PRODUCTS

DISODIUM PHOSPHATE DIHYDRATE

Disodium phosphate dihydrate is often used in the food industry in manufacturing of dairy products and as a pH regulator.
Disodium phosphate dihydrate is used in buffer solutions, biochemical assays, molecular biology (because of its reliable pH buffering around ~9).
Disodium phosphate dihydrate is used as a phosphate source in certain applications, possibly in water treatment, metal finishing, detergents.

CAS Number: 10028-24-7
EC Number: 231-448-7
Chemical formula: H5Na2O6P / Na₂HPO₄ · 2 H₂O (sometimes written as HNa₂O₄P · 2 H₂O)
Molecular Weight: 177.99 g/mol

SYNONYMS:
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Disodium hydrogen phosphate dihydrate, sec-Sodium phosphate dihydrate, di-sodium hydrogen phosphate dihydrate, Disodium acid orthophosphate dihydrate, Disodium acid phosphate dihydrate, Disodium hydrogenorthophosphate dihydrate, Phosphoric acid disodium salt dihydrate, Sodium hydrogen phosphate hydrate (2:1:2), UNII 94255I6E2T, H5Na2O6P, Disodium phosphate 2-hydrate, SCHEMBL275856, SodiumHydrogenphosphateDihydrate, dibasic dihydratesodium phosphate, CHEMBL2107560, Disodium orthophosphate dihydrate, sodium hydrogen phosphate dihydrate, AKOS015913903, AKOS028109191, FS32721, NS00134327, Sodium phosphate dibasic dihydrate, LR, >=98%, Sodium phosphate dibasic dihydrate, p.a., 99.0%, Q27163166, Sodium phosphate dibasic dihydrate, BioUltra, >=99.0% (T), Sodium phosphate dibasic dihydrate, purum p.a., >=98.0% (T), Sodium phosphate dibasic dihydrate, tested according to Ph.Eur., Disodium phosphate dihydrate;Disodium hydrogen phosphate dihydrate, Sodium phosphate dibasic dihydrate, Vetec(TM) reagent grade, 98%, Sodium phosphate dibasic dihydrate, BioUltra, for molecular biology, >=99.0% (T), Sodium phosphate dibasic dihydrate, puriss. p.a., buffer substance, >=99.5%

Disodium phosphate dihydrate is the dihydrate hydrate form of the dibasic sodium phosphate (hydrogen phosphate) salt.
Disodium phosphate dihydrate (Na₂HPO₄·2H₂O) is the hydrated form of the dibasic sodium phosphate salt.

Disodium phosphate dihydrate is a white crystalline solid, pH‐basic in solution (around ~9 at modest concentration), highly soluble in water, and used in diverse applications including laboratory buffers, industrial processes, and (with appropriate grade/regulation) food formulations.
Disodium phosphate dihydrate is a white crystalline, non-flammable substance.

Disodium phosphate dihydrate is odorless and has a bitter taste.
Disodium phosphate dihydrate is a hydrate that is the dihydrate form of disodium hydrogenphosphate.

Disodium phosphate dihydrate contains a disodium hydrogenphosphate.
Disodium phosphate dihydrate (DSP), also known as sodium phosphate dibasic dihydrate, has several applications in the food processing, pharmaceutical, and personal care industries.

Disodium phosphate dihydrate is generally immediately available in most volumes.
High purity, submicron and nanopowder of Disodium phosphate dihydrate forms may be considered.

USES and APPLICATIONS of DISODIUM PHOSPHATE DIHYDRATE:
Disodium phosphate dihydrate is often used in the food industry in manufacturing of dairy products and as a pH regulator.
Disodium phosphate dihydrate is not meant for direct use, but as a raw material for additional processing.

Laboratory reagent: Disodium phosphate dihydrate is used in buffer solutions, biochemical assays, molecular biology (because of its reliable pH buffering around ~9).
Industrial uses: Disodium phosphate dihydrate is used as a phosphate source in certain applications, possibly in water treatment, metal finishing, detergents.

(While specific data for the dihydrate form may be more limited, the general salt family is used for such.)
Food industry uses of Disodium phosphate dihydrate: The broader class (disodium phosphate salts) is used in food processing as pH regulators, emulsifiers, anti-caking agents etc.

