PRODUCTS

DIOXOLANE

Dioxolane is used as finishing agent and swelling agent in textiles.
Dioxolane acts as an intermediate for the preparation of acyclovir and vandetanib.
Dioxolane is an essential ingredient in industrial polymers.

CAS Number: 646-06-0
EC Number: 211-463-5
Molecular Formula: C₃H₆O₂
Molecular Weight: 74.08 g/mol

SYNONYMS:
1,3-Dioxolane, Dioxolane, Formaldehyde Ethylene Acetal, Ethylene Formal, Ethylene Glycol Formal, Glycol Formal, 1,3-Dioxacyclopentane, 1,3-Dioxycyclopentane, Formal Glycol, 1,3-Dioxolane, 1,3-Dioxacyclopentane, Dioxolane, 5-Crown-2, Formal glycol, 1,3-DIOXOLANE, 646-06-0, DIOXOLANE, Glycolformal, 1,3-Dioxacyclopentane, Formal glycol, 1,3-Dioxolan, Ethylene glycol formal, Glycol formal, Glycol methylene ether, 1,3-Dioxole, dihydro-, 5-Crown-2, DTXSID4027284, Y57RBG19JL, ELCOTAL DX, DTXCID107284, CHEBI:87597, RefChem:72794, CHEBI:39430, 211-463-5, 1,3-Dioxolane, Stabilized, Ethylene glycol methylene ether, MFCD00003207, 1,3-Dioxolane (stabilized with BHT), 1,3-Dioxlane, Dioxolan [Czech], 1,3-dioxalane, 25067-64-5, CCRIS 4912, Dioxolane, 1,3-, HSDB 5737, EINECS 211-463-5, UN1166, UNII-Y57RBG19JL, Formaldehyde ethylene acetal, 1,3 dioxolane, [1,3]dioxolane, [1,3]-dioxolane, Ethylene glycol, formal, EC 211-463-5, SCHEMBL3387, SCHEMBL23012, SCHEMBL76137, SCHEMBL76442, SCHEMBL452393, BRP102, SCHEMBL2640146, SCHEMBL5144293, 1,3-DIOXOLANE [HSDB], CHEMBL3187281, SCHEMBL16861374, 1,3-Dioxolane, >=99.5%, Tox21_300693, AKOS015856096, MSK14675-100A, FD54839, NCGC00248143-01, NCGC00254601-01, CAS-646-06-0, Dioxolane [UN1166] [Flammable liquid], 1,3-Dioxolane/Water 4:1 (v/v) solution, 1,3-Dioxolane/Water 9:1 (v/v) solution, D0861, D5539, NS00004542, 1,3-Dioxolane 100 microg/mL in Acetonitrile, D89731, 1,3-Dioxolane Solution in Acetonitrile, 100ug/mL, InChI=1/C3H6O2/c1-2-5-3-4-1/h1-3H, Q2234483, 1,3-Dioxacyclopentane,Anhydrous, Contains ~ 75 ppm BHT as inhibitor., 1,3-Dioxolane, anhydrous, contains ~75 ppm BHT as inhibitor, 99.8%, 1,3-Dioxolane, ReagentPlus(R), contains ~75 ppm BHT as inhibitor, 99%, 1,3-Dioxole, dihydro-, 1,3-dioxacyclopentane, 1,3-dioxolan, Dioxolan, Dioxolane, Ethylene glycol formal, Formal glycol, Glycolformal, dihydro-1,3-dioxole, ethylene glycol methylene ether, formaldehyde ethylene acetal, 1,3-dioxalane, 1,3-dioxolan, 1,3-dioxolane, 1,3-dioxole, dihydro-, ethylene glycol formal, formal glycol, Ethylene glycol formal, Formal glycol, Glycolformal, 1,3-Dioxacyclopentane, 1,3-Dioxolan, 1,3-Dioxole, dihydro-, Dioxolan, Dioxolane, Ethylene glycol methylene ether, Formaldehyde ethylene acetal, Formal glycol, 1,3-Dioxolane, 1,3-Dioxacyclopentane, Formaldehyde ethylene acetal, Ethylene glycol methylene ether, 1,3-Dioxolan [German] [ACD/IUPAC Name] 1,3-Dioxolane [ACD/Index Name] [ACD/IUPAC Name] 1,3-Dioxolane [French] [ACD/Index Name] [ACD/IUPAC Name] 1.3-dioxolane 211-463-5 [EINECS] 646-06-0 [RN] dioxolane, 1,3- MFCD00003207 [MDL number] 1,3-Dioxacyclopentane 1,3-Dioxole, dihydro- dioxolane [Wiki] Ethylene glycol formal Ethylene glycol, formal Formal glycol Formaldehyde ethylene acetal UN 1166

