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Crocetin is a natural apocarotenoid dicarboxylic acid, a diterpenoid, and a branched-chain dicarboxylic acid.
Crocetin was the first plant carotenoid to be recognized as early as 1818 while the history of saffron cultivation reaches back more than 3,000 years.
The major active ingredient of saffron is the yellow pigment crocin 2 (three other derivatives with different glycosylations are known) containing a gentiobiose (disaccharide) group at each end of the molecule.
CAS: 27876-94-4
MF: C20H24O4
MW: 328.4
EINECS: 248-708-0
Synonyms
CROCETIN;CROCETIN, TRANS-;8,8'-DIAPOCAROTENEDIOIC ACID;2,6,11,15-TETRAMETHYLHEXADECA-2,4,6,8,10,12,14-HEPTAENEDOIC ACID;TRANS-CROCETIN;8,8'-diapo-psi,psi-carotenedioic acid;Alpha-Crocetin;roceic acid
CrocetinCrocetin is found in the crocus flower together with its glycoside, crocin, and Gardenia jasminoides fruits.
Crocetin is also known as crocetic acid.
Crocetin forms brick red crystals with a melting point of 285 °C.
The chemical structure of crocetin forms the central core of crocin, the compound responsible for the color of saffron.
Crocetin is usually extracted commercially from gardenia fruit, due to the high cost of saffron.
A simple and specific HPLC-UV method has been developed to quantify the five major biologically active ingredients of saffron, namely the four crocins and crocetin.
A 20-carbon dicarboxylic acid which is a diterpenoid and natural carotenoid.
Found in the crocus flower, Crocetin has been administered as an anti-fatigue dietary supplement.
Crocetin is a carotenoid found in saffron, Crocus sativus, that has been used in traditional and modern medicine for various medical purposes, including as an anticancer agent in cancer chemotherapy.
Crocetin has also been studied for its potential to improve cerebral oxygenation, reduce damage in experimental atherosclerosis and arthritis, and suppress liver and bladder toxicity induced by different agents.
Crocetin is a high-purity carotenoid, which is a type of organic pigment.
Crocetin is derived from the stigmas of the saffron (Crocus sativus) flower, where it is obtained through meticulous extraction processes to ensure its purity and efficacy.
Crocetin acts primarily as an antioxidant, neutralizing free radicals and reducing oxidative stress within biological systems.
Crocetin modulates various signaling pathways, which can result in neuroprotective, anti-inflammatory, and potential anti-cancer activities.
Used extensively in scientific research, Crocetin is instrumental in studies of neurodegenerative diseases, such as Alzheimer's and Parkinson's, due to its ability to protect neuronal cells from oxidative damage.
Crocetin also finds applications in cardiovascular research, where its potential to improve blood flow and reduce plaque accumulation is of interest.
Furthermore, Crocetin's role in enhancing retinal function positions it as a valuable compound in ophthalmic studies, potentially aiding in the treatment of macular degeneration and other vision-related conditions.
Crocetin, also known as Transcrocetin, is a natural apocarotenoid dicarboxylic acid that is found in the crocus flower and Gardenia jasminoides (fruits).
Crocetin is also anticarcinogenic, antineoplastic, antioxidant and protective agent.
Crocetin forms brick red crystals with a melting point of 285 °C.
Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo.
Crocetin protects against hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats.
Crocin and crocetin may provide neuroprotection in rats by reducing the production of various neurotoxic molecules, based on an in-vitro cell study.
Crocetin is a natural carotenoid compound found in saffron, gardenia fruits, and other plants.
Crocetin is responsible for the distinctive color of these plants and has been studied for its potential health benefits.
Crocetin has antioxidant properties and may help to protect against oxidative stress and inflammation.
Crocetin has also been studied for its potential to reduce cholesterol levels and improve cognitive function.
Additionally, crocetin has been investigated for its properties and its ability to protect against liver damage caused by toxins and alcohol consumption.
Crocetin Chemical Properties
Melting point: 285°
Boiling point: 386.14°C (rough estimate)
density: 1.0786 (rough estimate)
refractive index: 1.4434 (estimate)
FEMA: 2998 | SAFFRON (CROCUS SATIVUS L.)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly, Heated), Methanol (Slightly)
form: Solid
pka: 4.39±0.19(Predicted)
color: Red to Very Dark Red
Stability: Light Sensitive
LogP: 4.312 (est)
Uses
Experimental treatment of arteriosclerosis by increasing oxygen diffusion through arterial walls, thus decreasing buildup of cholesterol.
Crocetin is a carotenoid derived from saffron, and is shown to have anticancer effects in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer.
Crocetin has been studied for its potential health benefits, which include its antioxidant properties that may help to protect against oxidative stress and inflammation.
Crocetin has also been investigated for its ability to reduce cholesterol levels, improve cognitive function, and to protect against liver damage caused by toxins and alcohol consumption.
Biological Activity
Crocetin is a natural apocarotenoid dicarboxylic acid, found naturally in saffron crocus and gardenia flowers, th at has been shown to exhibit antioxidant, antiproliferative, anti-inflammatory, cardioprotective, neuroprotective, and antinociceptive activity.
