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BATYL ALCOHOL

Batyl alcohol is a fatty alcohol that is found in liver oils of marine animals, bone marrow and breast milk.
Batyl alcohol is a long-chain fatty alcohol ether of glycerol, classified as an alkylglycerol.
Batyl alcohols chemical structure is characterized by a glycerol backbone in which the hydroxyl group at the sn-1 position is ether-linked to a saturated C18 alkyl chain (octadecyl group), while the remaining hydroxyl groups at the sn-2 and sn-3 positions are free.

CAS Number: 544-62-7
Molecular Formula: C21H44O3
Molecular Weight: 344.57
EINECS Number: 208-874-7

Synonyms:BATYL ALCOHOL, 544-62-7, Batilol, 3-octadecoxypropane-1,2-diol, 1-O-Octadecylglycerol, Stearyl monoglyceride, 1,2-Propanediol, 3-(octadecyloxy)-, Batilolum, Glycerol monooctadecyl ether, Glycerine 1-monostearyl ether, Monooctadecyl ether of glycerol, Glycerol octadecyl ether, CHEBI:34117, NSC-284200, 39YR661C4U, RefChem:561112, GlyTouCan:G63046TL, glyceryl 1-octadecyl ether, 3-octadecyloxy-propane-1,2-diol, G63046TL, 208-874-7, 3-(octadecyloxy)propane-1,2-diol, 1-O-Octadecyl-rac-glycerol, 3-(Octadecyloxy)-1,2-propanediol, Batilol [INN], Batylol, Glycerol 1-octadecyl ether, Glyceryl-1-octadecyl ether, C18:0 Glyceryl 1-ether, NSC 284200, Batyl alcohol, Batilol, MFCD00004720, 1-(Octadecyloxy)-2,3-dihydroxypropane, NSC284200, 4-Oxadocosane-1,2-diol, 3-Octadecyloxy-1,2-propanediol, DTXSID0047799, .alpha.-Octadecylether of glycerol, NCGC00095748-01, Batylalcohol, C14-22 Monoglycerides, 1,3-(octadecyloxy)-, WLN: Q1YQ1O18, DTXCID508956, MONOGLYCERIDES (125 MG)H1D2320.963MG/MG(AI), 3-octadecyloxypropane-1,2-diol, Batilolum [INN-Latin], dl-Batyl alcohol, CAS-544-62-7, alpha-Octadecylether of glycerol, EINECS 208-874-7, BRN 1725677, Bathyl alcohol, Batil alcohol, UNII-39YR661C4U, AI3-18451, DL-Batylalcohol, Batyl alcohol, 99%, Spectrum_001658, Spectrum2_001609, Spectrum3_000738, Spectrum4_001778, Spectrum5_000395, BATILOL [WHO-DD], C18:0 Glyceryl 1-ether, BATYL ALCOHOL [MI], BSPBio_002296, KBioGR_002296, KBioSS_002138, 4-01-00-02758 (Beilstein Handbook Reference), DivK1c_001035, SCHEMBL117051, SCHEMBL809161, SPECTRUM1503983, SPBio_001617, rac-Glycerol 1-octadecyl ether, orb1304631, SCHEMBL9851847, CHEMBL1482516, Glycerol alpha-Monostearyl Ether, rac-1-O-N-Octadecyl glycerol, SCHEMBL22587989, HMS503O11, KBio1_001035, KBio2_002138, KBio2_004706, KBio2_007274, KBio3_001516, OGBUMNBNEWYMNJ-UHFFFAOYSA-, NSC8716, NINDS_001035, HMS5082F11, NSC-8716, TCA99053, 01503944_BATYL, Tox21_111515, BDBM50535055, CCG-38893, AKOS015901733, Tox21_111515_1, CS-W011891, HY-W011175, SDCCGMLS-0066743.P001, IDI1_001035, NCGC00095748-02, NCGC00095748-04, AS-13696, FO111148, NCI60_002329, SY051623, DB-052579, B1202, NS00013390, S3982, D81795, SR-05000002606, (+/-)-3-(OCTADECYLOXY)-1,2-PROPANEDIOL, SR-05000002606-1, Q27115823, Batilol, Glycerol monooctadecyl ether, Stearyl monoglyceride, 1040243-48-8, InChI=1/C21H44O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-24-20-21(23)19-22/h21-23H,2-20H2,1H31,2-Propanediol,3-(octadecyloxy)-, 1-o-octadecylglycerol, Glycerine1-,, onostearylether, glycerolmonooctadecylether, monooctadecyletherofglycerol, 2 3-DIHYDROXYPROPYL-1-OCTADECYL ETHER, 1-O-OCTADECYL-RAC-GLYCEROL, (+)-BATYL ALCOHOL

