PRODUCTS

D-GLUCITOL

D-glucitol is used in low-calorie beverages to provide body and taste.
D-glucitol is used in dietary foods such as sugarless candy, chewing gum, and ice cream.
D-glucitol is also used as a crystallization modifier in soft sugar-based confections.

CAS Number: 50-70-4
E number: E420 (thickeners, ...)
Systematic IUPAC name: (2S,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
Chemical formula: C6H14O6
Molar mass: 182.17 g/mol

SYNONYMS:
D-Glucitol, (2S,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol, D-Sorbitol, Sorbogem, Sorbo, Trimethylsilyl ether of glucitol, d-Glucitol, 1,2,3,4,5,6-hexakis-O-(trimethylsilyl)-, Glucitol, hexakis-O-(trimethylsilyl)-, d-, 1,2,3,4,5,6-Hexakis-O-(trimethylsilyl)glucitol, D-Glucitol, hexakis-TMS, Glucitol, hexakis-TMS, Sorbitol, hexakis-O-(trimethylsilyl)-ether, Sorbitol, (6TMS), Sorbitol, TMS, Glucitol, TMS, D-Glucitol, TMS, D-Sorbitol (Glucitol), TMS, D-Sorbitol, sorbitol, 50-70-4, D-Glucitol, glucitol, (-)-Sorbitol, Glucarine, D-(-)-Sorbitol, Nivitin, Diakarmon, Sorbilande, Sorbostyl, Esasorb, Multitol, Neosorb, Sorbo, Sorbol, Cholaxine, Sionit, Sionite, Sionon, Siosan, Karion instant, Sorbitol F, Sorbex Rp, Sorbitol FP, D-Sorbol, Sionit K, Sorbex M, Sorbex R, Sorbex S, Sorbex X, Hexahydric alcohol, Sorbicolan, Sorvilande, Gulitol, D-Sorbite, Neosorb P 60, Foodol D 70, Neosorb 20/60DC, Glucitol, D-, Neosorb 70/70, Neosorb P 20/60, Karion, Karion (carbohydrate), (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol, FEMA No. 3029, Neosorb P 60W, Sorbitol (e420), DTXSID5023588, Sorbitol 3% in plastic container, Ins no.420(i), Ins-420(i), CHEBI:17924, SORBITOL 3.3% IN PLASTIC CONTAINER, 1,2,3,4,5,6-Hexanehexol, E 420, E-420(i), NSC-25944, 506T60A25R, 7B5697N, DTXCID903588, E420, Microlax Enema, RefChem:6499, GlyTouCan:G32374SR, GeriCare Sorbitol Solution, shediary turmeric face cream, CHEBI:30911, G32374SR, 200-061-5, 619-324-4, NSC25944, Sorbit, L-Gulitol, Sorbite, (2R,3R,4R,5S)-Hexane-1,2,3,4,5,6-hexaol, d-Sorbit, Neosorb 70/02, Probilagol, D-1,2,3,4,5,6-Hexanehexol, CCRIS 1898, G-ol, AI3-19424, MFCD00004708, HSDB 801, iso-sorbide, Glc-ol, NSC 25944, Resulax, Sorbilax, D-Sorbitol, for cell culture, D-Sorbit 1000 microg/mL in Methanol, Medevac, Sorbitur, (2S,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol, 26566-34-7, Sorbit DP, Sorbitol, D-Glucitol, CAS-50-70-4, SMR000112219, Sorbitol [USP:NF], EINECS 200-061-5, Solbitol, Sorbitol S, Sorbitol FK, UNII-506T60A25R, Sorbit D-Powder, Sorbit S, Sorbit W-Powder, Sorbitol CRS, Sorbit WP, Sorbitol (NF), D-Sorbitol solution, Neosorb P60, Kyowa Powder 50M, Sorbogem 712, Sorbitol (Glucitol), Sorbit D 70, Sorbit DP 50, Sorbit L 70, Sorbit T 70, Sorbit W 70, D-Sorbitol, 99%, Sorbit W-Powder 50, D-Sorbitol (Standard), D-sorbitol, D-glucitol, D-Sorbitol (JP18), SORBITOL [HSDB], SORBITOL [FCC], SORBITOL [USP], SORBITOL [II], SORBITOL [MI], SORBITOL [VANDF], D-Sorbitol, >=98%, D-SORBITOL [JAN], SCHEMBL763, Sorbit Kyowa Powder 50M, SORBITOL [MART.], bmse000115, bmse000803, bmse001007, D-SORBITOL [FHFI], Epitope ID:114708, SORBITOL [USP-RS], SORBITOL [WHO-DD], Isomalt impurity, sorbitol-, D-Sorbitol, NF/FCC grade, CHEMBL1682, MLS001333209, MLS001333210, SORBITOL [ORANGE BOOK], orb1310713, SCHEMBL7442569, D-Sorbitol, analytical standard, D-Sorbitol, for electrophoresis, SORBITOL [EP MONOGRAPH], D-Sorbitol, BioXtra, >=98%, HY-B0400B, HY-B0400E, HY-B0400R, D-Sorbitol, M400 (Excipient), MSK3102, D-Sorbitol, for synthesis, 99%, HMS2094K21, HMS2270A18, Pharmakon1600-01300028, HY-B0400, Tox21_201937, Tox21_303388, D-Sorbitol, >=98%, FCC, FG, EBC-26154, NSC759608, s2393, AKOS015899604, D-Sorbitol, plant cell culture tested, CCG-229392, DB01638, MS00451, NSC-759608, ISOMALT IMPURITY C [EP IMPURITY], NCGC00164353-01, NCGC00164353-02, NCGC00164353-03, NCGC00257447-01, NCGC00259486-01, AC-13186, CS-13177, MALTITOL IMPURITY A [EP IMPURITY], D-Sorbitol, SAJ first grade, >=97.0%, SBI-0206688.P002, SORBITOL-MANNITOL COMPONENT SORBITOL, D-Sorbitol, for molecular biology, >=98%, CS-1046513, D-Sorbitol, BioUltra, >=99.5% (HPLC), D-Sorbitol, SAJ special grade, >=99.0%, D-Sorbitol, Vetec(TM) reagent grade, 97%, E-420, NS00121242, S0065, SW220289-1, D-Sorbitol, crystallized, >=99.0% (HPLC), C00794, D00096, E70384, AB00919085_06, D-Sorbitol, liquid, tested according to Ph.Eur., EN300-7832133, F235654, ISOMALT IMPURITY, SORBITOL- [USP IMPURITY], Q245280, BRD-K66035042-001-10-1, BRD-K66035042-001-11-9, LACTITOL MONOHYDRATE IMPURITY E [EP IMPURITY], Sorbitol, European Pharmacopoeia (EP) Reference Standard, 75DE42C3-7C3B-4802-95E0-463F02268BDC, Sorbitol, United States Pharmacopeia (USP) Reference Standard, D-Sorbitol, BioReagent, cell culture tested, plant cell culture tested, Sorbitol, Pharmaceutical Secondary Standard, Certified Reference Material, 123236-29-3, D-Sorbitol,D-GLUCITOL,SORBITOL POWDER, SORBITOL LIQUID, Neosorb, SOBITOL, Sorbitol, D-SORBITOL,SORBITOL SYRUP,Esasorb, D-Glucitol, Diakarmon, Glucitol, L-Gulitol, D-1,2,3,4,5,6-hexanehexol, Nivitin, Sionit, Sionon, Sorbicolan, Sorbite, D-sorbitol, Sorbo, Sorbol, Cholaxine, D-Sorbol, Esasorb, Glucitol, D-, Gulitol, Karion, Neosorb, Sionite, Siosan, Sorbex M, Sorbex R, Sorbex Rp, Sorbex S, Sorbex X, Sorbilande, Sorbit, Sorbitol syrup C, Sorbostyl, Sorvilande, Sorbitol, (d), Cystosol, d-Sorbit, d-Sorbite, Hexahydric alcohol, Karion, instant, Liponic 70-NC, Resulax, Sorbilax, Sorbitur, (-)-Sorbitol, Sorbitol FP, Sorbitol F, D-(-)-Sorbitol, Glucarine, Multitol, Sionit K, Sorbit D, Sorbit DP, Probilagol (Salt/Mix)

D-glucitol is a sugar alcohol and a sugar substitute.
D-glucitol is a sugar alcohol that is naturally found in Toyon berries.
D-glucitol is odorless colorless solid.

