DISODIUM 5′-RIBONUCLEOTIDE

Disodyum 5′-Ribonucleotide is widely used in food production as a flavor enhancer.
Disodyum 5′-Ribonucleotide is used in products such as soups, broths, snacks, condiments, ready meals and many others.
Disodyum 5′-Ribonucleotide is widely used in the food industry.

CAS Numbers (indicative of mixture components):
4691-65-0 (disodium inosinate component)
5550-12-9 (disodium guanylate component)
EC / EINECS Definition: “Disodium 5′-ribonucleotide is essentially a mixture of disodium inosine-5′-monophosphate and disodium guanosine-5′-monophosphate
Food Additive Code (E-number): E635
Chemical Nature: Mixture of disodium inosinate (IMP) and disodium guanylate (GMP)
Molecular Formula: C20H23N9Na4O16P2
Typical Molecular Representations:
IMP part: C₁₀H₁₁N₄Na₂O₈P
GMP part: C₁₀H₁₂N₅Na₂O₈P

SYNONYMS:
Disodium 5′-ribonucleotide, Disodium 5-ribonucleotides, I+G, Flavor enhancer E635, disodium inosinate + disodium guanylate mixture, Sodium 5′-ribonucleotide, Disodium 5'-ribonucleotide, RefChem:589391, Sodium 5'-ribonucleotide, DTXSID3020544, 80702-47-2, tetrasodium,[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate,[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl phosphate, I plus G, Disodium5'-ribonucleotide, MFCD01746765, s11602, E635, Disodium 5 inverted exclamation marka-GMP-disodium 5 inverted exclamation marka-IMP, 267641-96-3, I+G, disodium 5'-O-phosphonatoinosine, disodium 5'-ribonucleotide, disodium inosine 5'-monophosphate, disodium inosine 5'-phosphate, disodium inosine-5'-monophosphate, sodium 5'-ribonucleotides, sodium ribonucleotides, Disodium 5'-ribonucleotide, 80702-47-2, tetrasodium,[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate,[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl phosphate, Disodium5'-ribonucleotide, Disodium 5 Ribonucleotide, tetrasodium,[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate,[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl phosphate, Disodium5'-ribonucleotide

Disodyum 5′-Ribonucleotides or I+G, E number E635, is a flavor enhancer which is synergistic with glutamates in creating the taste of umami.
Disodyum 5′-Ribonucleotide is produced by combining the sodium salts of the natural compounds guanylic acid (E626) and inosinic acid (E630).
Disodyum 5′-Ribonucleotides (I + G) is one of the most popular food additives and ingredients in most countries.

Disodyum 5′-Ribonucleotides, also known as I+G, E number E635, is a flavor enhancer which is synergistic with glutamates in creating the taste of umami.
Disodyum 5′-Ribonucleotide is a mixture of disodium inosinate (IMP) and disodium guanylate (GMP) and is often used where a food already contains natural glutamates (as in meat extract) or added monosodium glutamate (MSG).

Disodyum 5′-Ribonucleotide is produced by combining the sodium salts of the natural compounds guanylic acid (E626) and inosinic acid (E630).
Guanylates and inosinates are generally produced from meat, but partly also from fish.
They are thus not suitable for vegans and vegetarians.

Disodyum 5′-Ribonucleotide is a mixture of 98% monosodium glutamate and 2% E635 has four times the flavor enhancing power of monosodium glutamate (MSG) alone.
Disodyum 5′-Ribonucleotides, also known as I+G, is a flavor enhancer made of disodium inosinate and disodium guanylate with the ratio 1:1.

Disodyum 5′-Ribonucleotide consists of white or off-white crystals or powder.
The European food additive number for Disodyum 5′-Ribonucleotide is E635.
I+G is a natural, vegan, and gluten free ingredient that can be used as a flavor enhancer to substitute monosodium glutamate (MSG) in MSG free food.

Disodyum 5′-Ribonucleotide is produced by combining the sodium salts of the natural compounds guanylic acid (E626) and inosinic acid (E630).
Disodyum 5′-Ribonucleotide is a natural, vegan and gluten-free ingredient that can be used as a flavor enhancer to substitute MSG.
Disodyum 5′-Ribonucleotides, also designated as E635, is the disodium salt of 5′-ribonucleic acid.

