PRODUCTS

BUTYL METHOXYDIBENZOYLMETHANE

Butyl Methoxydibenzoylmethane is used sunscreen ingredient in moisturizers, shampoos, lipsticks and other decorative products.
Butyl Methoxydibenzoylmethane is added in sun protection products at a concentration of 1-2% and 2-3%.
Butyl Methoxydibenzoylmethane is often used together with octylmethoxycinnamate (OMC).

CAS Number: 70356-09-1
EC Number: 274-581-6
MDL NO: MFCD22421631
Molecular Weight: 310.4 g/mol
UV-A absorber: oil soluble
INCI name: Butyl Methoxydibenzoylmethane
USAN: Avobenzone
Chemical Composition: 1-(4-Methoxyphenyl)-3-(4-tert.-butylphenyl)propan-1,3-dione
Chemical names: 1-(4-Methoxyphenyl)-3-(4-tert.-butyl phenyl)propan-1,3-dione
Empirical Formula: C20H22O3

SYNONYMS:
3-(4-tert-Butylphenyl)-1-(4-methoxyphenyl)propane-1,3-dione, butylmethoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione, 3-(4-tert-Butylphenyl)-1-(4-methoxyphenyl)propane-1,3-dione, butylmethoxydibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, Avobenzone, 70356-09-1, Parsol 1789, Butyl methoxydibenzoylmethane, Escalol 517, Eusolex 9020, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, NeoHeliopan 357, Avobenzona, Avobenzonum, 4-tert-Butyl-4'-methoxy-dibenzoylmethane, 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione, 1-(4-(tert-Butyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 4-TERT-BUTYL-4'-METHOXYDIBENZOYLMETHANE, HSDB 7423, UNII-G63QQF2NOX, Avobenzonum [INN-Latin], G63QQF2NOX, Avobenzona [INN-Spanish], EINECS 274-581-6, 1,3-Propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-, NSC-758680, 1-(p-tert-Butylphenyl)-3-(p-methoxyphenyl)-1,3-propanedione, 1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)-1,3-propanedione, 4-methoxy-4'-tert-butyldibenzoylmethane, 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione, Avobenzone [USAN:USP:INN], DTXSID9044829, EC 274-581-6, NSC 758680, ANTHELIOS SX COMPONENT AVOBENZONE, NCGC00095112-01, CAPITAL SOLEIL COMPONENT AVOBENZONE, SHADE UVAGUARD COMPONENT AVOBENZONE, Avobenzonum (INN-Latin), Avobenzona (INN-Spanish), 1,3-Propanedione, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)-, AVOBENZONE (MART.), AVOBENZONE [MART.], AVOBENZONE (USP-RS), AVOBENZONE [USP-RS], 23644-60-2, Avobenzone (USAN:USP:INN), DTXCID7024829, AVOBENZONE (USP IMPURITY), AVOBENZONE [USP IMPURITY], 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propan-1,3-dione, AVOBENZONE (USP MONOGRAPH), AVOBENZONE [USP MONOGRAPH], 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1,3-propanedione, Parsol A, BMDBM cpd, SMR001562107, CAS-70356-09-1, butyl-methoxydibenzoylmethane, PONDSclarant b3, Ponds Clarant B3, MFCD00210252, Avobenzone (Standard), Spectrum_001715, PONDSVAO-B3, AVOBENZONE [MI], SpecPlus_000764, Avobenzone (USP/INN), AVOBENZONE [INN], Spectrum2_001663, Spectrum3_000990, Spectrum4_001116, Spectrum5_001358, AVOBENZONE [HSDB], AVOBENZONE [USAN], Avobenzone(Parsol 1789), AVOBENZONE [WHO-DD], Anti-Dark Moisturizing Cream, Avobenzone (Parsol 1789), SCHEMBL15650, BSPBio_002659, KBioGR_001592, KBioSS_002195, MLS002695918, MLS006010050, BIDD:ER0196, DivK1c_006860, SPECTRUM1504190, SPBio_001845, Avobenzone, analytical standard, AVOBENZONE [ORANGE BOOK], CHEMBL1200522, HY-B0316R, KBio1_001804, KBio2_002195, KBio2_004763, KBio2_007331, KBio3_001879, CHEBI:134751, HMS1922F17, HMS2093C04, HMS3655C22, HMS3715F14, Pharmakon1600-01504190, HY-B0316, Tox21_111427, Tox21_202796, CCG-39080, LEADERS SUNBUDDY ALL OVER SUN, NSC758680, s1904, 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedi- one, 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione, AKOS015838120, Tox21_111427_1, 1ST3417, AC-1682, DB09495, NCGC00095112-02, NCGC00095112-03, NCGC00095112-04, NCGC00095112-05, NCGC00260342-01, AS-12797, SBI-0052777.P002, B3382, NS00002639, SW219665-1, A10905, D03015, AB00053273_04, AB00053273_05, EN300-7406285, A836855, SR-05000001974, Q-200661, Q2775914, SR-05000001974-1, BRD-K14401183-001-10-7, BRD-K14401183-001-11-5, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-propane-1,3-dione, Avobenzone, United States Pharmacopeia (USP) Reference Standard, 1-(4-Methoxyphenyl)-3-(4-(tert)-butylphenyl)-1,3-propanedione, 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedi-one, Avobenzone, Pharmaceutical Secondary Standard; Certified Reference Material, 1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)-1,3-propanedione, Butyl methoxydibenzoylmethane, avobenzone, butyl methoxydibenzoylmethane, 4-t-butyl-4'-methoxy-dibenzoylmethane, 4-tert-butyl-4'-methoxy-dibenzoylmethane, 4-tert-butyl-4'-methoxydibenzoylmethane, 3-[4-(tert-butyl)phenyl]-1-(4-methoxyphenyl)propane-1,3-dione, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 1-(p-tert-butylphenyl)-3-(p-methoxyphenyl)-1,3-propanedione, 1-(4-(1,1-dimethyl ethyl)phenyl)-3-(4-methoxyphenyl) propane-1,3-dione, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1,3-propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)propane-1,3-dione, 1-(4-methoxyphenyl)-3-[4-(2-methyl-2-propanyl)phenyl]-1,3-propanedione, neo heliopan 357 (Symrise), 1,3-propanedione, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)-, 1,3-propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-, Avobenzone, AVOBENZONE, Parsol 1789, Escalol 517, PARSOL 1789, Parsol-1789, Eusolex 9020, parseal-1789, EUSOLEX(R) 9020, Sunscreener 1789, P-methoxydibenzoylmethane, Butyl Methoxydibenzoylmethane, 4-T-BUTYL-4'-METHOXY-DIBENZOYLMETHANE, 4-tert-butyl-4'-methoxy-dibenzoylmethane, 4-tert-Butyl-4'-methoxy-dibenzoylmethane, 2-pentoxy-1,3-diphenyl-propane-1,3-dione, 1-(P-T-BUTYLPHENYL)-3-(P-METHOXYPHENYL)-1,3-PROPANEDIONE, 1-(4-TERT-BUTYLPHENYL)-3-(4-METHOXYPHENYL) 1,3-PROPANEDIOL, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione, Avobenzone, Butyl-4-Methoxy-Dibenzoylmethane, 1,3-PROPANEDIONE,