Dioxolane, more precisely 1,3-Dioxolane, is a five-membered cyclic acetal belonging to the cyclic ether family.
Dioxolane contains two oxygen atoms within its ring structure and is widely used as a polar aprotic solvent, a chemical intermediate, and a protecting-group reagent in organic synthesis.
Due to its high solvency, low viscosity, and excellent miscibility with water and many organic solvents, Dioxolane has become an important solvent in pharmaceutical manufacturing, polymer chemistry, lithium battery electrolytes, coatings, adhesives, and laboratory synthesis.

Dioxolane is particularly valued for its ability to dissolve both polar and nonpolar compounds while remaining relatively stable under neutral conditions.
However, like other cyclic ethers, Dioxolane can form explosive peroxides during prolonged storage in the presence of air and light, making proper storage essential.
Dioxolane (CAS 646-06-0) is a high-performance heterocyclic solvent.

Dioxolane belongs to the chemical group of acetals.
Dioxolane is a heterocyclic acetal with the chemical formula (CH2)2O2CH2.
Dioxolane is related to tetrahydrofuran (THF) by replacement of the methylene group (CH2) at the 3-position with an oxygen atom.

The corresponding saturated 6-membered C4O2 rings are called dioxanes.
The isomeric 1,2-dioxolane (wherein the two oxygen centers are adjacent) is a peroxide.
Dioxolane appears as a clear colorless liquid.

Dioxolane is slightly denser than water.
Dioxolane is a cyclic acetal that is pentane in which the carbon atoms at positions 1 and 3 are replaced by oxygen atoms respectively.
Dioxolane is an intermediate for the preparation of Acyclovir-d4.

Dioxolane is a colorless, volatile liquid with a mild ether-like odor.
This cyclic acetal compound is highly soluble in water and miscible with a wide range of organic solvents, making it a versatile solvent and intermediate for a variety of chemical processes.
With its excellent chemical stability and low toxicity, 1,3-Dioxolane is a popular choice in high-performance industrial applications, particularly where other solvents may degrade or fail to deliver consistent results.

Dioxolane is a heterocyclic acetal with the chemical formula (CH2)2O2CH2.
Dioxolane is related to tetrahydrofuran by interchange of one oxygen for a CH2 group.

USES and APPLICATIONS of DIOXOLANE:
Dioxolane is used extensively because it functions as both an excellent solvent and a valuable synthetic intermediate.
One of Dioxolane's largest applications is as a polar aprotic solvent for pharmaceutical and specialty chemical manufacturing.
Its low viscosity and high solvency make Dioxolane particularly useful for reactions requiring efficient mixing and dissolution.

Major applications of Dioxolane include: Pharmaceutical synthesis, Fine chemical production, Polymer manufacturing, Resin formulations, Adhesive production, Coating formulations, Extraction processes, Laboratory solvent applications, Organic synthesis, Battery electrolyte formulations.
Dioxolane's ability to dissolve both inorganic salts and organic molecules makes it especially useful for advanced electrochemical systems.

Industrial manufacturers use Dioxolane as a powerful reaction medium and specialized cleaner for polymers.
Dioxolane is used as a solvent, in Mannich reaction, as an electrolyte in batteries.
Dioxolane is used as a solvent for paints, cellulose esters and in organic synthesis.

