calorie, and diet products due to its very high sweetness potency and minimal caloric contribution.

Advantame is used in carbonated soft drinks, flavored beverages, chewing gum, dairy products, desserts, confectionery, and tabletop sweetener formulations.
Because of its heat stability, Advantame can also be used in baked goods and cooked food products where earlier sweeteners like aspartame may degrade.
In pharmaceutical applications, advantame can be used to improve taste masking in oral medications such as syrups, chewable tablets, and powders.

Advantame is often used in combination with other sweeteners to achieve a more sugar-like taste profile and to reduce bitterness or aftertaste effects.
Advantame is approved as a food additive in several regions and is used primarily in low-calorie and sugar-free products.
Advantame is primarily used in food and beverage formulations requiring intense sweetness at very low concentrations.

Due to its clean, sugar-like taste, functionality, and cost effectiveness, Advantame can be used to partially replace caloric sweeteners and other high-potency sweeteners in foods and beverages while maintaining or enhancing the taste profile.
Since advantame blends well with caloric and non-caloric sweeteners, it provides food and beverage companies with an opportunity to reduce calories and manage their sweetness costs.

Advantame is a great flavour enhancer, enhancing many flavours such as dairy, fruit, citrus and mint.
Plus, Advantame can be used to extend chew time in chewing gum and enhance the taste of confections.
Advantame is also an excellent tool to mask off-tastes of functional ingredients such as added proteins, vitamins, and minerals.

-Flavour enhancement uses of Advantame:
Thanks to its compilation Advantame enhances many flavours in food, for example:
Fruit flavours (orange, apple, strawberry, grape, peach etc)
Mint, chocolate and cocoa flavours
Spiciness and saltiness (in seasonings and processed foods)

-Food Industry uses of Advantame: 
Advantame is used as a non-nutritional sweetener and flavor enhancer in a variety of food products.
Advantame is commonly found in beverages, dairy products, bakery goods, and confectionery.

-Advantame is utilized in many products for reducing calories and managing costs.
*Beverages: Soft drinks, hot and iced tea.
*Foods: Dairy products, yogurt, jams, and jellies.
*Other: Confectioneries, chewing gum, and tabletop sweeteners.

-Advantame can be used for:
*reducing calories
*quality improvement with its off-taste masking effect
*quality improvement with its flavour enhancement effect
*cost reduction
*Sugar substitution
Advantame can substitute other sweeteners up to 40% and reduce the amount of calories in the product.
The substitution ratio can be increased by blending with other ingredients.

-Off-taste masking uses of Advantame:
Advantame can also be used to mask lingering off-taste.
Proven concepts show that Advantame can mask many kinds of functional ingredients such as stevia (lingering/licorice off-taste), vitamins, minerals, polyphenols and amino acids etc.
As an example, when you apply 40ppm of Advantame the bitterness level can be masked with more than 50%.

CHEMICAL PROPERTIES of ADVANTAME:
Chemically, advantame is a modified dipeptide methyl ester structurally related to aspartame.
Advantame contains peptide bonds, aromatic rings, and a vanillyl-derived moiety, which significantly enhances its sweetness potency.
Advantame is highly stable compared to aspartame, especially under heat and acidic conditions, making it suitable for baked and processed foods.
Advantame does not readily hydrolyze under normal food processing conditions and shows strong resistance to degradation in acidic beverages.

Advantame does not participate in Maillard browning reactions and is chemically inert in most food matrices.
Advantame is metabolized in the body into inactive components at very low levels and does not accumulate.
Advantame shows strong sweetness receptor binding affinity, which is responsible for its extremely high sweetness potency even at trace concentrations.

PHYSICAL PROPERTIES of ADVANTAME:
Advantame is a white to off-white crystalline powder with no odor.
Advantame has an extremely sweet taste with minimal aftertaste compared to other high-intensity sweeteners.
Advantame is only slightly soluble in water and shows limited solubility in many organic solvents due to its large and complex molecular structure.