D-glucitol sinks and mixes with water.
D-glucitol is an odorless colorless solid.
D-glucitol sinks and mixes with water.

D-glucitol is the D-enantiomer of glucitol (also known as D-D-glucitol).
D-glucitol has a role as a sweetening agent, a laxative, a metabolite, a cathartic, a human metabolite, a food humectant, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite.

D-glucitol is an enantiomer of a L-glucitol.
D-glucitol is a polyhydric alcohol with about half the sweetness of sucrose.
D-glucitol occurs naturally and is also produced synthetically from glucose.

D-glucitol is a metabolite found in or produced by Escherichia coli.
D-glucitol has been reported in Stypocaulon, Salacia chinensis, and other organisms with data available.
D-glucitol is a sugar alcohol found in fruits and plants with diuretic, laxative and cathartic property.

Unabsorbed D-glucitol retains water in the large intestine through osmotic pressure thereby stimulating peristalsis of the intestine and exerting its diuretic, laxative and cathartic effect.
In addition, D-glucitol has one-third fewer calories and 60 % the sweetening activity of sucrose and is used as a sugar replacement in diabetes.

D-glucitol is a small molecule drug with a maximum clinical trial phase of IV (across all indications) and is indicated for constipation and has 8 investigational indications.
D-glucitol is a metabolite found in or produced by Saccharomyces cerevisiae.

L-glucitol is a metabolite found in or produced by Saccharomyces cerevisiae.
D-glucitol is a polyhydric alcohol with about half the sweetness of sucrose.
D-glucitol occurs naturally and is also produced synthetically from glucose.

D-glucitol is a white crystalline powder or colorless syrup with the formula C6H14O6 and molecular weight 182.17 g/mol.
D-glucitol is a polyhydric alcohol with about half the sweetness of sucrose, highly soluble in water (up to 2350 g/L at 25°C), and insoluble in most organic solvents.

Hygroscopic with a melting point of 95°C, D-glucitol occurs naturally in fruits and is produced synthetically from glucose via hydrogenation.
D-glucitol (/ˈsɔː(r)bɪtɒl/), less commonly known as glucitol (/ˈɡluːsɪtɒl/), is a sugar alcohol with a sweet taste which the human body metabolizes slowly.

D-glucitol can be obtained by reduction of glucose, which changes the converted aldehyde group (−CHO) to a primary alcohol group (−CH2OH).
Most D-glucitol is made from potato starch, but it is also found in nature, for example in apples, pears, peaches, and prunes.
D-glucitol is converted to fructose by D-glucitol-6-phosphate 2-dehydrogenase.

D-glucitol is an isomer of mannitol, another sugar alcohol; the two differ only in the orientation of the hydroxyl group on carbon 2.
While similar, the two sugar alcohols have very different sources in nature, melting points, and uses.
D-glucitol is referred to as a nutritive sweetener because it provides some dietary energy.

D-glucitol is partly absorbed from the small intestine and metabolized in the body, and partly fermented in the large intestine.
The fermentation produces short-chain fatty acids, acetic acid, propionic acid, and butyric acid, which are mostly absorbed and provide energy, but also carbon dioxide, methane, and hydrogen which do not provide energy.

Even though the heat of combustion of D-glucitol is higher than that of glucose (having two extra hydrogen atoms), the net energy contribution is between 2.5 and 3.4 kilocalories per gram, versus the approximately 4 kilocalories (17 kilojoules) for carbohydrates.
D-glucitol is often used in diet foods (including diet drinks and ice cream), mints, cough syrups, and sugar-free chewing gum.

