PRODUCTS

CALCIUM INOSINATE

Calcium inosinate is used by athletes to supposedly increase the oxygen capacity of their blood.
Calcium inosinate is found in instant noodles, potato chips and snacks, savoury rice, tinned vegetables, cured meats, packet soup.
The primary use of calcium inosinate is as a flavor enhancer in food products.

CAS Number: 38966-29-9
EC/EINECS Number: 233-140-8 (listed under EU food additive specifications)
Chemical Name: Calcium inosine-5′-monophosphate
Food Additive (E Number): E633
Molecular Formula: C₁₀H₁₁CaN₄O₈P (anhydrous)
Molar Mass: ≈ 386.19 g/mol

SYNONYMS:
Calcium 5′-inosinate, Calcium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)oxolan-2-yl]methyl phosphate, Calcium inosine-5′-monophosphate, E633, Calcium 5'-inosinate, Calcium inosinate, Ins No.633, 3387-37-9, Calcium inosine-5'-monophosphate, Inosinic acid, calcium salt, INS-633, DE2I245H9C, 5'-Inosinic acid, calcium salt (1:1), E-633, RefChem:573365, 38966-29-9, 3387-37-9 (1:1 SALT), UNII-DE2I245H9C, calcium, [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl phosphate, 38966-29-9, Calcium 5-inosinate, inosine monophosphate calcium, 5'-Inosinicacid,calcium salt, SCHEMBL1030877, SCHEMBL1030880, Calcium 5'-O-phosphonatoinosine, DTXSID00628642, Q725037, Calcium ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl phosphate, Calcium inosinate, Calcium inosine-5′-monophosphate, E633, Calcium 5′-inosinate, Inosinic acid calcium salt, INS-633, Calcium 5′-O-phosphonatoinosine, Inosine monophosphate calcium salt, Inosinic acid, calcium salt (1:1), Calcium IMP ([turn0search7][turn0search3]), calcium inosinate, calcium inosine-5'-monophosphate, calcium, [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate

Calcium inosinate is the calcium salt of Inosinic acid E630.
Inosinic acid is a natural acid, that is mainly present in animals.
Calcium inosinate is commercially prepared from meat or fish (sardines).

Calcium inosinate may also be produced by bacterial fermentation of sugars.
Calcium inosinate (E633) is the calcium salt of inosinate, a nucleotide found naturally in meat and fish.
Calcium inosinate is a compound that is added to foods as a flavor enhancer to improve the taste of foods.

Calcium inosinate is a calcium salt of the nucleoside inosine.
Under the E number E633, it is a food additive used as a flavor enhancer.
Calcium inosinate is a calcium salt of inosinic acid (inosine-5′-monophosphate, IMP), classified in the group of ribonucleotide flavor enhancers.

In Europe, Calcium inosinate is designated as food additive E633.
Calcium inosinate is widely used in the food industry to enhance savory flavor (umami) in processed foods, particularly in low-salt products, often in synergy with glutamate flavor enhancers such as monosodium glutamate (E621).

Commercially, Calcium inosinate is derived from animal sources such as meat or fish, but it can also be produced by microbial fermentation.
Calcium inosinate (E633) is a flavor enhancer used extensively in the food industry to boost savory or umami taste, especially in processed and reduced-salt foods.

Calcium inosinate is the calcium salt of inosine-5′-monophosphate, appears as a white crystalline powder, and is sparingly soluble in water.
Calcium inosinate is approved for food use in many regions, accepted as safe without a specific ADI, and is often used synergistically with other nucleotides and glutamates for optimal flavor enhancement.

Consumers with dietary restrictions or certain medical conditions may wish to note the source and purine metabolism implications of its use.
Calcium inosinate is a food additive with flavor enhancing role.
Calcium inosinate is the calcium salt of inosinic acid.

Inosinates do not give the “umami” taste specific to glutamates, but have the ability to enhance a lot of natural flavors and tastes, thus allowing the required the required amount of salt to be reduced.
Calcium inosinate is a calcium salt of the nucleoside inosine.

Under the E number E633, it is a food additive used as a flavor enhancer.
Calcium inosinate, designated as E633, is a calcium salt of inosinic acid, a natural compound predominantly found in animal tissues.
Calcium inosinate is primarily used in the food industry as a flavour enhancer.