Butyl Methoxydibenzoylmethane is a pale yellow powder with a weakly aromatic characteristic odor used in skin and sun care applications as a UV-A absorber.
Butyl Methoxydibenzoylmethane is insoluble in most standard solubilizers or bases including water, glycerin, mineral oil, and alcohol; soluble in isopropyl myristate and isopropyl adipate.

Butyl Methoxydibenzoylmethane is a recommended ingredient for medicated skin care and protective skin tone preparations, makeup creams and lotions, hand and face creams, moisturizing creams, And anti-aging formulations.
Butyl Methoxydibenzoylmethane, abbreviated as BMDBM, is an avobenzone, 1-(4-methoxyphenyl)-3-(4-tert-butylphenyl)-propane-1,3-dione.

Butyl Methoxydibenzoylmethane is one of the most common photoprotective compounds or UV filters in modern cosmetics.
Butyl Methoxydibenzoylmethane actively absorbs solar radiation in the range of 320-400 nm, therefore it is classified as a UVA filter.
Butyl Methoxydibenzoylmethane is soluble in oils and fatty acid esters in powder form.

Butyl methoxydibenzoylmethane, also known as avobenzone, is used for the formulation of sun protection.
Butyl Methoxydibenzoylmethane’s the only chemical sunscreen that provides sufficient UVA protection.
There are many types of UV absorbers, among which, this kind of absorbent has great practical research value.

Butyl Methoxydibenzoylmethane is a benzophenone ultraviolet absorber, is also a very important organic synthesis intermediates.
Butyl Methoxydibenzoylmethane is a synthetic UV absorber, is a good UV-A(>320nm) UV absorber, can block the full band (320 ~ 400nm) of UVA, is a high efficiency wide spectrum oil soluble UVA filter, and other UVB sunscreen, provides full UVA and UVB protection for the Prevention of light-induced skin cancer.