While one must check the specific grade and regulation for the dihydrate form.
Disodium phosphate dihydrate offers the convenience of stable crystalline hydrated form, but as with all chemical salts, proper handling, storage, and safety practices are essential.

Disodium phosphate dihydrate (DSP), also known as sodium phosphate dibasic dihydrate, has several applications in the food processing, pharmaceutical, and personal care industries.
Disodium phosphate dihydrate is used in laboratory, industrial, and other applications as a buffer, pH adjuster, and source of phosphate ions.

-Food processing uses of Disodium phosphate dihydrate:
Disodium phosphate dihydrate (DSP) is an additive in various processed food products.
Disodium phosphate dihydrate acts as a pH regulator, emulsifier, and texturizer.
Disodium phosphate dihydrate helps enhance flavor, improve texture, prevent spoilage, and stabilize acidity or alkalinity in food items such as breakfast cereals, cheese, processed meats, and dairy products.

-Pharmaceutical industry uses of Disodium phosphate dihydrate:
Disodium phosphate dihydrate (DSP) is used as a buffering agent, pH adjuster, and excipient in several medications.
Disodium phosphate dihydrate helps control and maintain the pH of formulations, ensuring the stability and effectiveness of drugs.
Disodium phosphate dihydrate is commonly found in tablets, capsules, and liquid medications.

-Personal care industry uses of Disodium phosphate dihydrate:
Disodium phosphate dihydrate (DSP) can be found in certain personal care products, such as shampoos, conditioners, and creams.
Disodium phosphate dihydrate acts as a pH adjuster, helping to ensure the optimal pH for the desired product performance and stability.

-Key applications of Disodium phosphate dihydrate:
Raw materials for the petrochemical industry.
Raw materials for the printing industry.
Raw materials for the food industry.
Raw materials for fertilizer production.
Raw materials for glass and ceramics production.

BENEFITS / WHY USED of DISODIUM PHOSPHATE DIHYDRATE:
Good buffering capacity around alkaline pH (the HPO₄²⁻/H₂PO₄⁻ system) which makes Disodium phosphate dihydrate useful when you need to maintain or adjust pH close to neutral/basic.
Disodium phosphate dihydrate is often more stable in certain conditions (less moisture uptake or less hygroscopic than anhydrous) which helps in solid handling.
The high solubility of Disodium phosphate dihydrate in water (for a salt) allows for preparation of concentrated solutions.
Reliable inorganic salt: relatively inexpensive, straightforward chemistry, stable under many conditions.

CHARACTERISTICS & ADDITIONAL PROPERTIES of DISODIUM PHOSPHATE DIHYDRATE:
pH of a 50 g/L solution at 20 °C: ~ 9.0-9.2

Purity / analytical specifications
e.g., one product lists an assay ≥99.0%.

Storage:
Typically keep dry, in sealed container to preserve crystalline form and water content.

Thermal behaviour:
As noted, the dihydrate loses water around ~92 °C (literature for the hydrate) for early decomposition.
Then further heating eventually leads to decomposition of the phosphate salt itself.

Appearance:
in product catalogues described as crystals or crystalline powder.

Chemical compatibility:
Generally stable, but strongly acidic conditions may shift the phosphate equilibrium; strong oxidizers may also need caution.

One spec lists “incompatible materials:
strong oxidizing agents, strong acids and strong bases.”

PROPERTIES of DISODIUM PHOSPHATE DIHYDRATE:
Disodium phosphate dihydrate is a colorless transparent sheet crystal.
Relative density of Disodium phosphate dihydrate is 1.52.
In the air, losing five molecules formed by seven water gesso items (Na2HPO4.7H2O) is easy.
Disodium phosphate dihydrate is soluble in water, not in alcohol.

BENEFITS of DISODIUM PHOSPHATE DIHYDRATE:
Disodium phosphate dihydrate is freely soluble in water and practically insoluble in ethanol.
Disodium phosphate dihydrate complies with Ph Eur, BP and USP specifications.

CHEMICAL BEHAVIOUR / ADDITIONAL PROPERTIES of DISODIUM PHOSPHATE DIHYDRATE:
In aqueous solution, the hydrogen phosphate (HPO₄²⁻) ion can act as a base (i.e., accept H⁺) which gives the solution a basic character.
Disodium phosphate dihydrate is stable under normal conditions as a salt; non-flammable.
When heated, hydrates release their water of crystallisation; the anhydrous form may condense to pyrophosphate under further heating.
(For example, the water-free form at ~250 °C converts into sodium pyrophosphate).

