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Cyclamic Acid and its Ca Salts are also used in oral care products such as toothpaste, mouthwash, dental gels, and breath fresheners because it provides sweetness without promoting tooth decay.
Cyclamic Acid and its Ca Salts are widely used as low-calorie sweeteners in the food and beverage industry.
Cyclamic Acid and its Ca Salts are commonly added to carbonated drinks, flavored beverages, fruit juices, and powdered drink mixes to provide sweetness with reduced sugar content.
Cyclamic Acid
CAS Number: 100-88-9
EC Number: 202-898-1
Molecular Formula: C6H13NO3S
Molecular Weight: 179.24 g/mol
Calcium Cyclamate
CAS Number: 139-06-0
EC Number: 205-349-4
Molecular Formula: C12H24CaN2O6S2
Molecular Weight: 396.54 g/mol
SYNONYMS:
Cyclamic Acid Synonyms
Cyclamic Acid, Cyclohexylsulfamic Acid, Cyclohexanesulfamic Acid, N-Cyclohexylsulfamic Acid, Cyclamate Acid, Cyclohexylaminosulfonic Acid, Sulfamic Acid Cyclohexyl Ester, Cyclohexanesulfamic acid, Hexamic acid, Cyclohexylsulfamic acid, Sulfamic acid, cyclohexyl-, Cyclohexylamidosulfuric acid, Cyclohexylaminesulfonic acid, N-Cyclohexylsulfamic acid, Sucaryl, Sucaryl acid, Zyklamat, Cyclohexanesulphamic acid, Cyclohexylamidosulphuric acid, Cyclohexylaminesulphonic acid, Cyclohexylsulphamic acid, N-Cyclohexylsulphamic acid, Cyclamate, NSC 220327, Polycat 200, Sulfamic acid, N-cyclohexyl-, Cyclohexylsulfamic acid, Cyclamic Acid, Cyclohexylsulfamic Acid, Cyclohexanesulfamic Acid, Cyclohexylaminosulfonic Acid, N-Cyclohexylsulfamic Acid, Cyclamate Acid, Sulfamic Acid Cyclohexyl Ester, N-Cyclohexylsulfamic Acid, Cyclohexanesulfamic Acid, Cyclohexylamidosulfuric Acid, Cyclohexylaminesulfonic Acid, Hexamic Acid, NSC 220327, Polycat 200, Cyclamate (free acid)
Calcium Cyclamate Synonyms
Calcium Cyclamate, Calcium Cyclohexylsulfamate, Calcium N-Cyclohexylsulfamate, Calcium Cyclamate Sweetener, Calcium Salt of Cyclamic Acid, E952b, INS 952b, Sulfamic acid,N-cyclohexyl-,calcium salt (2:1), Cyclohexanesulfamic acid,calcium salt (2:1), Sulfamic acid,cyclohexyl-,calcium salt (2:1), Calcium cyclamate, Calcium cyclohexanesulfamate, Calcium cyclohexylsulfamate, Cyclamate calcium, Cylan, Sucaryl Calcium, Cyclan, Dietil, Ca cyclamate, 201280-50-4, 1173146-35-4, 1259371-75-9
Cyclamic Acid and its Ca Salts are artificial sweetening agents widely used in the food and beverage industry.
Cyclamic Acid and its Ca Salts are known for their high sweetening power and low-calorie properties compared to ordinary sugar.
Cyclamic Acid and its Ca Salts provide a clean and stable sweet taste suitable for a wide variety of formulations.
Cyclamic Acid is approximately 30 to 50 times sweeter than sucrose, depending on the application and concentration.
Cyclamic Acid and its Ca Salts are valued for their good solubility, stability, and compatibility with other sweeteners.
Cyclamic Acid and its Ca Salts commonly appear as white crystalline powders that are odorless and easy to incorporate into industrial formulations.
Cyclamic Acid and its Ca Salts exhibit good thermal and chemical stability under processing conditions.
Cyclamic Acid and its Ca Salts are also popular in sugar-free, low-calorie, and diabetic-friendly product formulations.