Advantame is stable under dry conditions and has low volatility.
Advantame does not have a conventional melting point because Advantame decomposes before melting at elevated temperatures.
Advantame remains stable under typical food processing conditions, including moderate heating and a wide pH range.
Advantame's crystalline nature contributes to good handling stability, although its very low usage levels in applications make physical handling less significant in end-use formulations.

BENEFITS AND CHARACTERISTICS of ADVANTAME:
Advantame provides several key functional advantages.
Advantame's extremely high sweetness intensity allows for ultra-low usage levels, reducing cost and caloric contribution in formulations.
Advantame is stable under heat and acidic conditions, making it suitable for a wide range of processed food applications.

Advantame has a clean sweetness profile with reduced bitter or metallic aftertaste compared to some other high-intensity sweeteners.
Advantame is non-cariogenic, meaning it does not contribute to tooth decay.

Advantame is suitable for diabetic and weight-management products due to its negligible caloric impact.
Its strong stability and versatility make Advantame suitable for both liquid and solid food systems.
Another important characteristic is its synergy with other sweeteners, where Advantame can enhance sweetness perception while reducing undesirable flavor notes.

HOW ADVANTAME IS MADE:
Advantame is produced in several steps from aspartame and vanillin.
The cost is said to be one-hundredth of that for sugar.
First to be produced is vanillin, which gives vanilla its characteristic taste and aroma.

It can of course be extracted from vanilla, but in practice, it is made synthetically from lignin or guaiacol, both of which are extracted from wood.
The production of advantame begins with several steps that convert vanillin into hexamethylphosphoramide (HMPA).

In parallel, aspartame is prepared.
This is done by letting the bacteria Brevibacterium flavum and Corynebacterium glutamicum form amino acids in a fermentation process.
These amino acids are then synthesised into aspartame.

See the description in the article on aspartame.
Now it’s time for the great transformation scene.
In the presence of metal, an alkyl (a hydrocarbon compound) is transferred from HMPA to aspartame which then becomes advantame.

This is called alkylation.
The metal, which is often platinum or palladium, acts as a landing site where an aspartame molecule and an HMPA molecule can settle to do the transfer of the alkyl.
None of the metal is included; it’s just a catalyst.

During the final step, HMPA and advantame are dissolved in methanol.
Therefore, the solution needs to be crystallised, and the raw crystals washed.
Advantame is recrystallised, and the crystals are separated, rinsed and dried.

BENEFITS of ADVANTAME:
*Taste Enhancement
Utilize Advantame in a variety of applications to enhance a wide range of flavours such as dairy, fruit, citrus and mint.

*Cost Effective
Advantame can be used with other high potency sweeteners to reduce cost and improve taste.

*Application Variety
Advantame has proven to contribute exceptional taste in confectionery applications with its clean taste and high potency.

*Clean Sugar-Like Taste
The clean taste of Advantame allows it to sweeten your foods and beverages without sacrificing the taste profile of the product.

FEATURES of ADVANTAME:
Advantame is the sweetest sweetener ever developed.
Advantame is 20,000 times sweeter than sucrose.
Only a small amount is needed to achieve intense sweetness, making Advantame ideal for low-calorie and sugar-free products.

Advantame offers flexibility for a wide range of applications in many sectors, including food and beverages, feed additives, fertilizer additives, and cosmetic raw materials.
Advantame is approved by the US FDA and the European Commission.
Advantame meets rigorous safety standards that make it suitable for use in a wide variety of food and beverage products without compromising consumer health.

Advantame is an effective flavor enhancer that improves the overall taste experience of foods and beverages.
Advantame has a moisture content of ≤5% to ensure stability during storage and transport and to extend the product's shelf life.

Advantame has a solubility of 0.1 g/L at room temperature.
Advantame's extremely high sweetness level means that small amounts are sufficient for the desired sweetness, making it efficient to use.
Advantame is used as a food additive, feed additive, fertilizer additive, in cosmetics, raw materials, etc.

METABOLISM of ADVANTAME:
In humans, 89% of the ingested advantame is excreted in feces and 6.2% in urine.
Some is excreted unchanged, but most as metabolites.
Advantame is poorly absorbed, rapidly metabolized and only small amounts of it and its metabolites can be detected in blood shortly after ingestion.