Dioxolane is used as an extragent for waxes, fats and oils, stabilizer for halogenated hydrocarbons and co monomer in polyacetals preparation.
Dioxolane is used as finishing agent and swelling agent in textiles.
Dioxolane acts as an intermediate for the preparation of acyclovir and vandetanib.

Dioxolane is an essential ingredient in industrial polymers.
In polymerization reactions, Dioxolane acts as a chain length regulator and a chain transfer agent.
Dioxolane is mainly used for oil and fat solvent, extraction agent, solvent, electrolytic lithium, chlorine-based solvents stabilizers, pharmaceutical intermediates

Multifunctional solvent meeting a wide range of applications of Dioxolane: High solvent power, Fully miscible with water, Excellent atmospheric behavior, Good wetting properties, Good evaporation rate, Medium surface tension, Low viscosity, Cooperates with other solvents, Easy to combine with surfactants.
Dioxolane can be used as a thinner, solvent and a reagent.

Thanks to its excellent solvent power, Dioxolane can be used for a wide range of applications.
Dioxolane easily dissolves resins and is therefore often used in coatings and adhesives.
As cleaner, Dioxolane is used for the removal of resins (even polyurethanes) or for the removal of grease stains in oven cleaners.

Dioxolane is used in technical-quality paint stripper, Adhesive remover, Cleaner for resins, Surface treatment.
Dioxolane is used Coatings, Inks, Adhesives, Cleaners, Aerosols, Personal Care, pharmaceutical, Syntheses, Textile/Leather, Polyurethane

Dioxolane is used in the synthesis of new Vandetanib (V097100) analogs
Dioxolane is used as a solvent and as a comonomer in polyacetals.
Dioxolane is used as a solvent for paints, cellulose esters and in organic synthesis.

-Solvent for Industrial Processes uses of Dioxolane:
Dioxolane is widely used as a universal solvent due to its ability to dissolve polymers, resins, and other organic compounds.
Dioxolane is commonly utilized in coatings, adhesives, and inks to improve product performance and consistency.

Dioxolane is a universal solvent for resins and polymers
Dioxolane improves solubility and viscosity in coatings
Dioxolane is used in industrial adhesives and printing inks

-Chemical Intermediate uses of Dioxolane:
In the chemical manufacturing industry, Dioxolane serves as a reactive intermediate for the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals.
Its stable cyclic structure enables its use in the protection of functional groups during synthesis processes.

Dioxolane is used as an intermediate for pharmaceuticals and agrochemicals
Dioxolane protects functional groups during synthesis
Dioxolane is used in specialty chemical production

-Battery Electrolytes uses of Dioxolane:
In the electronics and energy storage industries, Dioxolane is used as a component in lithium battery electrolytes.
Its excellent ionic conductivity and chemical stability make Dioxolane ideal for improving battery performance and lifespan.

Dioxolane is used as a solvent for lithium-ion battery electrolytes
Dioxolane enhances ionic conductivity and battery stability
Dioxolane is used in high-performance battery applications

-Stabilizer for Chlorinated Solvents, uses of Dioxolane:
Dioxolane is often used as a stabilizer for chlorinated solvents, ensuring their chemical stability during storage and use.
This application of Dioxolane is especially relevant in the cleaning and degreasing industries.

Dioxolane stabilizes chlorinated solvents for industrial use
Dioxolane prevents degradation during storage
Dioxolane improves performance in cleaning and degreasing formulations

-Pharmaceuticals and Agrochemicals uses of Dioxolane:
In pharmaceuticals and agrochemicals, Dioxolane is used as both a solvent and an intermediate for synthesizing active ingredients.
Its stability and low toxicity make Dioxolane ideal for formulations that demand precision and consistency.

Dioxolane is used as an intermediate for pharmaceutical synthesis
Dioxolane is used in the production of agrochemical active ingredients
Dioxolane ensures product stability and performance

ORGANIC SYNTHESIS APPLICATIONS of DIOXOLANE:
One of the most important synthetic uses of Dioxolane is as a protecting-group reagent.
Dioxolane derivatives are widely used for protecting:
Aldehydes
Ketones
during multistep organic synthesis.