Most bacteria cannot use D-glucitol for energy, but it can be slowly fermented in the mouth by Streptococcus mutans, a bacterium that causes tooth decay.
In contrast, many other sugar alcohols such as isomalt and xylitol are considered non-acidogenic.
D-glucitol also occurs naturally in many stone fruits and berries from trees of the genus Sorbus.

USES and APPLICATIONS of D-GLUCITOL:
Cosmetics & Personal Care: Humectant & skin conditioning agent: D-glucitol enhances moisture and texture in creams, lotions, and shampoos.
D-glucitol is a humectant that is a polyol (polyhydric alcohol) produced by hydrogenation of glucose with good solubility in water and poor solubility in oil.

D-glucitol is approximately 60% as sweet as sugar, and has a caloric value of 2.6 kcal/g.
D-glucitol is highly hygroscopic and has a pleasant, sweet taste.
D-glucitol maintains moisture in shredded coconut, pet foods, and candy.

In sugarless frozen desserts, D-glucitol depresses the freezing point, adds solids, and contributes some sweetness.
D-glucitol is used in low-calorie beverages to provide body and taste.
D-glucitol is used in dietary foods such as sugarless candy, chewing gum, and ice cream.

D-glucitol is also used as a crystallization modifier in soft sugar-based confections.
D-glucitol is used to increase stability of silver nanoparticles and is also used as a sugar substitute.
D-glucitol can be used as raw material in vitamin C.

D-glucitol also can be used as feed syrup, injection fluids, and raw material of medicine tablet.
D-glucitol can be used as a drug dispersion agent and filler, cryoprotectant, anti-crystallizing agent, medicine stabilizer, wetting agent, capsule plasticizer, sweetening agent, and ointment matrix.

D-glucitol was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures.
D-glucitol is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.
D-glucitol was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures.

D-glucitol is a six-carbon sugar alcohol and can used as a sugar substitute.
D-glucitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement.
D-glucitol is used in bacterial culture media to distinguish the pathogenic Escherichia coli O157:H7 from most other strains of E. coli, because it is usually unable to ferment D-glucitol, unlike 93% of known E. coli strains.

A treatment for hyperkalaemia (elevated blood potassium) uses D-glucitol and the ion-exchange resin sodium polystyrene sulfonate (tradename Kayexalate).
The resin exchanges sodium ions for potassium ions in the bowel, while D-glucitol helps to eliminate it.

In 2010, the U.S. FDA issued a warning of increased risk for gastrointestinal necrosis with this combination.
D-glucitol is also used in the manufacture of softgel capsules to store single doses of liquid medicines.
D-glucitol is commonly used orally as a one-time dose of 30–150 millilitres (1.1–5.3 imp fl oz; 1.0–5.1 US fl oz) 70% solution.

D-glucitol may also be used as a one-time rectal enema.
As an over-the-counter drug, D-glucitol is used as a laxative to treat constipation.

-Medical applications of D-glucitol:
*Laxative:
As is the case with other sugar alcohols, foods containing D-glucitol can cause gastrointestinal distress.
D-glucitol can be used as a laxative when taken orally or as an enema.
D-glucitol works as a laxative by drawing water into the large intestine, stimulating bowel movements.
D-glucitol has been determined safe for use by the elderly, although it is not recommended without the advice of a physician.

-Sweetener uses of D-glucitol:
D-glucitol is a sugar substitute, and when used in food it has the INS number and E number 420.
D-glucitol is about 60% as sweet as sucrose (table sugar).

-Food Industry uses of D-glucitol:
*Sweetener:
D-glucitol is used as a low‑calorie sweetener (about 60 % sweetness of sucrose), commonly in sugar‑free foods such as candies, gums, and diet products.

*Humectant:
D-glucitol helps retain moisture in baked goods and other products.

*Bulking agent & stabilizer:
D-glucitol adds body and texture to foods.

-Pharmaceutical Use of D-glucitol:
*Laxative:
Oral D-glucitol solution acts as a non‑stimulant laxative for constipation relief.

*Irrigating Fluid:
D-glucitol is used in medical irrigation solutions.

*Excipient:
D-glucitol is used as sweetener, stabilizer, or isotonicity agent in medications.