Due to their cost-effectiveness and sweetness efficiency, Cyclamic Acid and its Ca Salts are important ingredients in modern food processing applications.
Cyclamic Acid and its Ca Salts are less soluble than sodium cyclamate but may be preferred in specific formulation systems where calcium compatibility is advantageous.
Cyclamic Acid and its Ca Salts are frequently blended with saccharin because the combination produces a sweetness profile closer to sucrose while reducing metallic or bitter aftertastes.
Cyclamic Acid and its Ca Salts remain important in industrial sweetener technology because of its processing stability, cost efficiency, and compatibility with large-scale beverage and food manufacturing systems.
Industrial manufacturers value Cyclamic Acid and its Ca Salts because it maintains stability during pasteurization, storage, and acidic processing conditions.
Cyclamic Acid and its Ca Salts'compatibility with other sweeteners allows formulation of balanced sweetness systems with improved sensory quality and reduced formulation cost.
Cyclamic Acid and its Ca Salts are synthetic high-intensity sweetening compounds used primarily in reduced-calorie and sugar-free food formulations.
Cyclamic acid is the acidic precursor compound, while Cyclamic Acid and its Ca Salts are the calcium salt form commonly utilized for its improved stability and functional properties in industrial applications.
USES and APPLICATIONS of CYCLAMIC ACID and ITS Ca SALTS:
Cyclamic Acid and its Ca Salts are frequently used in combination with sweeteners such as saccharin or aspartame to improve flavor profile and sweetness balance.
Cyclamic Acid and its Ca Salts are widely utilized in beverages, dairy products, confectionery items, baked goods, and pharmaceutical preparations.
Cyclamic acid is mainly used as an intermediate in the production of cyclamate sweeteners, while Cyclamic Acid and its Ca Salts are directly used as a high-intensity sweetener in many food and beverage applications.
Cyclamic Acid and its Ca Salts are commonly found in sugar-free soft drinks, flavored beverages, desserts, confectionery products, chewing gum, jams, jellies, bakery products, canned fruits, tabletop sweeteners, and low-calorie processed foods.
Cyclamic Acid and its Ca Salts are widely used as an artificial sweetener because it provides sweetness with minimal caloric contribution.
Cyclamic Acid and its Ca Salts are approximately 30–50 times sweeter than sucrose and are often blended with saccharin or other sweeteners to improve flavor quality and reduce bitter aftertastes.
Cyclamic Acid and its Ca Salts are valued for their good thermal stability, long shelf life, and suitability for food processing applications.
Cyclamic Acid and its Ca Salts are widely applied in beverages, confectionery, pharmaceuticals, tabletop sweeteners, and oral care products in countries where cyclamates are approved for use.
Cyclamic acid is a subtype of additive E952 and serves as the basis for obtaining cyclamate salts.
In the pharmaceutical industry, Cyclamic Acid and its Ca Salts are used in syrups, chewable tablets, vitamin supplements, oral suspensions, nutraceutical formulations, and medicinal products to improve taste and mask bitterness.
Cyclamic Acid and its Ca Salts' stability and pleasant sweetness profile make it suitable for oral dosage forms.
Cyclamic Acid and its Ca Salts are also used in oral care products such as toothpaste, mouthwash, dental gels, and breath fresheners because it provides sweetness without promoting tooth decay.
Cyclamic Acid and its Ca Salts are widely used as low-calorie sweeteners in the food and beverage industry.
Cyclamic Acid and its Ca Salts are commonly added to carbonated drinks, flavored beverages, fruit juices, and powdered drink mixes to provide sweetness with reduced sugar content.
Cyclamic Acid and its Ca Salts are used in dairy products such as yogurt, ice cream, flavored milk, and milk-based desserts.
In bakery applications, Cyclamic Acid and its Ca Salts help replace sugar in cakes, cookies, pastries, and other baked products.
Cyclamic Acid and its Ca Salts are frequently utilized in confectionery products including candies, chewing gum, chocolates, jellies, and sweets.