Calcium inosinate (E633) is a versatile and natural food additive with a long history of safe use.
Its ability to act as a flavour enhancer makes Calcium inosinate valuable in various food products.
While generally safe, Calcium inosinate is advisable to consume it in moderation to avoid potential adverse effects, especially for individuals with asthma or gout.

USES and APPLICATIONS of CALCIUM INOSINATE:
Calcium inosinate is used as an anti-caking agent in food preparation.
Calcium inosinate is often used in combination with monosodium glutamate (MSG) to enhance the umami flavor of food.
Calcium inosinate's often found in salty snacks, canned soups, sauces, seasonings and processed meats.

Calcium inosinate is found in instant noodles, potato chips and snacks, savory rice, canned vegetables, cured meats, and packaged soups.
Calcium inosinate is commonly used as a flavor enhancer in processed foods to impart a salty flavor known as umami.
Calcium inosinate is used by athletes to supposedly increase the oxygen capacity of their blood.

Calcium inosinate is found in instant noodles, potato chips and snacks, savoury rice, tinned vegetables, cured meats, packet soup.
The primary use of calcium inosinate is as a flavor enhancer in food products.
Calcium inosinate does not itself have a strong umami taste, but it significantly boosts the perception of savory flavors when combined with glutamate-based flavor enhancers such as MSG or other nucleotides.

Calcium inosinate is commonly added to processed foods where enhanced taste is desired, especially in low-sodium formulations.
Calcium inosinate is used in many products.

Calcium inosinate is mainly used in low sodium/salt products.
For industrial use, Calcium inosinate is obtained by bacterial fermentation of sugars or from meat or sardines, having plant or animal origin.
Calcium inosinate is used in the quantities on the recipes in all types of food, including alcoholic and non-alcoholic beverages.

-Typical applications of Calcium inosinate include:
*Seasonings and spice mixes
*Instant soups and noodle products
*Snack foods (e.g., chips)
*Sauces and condiments
*Ready meals and processed meats
*Salt substitutes
*Broths and bouillons
Because of its synergistic effect with glutamates, manufacturers frequently use Calcium inosinate in combination with other ribonucleotide enhancers for maximum flavor impact.

FUNCTIONAL CHARACTERISTICS of CALCIUM INOSINATE:
*Flavor enhancement:
Calcium inosinate works by amplifying savory taste (umami) especially in combination with glutamates

*Synergistic action:
Stronger together with monosodium glutamate or guanylate additives

*Used in low-salt products:
Calcium inosinate helps maintain flavor while reducing sodium content

*Stable in food processing:
Typically stable under normal cooking and processing temperatures

*Applicable in dry and aqueous systems:
Calcium inosinate can be used in powders as well as wet food formulations

*Typically used with other enhancers:
Often paired with disodium guanylate or disodium inosinate (other E-number ribonucleotides) to achieve desired taste

*Sparingly soluble in water:
Calcium inosinate affects how it is incorporated in formulations, often blended into seasonings or dispersions

MECHANISM OF FLAVOR ENHANCEMENT of CALCIUM INOSINATE:
Although calcium inosinate does not itself produce a distinct umami sensation, its nucleotide structure interacts with taste receptors on the tongue in a way that intensifies perception of savory flavors.
When used with glutamate — a known umami compound — the flavor system displays a synergistic effect, meaning the combined impact on taste is greater than the sum of the individual components.
This characteristic has made ribonucleotide salts popular in food formulation to achieve richer taste profiles at lower additive levels

PHYSICAL AND CHEMICAL PROPERTIES of CALCIUM INOSINATE:
Calcium inosinate appears as a white to off-white crystalline powder that is odorless and has a neutral to slightly basic pH in solution.
Calcium inosinate is sparingly soluble in water, meaning only limited amounts dissolve in water under standard conditions.
The molecule itself contains a purine base (hypoxanthine) linked to a ribose sugar and a phosphate group, with the phosphate coordinated to a calcium ion, giving the salt Calcium inosinate's unique structure and functional properties.
Because of its structure, Calcium inosinate is stable under typical food processing conditions but may slowly degrade at extreme pH or very high heat conditions.
The nucleotide backbone also makes Calcium inosinate highly polar as a molecule.