Butyl Methoxydibenzoylmethane is a synthetically produced substance in the form of a white to slightly yellow crystalline powder, which is very soluble in oil.
Butyl Methoxydibenzoylmethane works as an ultraviolet radiation absorber.

Paradoxically, Butyl Methoxydibenzoylmethane is very unstable in the sun and undergoes degradation.
Therefore, other substances are added to the resulting product to stabilize Butyl Methoxydibenzoylmethane and protect it from decay and loss of effectiveness.

Butyl Methoxydibenzoylmethane is problematic because it can cause skin damage or allergic reactions and is toxic to the environment.
Butyl Methoxydibenzoylmethane is not biodegradable.
The permitted percentage amount is 5% for the EU and 3% for the USA of the total content of Butyl Methoxydibenzoylmethane.

Butyl methoxydibenzoylmethane is a synthetic sunscreen ingredient that provides sun protection in the UVA range.
This type of radiation is present all day long, and penetrates deeply into skin, where Butyl Methoxydibenzoylmethane causes a cascade of damage that leads to many signs of aging.

Butyl Methoxydibenzoylmethane is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Butyl Methoxydibenzoylmethane is an synthetic, oil-soluble sun filter that absorbs both UV-A and UV-B radiation.

Butyl Methoxydibenzoylmethane is an organic sunscreen or chemical sunscreen.
That can protect against UVA in the wave frequency range from 320-390nm, which completely covers UVA I / UVA II.
Better known as avobenzone, butyl methoxydibenzoylmethane is globally approved.

In fact, Butyl Methoxydibenzoylmethane’s one of the most widely used UVA filters in the world and has been rigorously tested for safety and efficacy, with further safety studies ongoing.
Butyl Methoxydibenzoylmethane is a sun protection filter.

Butyl Methoxydibenzoylmethane absorbs UV rays.
Butyl Methoxydibenzoylmethane is also known as Avobenzone.
Butyl Methoxydibenzoylmethane is a derivative of dibenzoyl methane.

Butyl Methoxydibenzoylmethane is a member of dihydrochalcones.
Butyl Methoxydibenzoylmethane is dibenzoyl methane derivative.
Butyl Methoxydibenzoylmethane is oil soluble ingredient.

Butyl Methoxydibenzoylmethane has the ability to absorb ultraviolet light over wider range of wavelengths.
Butyl Methoxydibenzoylmethane is included in many commercially available sunscreens which are used as wide spectrum sunscreens.
Butyl Methoxydibenzoylmethane is very sensitive to light, to increase its stability and duration of action, photostablizers are added in the sunscreen product.

Butyl Methoxydibenzoylmethane has an absorption maximum of 357 nm.
Sunscreens containing Butyl Methoxydibenzoylmethane is indicated for providing protection from the sun.
In addition to limiting the skin's exposure to the sun, using sunscreen agents may help reduce long-term sun damage such as premature aging of the skin and skin cancer.

Butyl Methoxydibenzoylmethane is a sunscreen blocker.
Butyl Methoxydibenzoylmethane is a topical, broad range UV protector and blocks UVA I, UVA II, and UVB wavelengths, thereby limiting the impact of UV rays on skin. (NCI05)

Butyl Methoxydibenzoylmethane is a small molecule drug with a maximum clinical trial phase of IV (across all indications) that was first approved in 1992 and has 3 approved indications.
Butyl Methoxydibenzoylmethane is an oil-soluble UV-A filter that is approved for use in suncare preparations in many countries, including the USA, EU and Japan.

Butyl Methoxydibenzoylmethane can be used in protective hair compositions and it acts as a photo-stabilizer for different cosmetic products.
Because of its hydrophobic nature and its solubility in oil, Butyl Methoxydibenzoylmethane is particularly suitable for water-repellent and water-resistant formulations.

In the United States, Butyl Methoxydibenzoylmethane may be used as an over-the-counter sunscreen active up to 3%.
Butyl Methoxydibenzoylmethane's maximum permitted concentration extends to 5% within the European Union, where it’s been in use since 1978 (it was FDA-approved in 1996).

Many studies have shown that Butyl Methoxydibenzoylmethane becomes unstable when exposed to UV light, one reason reapplication during long periods of time outdoors is necessary.
To increase Butyl Methoxydibenzoylmethane's photostability, UV absorbers such as octocrylene and non-UV filters (e.g., diethylhexyl 2, 6-napththalate) often accompany avobenzone in a sunscreen formula.