52% of the ingested dose is excreted in feces as de-esterified advantame and 30% as N-(3-(3-hydroxy-4-methoxyphenyl))propyl-L-aspartic acid and as an equivalent molar amount of phenylalanine.
1% of the ingested dose is excreted in urine as the aforementioned aspartic acid analog, 1.9% as 5-(3-aminopropyl)-2-methoxyphenyl and 2.3% as de-esterified advantame.
Methanol forms in de-esterification, but this is considered insignificant at advantame concentrations intended to be used in foods, and in comparison to methanol naturally formed in body and to methanol naturally found in foods.

SWEETNESS of ADVANTAME:
Relative sweetness of advantame varies.
It depends on the concentration and food/matrix in which it is used.
In water solutions of advantame, that are equivalently sweet to water solutions of 3–14 percentage sucrose by weight (wt%), advantame is 7000–47700 times sweeter.
Relative sweetness of advantame increases logarithmically as the sucrose concentration of a comparably sweet sucrose solution increases, but eventually reaches a plateau.
By extrapolation, sweetness of an advantame water solution is estimated to reach a maximum at a concentration that is equivalent to a 15.8 wt% sucrose water solution.

HISTORY of ADVANTAME:
Ajinomoto developed advantame and announced its structure publicly in print in 2008.
At first advantame was identified by the laboratory code ANS9801.
Aspartame, neotame and aspartame N-substituted with asparagine via amide bond were selected as the lead compounds for research that lead to advantame.

BENEFITS of ADVANTAME:
Advantame is a new ultrahigh potency sweetener and flavor enhancer developed by Ajinomoto.
Advantame is derived from aspartame and vanillin.
Advantame is approximately 20,000 times sweeter than sugar and 100 times sweeter than aspartame.

Advantame has zero calories and a clean, sweet, sugar-like taste with no undesirable taste characteristics.
Suitable for most low- and non-calorie product formulations, Advantame can be used in cooking and baking.
Advantame gives food and drink manufacturers a new sweetening alternative to meet consumer demand for more low-calorie foods and beverages.

Substantial scientific evidence supports advantame’s safe use by the millions of consumers who seek to control their intake of carbohydrate-based sweeteners and calories.
Because advantame is much sweeter than most low and no-calorie sweeteners currently available, it is expected to be a top candidate for food and beverage formulations to meet the consumer demand for great tasting foods and beverages without the calories of sugar.

Advantame is a high-intensity, zero-calorie sweetener that is 20,000 times sweeter than sugar, approximately 100 times sweeter than aspartame, and more heat stable than aspartame.
Advantame is an N-substituted derivative of aspartame made from aspartame and vanillin, providing a clean, sweet taste without the added calories.

Advantame is heat-stable and pH-stable, making it ideal for use in a variety of baked goods, beverages, and other food products.
Advantame can withstand temperatures up to 240°C (464°F), ensuring that its sweetness remains intact even during high-temperature processing.

Additionally, Advantame is keto-friendly and safe for individuals with phenylketonuria (PKU).
Try Advantame for a sweet taste without the added sugar and calories.

CHEMISTRY of ADVANTAME:
Advantame is formally a secondary amine of aspartame and 3-(3-hydroxy-4-methoxyphenyl)propanal (HMPA).
Structurally advantame resembles a combination of aspartame and phyllodulcin.

Advantame has 2 stereocenters and 4 stereoisomers.
Advantame can be made from aspartame and vanillin.

Vanillin is transformed to HMPA in 4 steps.
3-hydroxy-4-methoxycinnamaldehyde (HMCA) is formed in the third step.
HMCA is hydrogenated to HMPA in the final step.

HMPA is selectively hydrogenated with palladium on aluminium oxide and platinum on carbon in one step to advantame in methanol with aspartame.
Product is crystallized.
Crude crystals are washed, recrystallized, washed and dried.

