PRODUCTS

E210

EC / List no.: 200-618-2
CAS no.: 65-85-0
Mol. formula: C7H6O2

E210 is a white (or colorless) solid with the formula C6H5CO2H.
E210 is the simplest aromatic carboxylic acid.
The name is derived from gum benzoin, which was for a long time its only source.
E210 occurs naturally in many plants and serves as an intermediate in the biosynthesis of many secondary metabolites.
Salts of benzoic acid are used as food preservatives.
E210 is an important precursor for the industrial synthesis of many other organic substances.
The salts and esters of E210 are known as benzoates

History
E210 was discovered in the sixteenth century.
The dry distillation of gum benzoin was first described by Nostradamus (1556), and then by Alexius Pedemontanus (1560) and Blaise de Vigenère (1596).

Justus von Liebig and Friedrich Wöhler determined the composition of E210 .
These latter also investigated how hippuric acid is related to E210 .

In 1875 Salkowski discovered the antifungal properties of E210 , which was used for a long time in the preservation of benzoate-containing cloudberry fruits.

Production
Industrial preparations
E210 is produced commercially by partial oxidation of toluene with oxygen.
The process is catalyzed by cobalt or manganese naphthenates.
The process uses abundant materials, and proceeds in high yield.

The first industrial process involved the reaction of benzotrichloride (trichloromethyl benzene) with calcium hydroxide in water, using iron or iron salts as catalyst.
The resulting calcium benzoate is converted to E210 with hydrochloric acid.
The product contains significant amounts of chlorinated E210 derivatives.
For this reason, E210 for human consumption was obtained by dry distillation of gum benzoin.
Food-grade E210 is now produced synthetically.

Laboratory synthesis
E210 is cheap and readily available, so the laboratory synthesis of E210 is mainly practiced for its pedagogical value.
E210 is a common undergraduate preparation.

E210 can be purified by recrystallization from water because of its high solubility in hot water and poor solubility in cold water.
The avoidance of organic solvents for the recrystallization makes this experiment particularly safe.
This process usually gives a yield of around 65%

By hydrolysis
Like other nitriles and amides, benzonitrile and benzamide can be hydrolyzed to E210 or its conjugate base in acid or basic conditions.

From Grignard reagent
Bromobenzene can be converted to E210 by "carboxylation" of the intermediate phenylmagnesium bromide.
This synthesis offers a convenient exercise for students to carry out a Grignard reaction, an important class of carbon–carbon bond forming reaction in organic chemistry.

Oxidation of benzyl compounds
Benzyl alcohol and benzyl chloride and virtually all benzyl derivatives are readily oxidized to E210 .

Uses:
E210 is mainly consumed in the production of phenol by oxidative decarboxylation at 300−400 °C:

C6H5CO2H + 1/2 O2 → C6H5OH + CO2
The temperature required can be lowered to 200 °C by the addition of catalytic amounts of copper (II) salts.
The phenol can be converted to cyclohexanol, which is a starting material for nylon synthesis.

Precursor to plasticizers
Benzoate plasticizers, such as the glycol-, diethyleneglycol-, and triethyleneglycol esters, are obtained by transesterification of methyl benzoate with the corresponding diol.
These plasticizers, which are used similarly to those derived from terephthalic acid ester, represent alternatives to phthalates.

Precursor to sodium benzoate and related preservatives
E210 and its salts are used as a food preservatives, represented by the E numbers E210, E211, E212, and E213. E210 inhibits the growth of mold, yeast and some bacteria.
E210 is either added directly or created from reactions with its sodium, potassium, or calcium salt.
The mechanism starts with the absorption of E210 into the cell.
If the intracellular pH changes to 5 or lower, the anaerobic fermentation of glucose through phosphofructokinase is decreased by 95%.
The efficacy of E210 and benzoate is thus dependent on the pH of the food.
Acidic food and beverages such as fruit juice (citric acid), sparkling drinks (carbon dioxide), soft drinks (phosphoric acid), pickles (vinegar) or other acidified food are preserved with E210 and benzoates.