Synthetic and natural antioxidants (such as vitamin E ubiquinone, glutathione, and diethylhexyl syringylidenemalonate) have can also improve Butyl Methoxydibenzoylmethane’s photostability, as can the proper choice of emollients, one example being caprylic/capric triglyceride.
Other ingredients used to stabilize avobenzone and allow Butyl Methoxydibenzoylmethane to be used with other filters such as octinoxate include polyester-8 and ethylhexyl methoxycrylene.

Butyl Methoxydibenzoylmethane is one of several sunscreen ingredients currently undergoing further safety testing under the purview of the United States Food and Drug Administration (FDA).
This testing is to gain a better understanding of the systemic absorption, metabolism, and elimination of these sunscreen actives when small amounts enter the body via topical use.

Butyl Methoxydibenzoylmethane’s important to know that the presence of this or other sunscreen actives in the body does not mean your health is at risk.
Butyl Methoxydibenzoylmethane is particularly suitable for water-repellent and water-resistant formulations, as it is hydrophobic and oil-soluble.
Butyl Methoxydibenzoylmethane is globally the only available chemical sunscreen that provides proper UV-A protection.

This makes Butyl Methoxydibenzoylmethane the gold standard of UV-A protection.
Butyl Methoxydibenzoylmethane is also known under the name Avobenzone.
Butyl Methoxydibenzoylmethane is an organic molecule and an oil-soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays.

The photostability of Butyl Methoxydibenzoylmethane is further increased when sunscreens are formulated with antioxidant compounds.
Mangiferin, glutathione, ubiquinone, vitamin C, vitamin E, beta-carotene and trans-resveratrol have all demonstrated some ability to protect Butyl Methoxydibenzoylmethane from photodegradation.

The stability and efficacy of Butyl Methoxydibenzoylmethane seems to continue to increase as a greater amount of antioxidants are added to the sunscreen.
According to some studies, "the most effective sunscreens contain Butyl Methoxydibenzoylmethane and titanium dioxide.

Butyl Methoxydibenzoylmethane can degrade faster in light in combination with mineral UV absorbers like zinc oxide and titanium dioxide, though with the right coating of the mineral particles this reaction can be reduced.
A manganese doped titanium dioxide may be better than undoped titanium dioxide to improve Butyl Methoxydibenzoylmethane's stability.

Butyl Methoxydibenzoylmethane is a special snowflake as it is the only globally available chemical sunscreen agent that provides proper UVA protection (in the US, new generation sunscreen agents are not approved because of impossible FDA regulations).
Butyl Methoxydibenzoylmethane is the global gold standard of UVA protection and is the most used UVA sunscreen in the world.

USES and APPLICATIONS of BUTYL METHOXYDIBENZOYLMETHANE:
Butyl Methoxydibenzoylmethane is utilized in association with recognized UV-B absorbers such as OMC in everyday cosmetic preparations like creams and lotions.
Butyl Methoxydibenzoylmethane can also be used in sunscreen preparations where an adequate concentration of both filters gives rise to excellent sun protection by blocking UV-A/UV-B radiations.

A wider range of ultraviolet light wavelengths can be absorbed by Butyl Methoxydibenzoylmethane.
Butyl Methoxydibenzoylmethane is present in a lot of broad-range sunscreens that are commercially available.
It functions as a sunblock. A topical UV protector with a broad spectrum, Butyl Methoxydibenzoylmethane blocks UVA I, UVA II, and UVB wavelengths, reducing the damage that UV rays can do to the skin.

Butyl Methoxydibenzoylmethane acts as an effective UVA absorber for wide range of applications.
Butyl Methoxydibenzoylmethane should be used in association with effective UVB absorbers to achieve formulations with broad-spectrum protection.
Butyl Methoxydibenzoylmethane is used in sun care formulations

Application/Recommended for Butyl Methoxydibenzoylmethane: Sun care (Sun protection, After-sun & Self-tanning)>Sun protection
Butyl Methoxydibenzoylmethane provides broad-spectrum protection for the skin and is widely used in sun care preparations.
In addition, Butyl Methoxydibenzoylmethane is used for the formulation of protective hair care preparations.

In some cases, Butyl Methoxydibenzoylmethane is used as a photo-antioxidant to protect products from photo-oxidation.
Butyl Methoxydibenzoylmethane is used sunscreen ingredient in moisturizers, shampoos, lipsticks and other decorative products.
Butyl Methoxydibenzoylmethane is added in sun protection products at a concentration of 1-2% and 2-3%.