Disodyum 5′-Ribonucleotide is a food additive flavor enhancer composed of disodium inosinate and disodium guanylate.
Disodyum 5′-Ribonucleotide appears as a white crystalline powder that dissolves in water and has no distinctive odor, but it profoundly enhances umami taste in combination with glutamates such as MSG.

Widely used across savory food industries, Disodyum 5′-Ribonucleotide is generally regarded as safe when used within good manufacturing practice and has been evaluated by international food safety authorities with an “ADI Not Specified” outcome.
Disodyum 5′-Ribonucleotides or I+G, E number E635, is a flavor enhancer which is synergistic with glutamates in creating the taste of umami.

Disodyum 5′-Ribonucleotide is a mixture of disodium inosinate (IMP) and disodium guanylate (GMP) and is often used where a food already contains natural glutamates (as in meat extract) or added monosodium glutamate (MSG).
Disodyum 5′-Ribonucleotide is produced by combining the sodium salts of the natural compounds guanylic acid (E626) and inosinic acid (E630).

A mixture composed of 98% monosodium glutamate and 2% Disodyum 5′-Ribonucleotide has four times the flavor enhancing power of monosodium glutamate (MSG) alone.
Disodyum 5′-Ribonucleotides, also known as I+G, is a flavor enhancer made of disodium inosinate (E631) and disodium guanylate (E627) with the ratio 1:1.

The European food additive number for Disodyum 5′-Ribonucleotide is E635.
Disodyum 5′-Ribonucleotide is a mixture of nucleotides disodium guanylate and disodium inosinate, in the proportion of 50% each.
Disodyum 5′-Ribonucleotide is a flavor enhancer blend commonly used in the food industry.

Disodyum 5′-Ribonucleotide is not a single chemical but a defined mixture of two nucleotide salts: disodium inosinate (IMP) and disodium guanylate (GMP), typically in nearly equal proportions.
When Disodyum 5′-Ribonucleotide is labeled as a food ingredient, this combination is often identified by the European food additive number E635.

Disodyum 5′-Ribonucleotide's primary functional role in foods is to intensify umami (savory) taste, especially in synergy with glutamates such as MSG.
Disodyum 5′-Ribonucleotide is a food additive widely used as flavor enhancer in food and beverage industries.

Disodyum 5′-Ribonucleotide is food additive with flavor enhancing role.
Disodyum 5′-Ribonucleotide is the mixture of the calcium salts of guanylic acid and inosinic acid.
For industrial use, Disodyum 5′-Ribonucleotide is obtained by bacterial fermentation of sugars or from meat or sardines, having plant or animal origin.

Inosinates and guanylates do not give the “umami” taste specific to glutamates, but have the ability to enhance a lot of natural flavors and tastes, thus allowing the required the required amount of salt to be reduced.
Disodyum 5′-Ribonucleotide is a flavour enhancer.

Guanylates and inosinates do not have the specific umami taste but strongly enhance many other flavours, thereby reducing the amounts of salt or other flavour enhancers needed in a product.

Disodyum 5′-Ribonucleotide is white to almost white crystal or powder, no smell, have a special taste, soluble in water (25g/100ml water, 20 degrees C), slightly soluble in acetone, ethyl ether and ethanol.
A mixture of 98% monosodium glutamate and 2% Disodyum 5′-Ribonucleotide has four times the flavor enhancing power of monosodium glutamate (MSG) alone.

 
USES and APPLICATIONS of DISODIUM 5′-RIBONUCLEOTIDE:
Disodyum 5′-Ribonucleotide is a natural, vegan, and gluten free ingredient that can be used as a flavor enhancer to substitute monosodium glutamate (MSG) in MSG free food.
Disodyum 5′-Ribonucleotide can also be used with MSG at the usage level around 2-10% of MSG to provide a synergistic enhancement of umami taste in sauces, seasonings and condiments.

Disodyum 5′-Ribonucleotide is widely used in food production as a flavor enhancer.
Disodyum 5′-Ribonucleotide is used in products such as soups, broths, snacks, condiments, ready meals and many others.
This additive, Disodyum 5′-Ribonucleotide, helps improve the flavor of a dish without adding more salt.

Disodyum 5′-Ribonucleotide is a food additive mainly used as a flavor enhancer that improves the taste of foods and adds depth to them.
Disodyum 5′-Ribonucleotide is widely used in the food industry.
Uses of Disodyum 5′-Ribonucleotide: Flavored Noodles, Snack Foods, Chips, Crackers, Sauces, Fast Food.