At 15 °C the solubility of advantame is 0.76 g/L in water, 7.98 g/L in ethanol and 1.65 g/L in ethyl acetate.
At 25 °C the solubilities are 0.99 g/L, 13.58 g/L and 2.79 g/L, respectively.
At 40 °C the solubilities are 2.10 g/L, 38.27 g/L and 7.96 g/L, respectively.
At 50 °C the solubilities are 3.10 g/L, 98.68 g/L and 16.00 g/L, respectively.

Advantame as a dry powder degrades very slowly at 25 °C and 60% relative humidity and can last for years under such conditions.
Advantame can last for more than a year in aqueous solutions at pH 3.2.

This corresponds to the typical pH of soft drinks.
Advantame degrades faster at higher temperatures and humidity, but is generally more stable than aspartame.
Unlike aspartame, advantame does not form a diketopiperazine via intra-molecular cyclization due to steric hindrance by the vanillyl group.

ADVANTAGES OF ADVANTAME:
*20,000 times sweeter than sugar and 100 times sweeter than aspartame.
*Advantame has no off-flavour or undesirable aftertaste.
*Taste profile very similar to aspartame.
*Advantame is more stable than aspartame when heated and at higher pH-values.
*Advantame is completely stable in dry form.
*Gives no energy (adds 0 calories).
*Advantame does not affect the blood sugar level (GI = 0).
*Cheap to manufacture.
*No health problems.

DISADVANTAGES OF ADVANTAME:
*It’s hard to find any negative to say about advantame – except it is artificial.
*There is only one thing you really should take into consideration.
*It takes a second before the taste buds register advantame, which means that you have to use another sweetener as a buffer.

HOW ADVANTAME CAN BE USED:
Advantame is mainly used to replace sugar and other bulk sweeteners.
Tests show advantame can replace up to 40 per cent of sugar without any effect on taste.
Advantame may be used in a variety of products.

ADVANTAME SAFER THAN ASPARTAME:
Advantame is made from aspartame.
Does this mean that advantame has the same health issues as aspartame?
In the body, aspartame is broken down into, among other things, phenylalanine.
For most people, this in its turn is broken down to tyrosine.
However, for persons with the congenital disease phenylketonuria, phenylalanine is not broken down but concentrated in the blood.
Eventually, that leads to brain damage.

SO, DOES ADVANTAME HAVE THE SAME ISSUE?
No.
Phenylalanine is not formed when advantame is broken down.
So what happens in the body?

What happens in the body?
On its way through the gastrointestinal tract, advantame undergoes hydrolysis and becomes a carboxylic acid and methanol.
Formic acid, acetic acid and butyric acid are examples of other carboxylic acids.

The one formed during hydrolysis of advantame is called ANS9801-acid.
The body cannot absorb either advantame or the acid it forms.

Everything comes out the natural way.
Between 87 and 93 per cent via faeces and the rest via urine.
The methanol that is formed is considered harmless due to its small amount.

KEY CHARACTERISTICS of ADVANTAME:
*Sweetness Intensity: 
~20,000x sweeter than sugar, and ~110x sweeter than aspartame.

*Stability: 
Highly stable at high temperatures and in various pH conditions, making it superior to aspartame for baking.

*Safety: 
Approved by the FDA with an acceptable daily intake (ADI) of 32.8 mg/kg of body weight.

*Taste Profile: 
Advantame provides a clean, sugar-like taste with no significant off-flavors, also capable of masking unpleasant tastes from other ingredients.

*Structure: 
An aspartame analog that does not produce diketopiperazine, which contributes to its stability.

SAFETY of ADVANTAME:
So, is advantame safe?
The short answer is yes.
Advantame has been extensively tested on everything from mice to humans without any adverse effects in either the short or long term.
But for safety’s sake, the European Food Safety Authority (EFSA) has set 5 milligrams per kilogram of body weight and day as an acceptable daily intake (ADI).

It is far below the doses of over 7,000 milligrams with which advantame has been tested.
Advantame may see meagre with 5 mg/kg body weight and day.
But the fact is that even large consumers of sweetened products can never get more than a few micrograms per kilogram of body weight and day.
So the limit is abundant.