This temporary protection allows chemists to perform additional reactions without affecting sensitive carbonyl groups.
After synthesis, the protecting group can be removed under acidic conditions.

Dioxolane also serves as a reaction medium for:
Organometallic chemistry
Condensation reactions
Polymerization reactions
Catalytic transformations

BATTERY APPLICATIONS of DIOXOLANE:
Dioxolane has become increasingly important in lithium battery technology.
Dioxolane is commonly used as a solvent component in:
Lithium metal batteries
Lithium-sulfur batteries
Electrolyte formulations

Dioxolane's favorable characteristics include:
Low viscosity
Good ionic conductivity
Wide liquid temperature range
Excellent salt solubility
These properties improve electrolyte performance and battery efficiency.

INDUSTRIAL CHARACTERISTICS of DIOXOLANE:
Commercial production of Dioxolane typically involves the acid-catalyzed reaction of:
Ethylene glycol
Formaldehyde
forming the cyclic acetal ring.

Industrial characteristics include:
High purity production
Efficient manufacturing
Good storage stability when properly protected
Excellent solvent performance
Low production cost
Broad industrial compatibility
Dioxolane is widely available in laboratory, pharmaceutical, and industrial grades.

BENEFITS AND ADVANTAGES of DIOXOLANE:
Dioxolane offers numerous technical advantages.
Dioxolane's greatest strengths include combining high solvency with complete water miscibility.

Major benefits of Dioxolane include:
Excellent solvent power
Low viscosity
High volatility for rapid drying
Complete water miscibility
Good polymer compatibility
Useful protecting-group chemistry
Efficient reaction medium
Good electrolyte performance
Easy removal by evaporation
Versatile industrial applications
These properties explain Dioxolane's widespread use across multiple industries.

CHARACTERISTICS of DIOXOLANE:
Dioxolane is a colorless, highly flammable cyclic ether that combines excellent solvent performance with remarkable versatility in chemical synthesis.
Dioxolane's five-membered ring structure provides outstanding solvency, complete water miscibility, low viscosity, and useful acetal chemistry, making it valuable in pharmaceuticals, polymer manufacturing, coatings, adhesives, laboratory chemistry, and advanced battery technology.
Dioxolane's greatest strengths include excellent solvent power, broad chemical compatibility, efficient protecting-group chemistry, rapid evaporation, and electrolyte performance.

A JOURNEY THROUGH TIME: THE RISE OF DIOXOLANE:
Every great chemical compound has a story, and Dioxolane’s journey reflects the evolution of modern industry.
Dioxolane's roots stretch back to the early twentieth century, when advances in organic synthesis first made it possible to construct this elegant ring system.
As laboratories pushed the boundaries of what was possible, the search for robust, efficient solvents led to the emergence of dioxolane as an industrial workhorse.
By the 1960s and 1970s, Dioxolane had found its way into large-scale manufacturing, particularly in the production of high-performance polymers.
The drive for efficiency and reliability in these decades set the stage for 1,3-dioxolane to become a staple in chemical plants worldwide.

FROM DISCOVERY TO INDUSTRIAL MARVEL
The initial synthesis of 1,3-dioxolane was more than just a chemical curiosity.
Its ease of formation from simple aldehydes and ethylene glycol made Dioxolane a practical choice for industrial chemists.
As the world demanded new materials and cleaner processes, 1,3-dioxolane’s versatility quickly became apparent.
Dioxolane's adoption marked a shift, allowing manufacturers to streamline production and reduce waste, long before sustainability became a buzzword.

KEY MILESTONES IN CHEMICAL ADVANCEMENT of DIOXOLANE:
Several pivotal moments highlight the ascent of Dioxolane.
In the 1990s, Dioxolane's use in lithium-ion battery electrolytes revolutionized portable electronics, offering improved ionic conductivity and stability.
Pharmaceutical chemists, meanwhile, embraced Dioxolane as a protecting group, enabling the synthesis of complex molecules that were previously out of reach.
These advances underscore a key industry lesson: the right molecule, at the right time, can change the trajectory of entire sectors.
Understanding this history reminds us that innovation is built on the shoulders of compounds like Dioxolane, whose impact often extends far beyond the lab.

