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Cas number: 6217-54-5

All-cis-docosa-4,7,10,13,16,19-hexaenoic acid is a docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19. It has a role as a nutraceutical, an antineoplastic agent, a human metabolite, a Daphnia tenebrosa metabolite, a mouse metabolite and an algal metabolite. It is a docosahexaenoic acid and an omega-3 fatty acid.

Synonyms: Docosahexaenoic acid; Doconexent; Cervonic acid; 6217-54-5; all-cis-DHA; (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid; Doconexento; Doconexentum; Doxonexent; AquaGrow Advantage; all-Z-Docosahexaenoic acid; Martek DHA HM; Ropufa 60; cis-4,7,10,13,16,19-Docosahexaenoic acid; Docosahexaenoate; UNII-ZAD9OKH9JC; (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid;Docosahexaenoic acid (all-Z); CCRIS 7670; all-cis-4,7,10,13,16,19-Docosahexaenoic acid; ZAD9OKH9JC; 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid; all-cis-docosa-4,7,10,13,16,19-hexaenoic acid; DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID; 4,7,10,13,16,19-Docosahexaenoic acid, (all-Z); CHEMBL367149; docosahexaenoic acid(DHA); CHEBI:28125; delta4,7,10,13,16,19-Docosahexaenoic acid; 4-cis,7-cis,10-cis,13-cis,16-cis,19-cis-Docosahexaenoic acid;
(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid; (all-Z)-4,7,10,13,16,19-Docosahexaenoic acid; OMEGA-3 MARINE TRIGLYCERIDES;  efalex; NCGC00161345-04; DOCOSAHEXAENOIC ACID (22:6 n-3); 22:6(n-3); cis-4,7,10,13,16,19-Docosahexanoic acid; 4,7,10,13,16,19-Docosahexaenoic acid; C22:6n-3,6,9,12,15,18; Monolife 50; Doconexent [INN]; Marinol D 50TG; 4,7,10,13,16,19-Docosahexaenoic acid, (4Z,7Z,10Z,13Z,16Z,19Z); SR-05000002130; Doconexentum [INN-Latin]; Doconexento [INN-Spanish]; DHA-[21,21,22,22,22-d5]; Cervonate; 1fdq; DHA algae oil; FA 22:6; Algal DHA; Omega 3 fatty acid; all-Z-Docosahexaenoate; Cervonic acid|||DHA; Spectrum5_002062; Docosahexaenoic acid (6CI); SCHEMBL19577; BSPBio_001298; Docoshexaenoic Acid (Powder); Docosahexaenoic Acid 6217-54-5; Docosahexaenoic acid (22:6(n-3)); 4,7,10,13,16,19-Docosahexaenoate; all cis- Docosahexaenoic acid (cis-DHA); CAS-6217-54-5; cis-4,7,10,13,16,19-Docosahexanoate; 
4,7,10,13,16,19-Docosahexaenoic acid, (all cis); cis-4,7,10,13,16,19-Docosahexaenoic acid, >=98%; z,z,z,z,z,z-docosa4,7,10,13,16,19-hexaenoic acid; (all-Z)-4,7,10,13,16,19-Docosahexaenoic Acid, DHA; C22H32O2 (cis-4,7,10,13,16,19-docosahexaenoic acid); 4,7,10,13,16,19-Docosahexaenoic acid, (all-Z)- (8CI); cis-4,7,10,13,16,19-Docosahexaenoic acid, analytical standard; (4Z,7Z,10Z,13Z,16Z, 19Z)-docosa-4,7,10,13,16,19-hexaenoic acid

Molecular Formula: C22H32O2

Molecular Weight: 328.5 g/mol

A mixture of fish oil and primrose oil, doconexent is used as a high-docosahexaenoic acid (DHA) supplement. DHA is a 22 carbon chain with 6 cis double bonds with anti-inflammatory effects. It can be biosythesized from alpha-linolenic acid or commercially manufactured from microalgae. It is an omega-3 fatty acid and primary structural component of the human brain, cerebral cortex, skin, and retina thus plays an important role in their development and function.

The amino-phospholipid DHA is found at a high concentration across several brain subcellular fractions, including nerve terminals, microsomes, synaptic vesicles, and synaptosomal plasma membranes.Doconexent is a polyunsaturated very long-chain fatty acid with a 22-carbon backbone and 6 double bonds, originating from the 3rd, 6th, 9th, 12th, 15th and 18th positions from the methyl end. They may belong to one of several groups of multicellular algae: the red algae, green algae, and brown algae. Hydrocolloids have attained commercial significance, especially in food production as food additives.

The food industry exploits the gelling, water-retention, emulsifying and other physical properties of these hydrocolloids. Most edible seaweeds are marine algae whereas most freshwater algae are toxic. Some marine algae contain acids that irritate the digestion canal, while some others can have a laxative and electrolyte-balancing effect. Most marine macroalgae are nontoxic in normal quantities, but members of the genus Lyngbya are potentially lethal.Seaweed has been a part of diets in China, Japan and Korea since prehistoric times.

Most edible seaweeds are marine algae whereas most freshwater algae are toxic. Some marine algae contain acids that irritate the digestion canal, while some others can have a laxative and electrolyte-balancing effect. Seaweeds are used extensively as food in coastal cuisines around the world.Seaweed contains high levels of iodine relative to other foods. Algae fuel, algal biofuel, or algal oil is an alternative to liquid fossil fuels that uses algae as its source of energy-rich oils. Also, algae fuels are an alternative to commonly known biofuel sources, such as corn and sugarcane.