PHYSICAL and CHEMICAL PROPERTIES of ADVANTAME:
CAS Number: 714229-20-6
EC Number: 429-450-3 (commonly assigned in regulatory inventories)
Molecular Formula: C₂₄H₃₀N₂O₇
Molecular Weight: 476.51 g/mol
Chemical formula: C24H30N2O7
Molar mass: 458.511 g·mol−1
Appearance: white to yellow powder
Melting point: 101.5 °C (214.7 °F; 374.6 K)

Solubility in water: 0.99 g/L at 25 °C
Molecular Weight: 476.5 g/mol
Hydrogen Bond Donor Count: 5
Hydrogen Bond Acceptor Count: 9
Rotatable Bond Count: 14
Exact Mass: 476.21586598 Da
Monoisotopic Mass: 476.21586598 Da

Topological Polar Surface Area: 135 Ų
Heavy Atom Count: 34
Formal Charge: 0
Complexity: 624
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 2
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes
FDA UNII: 3ZA6810AWX
Molecular Weight: 476.52664000
Formula: C24 H32 N2 O8
Assay: 95.00 to 100.00

Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC (0.00 °C.) (est)
Soluble in: alcohol water, 12.48 mg/L @ 25 °C (est)
Insoluble in: water
Empirical Formula (Hill Notation): C24H30N2O7 · H2O
CAS Number: 714229-20-6
Molecular Weight: 476.52

MDL number: MFCD28144745
UNSPSC Code: 85151701
NACRES: NA.24
Physical state: powder
Color: white
Odor: No data available
Melting point/freezing point: Melting point/ range: 99,3 - 101,5 °C
Initial boiling point and boiling range: No data available

Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity: Viscosity, kinematic: No data available; 
Viscosity, dynamic: No data available
Water solubility: No data available

Partition coefficient n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: Not classified as explosive
Oxidizing properties: none

Other safety information: No data available
Molecular Formula / Molecular Weight C24H30N2O7·H2O = 476.53
Physical State (20 deg.C): Solid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas: Store under inert gas
Condition to Avoid: Air Sensitive
CAS RN: 714229-20-6
Reaxys Registry Number: 35359687
MDL Number: MFCD28144745

CAS number: 714229-20-6 (monohydrate)
Molecular Formula: C24H30N2O7·H2O
Molecular Weight: 476.52 g/mol.
Synonyms: (3S)-3-{[3-(3-Hydroxy-4-methoxyphenyl)propyl]amino}-4-{[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino}-4-oxobutanoic acid
Source: Synthetic
Physical Form: Solid
Solubility: Sparingly soluble in water and ethanol
Standard: Food Grade

Appearance: White to off-white powder
Assay (dry basis): 97.0% - 102.0%
Specific Rotation: -45.0° to -38.0°
Advantame Acid: 1.0% max.
Total Other Related Substances: 1.5% max.
Moisture: 5.0% max.
Chemical Formula: C20H30N2O5
Molecular Weight: 378.47 g/mol

Appearance: White crystalline powder
Sweetness: Approximately 7,000 to 13,000 times sweeter than sucrose
Product Line: Advantame
CAS: 714229-20-6
Linear Formula: C24H30N2O7 · H2O
Synonym: N-[N-[3-(3-Hydroxy-4-methoxyphenyl)propyl]-alpha-L-aspartyl]-L-phenylalanine 1-methyl ester monohydrate
Type: Analytical Standard
Formula Weight: 476.52

Percent Purity: ≥97.0% (HPLC)
Grade: Analytical Standard
CAS Number: 714229-20-6
Purity: ≥97% (HPLC)
Molecular Formula: C24H30N2O7·H2O
Molecular Weight: 476.53
MDL Number: MFCD28144745
Appearance: White to off-white powder
Conditions: Store at 2 - 8 °C, under inert gas

FIRST AID MEASURES of ADVANTAME:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of ADVANTAME:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of ADVANTAME:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of ADVANTAME:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

 
HANDLING and STORAGE of ADVANTAME:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of ADVANTAME:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available