PURPOSE IN PRODUCTS of CALCIUM INOSINATE:
Calcium inosinate serves several functions in food products:
Flavour Enhancer:
Calcium inosinate enhances the overall taste of food, particularly in savoury products, by intensifying the natural flavours present.

HEALTH CONSIDERATIONS of CALCIUM INOSINATE:
Calcium inosinate is generally considered safe for consumption.
However, individuals with asthma should avoid inosinates, as they may trigger asthmatic reactions.
Additionally, since inosinates are metabolised into purines, individuals suffering from gout should exercise caution.
The concentrations used in food products are typically low, reducing the likelihood of adverse effects.

IMPACT ON CHILDREN of CALCIUM INOSINATE:
Calcium inosinate is safe for children when consumed in typical dietary amounts.
Nonetheless, excessive intake should be avoided to prevent potential digestive issues.

IMPACT ON TASTE of CALCIUM INOSINATE:
Calcium inosinate is tasteless and odourless, making it an ideal ingredient for various food products without altering their flavour profiles.

COMPATIBILITY WITH OTHER ADDITIVES of CALCIUM INOSINATE:
Calcium inosinate is compatible with various other food additives, including sugars and other hydrocolloids.
Its water-binding properties make Calcium inosinate suitable for use in products requiring moisture retention.

NATURAL OCCURRENCE of CALCIUM INOSINATE:
Calcium inosinate is naturally found in animal tissues, particularly in meat and fish.
Calcium inosinate is commercially produced from meat or fish, such as sardines, and may also be synthesised through bacterial fermentation of sugars.

ALTERNATIVES AND SUBSTITUTES of CALCIUM INOSINATE:
For those seeking alternatives to calcium inosinate, options include:

*Monosodium Glutamate (MSG):
A widely used flavour enhancer that provides a savoury taste.

*Disodium Guanylate (E627):
Another flavour enhancer often used in conjunction with other additives to enhance taste.

ORIGIN of CALCIUM INOSINATE:
Calcium salt of inosinic acid (E630), a natural acid, that is mainly present in animals.
Commercially prepared from meat or fish (sardines).
May also be produced by bacterial fermentation of sugars.

FUNCTION & CHARACTERISTICS of CALCIUM INOSINATE:
Flavour enhancer.
Inosinic acid and inosinates do not have the specific umami taste but strongly enhance many other flavours, thereby reducing the amounts of salt or other flavour enhancers needed in a product.

CALCIUM INOSINATE MARKET SIZE of CALCIUM INOSINATE:
The global calcium inosinate market size was worth around USD 1394 Million in 2024 and is predicted to grow to around USD 1920.12 Million by 2034 with a compound annual growth rate (CAGR) of roughly 3.4% between 2025 and 2034.

The report analyzes the global calcium inosinate market's drivers, restraints/challenges, and the effect they have on the demands during the projection period.
In addition, the report explores emerging opportunities in the calcium inosinate industry.

PHYSICAL and CHEMICAL PROPERTIES of CALCIUM INOSINATE:
Chemical Formula: C10H11CaN4O8P
Molar Mass: 386.270 g·mol−1
Solubility in Water: sparingly
Molecular Weight: 386.27 g/mol
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 10
Rotatable Bond Count: 3
Exact Mass: 385.9940412 Da
Monoisotopic Mass: 385.9940412 Da
Topological Polar Surface Area: 181 Å²

Heavy Atom Count: 24
Formal Charge: 0
Complexity: 543
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 4
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Appearance: white crystalline powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in: water, slightly
Name: Calcium inosinate
Chemical Name: Calcium inosine-5′-monophosphate
CAS Number: 38966-29-9
EC/EINECS Number: 233-140-8

Food Additive (E Number): E633
Molecular Formula: C₁₀H₁₁CaN₄O₈P
Molar Mass: ≈ 386.19 g/mol
Physical Form: Odorless, white to off-white crystalline powder
Solubility: Sparingly soluble in water
pH (in dilute aqueous solution): ~7.0–8.0
Appearance: White crystalline powder
Typical Odor: None detectable

FIRST AID MEASURES of CALCIUM INOSINATE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of CALCIUM INOSINATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of CALCIUM INOSINATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of CALCIUM INOSINATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of CALCIUM INOSINATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of CALCIUM INOSINATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available