Typical concentrations of E210 as a preservative in food are between 0.05 and 0.1%.
Foods in which E210 may be used and maximum levels for its application are controlled by local food laws.

Concern has been expressed that E210 and its salts may react with ascorbic acid (vitamin C) in some soft drinks, forming small quantities of carcinogenic benzene.

Medicinal
E210 is a constituent of Whitfield's ointment which is used for the treatment of fungal skin diseases such as tinea, ringworm, and athlete's foot.
As the principal component of gum benzoin, E210 is also a major ingredient in both tincture of benzoin and Friar's balsam.
Such products have a long history of use as topical antiseptics and inhalant decongestants.

E210 was used as an expectorant, analgesic, and antiseptic in the early 20th century.

Niche and laboratory uses
In teaching laboratories, E210 is a common standard for calibrating a bomb calorimeter.

Biology and health effects
E210 occurs naturally as do its esters in many plant and animal species.
Appreciable amounts are found in most berries (around 0.05%).
Ripe fruits of several Vaccinium species (e.g., cranberry, V. vitis macrocarpon, bilberry, V. myrtillus) contain as much as 0.03–0.13% free E210.
E210 is also formed in apples after infection with the fungus Nectria galligena.
Among animals, E210 has been identified primarily in omnivorous or phytophageous species, e.g., in viscera and muscles of the rock ptarmigan (Lagopus muta) as well as in gland secretions of male muskoxen (Ovibos moschatus) or Asian bull elephants (Elephas maximus).
Gum benzoin contains up to 20% of E210 and 40% benzoic acid esters.

In terms of its biosynthesis, benzoate is produced in plants from cinnamic acid.
A pathway has been identified from phenol via 4-hydroxybenzoate.

E210 appears as a white crystalline solid. Slightly soluble in water.
The primary hazard is the potential for environmental damage if released.
Immediate steps should be taken to limit spread to the environment.
Used to make other chemicals, as a food preservative, and for other uses.

E210 is a compound comprising a benzene ring core carrying a carboxylic acid substituent.
E210 has a role as an antimicrobial food preservative, an EC 3.1.1.3 (triacylglycerol lipase) inhibitor, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor, a plant metabolite, a human xenobiotic metabolite, an algal metabolite and a drug allergen.
E210 is a conjugate acid of a benzoate.

E210 is a Nitrogen Binding Agent.
The mechanism of action of E210 is as an Ammonium Ion Binding Activity.

Industry Uses
• Adhesives and sealant chemicals
• Agricultural chemicals (non-pesticidal)
• CHEMICAL DISTRIBUTION
• Cosmetics and personal care
• Finishing agents
• Food and beverage additive, preservative.
• Heat Stabilizer
• Intermediates
• Lubricants and lubricant additives
• Paint additives and coating additives not described by other categories
• Plasticizers
• Solvents (for cleaning and degreasing)
• Solvents (which become part of product formulation or mixture)
• Surface active agents

Consumer Uses
• Adhesives and sealants
• Agricultural products (non-pesticidal)
• Anti-freeze and de-icing products
• Automotive care products
• Building/construction materials not covered elsewhere
• CHEMICAL DISTRIBUTION
• Cleaning and furnishing care products
• Electrical and electronic products
• Floor coverings
• Food / Beverage / Nutrition use.
• Laundry and dishwashing products
• Lubricants and greases
• Mixed Metal Heat Stabilizer
• Non-TSCA use
• Paints and coatings
• Personal care products
• Plastic and rubber products not covered elsewhere
• Toys, playground, and sporting equipment

Household Products
• Auto Products
• Inside the Home
• Personal Care
• Pet Care

Methods of Manufacturing
Liquid-Phase Oxidation of Toluene with Molecular Oxygen.
In a typical modern process the oxidation is conducted at 165 °C and 0.9 MPa.
The reaction heat is removed by external circulation of the contents of the reactor.
The pressure of the liquid discharged from the reactor is reduced to atmospheric, and unreacted toluene is recovered.
• E210 is purified by rectification.
The bottom residue is extracted to recover the cobalt catalyst.
The exhaust gas is cooled to recover most of the toluene, purified, and vented.