When made from seaweed (macroalgae) it can be known as seaweed fuel or seaweed oil. Several companies and government agencies are funding efforts to reduce capital and operating costs and make algae fuel production commercially viable. In 1942 Harder and Von Witsch were the first to propose that microalgae be grown as a source of lipids for food or fuel.Aach showed that Chlorella pyrenoidosa could be induced via nitrogen starvation to accumulate as much as 70% of its dry weight as lipids

It is a polyphyletic grouping that includes species from multiple distinct clades. Included organisms range from unicellular microalgae, such as Chlorella and the diatoms, to multicellular forms, such as the giant kelp, a large brown alga which may grow up to 50 metres (160 ft) in length. Most are aquatic and autotrophic and lack many of the distinct cell and tissue types, such as stomata, xylem and phloem, which are found in land plants. The largest and most complex marine algae are called seaweeds, while the most complex freshwater forms are the Charophyta, a division of green algae which includes, for example, Spirogyra and stoneworts.

No definition of algae is generally accepted. One definition is that algae "have chlorophyll as their primary photosynthetic pigment and lack a sterile covering of cells around their reproductive cells".[2] Although cyanobacteria are often referred to as "blue-green algae", most authorities exclude all prokaryotes from the definition of algae. While fish oil also supplies omega-3s, algae oil may provide a great plant-based alternative if you don’t eat seafood or can’t tolerate fish oil. Algae itself includes 40,000 species that range from single-celled microscopic organisms known as microalgae to kelp and seaweed. All types rely on energy from sunlight or ultraviolet (UV) light and carbon dioxide.

Omega-3 fatty acids are a family of polyunsaturated fats found in plants and fish. They supply essential fats that your body can’t make on its own, so you have to get from your diet. Several types exist, but most research focuses on EPA, DHA, and alpha-linolenic acid. However, the process isn’t very efficient, so it’s best to get all three from your diet. Algae oil is an oil made from certain marine algae. Like fish oil, algal oil is used as a source of omega-3 fatty acids. Two of the most important omega-3 fatty acids contained in algal oil are docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Algal oil is used in foods and as a medicine.

Algal oil is most commonly used along with another fatty acid to fortify infant formula. It is also used for improving thinking skills in children and older people, lowering cholesterol, improving vision in people with a certain eye condition (retinitis pigmentosa), and many other conditions, but there is no good scientific evidence to support these uses. Don't confuse algal oil with algae such as blue-green algae, brown algae, chlorella, or laminaria. Also, don't confuse algal oil with DHA or EPA from other sources such as fish oil.

Algal oil contains omega-3 and omega-9 fatty acids. These fatty acids can reduce inflammation (swelling), improve levels of some fats in the blood, and help with brain function. Decline in memory and thinking skills that occurs normally with age. Some research shows that taking algal oil can improve an older person's ability to remember past events. It also seems to improve some forms of learning. But taking algal oil doesn't seem to improve short-term memory related to reasoning and decision-making in older people. And it doesn't seem to improve higher-level thinking skills.

Child development. Taking algal oil while breastfeeding doesn't seem to improve vision of the breastfed infant by the age of 4 or 8 months. It also doesn't seem to improve most measures of brain development in the child by the age of 5 years. But it might improve motor skills in the child by the age of 30 months and attention at the age of 5 years. Memory and thinking skills (cognitive function). It's unclear if taking algal oil can improve reading skills in children who are poorer readers. Results are conflicting. Taking algal oil doesn't seem to improve reading skills in children who are better readers.

Heart disease. Eating 1.5 tablespoons per day of an algal oil that is high in oleic acid may help to prevent heart disease. But research is limited. High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Taking algal oil might help lower blood fats called triglycerides. It might also increase high-density lipoprotein or "good" cholesterol. But taking algal oil seems to also increase low-density lipoprotein or "bad" cholesterol. Most research has involved patients without heart disease. So, it's unclear if algal oil can improve cholesterol or reduce the risk of heart-related events in people with heart disease.

Low bone mass (osteopenia). Early research shows that taking algal oil along with calcium and vitamin D doesn't improve bone mass better than taking just calcium and vitamin D. An inherited eye condition that causes poor night vision and loss of side vision (retinitis pigmentosa). Taking algal oil doesn't seem to slow the breakdown of cells in the retina in males with this eye condition. The breakdown of these cells can lead to loss of side vision and difficulty seeing at night. But taking algal oil might slow the loss of visual field sensitivity.
ADHD. Autism. Cystic fibrosis. Infant development. Other conditions.

Algal oil is LIKELY SAFE for most adults when taken by mouth. High Stability High Oleic (HSHO) Algae Oil is one of the most stable liquid bio-based oils on the market, delivering versatility in eco-friendly formulations for skin and hair care. During a controlled manufacturing process, the algae efficiently convert simple sugars into triglyceride oils. This process takes place far from fragile ecosystems, resulting in minimal environmental impact while ensuring rapid scalability and reproducibility.

Adds emolliency and moisturization properties
Adds emolliency without greasiness
Adds gloss to lip care and hair care formulations
Aides in conditioning the scalp
Controls hair frizz
Emollient in both hair and skin formulations
Exceptional oxidative stability
Good slip
Good spreadability and fast absorbency in creams and lotions
Improves hair manageability
Non-greasy skin feel
Protects and repairs hair fiber
Water insoluble
Body Lotions/Creams/Gels
Body Washes
Eye Area Skin Care Products
Facial Care Products
Styling Products

DHA plays a major role in the development of the brain during foetal, neonatal and infant stages. Maternal dietary intake of DHA during pregnancy and breast feeding may help support cognitive function development in infants.

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