Cyclamic Acid and its Ca Salts are used in table-top sweetener formulations for tea, coffee, and other beverages.
In the pharmaceutical industry, Cyclamic Acid and its Ca Salts are applied in syrups, chewable tablets, lozenges, vitamin supplements, and oral medicines to improve taste.
Cyclamic Acid and its Ca Salts are also used in diabetic-friendly and reduced-calorie food formulations due to their low energy value.
Cyclamic Acid and its Ca Salts is often blended with other sweeteners such as saccharin or aspartame to improve sweetness quality and reduce aftertaste.
Their good thermal and chemical stability makes Cyclamic Acid and its Ca Salts suitable for cooking, baking, and processed food applications.
Cyclamic Acid and its Ca Salts are used in canned fruits, jams, jellies, sauces, and preserved foods to maintain sweetness without adding sugar.
In the personal care industry, Cyclamic Acid and its Ca Salts may be included in oral care products such as toothpaste and mouthwash.
Cyclamic Acid and its Ca Salts are valued for their high sweetening efficiency, cost-effectiveness, and broad industrial applicability.
In the food industry, cyclamic acid itself is rarely used due to its limited solubility and inconvenient application, but it is the starting material for the production of more stable and practical salts — sodium cyclamate and Cyclamic Acid and its Ca Salts.
The chemical formula of cyclamic acid is C₆H₁₁NO₃S.
It is obtained synthetically: the starting material is cyclohexylamine, which reacts with sulfamic acid or sulfur trioxide, forming acid crystals.
Externally, additive E952(i) is a white crystalline powder with no odor.
Cyclamic acid is thermostable and resistant to acids, but poorly soluble in water, which limits its independent use.
In the food industry, it serves as an intermediate product and is mainly used for the synthesis of cyclamate salts.
CHARACTERISTICS of CYCLAMIC ACID and ITS Ca SALTS:
Cyclamic acid and Cyclamic Acid and its Ca Salts are characterized by their efficient sweetening performance, low caloric contribution, and good manufacturing stability.
Cyclamic Acid and its Ca Salts provide a relatively clean sweetness profile compared with some other synthetic sweeteners and is often preferred in blended systems for flavor optimization.
One important characteristic is the synergistic effect with saccharin and other sweeteners.
This synergy enhances sweetness intensity while minimizing undesirable aftertastes.
Cyclamic Acid and its Ca Salts also exhibit good stability in acidic beverages and processed food systems, making it useful for industrial applications.
Cyclamic Acid and its Ca Salts are economically attractive due to their relatively low production cost and effectiveness at low concentrations.
Cyclamic Acid and its Ca Salts also demonstrate long shelf stability and resistance to degradation during storage and thermal processing.
BENEFITS of CYCLAMIC ACID and ITS Ca SALTS:
Low-calorie sweetening agent
Good sweetness efficiency
Economical compared with many newer sweeteners
Stable during thermal processing
Suitable for acidic beverages
Long shelf life
Non-cariogenic
Useful in sweetener blends
Improved flavor profile when combined with saccharin
Suitable for sugar-free and reduced-calorie products
Effective bitterness masking in pharmaceutical formulations
Stable during storage and industrial processing
SODIUM CYCLAMATE VS CYCLAMIC ACID AND ITS CA SALTS:
Cyclamates refer to salts of cyclamic acid (cyclohexylsulfamic acid), usually related to its sodium and calcium salts.
Sodium cyclamate is the most used form, while Cyclamic Acid and its Ca Salts can be used as its replacement in low-sodium or sodium-free products.
The latter is not used widely as it will cause gelation and precipitation in some applications.
Cyclamic Acid and its Ca Salts can be produced by sulfonating cyclohexylamine with chlorosulfonic acid or sulfamate to cyclohexylsulfamate, then neutralization with NaOH or Ca(OH)2.
