ASCORBYL ISOSTEARATE

Ascorbyl Isostearate is the oil soluble derivative of the vitamin C. 
After the absorption by the skins and through the action of enzyme, VC Isostearate is regenerated into vitamin C in the body, so as to improve the defect of vitamin C which may easily be oxidized and discolored.
Ascorbyl Isostearate is a fatty acid ester.

CAS:    10605-09-1
MF:    C24H42O7
MW:    442.59
EINECS:    234-231-5

Synonyms
6-(stearoyloxy)-L-ascorbic acid;4,5-dihydroxy-2-(1-hydroxy-2-octadecoxyethyl)-3-furanone;6-O-Stearoyl-L-ascorbic Acid;[2-(4,5-dihydroxy-3-oxo-furan-2-yl)-2-hydroxy-ethyl] octadecanoate;[2-(4,5-dihydroxy-3-oxofuran-2-yl)-2-hydroxyethyl] octadecanoate;stearic acid [2-(4,5-dihydroxy-3-keto-2-furyl)-2-hydroxy-ethyl] ester;6-o-stearylascorbic acid;6-O-STEAROYL-L-ASCORBIC ACID

Ascorbyl Isostearate is an ester formed from ascorbic acid and stearic acid. 
In addition to its use as a source of vitamin C, Ascorbyl Isostearate is used as an antioxidant food additive in margarine (E number E305). 
The USDA limits its use to 0.02% individually or in conjunction with other antioxidants.
Ascorbyl Isostearate. 
Ascorbyl Isostearate is the oil resoluble derivative of the vitamin C. Inhibits the generation of melanin as well as blocks up the oxidizing chain in the course of melanin generation and thus reduces the melanin. 
Ascorbyl Isostearate accelerates the synthesis of collagen and scavenges the free oxygen radicals. 
Ascorbyl Isostearate inhibits the oxidation of lipid, and has the function of anti-aging. 
Possesses good resistance to acid and heat. 
Ascorbyl Isostearate can be dissolved in various oily compounds.

Ascorbyl Isostearate 6-stearate, with the CAS number 10605-09-1, is an ester formed from ascorbic acid (vitamin C) and stearic acid. This compound is characterized by its role as a non-ionic surfactant and emulsifier, often utilized in food, cosmetic, and pharmaceutical formulations. 
Ascorbyl Isostearate exhibits good solubility in organic solvents while being less soluble in water, which can enhance the stability and bioavailability of ascorbic acid in various applications. 
Ascorbyl Isostearate is known for its antioxidant properties, contributing to the preservation of products by preventing oxidative degradation. 
Additionally, Ascorbyl Isostearate can improve the texture and consistency of formulations, making it valuable in the development of creams, lotions, and dietary supplements. 
Ascorbyl Isostearate's safety profile is generally favorable, but like all additives, it should be used within established guidelines to ensure consumer safety. 
Overall, Ascorbyl Isostearate serves as a multifunctional ingredient, combining the benefits of vitamin C with the properties of fatty acids.

Ascorbyl Isostearate Chemical Properties
Melting point: 117 °C
Boiling point: 536.0±50.0 °C(Predicted)
density: 1.125
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 3.96±0.10(Predicted)
color: White to Pale Brown
Major Application: (Pharmaceutical small molecule)
InChI: InChI=1S/C24H42O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(26)30-18-19(25)23-21(27)22(28)24(29)31-23/h19,23,25,27-28H,2-18H2,1H3/t19-,23+/m0/s1
InChIKey: LITUBCVUXPBCGA-WMZHIEFXSA-N

Uses    
Ascorbyl Isostearate is used to specifically target anti-tumoral dehydrocrotonin nanoparticles.
Ascorbyl Isostearate is a lipophilic ester derivative of ascorbic acid (Vitamin C) and stearic acid. 
Ascorbyl Isostearate's enhanced cell membrane permeability makes it a valuable compound for biochemical and cancer biology research. 
Studies have demonstrated that Ascorbyl Isostearate exhibits potent anti-proliferative and apoptosis-inducing properties in various human cancer cell lines, including cervical (HeLa) and ovarian carcinoma cells. 
Research indicates its mechanism of action involves generating reactive oxygen species (ROS), modulating membrane fluidity and permeability, and impacting key cellular signaling pathways. 
Ascorbyl Isostearate has been shown to arrest the cell cycle at the sub-G0/G1 and S/G2-M phases and to inhibit the PI3K/AKT signaling pathway, which is crucial for cell growth and survival. 
In vivo studies have shown that administration of Ascorbyl Isostearate can induce the involution of human ovarian carcinoma xenografts in models. 
Beyond its applications in life science research, Ascorbyl Isostearate is also recognized as an antioxidant food additive (E number E305). 
Ascorbyl Isostearate is intended for laboratory research purposes only and is not classified or intended for diagnostic, therapeutic, or human consumption use. 
Researchers should handle Ascorbyl Isostearate with appropriate safety precautions.