Butyl Methoxydibenzoylmethane is often used together with octylmethoxycinnamate (OMC).
According to EU Regulation 1223/2009 and CU TR 009/2011, Butyl Methoxydibenzoylmethane is allowed to be used as a UV filter at a maximum permissible concentration of 5%.

Butyl Methoxydibenzoylmethane is one of the most used UVA filters in tanning cosmetics and personal care products.
Butyl Methoxydibenzoylmethane is commonly referred to as avobenzone.
Butyl Methoxydibenzoylmethane can be added to creams, hair washes and conditioners, deodorants, perfumes and nail products to protect against sun damage.

Butyl Methoxydibenzoylmethane is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Butyl Methoxydibenzoylmethane is used in the following products: cosmetics and personal care products and perfumes and fragrances.

Other release to the environment of Butyl Methoxydibenzoylmethane is likely to occur from: indoor use as processing aid and outdoor use as processing aid.
Butyl Methoxydibenzoylmethane is used in the following products: cosmetics and personal care products and perfumes and fragrances.
This substance is used in the following areas: formulation of mixtures and/or re-packaging.

Other release to the environment of Butyl Methoxydibenzoylmethane is likely to occur from: indoor use as processing aid, outdoor use as processing aid and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Butyl Methoxydibenzoylmethane is used in the following products: cosmetics and personal care products and perfumes and fragrances.

Release to the environment of Butyl Methoxydibenzoylmethane can occur from industrial use: formulation of mixtures and formulation in materials.
Butyl Methoxydibenzoylmethane is used in the following products: cosmetics and personal care products.
Butyl Methoxydibenzoylmethane has an industrial use resulting in manufacture of another substance (use of intermediates).

Release to the environment of Butyl Methoxydibenzoylmethane can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates).
Release to the environment of Butyl Methoxydibenzoylmethane can occur from industrial use: manufacturing of the substance.

The use of Butyl Methoxydibenzoylmethane in the formula must not contain Zinc Oxide, Titanium Dioxide and Octyl methoxycinnamate.
This is because it will cause Butyl Methoxydibenzoylmethane to deteriorate quickly.
Butyl Methoxydibenzoylmethane is being used in a wide range of cosmetic products to provide an appropriate Sun Protection Factor (SPF) in sunscreens or to protect cosmetics against UV radiation.

Butyl Methoxydibenzoylmethane is approved for the use in sun care preparations in many countries worldwide.
Butyl Methoxydibenzoylmethane is an organic sunscreen or chemical sunscreen that can protect against UVA in the wave frequency range from 320-390nm, which completely covers UVA I / UVA II.

Butyl Methoxydibenzoylmethane is being used in a wide range of cosmetic products to provide an appropriate Sun Protection Factor (SPF) in sunscreens or to protect cosmetics against UV radiation.

Applications of Butyl Methoxydibenzoylmethane: Bath products, Cleansing, Cosmetics, Fragrance, Hair care, Nail care, Skin care. and Sunscreens.
Butyl Methoxydibenzoylmethane is an synthetic, oil-soluble sun filter that absorbs both UV-A and UV-B radiation.

BENEFITS OF BUTYL METHOXYDIBENZOYLMETHANE:
Butyl Methoxydibenzoylmethane is a very effective UVA I absorber for a wide range of applications
Maximum absorption is at 357nm with a specific extinction of about 1100 and Butyl Methoxydibenzoylmethane has additional absorbing properties in the UVA II spectrum.

Butyl Methoxydibenzoylmethane is an oil soluble, crystalline powder with a slight aromatic odor.
Adequate solubility in the formulation must be ensured in order to avoid recrystallization of the Butyl Methoxydibenzoylmethane.

Butyl Methoxydibenzoylmethane should be used in association with effective UVB absorbers to achieve formulations with broad-spectrum protection
Approved world-wide.

Concentration maximum varies according to locallegislation
Butyl Methoxydibenzoylmethane is a safe and effective UVB absorber. Safety and efficacy studies are available on request

BUTYL METHOXYDIBENZOYLMETHANE AT A GLANCE:
*A globally approved synthetic UVA filter
*Must be used with sunscreen ingredients that provide UVB protection
*Requires special ingredients to improve stability in the presence of UV light
*Is one of several UV filters undergoing more detailed safety assessments
*Also known as avobenzone and Parsol 1789

BENEFITS OF BUTYL METHOXYDIBENZOYLMETHANE:
Butyl Methoxydibenzoylmethane has the ability to absorb UV light over a wide range of wavelengths and convert it into less damaging infrared radiation (heat).
Butyl Methoxydibenzoylmethane increases the stability of chemical hair colors.
Butyl Methoxydibenzoylmethane prevents natural- and synthetic hair dyes from fading in the sun.