-Industrial uses of D-glucitol:
*Plasticizer & stabilizer:
D-glucitol is used in polymer films and materials.

*Raw material in synthesis:
D-glucitol is used as a feedstock or intermediate in chemical production.

PHARMACEUTICAL APPLICATIONS of D-GLUCITOL:
D-glucitol is widely used as an excipient in pharmaceutical formulations.
D-glucitol is also used extensively in cosmetics and food products.
D-glucitol is used as a diluent in tablet formulations prepared by either wet granulation or direct compression.

D-glucitol is particularly useful in chewable tablets owing to its pleasant, sweet taste and cooling sensation.
In capsule formulations, D-glucitol is used as a plasticizer for gelatin.
D-glucitol has been used as a plasticizer in film formulations.

In liquid preparations, D-glucitol is used as a vehicle in sugar-free formulations and as a stabilizer for drug, vitamin, and antacid suspensions.
Furthermore, D-glucitol is used as an excipient in liquid parenteral biologic formulations to provide effective protein stabilization in the liquid state.

D-glucitol has also been shown to be a suitable carrier to enhance the in vitro dissolution rate of indomethacin.
In syrups, D-glucitol is effective in preventing crystallization around the cap of bottles.
D-glucitol is also used in injectable and topical preparations, and therapeutically as an osmotic laxative.
D-glucitol may also be used analytically as a marker for assessing liver blood flow.

MISCELLANEOUS USES of D-GLUCITOL:
A mixture of D-glucitol and potassium nitrate has found some success as an amateur solid rocket fuel.
D-glucitol has similar performance to sucrose-based rocket candy, but is easier to cast, less hygroscopic and does not caramelize.

D-glucitol is identified as a potential key chemical intermediate for production of fuels from biomass resources.
Carbohydrate fractions in biomass such as cellulose undergo sequential hydrolysis and hydrogenation in the presence of metal catalysts to produce D-glucitol.

Complete reduction of D-glucitol opens the way to alkanes, such as hexane, which can be used as a biofuel.
Hydrogen required for this reaction can be produced by aqueous phase catalytic reforming of D-glucitol.

19 C6H14O6 → 13 C6H14 + 36 CO2 + 42 H2O
The above chemical reaction is exothermic, and 1.5 moles of D-glucitol generate approximately 1 mole of hexane.
When hydrogen is co-fed, no carbon dioxide is produced.

D-glucitol based polyols are used in the production of polyurethane foam for the construction industry.
D-glucitol is also added after electroporation of yeasts in transformation protocols, allowing the cells to recover by raising the osmolarity of the medium.

HEALTH CARE, FOOD, AND COSMETIC USES of D-GLUCITOL:
D-glucitol often is used in modern cosmetics as a humectant and thickener.
D-glucitol is also used in mouthwash and toothpaste.
Some transparent gels can be made only with D-glucitol, because of its high refractive index.

D-glucitol is used as a cryoprotectant additive (mixed with sucrose and sodium polyphosphates) in the manufacture of surimi, a processed fish paste.
D-glucitol is also used as a humectant in some cigarettes.

Beyond its use as a sugar substitute in reduced-sugar foods, D-glucitol is also used as a humectant in cookies and low-moisture foods like peanut butter and fruit preserves.
In baking, D-glucitol is also valuable because it acts as a plasticizer, and slows down the staling process.

MEDICAL IMPORTANCE of D-GLUCITOL:
Aldose reductase is the first enzyme in the D-glucitol-aldose reductase pathway responsible for the reduction of glucose to D-glucitol, as well as the reduction of galactose to galactitol.
Too much D-glucitol trapped in retinal cells, the cells of the lens, and the Schwann cells that myelinate peripheral nerves, is a frequent result of long-term hyperglycemia that accompanies poorly controlled diabetes.
This can damage these cells, leading to retinopathy, cataracts and peripheral neuropathy, respectively.

D-glucitol is fermented in the colon and produces short-chain fatty acids, which are beneficial to overall colon health.

BENEFITS & CHARACTERISTICS of D-GLUCITOL:
*Lower caloric content:
D-glucitol provides energy but less than sucrose.