Batyl alcohol is often extracted from natural sources such as shark liver oil, fish oils, and certain plant oils, though it can also be synthesized chemically for industrial use.
Due to its structural similarity to endogenous lipids, it is sometimes considered a bioactive compound with potential health-promoting properties, including supporting immune function, enhancing skin barrier properties, and promoting cellular metabolism in certain contexts.
Batyl alcohol is an alkyl glyceryl ether.

This dual nature—hydrophobic long-chain alkyl group and hydrophilic glycerol moiety—makes Batyl Alcohol a amphiphilic molecule, allowing it to interact with both lipid environments and aqueous phases, which is particularly important in cosmetic, pharmaceutical, and biochemical formulations.
The molecule is a white, waxy solid at room temperature and exhibits high melting points typical of long-chain alcohols, giving it structural stability in formulations that require long-term shelf life and resistance to oxidation.
Batyl alcohol is practically insoluble in water, yet it dissolves readily in oils, organic solvents, and lipid-based delivery systems, making it ideal as an emollient, solubilizer, and stabilizer.

Batyl alcohol is typically used as a functional lipid, emollient, solubilizer, and penetration enhancer.
Batyl alcohol is often included in creams, lotions, ointments, liposomes, and serums where it can stabilize emulsions, improve skin feel, and enhance the delivery of active ingredients through the stratum corneum.
Batyl alcohols glycerol ether structure allows it to integrate into lipid bilayers of the skin and other biological membranes, making it valuable in cosmetic science and dermatological formulations.

From a chemical database perspective, Batyl Alcohol is recognized under multiple identifiers, including CAS number 544-62-7, EINECS 208-874-7, and INN Batilol, and it is indexed in various chemical registries and pharmacological databases due to its widespread use and biological relevance.
Batyl alcohol is a white, waxy solid at room temperature and is practically insoluble in water but soluble in oils, organic solvents, and surfactant systems, which makes it highly versatile in cosmetic, pharmaceutical, and nutritional applications.

Batyl alcohol is a monoether formed by condensation of stearyl alcohol with one of the two primary alcohol sites of glycerol.
Batyl alcohol is an organic compound with the formula HOCH2CH(OH)CH2OC18H37.

Batyl Alcohol, also known chemically as 1-O-Octadecylglycerol, 3-octadecyloxypropane-1,2-diol, or glyceryl 1-octadecyl ether, is a naturally occurring long-chain fatty alcohol ether of glycerol that belongs to the class of alkylglycerols.
Batyl alcohol is a colorless solid.
Together with S-selachyl alcohol and S-chimyl alcohol, S-batyl alcohol is a component of some lipid membranes.

Structurally, it consists of a glycerol backbone in which the hydroxyl group at the first carbon is ether-linked to a long, saturated C18 fatty chain (octadecyl group), while the remaining hydroxyl groups on the glycerol remain free.
This unique structure gives Batyl alcohol both lipophilic (oil-loving) properties from the long alkyl chain and hydrophilic (water-compatible) properties from the free hydroxyl groups, allowing it to interact effectively with lipid membranes and emulsified systems.