Disodyum 5′-Ribonucleotide is a mixture of disodium inosinate (IMP) and disodium guanylate (GMP) and is often used where a food already contains natural glutamates (as in meat extract) or added monosodium glutamate (MSG).
Disodyum 5′-Ribonucleotide is primarily used in flavored noodles, snack foods, chips, crackers, sauces and fast foods.

Disodyum 5′-Ribonucleotide is primarily used in flavored noodles, snack foods, chips, crackers, sauces and fast foods.
Disodyum 5′-Ribonucleotide can also be used with MSG at the usage level around 2-10% of MSG to provide a synergistic enhancement of umami taste in sauces, seasonings and condiments.

Disodyum 5′-Ribonucleotide is a mixture of disodium inosinate (IMP) and disodium guanylate (GMP) and is often used where a food already contains natural glutamates (as in meat extract) or added monosodium glutamate (MSG).
Disodyum 5′-Ribonucleotide is primarily used in flavored noodles, snack foods, chips, crackers, sauces and fast foods.

Applications of Disodyum 5′-Ribonucleotide: As an MSG substitute, In ready-to-eat foods, In sauces, In snack products such as chips.
Disodyum 5′-Ribonucleotide can be used in synergy with MSG (E621) to provide umami taste or as a replacement for MSG.
Disodyum 5′-Ribonucleotide is primarily used in flavored noodles, snack foods, chips, crackers, sauces and fast foods.

Disodyum 5′-Ribonucleotides is widely used as Fluorescent indicator in various other industries.
Disodyum 5′-Ribonucleotide in Cosmetics: Not enough is known about application of Disodyum 5′-Ribonucleotides in Cosmetics.
Disodyum 5′-Ribonucleotide in Agriculture/Animal Feed: Disodyum 5′-Ribonucleotide is widely used as Insecticide in Agriculture/Animal Feed.

Disodyum 5′-Ribonucleotide is used as Insecticide: in Pesticides to kill pests.
As a flavoring , Disodyum 5′-Ribonucleotides can be used in a wide variety of industries including: food production, beverage, pharmaceutical, agriculture/animal feed, and various other industries.

Disodyum 5′-Ribonucleotide is used in the quantities on the recipes in all types of food, including alcoholic and non-alcoholic beverages.
Disodyum 5′-Ribonucleotide is used in many products.
Disodyum 5′-Ribonucleotide is mainly used in low sodium/salt products.

Disodyum 5′-Ribonucleotide is primarily used in flavored noodles, snack foods, chips, crackers, sauces and fast foods.
Uses of Disodyum 5′-Ribonucleotide: Flavoured crisps, instant noodles, manufactured pies

-Disodyum 5′-Ribonucleotide in Pharmaceutical:
Disodyum 5′-Ribonucleotide is widely used as intermediate in Pharmaceutical.
Disodyum 5′-Ribonucleotide is used as intermediate: in nucleotide drugs manufacturing.

-Aroma enhancer uses of Disodyum 5′-Ribonucleotide:
As Fluorescent indicator: Disodyum 5′-Ribonucleotide is used in Analytical Chemistry to act as Fluorescent indicator.
As aroma enhancer: Disodyum 5′-Ribonucleotide is used in Detergent to enhance aroma.

-Disodyum 5′-Ribonucleotide is used in Beverage:
Disodyum 5′-Ribonucleotides is widely used as flavor enhancer in beverage.
Disodyum 5′-Ribonucleotide is used as flavor enhancer: in beverage industries to increase flavor significantly when using together with monosodium glutamate.

-The following are the common food uses of Disodyum 5′-Ribonucleotide and the added levels recommended by the manufacturer, Ajinomoto:
Meat products: ≥ 0.01%
Broths: 0.50 – 1.00%
Soups: 0.20 – 0.30%
Spices (10% salt or higher): 0.25-2.8%
Snacks: 0.02 – 0.03%
Tomato sauce: 0.02 – 0.04%
Mustard: 0.02 – 0.04%
Salad dressings: 0.01 – 0.02%
Vegetable preserves, fish byproducts, frozen food, biscuits, pasta / dough: 0.01%

DISODIUM 5′-RIBONUCLEOTIDE IN FOOD PRODUCTION:
Disodyum 5′-Ribonucleotides is widely used as flavor enhancer in food production.
Disodyum 5′-Ribonucleotide is used as flavor enhancer: in family seasoning to increase flavor significantly when using together with monosodium glutamate.
Disodyum 5′-Ribonucleotide is used as flavoring agents: in meat product and instant food to cover up odors and enhance flavor.