*Dental health:
D-glucitol does not promote tooth decay (non‑cariogenic).

*Low glycemic impact:
D-glucitol is absorbed slowly, with less influence on blood glucose.

*Moisture retention:
D-glucitol improves texture and shelf life of formulations.

*Natural occurrence:
D-glucitol is found in apples, pears, peaches, prunes, and other fruits.

CHEMICAL PROPERTIES of D-GLUCITOL:
D-glucitol is sorbitol.
D-glucitol is a hexahydric alcohol related to mannose and is isomeric with mannitol.

D-glucitol occurs as an odorless, white or almost colorless, crystalline, hygroscopic powder.
Four crystalline polymorphs and one amorphous form of D-glucitol have been identified that have slightly different physical properties, eg melting point.

D-glucitol is available in a wide range of grades and polymorphic forms, such as granules, flakes, or pellets that tend to cake less than the powdered form and have more desirable compression characteristics.
D-glucitol has a pleasant, cooling, sweet taste and has approximately 50–60% of the sweetness of sucrose.

OCCURRENCE of D-GLUCITOL:
D-glucitol is one of the most widely found sugar alcohols in nature with relatively high concentrations occurring in apples, pears, plums, peaches and apricots.
Also reported D-glucitol is found in several varieties of berries, seaweed and algae.

AIR & WATER REACTIONS of D-GLUCITOL:
D-glucitol is water soluble.
D-glucitol shows reactivity
D-glucitol is an alcohol.

PREPARATION METHOD of D-GLUCITOL:
D-glucitol occurs naturally in the ripe berries of many trees and plants.
D-glucitol was first isolated in 1872 from the berries of the Mountain Ash (Sorbus americana).

Industrially, D-glucitol is prepared by high-pressure hydrogenation with a copper–chromium or nickel catalyst, or by electrolytic reduction of glucose and corn syrup.
If cane or beet sugars are used as a source, the disaccharide is hydrolyzed to dextrose and fructose prior to hydrogenation.

synthetic
D-glucitol is manufactured by hydrogenation of glucose with hydrogen and active nickel catalyst.
D-glucitol is commercially available as 70% syrup or as a pure white powder.

SYNTHESIS of D-GLUCITOL:
D-glucitol may be synthesised via a glucose reduction reaction in which the converted aldehyde group is converted into a hydroxyl group.
The reaction requires NADH and is catalyzed by aldose reductase.
Glucose reduction is the first step of the polyol pathway of glucose metabolism, and is implicated in multiple diabetic complications.
C6H12O6 + NADH + H+ → C6H14O6 + NAD+

The mechanism involves a tyrosine residue in the active site of aldehyde reductase.
The hydrogen atom on NADH is transferred to the electrophilic aldehyde carbon atom; electrons on the aldehyde carbon-oxygen double bond are transferred to the oxygen that abstracts the proton on tyrosine side chain to form the hydroxyl group.

The role of aldehyde reductase tyrosine phenol group is to serve as a general acid to provide proton to the reduced aldehyde oxygen on glucose.
Glucose reduction is not the major glucose metabolism pathway in a normal human body, where the glucose level is in the normal range.

However, in diabetic patients whose blood glucose level is high, up to 1/3 of their glucose could go through the glucose reduction pathway.
This will consume NADH and eventually leads to cell damage.

PHYSICAL and CHEMICAL PROPERTIES of D-GLUCITOL:
Chemical formula: C6H14O6
Molar mass: 182.17 g/mol
Appearance: White crystalline powder
Density: 1.49 g/cm3
Melting point: 94–96 °C (201–205 °F; 367–369 K)
Solubility in water: 2350 g/L[2] (25 °C (77 °F))
log P: −4.67
Magnetic susceptibility (χ): −107.80·10−6 cm3/mol
CAS Number: 50-70-4
E number: E420 (thickeners, ...)