PHYSICAL AND CHEMICAL PROPERTIES of DIOXOLANE:
Dioxolane is a colorless, highly volatile liquid with a characteristic ether-like odor.
Dioxolane's five-membered ring contains two oxygen atoms, giving the molecule excellent solvent properties and relatively low viscosity.

Dioxolane behaves as a polar aprotic solvent capable of dissolving a wide variety of organic compounds, polymers, salts, and reaction intermediates.
Unlike open-chain acetals, the cyclic structure provides improved stability under neutral and basic conditions.
However, strong acids readily hydrolyze the ring, regenerating formaldehyde and ethylene glycol.

CHEMICAL PROPERTIES of DIOXOLANE:
Dioxolane is chemically stable under ordinary storage conditions when protected from air, moisture, and oxidizing conditions.
The cyclic acetal structure makes Dioxolane less reactive than many aldehydes while preserving useful chemical functionality.

Important chemical characteristics of Dioxolane include:
Polar aprotic solvent
Cyclic acetal structure
Two oxygen atoms in a five-membered ring
Excellent solvency
High volatility
Low viscosity
Completely miscible with water
Peroxide-forming tendency during storage
Dioxolane readily participates in acetal chemistry and serves as both a solvent and a protecting-group reagent.

MOLECULAR STRUCTURE AND CHARACTERISTICS of DIOXOLANE:
The molecular structure of Dioxolane consists of a five-membered ring containing:
Three carbon atoms
Two oxygen atoms
A saturated cyclic framework
The oxygen atoms contribute electron density that enhances solvent performance while maintaining relatively low steric hindrance.

Structural characteristics include:
Five-membered cyclic ring
Cyclic ether functionality
Cyclic acetal functionality
Flexible ring geometry
Good electron-donating oxygen atoms
Low molecular weight
Moderate polarity
The ring structure contributes to Dioxolane's favorable physical properties compared with many linear ethers.

THERMAL CHARACTERISTICS of DIOXOLANE:
Dioxolane possesses relatively good thermal stability under neutral conditions.
However, because of its:
Low flash point
Low boiling point
High vapor pressure
the liquid evaporates readily at room temperature.

When exposed to fire or excessive heat, decomposition may produce:
Carbon monoxide
Carbon dioxide
Irritating organic vapors
Dioxolane should therefore be handled away from ignition sources.

SOLUBILITY BEHAVIOR of DIOXOLANE:
One of Dioxolane's greatest strengths is its remarkable solvent versatility.
Dioxolane is completely miscible with:
Water
Ethanol
Methanol
Acetone
Ether
Benzene
Toluene

Dioxolane dissolves numerous:
Organic compounds
Resins
Polymers
Salts
Pharmaceutical intermediates
Its combination of water miscibility and organic solvency makes Dioxolane especially valuable in pharmaceutical manufacturing.

CHEMICAL REACTIVITY of DIOXOLANE:
Dioxolane participates in several important reactions.
Dioxolane undergoes:
Acid-catalyzed hydrolysis
Acetal formation
Ring-opening reactions
Oxidation
Peroxide formation during storage

The most significant storage-related reaction is gradual peroxide formation upon prolonged exposure to oxygen and light.
This behavior is shared with several other cyclic ethers and requires periodic peroxide testing for stored material.

SYNTHESIS OF DIOXOLANE:
Dioxolane is a five-membered, nonplanar, fully saturated oxygen heterocycle with two oxygen atoms at the 1,3-positions of the cyclic system.
Dioxolane closely resembles THF because the methylene group at position 3 is replaced by an oxygen atom.
In other words, it is a five-membered cyclic acetal.
Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.

PHYSICAL PROPERTIES of DIOXOLANE:
Dioxolane is a colorless liquid.
Dioxolane is fully miscible with water, ether, acetone, and THF.
Dioxolane readily dissolves waxes, plastics, fats, and oils, with a bp of 78°C.
Dioxolane acts as a base and forms salts with strong acids.