WHAT IS BUTYL METHOXYDIBENZOYLMETHANE USED FOR?
Butyl Methoxydibenzoylmethane is used in the creation of sun protection products.
When Butyl Methoxydibenzoylmethane is used in sun protection products in the US, it will be listed on the label as Avobenzone.

When applied to the skin, Butyl Methoxydibenzoylmethane blocks UV rays.
By absorbing UV rays, Butyl Methoxydibenzoylmethane can also be used to shield cosmetics and personal care items from deterioration.

Butyl Methoxydibenzoylmethane is globally the only available chemical sunscreen that provides proper UV-A protection.
This makes Butyl Methoxydibenzoylmethane the gold standard of UV-A protection.
Butyl Methoxydibenzoylmethane is approved for use in sun care preparations at a maximum concentration of 3% in America and a maximum of 5% in Europe.

ORIGIN OF BUTYL METHOXYDIBENZOYLMETHANE:
Butyl Methoxydibenzoylmethane is made by reacting 4-methoxyacetophenone in toluene with 4-tert-butylbenzoic methyl ester in the presence of sodium amide via Claisen condensation (from 4-tert-butylbenzoic acid by esterification with methanol).

WHAT DOES BUTYL METHOXYDIBENZOYLMETHANE DO IN A FORMULATION?
*Uv absorber
*Uv filter

SAFETY PROFILE OF BUTYL METHOXYDIBENZOYLMETHANE:
The Food and Drug Administration (FDA) reviewed the safety of Butyl Methoxydibenzoylmethane and approved its use as an active ingredient in Over-the-Counter (OTC) sunscreen drug products at concentrations up to 3%.
When used in OTC sunscreen products, Butyl Methoxydibenzoylmethane is called Avobenzone.

The Cosmetic Ingredient Review (CIR) has deferred evaluation of Butyl Methoxydibenzoylmethane because the safety has been assessed by FDA.
This deferral of review is according to the provisions of the CIR Procedures.

Some studies suggest that some sunscreen ingredients, including Butyl Methoxydibenzoylmethane, may have acted like the hormone, estrogen.
Therefore, the European Commission’s Scientific Committee for Cosmetic Products and Non-Food Products Intended for Consumers (SCCNFP) was asked to consider if UV filters as used in sunscreen products have estrogenic effects which have the potential to affect human health.

The SCCNFP concluded that UV filters used in sunscreen products allowed in the European market have no estrogenic effects that could potentially affect human health.

ALTERNATIVES OF BUTYL METHOXYDIBENZOYLMETHANE:
*ZINC OXIDE,
*TITANIUM DIOXIDE

SYNTHESIS METHOD OF BUTYL METHOXYDIBENZOYLMETHANE:
at present, the main methods of synthesizing Butyl Methoxydibenzoylmethane are as follows:
① condensation addition water elimination method, that is, P-methoxyacetophenone and p-tert-butylbenzaldehyde are condensed, bromine is added, alkynes are eliminated and hydrated to obtain a product with a yield of 58%.

This method has a long route, high cost and low yield, namely, P-methoxy acetophenone and p-tert-butyl benzoic acid methyl ester reaction, the yield is 63.6%, the method is low cost, easy to operate, but the yield is low;

③ aldehyde and ketone condensation method, namely P-methoxy acetophenone and p-tert-butyl benzaldehyde through condensation synthesis alcohol, oxidation, the yield is 34.6%, the method is easy to operate, high cost, low yield.
biological activity
Butyl Methoxydibenzoylmethane is an oil-soluble sunscreen that absorbs the full spectrum of UVA rays, it is a derivative of dibenzo ylmethane.

WHAT IS BUTYL METHOXYDIBENZOYLMETHANE AND WHERE IS BUTYL METHOXYDIBENZOYLMETHANE FOUND?
Butyl Methoxydibenzoylmethane is a UVA adsorbing agent and found in sunscreen cosmetics of all types, including creams, lotions, lipsticks and sun oils.
Further research may identify additional product or industrial usages of Butyl Methoxydibenzoylmethane.

FUNCTIONS OF BUTYL METHOXYDIBENZOYLMETHANE:
*Stabilising :
Butyl Methoxydibenzoylmethane improves ingredients or stability of the formula and shelf life

*Uv absorber :
Butyl Methoxydibenzoylmethane protects the cosmetic product from UV-light effects

*Uv filter :
Filters certain UV rays to protect the skin or hair from the harmful effects of these rays.