Molecular Weight: 182.17 g/mol
XLogP3: -3.1
Hydrogen Bond Donor Count: 6
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 5
Exact Mass: 182.07903816 Da
Monoisotopic Mass: 182.07903816 Da

Topological Polar Surface Area: 121 Å²
Heavy Atom Count: 12
Formal Charge: 0
Complexity: 105
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 4
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical state: crystals
Color: white
Odor: No data available
Melting point/freezing point: Melting point/ range: 98 - 100 °C
Initial boiling point and boiling range: 105 °C at 1.013 hPa

Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: Not applicable
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 5,0 - 7 at 182 g/l at 25 °C
Viscosity: Viscosity, kinematic: No data available
Viscosity: Viscosity, dynamic: No data available

Water solubility: 182 g/l at 20 °C - completely soluble
Partition coefficient n-octanol/water: No data available
Vapor pressure: < 0,1 hPa at 25 °C
Density: 1,49 g/cm3 at 20 °C
Relative density: No data available
Relative vapour density: No data available
Particle characteristics: No data available
Explosive properties: No data available

Oxidizing properties: none
Other safety information: No data available
Melting point: 98-100 °C (lit.)
alpha: 4 º (per eur. pharm.)
Boiling point: bp760 105°
bulk density: 450 kg/m3
density: 1.28 g/mL at 25 °C
Vapor-tight: <1 (vs air)
Vapor pressure: <0.1 mm Hg (25 °C)

Refractive index: n20/D 1.46
FEMA: 3029 | D-SORBITOL
Flash point: >100°C
storage temp.: room temp
solubility: Very soluble in water, slightly soluble in ethanol
State of matter: liquid
pka: pKa (17.5°): 13.6
Color: White
Little ones: 1.28

Odor: Odorless
Acid-base indicators (pH indicators): 5 - 7 at 182 g/l at 25 °C
PH: 5.0-7.0 (25℃, 1M in H2O)
Optical rotation: [α]20/D 1.5±0.3°, c = 10% in H2O
Type of odor: caramellic
Water solubility: SOLUBLE
Sensitive: Hygroscopic
maximum wavelength (λmax): λ: 260 nm Amax: 0.04
maximum wavelength (λmax): λ: 280 nm Amax: 0.045
Merck: 14,8725

BRN: 1721899
Dielectric constant: 33.5 (27°C)
Stability: Stable. Avoid strong oxidizing agents. Protect from moisture.
Cosmetic ingredients and their functions: PERFUMING
Cosmetic ingredients and their functions: HUMECTANT
Cosmetic ingredients and their functions: FRAGRANCE
Cosmetic ingredients and their functions: SKIN CONDITIONING
InChIKey: FBPFZTCFMRRESA-JGWLITMVSA-N
LogP: -4.67

CAS Database: 50-70-4 (CAS DataBase Reference)
NIST chemical information: Sorbitol (50-70-4)
EPA chemical information: Sorbitol (50-70-4)
Security:
Labeling of dangerous: Xi
R-phrases: 36/37/38
S-phrases: 8-36-26-24/25
WGK Germany: 2
RTECS No.: LZ4290000
F: 3

Auto-ignition temperature: 420 °C
TSCA: Yes
HS Code: 29054491
Compound Type: Sugar alcohol (polyol) – reduced form of glucose.
Structure: Six-carbon chain with six hydroxyl (–OH) groups (hexane-1,2,3,4,5,6-hexol).
Functional Groups: Multiple primary and secondary alcohol groups (polyhydric alcohol).
Stereochemistry: D-form is the biologically and industrially relevant enantiomer.
Classification: Polyol with the formula HOCH₂(CHOH)₄CH₂OH.

Appearance: White crystalline powder or colorless syrup (depending on form)
State: Solid (crystalline) or syrupy liquid
Density: approx. 1.28–1.49 g/cm³ (solid)
Melting Point: ~94–100 °C
Boiling Point: Thermally decomposes rather than boiling at atmospheric pressure; approximate 290–296 °C
Solubility: Very soluble in water; slightly soluble in ethanol
Odor/Taste: Odorless; mildly sweet taste
Hygroscopic: Can absorb moisture under normal conditions

FIRST AID MEASURES of D-GLUCITOL:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of D-GLUCITOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of D-GLUCITOL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of D-GLUCITOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of D-GLUCITOL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of D-GLUCITOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available