SYNTHESIS OF DIOXOLANE:
The parent Dioxolane has been obtained through condensation of ethylene glycol with formaldehyde in toluene using p-toluenesulfonic acid as catalyst.
The same has also been obtained by the reaction of ethylene oxide with formaldehyde using SnCl4 or tetraethylammonium bromide as catalyst.
Acetalization or ketalization of aldehyde and ketones with ethylene glycol in the presence of p-toluenesulfonic acid forms mono- and disubstituted Dioxolane separately.
Synthesis of 2-methyl-1,3-dioxolane has been reported by heating vinyl ether with KOH.

AS A CLASS OF COMPOUNDS, DIOXOLANE:
Dioxolanes are a group of organic compounds containing the dioxolane ring.
Dioxolanes can be prepared by acetalization of aldehydes and ketalization of ketones with ethylene glycol.
(+)-cis-Dioxolane is the trivial name for L-(+)-cis-2-methyl-4-trimethylammoniummethyl-1,3-dioxolane iodide which is a muscarinic acetylcholine receptor agonist.

PROTECTING GROUPS of DIOXOLANE:
Organic compounds containing carbonyl groups sometimes need protection so that they do not undergo reactions during transformations of other functional groups that may be present.
A variety of approaches to protection and deprotection of carbonyls including as dioxolanes are known.
For example, consider the compound methyl cyclohexanone-4-carboxylate, where lithium aluminium hydride reduction will produce 4-hydroxymethylcyclohexanol.

The ester functional group can be reduced without affecting the ketone by protecting the ketone as a ketal.
The ketal is produced by acid catalysed reaction with ethylene glycol, the reduction reaction carried out, and the protecting group removed by hydrolysis to produce 4-hydroxymethylcyclohexanone.

NaBArF4 can also be used for deprotection of acetal or ketal-protected carbonyl compounds.
For example, deprotection of 2-phenyl-1,3-dioxolane to benzaldehyde can be achieved in water in five minutes at 30 °C.
PhCH(OCH2)2 + H2O →30 °C / 5 min NaBAr4 PhCHO + HOCH2CH2OH

NATURAL PRODUCTS of DIOXOLANE:
Neosporol is a natural product that includes a Dioxolane moiety, and is an isomer of sporol which has a 1,3-dioxane ring.
The total synthesis of both compounds has been reported, and each includes a step in which a dioxolane system is formed using trifluoroperacetic acid (TFPAA), prepared by the hydrogen peroxide – urea method.
This method involves no water, so Dioxolane gives a completely anhydrous peracid, necessary in this case as the presence of water would lead to unwanted side reactions.
CF3COOCOCF3 + H2O2•CO(NH2)2 → CF3COOOH + CF3COOH + CO(NH2)2

In the case of neosporol, a Prilezhaev reaction with trifluoroperacetic acid is used to convert a suitable allyl alcohol precursor to an epoxide, which then undergoes a ring-expansion reaction with a proximate carbonyl functional group to form the dioxolane ring.
A similar approach is used in the total synthesis of sporol, with the dioxolane ring later expanded to a dioxane system.

PHYSICAL and CHEMICAL PROPERTIES of DIOXOLANE:
Chemical Name: 1,3-Dioxolane
Common Name: Dioxolane
IUPAC Name: 1,3-Dioxolane
CAS Number: 646-06-0
EC Number: 211-463-5
Molecular Formula: C₃H₆O₂
Molecular Weight: 74.08 g/mol
PubChem CID: 12501
ChemSpider ID: 11981
Chemical Class: Cyclic ether, Cyclic acetal, Polar aprotic solvent
Appearance: Colorless liquid

Physical State: Liquid
Odor: Ether-like, sweet
Physical State: Liquid
Appearance: Colorless liquid
Color: Colorless
Odor: Ether-like, sweet
Molecular Formula: C₃H₆O₂
Molecular Weight: 74.08 g/mol
Melting Point: -95°C
Boiling Point: 74–75°C
Density: 1.06 g/cm³ (20°C)