FUNCTIONAL USES of DISODIUM 5′-RIBONUCLEOTIDE:
Disodyum 5′-Ribonucleotide is primarily used in food manufacturing as a flavor enhancer.
Disodyum 5′-Ribonucleotide's main applications include:

*Instant noodles and soups
*Snack foods and chips
*Sauces, gravies, and seasoning blends
*Canned and processed foods
*Savory snacks such as crackers
*Meat and poultry products

The blend is particularly effective when used together with monosodium glutamate (MSG, E621) because the nucleotide salts synergistically amplify umami perception, allowing a stronger savory taste with less overall additive use.
A well-known example is that a mixture containing about 2 % Disodyum 5′-Ribonucleotide and 98 % MSG exhibits a significantly stronger flavor-enhancing effect than MSG alone.

CHARACTERISTICS & BENEFITS of DISODIUM 5′-RIBONUCLEOTIDE:
*Umami enhancement: 
Strongly potentiates savory taste in foods, especially with glutamates.

*Synergy with MSG: 
Disodyum 5′-Ribonucleotide reduces the need for high glutamate or salt content for comparable flavor.

*Versatility: 
Useful in a broad range of savory products across food sectors.

*Processing compatibility: 
Disodyum 5′-Ribonucleotide is stable under typical food processing conditions (mixing, heating, cooling).

PROPERTIES of DISODIUM 5′-RIBONUCLEOTIDE:
Disodyum 5′-Ribonucleotide is characterized by strong flavor enhancing effects.
Disodyum 5′-Ribonucleotide has the ability to enrich and enhance the natural flavor of foods, making them a popular ingredient in the food industry.
In addition, Disodyum 5′-Ribonucleotide is water-soluble, making them easy to mix with other ingredients.

WHERE TO BUY DISODIUM 5′-RIBONUCLEOTIDE?
Disodyum 5′-Ribonucleotides (E635) are available in grocery stores, both stationary and online.
Disodyum 5′-Ribonucleotide can be found in the food additives section, usually in powder or granule form.
Disodyum 5′-Ribonucleotide is advisable to check the product’s label before purchasing to ensure that it meets expected quality standards.

USAGE of DISODIUM 5′-RIBONUCLEOTIDE:
Disodyum 5′-Ribonucleotide can be used as a flavour enhancer.
In synergy with monosodium glutamate, Disodyum 5′-Ribonucleotide doubles the umami effect, imparts a rich meaty aroma to food and enhances the overall flavour.
With excellent solubility and stability, Disodyum 5′-Ribonucleotide is specifically designed for industrial production to meet the requirements of efficient and stable production.

FEATURES of DISODIUM 5′-RIBONUCLEOTIDE:
Disodyum 5′-Ribonucleotide is ready-to-use product, accelerating research progress, enhancing application performance.

DISODIUM 5′-RIBONUCLEOTIDE AND THEIR FUNCTIONS IN FOODS
Disodyum 5′-Ribonucleotides play a key role as flavor enhancers in the food industry.
Their addition to a dish can increase the level of flavor intensity, making food products more appealing to consumers.
In addition, Disodyum 5′-Ribonucleotide makes it possible to reduce the salt content of products, which is important for health reasons.

HOW IS DISODIUM 5′-RIBONUCLEOTIDE MADE?
Both E631 and E627 can be produced from yeast extract or from the fermentation of carbohydrate and then through reaction with sodium hydroxide.

PROPERTIES of DISODIUM 5′-RIBONUCLEOTIDE:
*Appearance
Disodyum 5′-Ribonucleotide is an odourless, white powder or granular.

*Stability
Disodyum 5′-Ribonucleotide is easy to absorb water in the air, around 20-30% of water.

*Solubility
In Water: Disodyum 5′-Ribonucleotide is soluble in water, 25g in 100ml water in 20 degree.
In Organic Solvents: Disodyum 5′-Ribonucleotide is sparingly soluble in ethanol, practically insoluble in ether.