BUTYL METHOXYDIBENZOYLMETHANE INCLUDES:
Butyl Methoxydibenzoylmethane is present in 4.27% of cosmetics.
*Sunscreen lip balm (60.77%)
*Children sun cream (59.38%)
*Anti-ageing sun cream (58.49%)
*Adult sun cream (57.88%)
*Perfume set for men (56.23%)

IS BUTYL METHOXYDIBENZOYLMETHANE SAFE?
Butyl methoxydibenzoylmethane was tested by the Food and Drug Administration, approving its use in sunscreen products.
The European Commission’s Scientific Committee for Cosmetic Products and Non-Food Products also confirmed that sunscreen products don't negatively affect the human health.

IS BUTYL METHOXYDIBENZOYLMETHANE GOOD FOR SKIN?
Butyl methoxydibenzoylmethane is healthy for the skin as it protects the skin and scalp from sun damage by absorbing UVA and UVB rays.
However, studies have shown that extended exposure to the sun while using products with butyl methoxydibenzoylmethane on a regular basis should be avoided.

FUNCTIONS OF BUTYL METHOXYDIBENZOYLMETHANE:
*UV absorber
*Sunscreen
*Light Stabilizer
*UV filters

VARIOUS OF BUTYL METHOXYDIBENZOYLMETHANE:
As an enolate, Butyl Methoxydibenzoylmethane forms with heavy metal ions (such as Fe3+) colored complexes, and chelating agents can be added to suppress them.

Stearates, aluminum, magnesium and zinc salts can lead to poorly soluble precipitates.
Manufacturers also recommend to avoid the inclusion of iron and ferric salts, heavy metals, formaldehyde donors and PABA and PABA esters.

Butyl Methoxydibenzoylmethane in sunscreen may stain clothes yellow-orange and make them sticky if washed in iron-rich water, as it reacts with iron to produce rust.

The damage can be undone with a rust remover or stain remover.
The staining properties of sunblock made with Butyl Methoxydibenzoylmethane are particularly noticeable on fiberglass boats with white gelcoat.

Butyl Methoxydibenzoylmethane also reacts with boron trifluoride to form a stable crystalline complex that is highly fluorescent under UV irradiation.
The emission color of the crystals depends on the molecular packing of the boron Butyl Methoxydibenzoylmethane complex.

The photoluminescence may also be altered by mechanical force in the solid state, resulting in a phenomenon called "mechanochromic luminescence".
The altered emission color recovers itself slowly at room temperature or more swiftly at higher temperatures.

Absorbance spectrum
Butyl Methoxydibenzoylmethane has a peak absorbance around 360 nm when dissolved. The peak may shift slightly depending on the solvent.

PROPERTIES OF BUTYL METHOXYDIBENZOYLMETHANE:
Butyl Methoxydibenzoylmethane is a whitish to yellowish crystalline powder with a weak odor, dissolving in isopropanol, dimethyl sulfoxide, decyl oleate, capric acid/caprylic, triglycerides and other oils.

Butyl Methoxydibenzoylmethane is not soluble in water.
Butyl Methoxydibenzoylmethane is a dibenzoylmethane derivative.

Butyl Methoxydibenzoylmethane exists in the ground state as a mixture of the enol and keto forms, favoring the chelated enol.
This enol form is stabilized by intramolecular hydrogen-bonding within the β-diketone.

Butyl Methoxydibenzoylmethane's ability to absorb ultraviolet light over a wider range of wavelengths than many other sunscreen agents has led to its use in many commercial preparations marketed as "broad spectrum" sunscreens.
Butyl Methoxydibenzoylmethane has an absorption maximum of 357 nm

HISTORY OF BUTYL METHOXYDIBENZOYLMETHANE:
Butyl Methoxydibenzoylmethane was patented in 1973 and was approved in the EU in 1978.
Butyl Methoxydibenzoylmethane was approved by the FDA in 1988.

As of 2021, the FDA announced that they do not support Butyl Methoxydibenzoylmethane as being generally recognized as safe and effective (GRASE) citing the need for additional safety data.
Butyl Methoxydibenzoylmethane was banned in 2020 by the Palau government citing reef-toxicity concerns.

PREPARATION OF BUTYL METHOXYDIBENZOYLMETHANE:
Butyl Methoxydibenzoylmethane is prepared by reacting 4-tert-butylbenzoic methyl ester (from 4-tert-butylbenzoic acid by esterification with methanol) with 4-methoxyacetophenone in toluene in the presence of sodium amide via Claisen condensation.

