PRODUCTS

DIPOTASSIUM GUANYLATE

Dipotassium guanylate is widely used as a food additive.
Dipotassium guanylate is commonly used in the production of processed foods, meats, soups, condiments, as well as in powdered products such as instant soups and sauces.
Dipotassium guanylate is also used in the pharmaceutical industry as a flavor regulator in medicines.

CAS Number: 3254-39-5
EC Number: 221-849-5
IUPAC name: Dipotassium 5′-guanylate (dipotassium guanosine‑5′‑monophosphate)
E number: E628 (flavour enhancer)
Molecular formula: K₂C₁₀H₁₂N₅O₈P
Molecular weight: ~439.40 g/mol

SYNONYMS:
Potassium 5′-guanylate, Potassium guanylate, 5′-Guanosine monophosphate dipotassium salt, 5′-Guanylic acid dipotassium salt, dipotassium 5′-O-phosphonatoguanosine, E628, INS 628, Dipotassium 5′-guanylate, Dipotassium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, 5′-Guanosine monophosphate dipotassium salt, 5′-Guanylic acid dipotassium salt, E628, Dipotassium 5'-guanylate, 3254-39-5, Dipotassium guanylate, UNII-R87C8160YV, R87C8160YV, potassium guanylate, EINECS 221-849-5, POTASSIUM 5'-GUANYLATE, INS NO.628, INS NO. 628, INS-628, E-628, DIPOTASSIUM GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE 5'-MONOPHOSPHATE DIPOTASSIUM SALT, Potassium guanylatePotassium 5'-guanylate, 221-849-5, 5'-Guanylic acid, dipotassium salt, dipotassium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, E628, SCHEMBL3802708, DTXSID80954279, 5'-Guanylic acid,dipotassium salt, 5'-GUANYLIC ACID, POTASSIUM SALT (1:2), Q5280047, dipotassium guanosine-5'-monophosphate, dipotassium guanylate, dipotassium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, 5'-guanylic acid dipotassium salt, potassium 5'-guanylate, potassium guanylate, 5'-GUANYLIC ACID, POTASSIUM SALT (1:2), DIPOTASSIUM 5'-GUANYLATE, DIPOTASSIUM GUANOSINE-5'-MONOPHOSPHATE, DIPOTASSIUM GUANYLATE, E628, E-628, GUANOSINE 5'-MONOPHOSPHATE DIPOTASSIUM SALT, INS NO. 628, INS NO.628, INS-628, POTASSIUM 5'-GUANYLATE, POTASSIUM GUANYLATE, dipotassium guanosine-5'-monophosphate, dipotassium guanylate, dipotassium,[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, 5'-guanylic acid dipotassium salt, potassium 5'-guanylate, potassium guanylate, Dipotassium 5'-guanylate, 3254-39-5, Dipotassium guanylate, UNII-R87C8160YV, R87C8160YV, potassium guanylate, EINECS 221-849-5, POTASSIUM 5'-GUANYLATE, INS NO.628, INS NO. 628, INS-628, E-628, DIPOTASSIUM GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE 5'-MONOPHOSPHATE DIPOTASSIUM SALT, RefChem:134793, Potassium guanylate, Potassium 5'-guanylate, 221-849-5, 5'-Guanylic acid, dipotassium salt, dipotassium,[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, E628, SCHEMBL3802708, DTXSID80954279, 5'-Guanylic acid,dipotassium salt, Dipotassium 5'-O-phosphonatoguanosine, 5'-GUANYLIC ACID, POTASSIUM SALT (1:2), Q5280047

Dipotassium guanylate (E628) is an organic chemical compound that belongs to the group of flavor enhancers.
Dipotassium guanylate is the potassium salt of guanylic acid, which is produced synthetically.
Dipotassium guanylate is in the form of a white powder with very fine grains.

Dipotassium Guanylate is the potassium salt of guanylic acid E626.
Guanylic acid is a natural acid, which is part of RNA, one of the genetic carrier molecules in the cell.
Dipotassium guanylate is thus part of all cells in all living organisms.

Dipotassium guanylate is commercially prepared from yeast extract or sardines.
Dipotassium guanylate is an inorganic potassium salt derived from guanosine monophosphate (GMP), a naturally occurring nucleotide that plays an important role in biological energy transfer and signal transduction.

Chemically, dipotassium guanylate is the dipotassium salt of guanylic acid.
The presence of two potassium ions improves Dipotassium guanylate’s water solubility and stability compared to the free acid.
Dipotassium guanylate appears as a white to off-white crystalline powder, is odorless, and has a characteristic umami taste.

Dipotassium guanylate dissolves readily in water but is practically insoluble in most organic solvents such as ethanol or ether.
Dipotassium guanylate is stable under normal storage conditions but may degrade at very high temperatures or under strongly acidic conditions.

USES and APPLICATIONS of DIPOTASSIUM GUANYLATE:
Dipotassium guanylate is widely used as a food additive.
Dipotassium guanylate is commonly used in the production of processed foods, meats, soups, condiments, as well as in powdered products such as instant soups and sauces.

Dipotassium guanylate is also used in the pharmaceutical industry as a flavor regulator in medicines.
Common applications of Dipotassium guanylate: Chips, snacks, powder soups, pâtés, pizza, sauces, spices, rice, pre-cooked foods, olives, charcuterie, meat products, fish derivatives, dietetic products to reduce salt content.