USUAGE of DISODIUM 5′-RIBONUCLEOTIDE:
Disodyum 5′-Ribonucleotide, E number E635, is a flavor enhancer which is synergistic with glutamates in creating the taste of umami.
Disodyum 5′-Ribonucleotide is a mixture of disodium inosinate (IMP) and disodium guanylate (GMP) and is often used where a food already contains natural glutamates (as in meat extract) or added monosodium glutamate (MSG).

Disodyum 5′-Ribonucleotide is produced by combining the sodium salts of the natural compounds guanylic acid (E626) and inosinic acid (E630).
Guanylates and inosinates can be found in animal and also plant.
While for commercial product, they are produced by fermentation process with raw material from plant origin.

FUNCTION & PROPERTIES of DISODIUM 5′-RIBONUCLEOTIDE:
Disodyum 5′-Ribonucleotide acts as a flavor enhancer.
Disodyum 5′-Ribonucleotide does not provide a distinct taste on its own but significantly boosts other flavors.
Disodyum 5′-Ribonucleotide helps reduce the need for salt and other flavor enhancers.
Disodyum 5′-Ribonucleotide works synergistically with MSG to intensify taste.

IS DISODIUM 5′-RIBONUCLEOTIDE SAFE?
Yes, Disodyum 5′-Ribonucleotide's safety when used as a food additive has been approved by the U.S. Food and Drug Administration (FDA), European Food Safety Authority (EFSA), Joint FAO/WHO Expert Committee on Food Additives (JECFA), as well as other authorities.

Foods to which Food Additive can be added:
Disodyum 5′-Ribonucleotide is used in permitted finished products, taking into account the relevant limitations, in accordance with the regulations in the Turkish Food Codex Regulation on Food Additives and vertical communiqués.
When the necessary information cannot be obtained in the regulations and communiqués, the legal regulatory authorities of the relevant country can be consulted.

PHYSICAL and CHEMICAL PROPERTIES of DISODIUM 5′-RIBONUCLEOTIDE:
Name: Disodium 5′-ribonucleotide
Food Additive Code (E-number): E635
Chemical Nature: Mixture of disodium inosinate (IMP) and disodium guanylate (GMP)
Typical Molecular Representations:
IMP part: C₁₀H₁₁N₄Na₂O₈P
GMP part: C₁₀H₁₂N₅Na₂O₈P
CAS Numbers (indicative of mixture components):
4691-65-0 (disodium inosinate component)
5550-12-9 (disodium guanylate component)

EC / EINECS Definition: “Disodium 5′-ribonucleotide is essentially a mixture of disodium inosine-5′-monophosphate and disodium guanosine-5′-monophosphate
Appearance: White or nearly white crystals or crystalline powder
Odor: Odorless
Solubility: Soluble in water; sparingly soluble in ethanol; practically insoluble in ether
pH (aqueous solution): Approximately 7.0–8.5 for a 5 % solution
Stability: Chemically stable under normal conditions; decomposes at high temperatures rather than melting
Taste: Little to no inherent taste itself, but strongly enhances savory/umami when combined with glutamates

Molecular Weight: 799.4 g/mol
Hydrogen Bond Donor Count: 7
Hydrogen Bond Acceptor Count: 20
Rotatable Bond Count: 6
Exact Mass: 799.03287680 Da
Monoisotopic Mass: 799.03287680 Da
Topological Polar Surface Area: 389 Ų
Heavy Atom Count: 51
Formal Charge: 0

Complexity: 1130
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 8
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 6
Compound Is Canonicalized: Yes

Appearance: white crystalline powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in: water, 1e+006 mg/L @ 25 °C (est)
Type: Raw material
Applications: Food Industry
Storage: 2-8°C; cool, dry place
Shelf Life: 12-24 months
Appearance: powder

Molecular Weight: 799.4
Instruction: Avoid inhalation during use, prevent contact with skin or mucous membranes, 
and rinse with water immediately after accidental contact
Production Methods: Fermentation extracted
Shipping: Timely shipping by optional means
Formula: C20H23N9Na4O16P2
Specification: Standard and Custom Specifications

FIRST AID MEASURES of DISODIUM 5′-RIBONUCLEOTIDE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of DISODIUM 5′-RIBONUCLEOTIDE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of DISODIUM 5′-RIBONUCLEOTIDE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of DISODIUM 5′-RIBONUCLEOTIDE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of DISODIUM 5′-RIBONUCLEOTIDE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of DISODIUM 5′-RIBONUCLEOTIDE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available