According to a recent patent application, yields of up to 95% are obtained with the same starting materials in toluene in the presence of potassium methoxide.

It is subject to keto-enol tautomerism and exists predominantly enol when dissolved.
Upon UV radiation, it may convert to keto form, while converting back to enol form after placing in dark

FUNCTIONS OF BUTYL METHOXYDIBENZOYLMETHANE IN COSMETIC PRODUCTS:
*FRAGRANCE FUNCTIONAL
Functional ingredient (excipient) of perfume oils and / or flavours

*LIGHT STABILIZER
Protecting the cosmetic product from deterioration effects of light

*UV ABSORBER
Butyl Methoxydibenzoylmethane protects the cosmetic product from damage caused by UV light

*UV FILTER
Butyl Methoxydibenzoylmethane protects skin or hair from harmful UV radiation

PHYSICAL and CHEMICAL PROPERTIES of BUTYL METHOXYDIBENZOYLMETHANE:
Chemical formula: C20H22O3
Molar mass: 310.39 g/mol
Appearance: colorless crystal
CAS Number: 70356-09-1
Chem/IUPAC Name: 1-[4-(1,1-Dimethylethyl)phenyl]-3-(4-methoxyphenyl)propane-1,3-dione
EINECS/ELINCS No: 274-581-6
COSING REF No: 31713
Melting Point: 83.5°C
Solubility: Insoluble in water
Soluble in: isopropanol, decyl oleate, capric/caprylic triglyceride, castor oil

CAS No.: 70356-09-1
EINECS: 274-581-6
UV-A absorber: oil soluble
Molecular Weight: 310.4 g/mol
INCI name: Butyl Methoxydibenzoylmethane
USAN: Avobenzone
Chemical names: 1-(4-Methoxyphenyl)-3-(4-tert.-butyl phenyl)propan-1,3-dione
Empirical Formula: C20H22O3
Assay (GLC) %: 95.0 – 100.0
Single impurity >3.0%: not detectable
Sum of impurities >4.5%: not detectable

Loss on drying (USP)%: max. 0.5
Melting point °C: 81.0 – 86.0
Specific extinction E 1%, in methanol λ max. 357 nm: 1100.0 – 1210.0
Shelf life and storage conditions: 36 months in the original, unopened container, dry, at 5 to 40°C
CAS NO: 70356-09-1
Molecular Formula: C20H22O3
Molecular weight: 310.387
EINECS NO: 274-581-6
MDL NO: MFCD22421631
Molecular Weight: 310.4 g/mol
XLogP3-AA: 4.8
Hydrogen Bond Donor Count: 0

Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 6
Exact Mass: 310.15689456 Da
Monoisotopic Mass: 310.15689456 Da
Topological Polar Surface Area: 43.4Å²
Heavy Atom Count: 23
Formal Charge: 0
Complexity: 405
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical state: solid
Color: No data available
Odor: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available

Decomposition temperature: No data available
pH: No data available
Viscosity:
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available

Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
CAS: 70356-09-1
EINECS: 274-581-6
InChI: InChI=1/C20H22O3/c1-2-3-10-15-23-20(18(21)16-11-6-4-7-12-16)19(22)17-13-8-5-9-14-17/h4-9,11-14,20H,2-3,10,15H2,1H3
InChIKey: GTIRDWBOUTYFQO-UHFFFAOYSA-N
Molecular Formula: C20H22O3
Molar Mass: 310.39
Density: 1.079
Melting Point: 81-84°C

Boiling Point: 463.6±35.0 °C (Predicted)
Flash Point: 201.4°C
Water Solubility: 27μg/L at 20℃
Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
Vapor Pressure: 0Pa at 25℃
Appearance: Colorless to pale yellow powder
Color: White to Pale Yellow
Maximum Wavelength (λmax): ['356nm (EtOH) (lit.)']
Merck: 14,888
pKa: 9.74±0.13 (Predicted)
Storage Condition: Inert atmosphere, Room Temperature
Refractive Index: 1.546
MDL: MFCD00210252

FIRST AID MEASURES of BUTYL METHOXYDIBENZOYLMETHANE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of BUTYL METHOXYDIBENZOYLMETHANE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of BUTYL METHOXYDIBENZOYLMETHANE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of BUTYL METHOXYDIBENZOYLMETHANE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of BUTYL METHOXYDIBENZOYLMETHANE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of BUTYL METHOXYDIBENZOYLMETHANE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available