PROPERTIES of CYCLAMIC ACID and ITS Ca SALTS:
Other names Sodium cyclohexylsulfamate, sodium cyclohexanesulfamate
CAS number 139-05-9
Chemical formula C6H12NNaO3S (anhydrous), C6H12NNaO3S•2H2O (dihydrate)
Molecular weight 201.22 (anhydrous)
237.22 (dihydrate)
Two types
Cyclamic Acid and its Ca Salts' food grade can be divided into anhydrous and dihydrate forms according to the content of crystal water.
The former (NF grade) is needle powder, while the latter (CP grade) with tablet appearance.
STRUCTURE of CYCLAMIC ACID and ITS Ca SALTS:
Solubility
Soluble in water, practically insoluble in ethanol, and insoluble in most organic solvents.
Taste
30 times as sweet as sugar, so that only a little amount is needed to achieve the same sweet taste.
Without bitter aftertaste which occurs in sodium saccharin.
Synergy
Cyclamic Acid and its Ca Salts are commonly blended with sodium saccharin in a 10-to-1 ratio to mask the bitter after taste and produce a synergistic sweetening effect.
Cyclamic Acid and its Ca Salts can also be blended with aspartame and acesulfame potassium to improve product stability.
Other properties
Heat stable, so can be used in cooking and baking.
The lowest price among artificial sweeteners (sucralose, aspartame, acesulfame potassium, neotame, saccharin).
PHYSICAL and CHEMICAL PROPERTIES of CYCLAMIC ACID and ITS Ca SALTS:
Cyclamic Acid
Appearance: White crystalline powder
Odor: Odorless
Taste: Sweet
Physical State: Solid
Solubility: Slightly soluble in water
Melting Point: Approximately 168–170°C
Density: Approximately 1.37 g/cm³
Hygroscopicity: Low
Stability: Stable under standard storage conditions
Chemical Class: Sulfamic acid derivative
Functional Groups:
Sulfamate group
Cyclohexyl ring
Acidity: Weak acid
pKa: Approximately 1.9
Reactivity: Low under normal handling conditions
Flammability: Non-flammable
Oxidation Stability: Stable under ordinary conditions
Calcium Cyclamate
Appearance: White crystalline powder or granules
Odor: Odorless
Taste: Sweet and clean
Sweetness Intensity: Approximately 30–50 times sweeter than sucrose
Physical State: Solid
Solubility in Water: Moderately soluble
Solubility in Alcohol: Slightly soluble
Bulk Density: Variable depending on commercial grade
Thermal Stability: Good heat resistance
pH Stability: Stable over broad pH ranges
Hygroscopicity: Low to moderate
Volatility: Non-volatile
Shelf Stability: Good long-term storage stability
Chemical Class: Calcium sulfamate salt
Ionic Character: Calcium salt of cyclamic acid
Chemical Stability: Stable under normal food processing conditions
Reactivity: Low chemical reactivity
Compatibility: Compatible with many food ingredients and sweetener systems
Synergistic Sweetening: Commonly blended with saccharin
Thermal Resistance: Stable during pasteurization and moderate baking conditions
Hydrolysis Resistance: Stable under moderate pH conditions
Oxidation Resistance: Good oxidative stability
Molecular Weight: 396.53700
Exact Mass: 396.07000
EC Number: 205-349-4
UNII: X12LMJ1WYL
DSSTox ID: DTXSID9057892
Color/Form: Crystalline solid
PSA: 155.22000
XLogP3: 3.68120
Appearance: white crystals
Refractive Index: INDEX OF REFRACTION: 1.507 (ALPHA), 1.518 (BETA), 1.545 (GAMMA) /DIHYDRATE/
Water Solubility: Soluble in water. Insoluble in most organic solvents.
Taste: Strong, sweet taste
FIRST AID MEASURES of CYCLAMIC ACID and ITS Ca SALTS:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available
ACCIDENTAL RELEASE MEASURES of CYCLAMIC ACID and ITS Ca SALTS:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of CYCLAMIC ACID and ITS Ca SALTS:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of CYCLAMIC ACID and ITS Ca SALTS:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of CYCLAMIC ACID and ITS Ca SALTS:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
STABILITY and REACTIVITY of CYCLAMIC ACID and ITS Ca SALTS:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available