Melting point: 71-73 °C (lit.)
Alpha: D20 +1.14° (c = 6.6 in CHCl3)
Boiling point: 419.64 °C (rough estimate)
Density: 0.9975 (rough estimate)
Vapor pressure: 0 Pa at 25 °C
Refractive index: 1.5192 (estimate)
Storage temp.: Sealed in dry, Room Temperature
Solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
Form: Solid
pKa: 13.68 ± 0.20 (Predicted)
Color: White to Off-White
Merck: 14,1011
BRN: 1725677
LogP: 7.8 at 25 °C

Batyl Alcohol is generally compatible with a wide range of oils, esters, silicones, and surfactants, making it versatile in both cosmetic and pharmaceutical formulations.
Batyl alcohol is an alkyl glyceryl ether.
This means that the ethylhexyl group is bound to glycerin at one end by an ether linkage.

Although they are also alkyl glyceryl ethers, Batyl Alcohol and Chimyl Alcohol (may also be called Cetyl Glyceryl Ether) have traditionally been used as cosmetic labeling names for these alkyl glyceryl ethers.
Batyl alcohol and Isostearyl Glyceryl Ether are also alkyl glyceryl ethers that may be used in cosmetic products.
Despite the different types of names for these ingredients, they all consist of an alkyl group bound to glycerin by an ether linkage.

Batyl alcohol and the other alkyl glyceryl ether ingredients may be used in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products.
Batyl Alcohol naturally occurs in marine oils, particularly shark liver oil, as well as in certain fish, seal, and plant-derived lipids.
In these sources, it exists alongside other alkylglycerols, contributing to the bioactive lipid fraction that has been associated with immune-supporting and cellular signaling functions.

Because of its structural similarity to endogenous glycerol ethers found in human tissues, it has been studied for its potential physiological benefits, including modulation of the immune system, enhancement of skin barrier function, and support for lipid metabolism.
Synthetic methods are also used in industrial production to produce Batyl Alcohol with high purity for cosmetic, pharmaceutical, and nutraceutical applications.

An alkylglycerol that is glycerol in which one of the primary hydroxy groups has been converted to the corresponding octadecyl ether.
Batyl alcohol is used in cosmetics as a stabilising ingredient and skin-conditioning agent.
Batyl alcohol is found in the liver of the shark Centrophorus squamosus.

The name batyl is derived from a classification of rays, order Batoidea.
Like other glyceryl ethers, those derived from batyl alcohol are not saponifiable.
Batyl alcohol and related glycyl ethers are susceptible to oxidation catalyzed by glyceryl-ether monooxygenases.

The net oxidation gives glycerol and the carboxylic acid: HOCH2CH(OH)CH2OC18H37 + 1.5 O2 → HOCH2CH(OH)CH2OH + HO2CHC17H35 + H2O
Batyl alcohol and related glycyl ethers are also susceptible to dehydrogenation catalyzed unsaturases to give the vinyl ethers called plasmalogens: HOCH2CH(OH)CH2OC18H37 + [O] → HOCH2CH(OH)CH2OCH=CHC16H35 + H2O

Mono-ether of glycerin and stearyl alcohol, a synthetic equivalent to naturally occurring alkyl glyceryl ether.
By adding a small amount, emulsions that thickens and have good texture can be prepared.
Batyl alcohol has an anti-inflammatory effect.

Batyl Alcohol acts as a softening and moisturizing agent in creams, lotions, and ointments, improving the texture, spreadability, and overall skin feel of topical products.
Due to its lipophilic ether chain, it can integrate into lipid membranes, increasing the permeability of active ingredients through the skin and enhancing bioavailability of certain actives.

Its amphiphilic structure allows Batyl Alcohol to stabilize oil-in-water or water-in-oil emulsions, preventing phase separation and improving formulation longevity.
Research indicates that Batyl Alcohol may act as a functional lipid in cellular systems, supporting immune function, hematopoiesis, and possibly cognitive health, although these effects are typically associated with nutritional or pharmaceutical dosages rather than topical cosmetic use.

Uses Of Batyl alcohol:
Batyl Alcohol can also be used in shampoos, conditioners, and leave-in hair treatments as a conditioning agent that improves hair manageability, smoothness, and shine.
Its long alkyl chain can coat the hair shaft, providing moisture retention and protection against mechanical stress or environmental damage such as UV radiation or heat styling.
Beyond cosmetic uses, Batyl Alcohol is sometimes included in pharmaceutical formulations as a functional lipid excipient that enhances drug solubility, bioavailability, or stability.