PHYSICAL and CHEMICAL PROPERTIES of DISODIUM PHOSPHATE DIHYDRATE:
CAS Number: 10028-24-7
EC / EINECS Number: 231-448-7
Chemical formula: Na₂HPO₄ · 2 H₂O (sometimes written as HNa₂O₄P · 2 H₂O)
Molar mass: ~ 177.99 g/mol
Appearance: crystalline solid (typically white crystals)
Odor: odorless (typical for this inorganic salt)
Form / Colour: Colourless to white crystalline solid.
Density: ~ 2.1 g/cm³ at 20 °C (for the dihydrate)

Linear Formula: Na2HPO4 · 2H2O
Molecular Formula: Na2HPO4·2(H2O)
Molecular Weight: 177.96–177.99 g/mol
CAS Number: 10028-24-7
MDL Number: MFCD00149182
UNSPSC Code: 12352302
EC Index Number: 231-448-7
Physical State: Solid

Color: Off-white
Odor: No data available
Melting Point / Freezing Point: No data available
Initial Boiling Point and Boiling Range: No data available
Flammability (solid, gas): The product is not flammable
Upper/Lower Flammability or Explosive Limits: No data available
Flash Point: Not applicable
Autoignition Temperature: No data available
Decomposition Temperature: No data available

pH: No data available
Viscosity, Kinematic: No data available
Viscosity, Dynamic: No data available
Water Solubility: No data available
Partition Coefficient (n-octanol/water): Not applicable for inorganic substances
Vapor Pressure: No data available
Density: 2.1 g/cm³ at 20 °C
Relative Density: No data available
Relative Vapor Density: No data available

Particle Characteristics: No data available
Explosive Properties: Not classified as explosive
Oxidizing Properties: None
Other Safety Information: Bulk density ca. 850–1,000 kg/m³
Solubility: Soluble in water. For example: pH ~9.0–9.2 for 50 g/L at 20 °C
Separation of Crystal Water: For the dihydrate, the crystal water is lost at around 92 °C
Hygroscopicity: As a hydrate, it is more stable than some other hydrates, but standard care for water content is recommended
Melting / Decomposition: The dihydrate form may lose water and decompose; one source lists “melting point/range 450 °C” (likely decomposition)

Molecular Weight: 177.99 g/mol
Exact Mass: 177.96191344 Da
Monoisotopic Mass: 177.96191344 Da
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 0
Topological Polar Surface Area: 85.4 Å²
Heavy Atom Count: 9
Formal Charge: 0

Complexity: 46.5
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 5
Compound Is Canonicalized: Yes

CAS Number: 10028-24-7
UNII: 94255I6E2T
Chemical Formula: H5Na2O6P
Linear Formula: Na2HPO4 · 2H2O
InChI: InChI=1S/2Na.H3O4P.2H2O/c;;1-5(2,3)4;;/h;;(H3,1,2,3,4);21H2/q2+1;;;/p-2
InChI Key: KDQPSPMLNJTZAL-UHFFFAOYSA-L
IUPAC Name: Disodium dihydrate hydrogen phosphate
SMILES: O.O.[Na+].[Na+].OP([O-])([O-])=O
EC Number: 231-448-7
MDL Number: MFCD00149182

UNSPSC Code: 12352302
PubChem Substance ID: 329753513
NACRES: NA.21
Assay: 98.5–101.0% (calc. to the dried substance)
Form: Crystals
logP: −1
pKa (Strongest Acidic): 1.8
Physiological Charge: −2
Hydrogen Acceptor Count: 4
Hydrogen Donor Count: 1

Polar Surface Area: 83.42 Å²
Rotatable Bond Count: 0
Refractivity: 12.41 m³·mol⁻¹
Polarizability: 5.24 Å³
Number of Rings: 0
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: No
Veber's Rule: No
MDDR-like Rule: No

FIRST AID MEASURES of DISODIUM PHOSPHATE DIHYDRATE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of DISODIUM PHOSPHATE DIHYDRATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of DISODIUM PHOSPHATE DIHYDRATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of DISODIUM PHOSPHATE DIHYDRATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of DISODIUM PHOSPHATE DIHYDRATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of DISODIUM PHOSPHATE DIHYDRATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available