Vapor Density: 2.56 (air = 1)
Vapor Pressure: Approximately 250 mmHg (20°C)
Flash Point: -1°C
Autoignition Temperature: Approximately 274°C
Explosive Limits: 2.3–28.3% (air)
Water Solubility: Completely miscible
Solubility: Miscible with alcohols, ethers, ketones, aromatic hydrocarbons
Refractive Index: 1.399
Dynamic Viscosity: Approximately 0.56 mPa·s
Dielectric Constant: Approximately 7.0

Log P: -0.27
Chemical Formula: C3H6O2
Molar Mass: 74.08 g/mol
Density: 1.06 g/cm3
Melting Point: −95 °C (−139 °F; 178 K)
Boiling Point: 75 °C (167 °F; 348 K)
Molecular Weight: 74.08 g/mol
XLogP3: -0.4
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 0

Exact Mass: 74.036779430 Da
Monoisotopic Mass: 74.036779430 Da
Topological Polar Surface Area: 18.5 Å²
Heavy Atom Count: 5
Formal Charge: 0
Complexity: 24.1
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
ECHA EINECS - REACH Pre-Reg: 211-463-5
FDA UNII: Y57RBG19JL
Nikkaji Web: J1.719A
MDL: MFCD00003207
XlogP3: -0.40 (est)
Molecular Weight: 74.07922000
Formula: C3 H6 O2
Appearance: colorless to pale yellow clear liquid (est)

Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 1.06000 @ 25.00 °C.
Melting Point: -95.00 °C. @ 760.00 mm Hg
Boiling Point: 78.00 °C. @ 760.00 mm Hg
Vapor Pressure: 79.000000 mmHg @ 20.00 °C.
Vapor Density: 2.6 (Air = 1)
Flash Point: 27.00 °F. TCC (-2.78 °C.)
logP (o/w): -0.370
Soluble in: alcohol
Soluble in: ether

Soluble in: water, 2.769e+005 mg/L @ 25 °C (est)
Soluble in: water, 1.00E+06 mg/L @ 25 °C (exp)
Linear Formula: OCH2CH2OCH2
CAS Number: 646-06-0
Molecular Weight: 74.08
PubChem Substance ID: 329752533
UNSPSC Code: 12352200
Beilstein/REAXYS Number: 102453
MDL Number: MFCD00003207
Assay: ≥99.5%

Bp: 75-76 °C/1.013 hPa
Vapor Pressure: 70 mmHg (20 °C)
Empirical Formula (Hill Notation): C3H6O2
CAS Number: 646-06-0
Molecular Weight: 74.08
UNSPSC Code: 12352005
EC Index Number: 211-463-5
NACRES: NA.22
MDL Number: MFCD00003207
Assay: 99% (GC)
Grade: synthesis grade

Bp: 74-75 °C/1013 hPa
Vapor Pressure: 133 hPa (20 °C)
Physical State: liquid
Colour: colourless
Odour: odourless
Melting Point/Range: -95 °C
Boiling Point/Boiling Range: 75 - 76 °C (1.013 hPa)
Flammability: No data available
Upper Explosion Limit/Upper Flammability Limit: No data available
Lower Explosion Limit/Lower Flammability Limit: No data available

Flash Point: -3 °C
Method: closed cup
Autoignition Temperature: 274 °C
Decomposition Temperature: No data available
pH: No data available
Viscosity, Dynamic: 0,6 mPa.s (20 °C)
Viscosity, Kinematic: No data available
Flow Time: No data available
Water Solubility: soluble
Partition Coefficient: n-octanol/water: log Pow: 0,37

Vapour Pressure: 93 hPa (20 °C)
Relative Density: No data available
Density: 1,064 g/cm3
Relative Vapour Density: 2,56 (Air = 1.0)
Explosives: No data available
Oxidizing Properties: No data available
Burning Rate: No data available
Self-Ignition: 250 °C
Evaporation Rate: No data available
Surface Tension: 71,7 mN/m, 20 °C
Molecular Weight: 74,08 g/mol

FIRST AID MEASURES of DIOXOLANE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of DIOXOLANE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of DIOXOLANE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of DIOXOLANE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of DIOXOLANE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of DIOXOLANE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available

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