In nutraceuticals, particularly those derived from marine oils, it is valued for its potential biological activity, including support for immune function, blood lipid metabolism, and cellular health.
Batyl Alcohol is highly versatile due to its solubility in oils and organic solvents and compatibility with a wide range of surfactants, emulsifiers, and active ingredients.
This versatility allows formulators to create products with improved texture, stability, and performance, from luxurious creams to lightweight lotions and sophisticated delivery systems.

Batyl Alcohol is a multi-functional ingredient used primarily as a moisturizing emollient, emulsion stabilizer, penetration enhancer, and bioactive lipid in cosmetics, hair care products, liposomal carriers, pharmaceutical formulations, and nutraceuticals.
Its amphiphilic structure, compatibility with lipid membranes, and natural similarity to endogenous glycerol ethers make it particularly valuable in enhancing formulation stability, improving ingredient delivery, and supporting skin and hair health.

Batyl Alcohol is used to synthesize amphiphilic alkylglycerolipids with antitumor activities.
Batyl alcohol is also used in cosmetic compounds for prevention or treatment of erythema or dermatitis or promotion of wound healing.
Batyl alcohol is fat soluble.

Batyl alcohol has moisture retaining properties, so mostly it is used as an emulsion stabilizer.
It creates a film over the skin which prevents water loss.
Batyl alcohol conditions dry and irritated skin.

Batyl Alcohol is commonly incorporated into creams, lotions, ointments, and serums because it functions as an effective emollient, softening the skin by forming a thin, protective lipid layer on the surface.
This lipid layer prevents transepidermal water loss, thereby helping to maintain hydration, smoothness, and overall skin suppleness.
Its long-chain glycerol ether structure allows it to mimic natural lipids in the skin, making it particularly suitable for dry, sensitive, or aging skin formulations where barrier support is critical.

Due to its amphiphilic nature, Batyl Alcohol is used as a stabilizer in both oil-in-water and water-in-oil emulsions, ensuring that oils and aqueous phases remain homogeneously mixed over time.
This is especially important in products such as lotions, creams, and topical gels, where phase separation could compromise both the appearance and performance of the product.
Batyl alcohols stabilizing properties also enhance the shelf life and physical integrity of emulsified formulations under varying temperature and storage conditions.

Batyl Alcohol is frequently employed in cosmetic and pharmaceutical preparations to facilitate the delivery of bioactive compounds through the stratum corneum, the outermost layer of the skin.
By intercalating into the lipid bilayers of the skin, it can temporarily increase membrane fluidity, allowing active ingredients such as vitamins, antioxidants, peptides, or other lipophilic compounds to penetrate more efficiently and exhibit enhanced efficacy in the targeted tissues.

Because of its structural compatibility with lipid bilayers, Batyl Alcohol is often incorporated into liposomes, niosomes, and other lipid-based nanocarrier systems.
In these applications, it helps stabilize vesicle membranes, maintain particle integrity, and improve the bioavailability and controlled release of encapsulated ingredients.
This makes it a critical component in advanced topical and oral delivery technologies.

Safety Profile Of Batyl alcohol:
Batyl alcohol is generally non-corrosive but should still be handled with caution in laboratory or manufacturing settings. Proper eye protection is recommended to prevent accidental exposure.
Although rare, some individuals may develop allergic contact dermatitis upon prolonged exposure to Batyl Alcohol.
Symptoms can include localized redness, itching, rash, or mild swelling.

Formulators typically perform patch testing or safety assessments to ensure that finished products are unlikely to trigger sensitization at the concentrations used in consumer products.
Batyl Alcohol is generally considered safe for topical use at typical cosmetic concentrations, but in its raw or concentrated form, it may cause mild skin irritation in sensitive individuals.
Direct contact with undiluted Batyl Alcohol can lead to redness, itching, or a temporary burning sensation, particularly on broken or compromised skin.

Repeated or prolonged exposure without proper formulation can increase the risk of dermatitis, although this is uncommon in regulated cosmetic products.
Contact of Batyl Alcohol with the eyes, especially in high concentrations or as an undiluted chemical, may cause temporary irritation, tearing, or redness.