Dipotassium Guanylate is found in instant noodles, potato chips and snacks, savoury rice, tinned vegetables, cured meats, packet soup.
In its commercial form, dipotassium guanylate is widely known as a food additive with the code E627 and is primarily used as a flavor enhancer.
From a functional perspective, dipotassium guanylate is valued for its strong synergistic effect with monosodium glutamate (MSG) and disodium inosinate (E631).

When used together, these compounds significantly intensify umami perception even at very low concentrations.
Because of this synergy, dipotassium guanylate is rarely used alone; instead, it is commonly formulated into blended flavor enhancers used in soups, sauces, snack seasonings, instant noodles, processed meats, and savory ready-to-eat foods.

This allows manufacturers to achieve a rich savory profile while keeping overall additive levels low.
Industrially, dipotassium guanylate is typically produced by fermentation processes using carbohydrate substrates such as glucose, followed by extraction, purification, and neutralization with potassium salts.

This fermentation-based origin makes Dipotassium guanylate suitable for large-scale food production and generally acceptable for vegetarian diets, depending on the processing aids used.
In terms of safety, dipotassium guanylate is considered safe for use in foods when applied within regulatory limits.

Dipotassium guanylate has been evaluated by international food safety authorities and is permitted in many regions, including the European Union, where it is regulated under food additive legislation.
Dipotassium guanylate is metabolized in the body to purine derivatives and ultimately excreted, similar to naturally occurring nucleotides found in common foods.

Beyond food applications, dipotassium guanylate is sometimes used in research and pharmaceutical contexts as a reference compound or biochemical reagent related to nucleotide chemistry.
Its defined structure and high purity make Dipotassium guanylate useful for analytical and formulation studies, although such uses are far less common than its role in the food industry.

Overall, dipotassium guanylate is a technically important ingredient in modern flavor technology.
Its strong umami-enhancing capability, high water solubility, and good stability make Dipotassium guanylate a valuable tool for improving taste profiles in a wide range of savory products while maintaining regulatory compliance and cost efficiency.

-Food additive with flavor enhancing role:
Dipotassium guanylate is the potassium salt of guanylic acid, a natural acid, component of ribonucleic acid.
For industrial use, Dipotassium guanylate is obtained from yeast or from sardines, having plant or animal origin.

Guanylates do not give the “umami” taste specific to glutamates, but have the ability to enhance a lot of natural flavors and tastes, thus allowing the required amount of salt to be reduced.
Dipotassium guanylate is used in the quantities on the recipes in all types of food, including alcoholic and non-alcoholic beverages.

PROPERTIES of DIPOTASSIUM GUANYLATE:
Dipotassium guanylate is water-soluble, which makes it easy to use in the food industry.
Dipotassium guanylate has the ability to enhance the flavor of foods, especially when combined with other flavor enhancers such as monosodium glutamate (E621) and disodium inosinate (E631).

WHERE TO BUY DIPOTASSIUM GUANYLATE?
Dipotassium guanylate (E628) is available in grocery stores, both stationary and online.
Dipotassium guanylate can be found in the food section or as an ingredient in finished products.
In addition, industrial manufacturers may purchase Dipotassium guanylate in larger quantities from chemical suppliers.

DIPOTASSIUM GUANYLATE AND ITS FUNCTIONS IN FOODS:
Dipotassium guanylate plays an important role as a flavor enhancer in the food industry.
Dipotassium guanylate's addition to food allows to increase the intensity of flavor and improve the organoleptic qualities of food products.
Dipotassium guanylate can make foods appear more aromatic and tasty, which contributes to their appeal to consumers.

PHYSICAL and CHEMICAL PROPERTIES of DIPOTASSIUM GUANYLATE:
IUPAC name: Dipotassium 5′-guanylate (dipotassium guanosine‑5′‑monophosphate)
CAS: 3254-39-5
EC / EINECS: 221‑849‑5
PubChem CID: 22841446
ChemSpider ID: 18598953
Molecular formula: K₂C₁₀H₁₂N₅O₈P
Molecular weight: ~439.40 g/mol
Appearance: White or colorless crystalline powder; odorless
Solubility: Freely soluble in water; practically insoluble in ethanol

Structure details: Sugar-phosphate backbone with guanine base, two K⁺ counterions
Chemical formula: C10H12K2N5O8P
Molar mass: 439.403 g·mol−1
Molecular Weight: 439.40 g/mol
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 10
Rotatable Bond Count: 3
Exact Mass: 438.9697623 Da
Monoisotopic Mass: 438.9697623 Da

Topological Polar Surface Area: 207 Å²
Heavy Atom Count: 26
Formal Charge: 0
Complexity: 586
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 4
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes

Appearance: white crystalline powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in: water, 1e+006 mg/L @ 25 °C (est)
ECHA EINECS - REACH Pre-Reg: 221-849-5
FDA UNII: R87C8160YV
Molecular Weight: 439.40460200
Formula: C10 H12 K2 N5 O8 P
Appearance: white crystalline powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No

Soluble in: water, 1e+006 mg/L @ 25 °C (est)
Ingredients: Dipotassium Guanylate (E628)
Solubility: Freely Soluble in Water
Application: Flavor Enhancer, Food Industry
Source: Other, Chemical Synthesis
Chemical Composition: C10H12K2N5O8P
Product Type: Food Additive
Form: Powder
Color: White
Shelf Life: 2 Years
Moisture: <5.0%
Flavor: Umami

FIRST AID MEASURES of DIPOTASSIUM GUANYLATE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of DIPOTASSIUM GUANYLATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of DIPOTASSIUM GUANYLATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of DIPOTASSIUM GUANYLATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of DIPOTASSIUM GUANYLATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of DIPOTASSIUM GUANYLATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available