General Manufacturing Information
Industry Processing Sectors
• Adhesive manufacturing
• All other basic organic chemical manufacturing
• All other chemical product and preparation manufacturing
• Custom compounding of purchased resin
• Food, beverage, and tobacco product manufacturing
• Miscellaneous manufacturing
• Oil and gas drilling, extraction, and support activities
• Paint and coating manufacturing
• Personal care and cosmetics
• Pesticide, fertilizer, and other agricultural chemical manufacturing
• Petrochemical manufacturing
• Petroleum lubricating oil and grease manufacturing
• Plastic material and resin manufacturing
• Plastics product manufacturing
• Rubber product manufacturing
• Soap, cleaning compound, and toilet preparation manufacturing
• Textiles, apparel, and leather manufacturing
• Transportation equipment manufacturing
• Wholesale and retail trade

E210 is the simplest member of the aromatic carboxylic acid family.
E210 is a weak acid that is a precursor for the synthesis of many important organic compounds.
More than 90 percent of commercial E210 is converted directly to phenol and caprolactam.
Its use in the production of glycol benzoates for the application of plasticizer in adhesive formulations is increasing.
The organic compound is also used in the manufacture of alkyd resins and drilling mud additive for crude oil recovery applications.
E210 is also used as a rubber polymerization activator, retardant, resins, alkyd paint, plasticizers, dyestuffs, and fibers.
E210 and its esters occur in apricots, cranberries, mushrooms and jasmine plants.
The history of E210 dates back to sixteenth century.
In the year of 1875 Salkowski a prominent scientist discovered its antifungal abilities.
In medicine, E210 is the principal component of benzoin resin, and is a constituent of Whitfield’s ointment which is used for the treatment of fungal skin diseases such as tinea, ringworm, and athlete’s foot.
Chemical Properties Scaly or needle like crystals.
With the smell of formaldehyde or benzene.
Slightly soluble in water, soluble in ethanol, methanol, diethyl ether, chloroform, benzene, toluene, CS2, CCl4 and turpentine.

HISTORY
E210 was found in the 16th century.
In 1556, Nostradamus first described carbonization effect of benzoin. After the Alexius Pedemontanus and Brian blessed decipher were discovered in 1560 and 1596.
In 1875, the salkowski discovered the antifungal potency of E210, so benzoic acid is used for long term preservation cloudberry.

Food Preservatives
E210 and sodium benzoate are commonly used food preservative.
In acidic conditions, it has inhibitory effect on yeast and mold.
When pH value is 3 antibacterial strength, when pH was 6 for a lot of mould effect is very poor, so the inhibition the optimum pH value is 2.5-4.0.
In the food industry with plastic barrels concentrated fruit and vegetable juice, the maximum usage shall not exceed 2.0g/kg, in the jam (not including canned), fruit juice (taste) drinks, soy sauce, vinegar in the maximum amount is 1.0g/kg, in Wine, candy, wine in the maximum amount of 0.8g/kg in the low salt, pickles, sauces, candied fruit, use the largest 0.5g/kg in carbonate, use the largest beverage 0.2g/kg.
Because of solubility of E210, when used will be stirring, or dissolved in a small amount of hot water or ethanol.
The use of concentrated fruit juice in the soft drink used for E210 easily volatile with steam, it is commonly used in the sodium salt.
E210 in food industry is a common preservative in dairy products, but not allowed to be added.
In general, E210 is considered to be safe.
But for some special populations, including infants, long-term intake of E210 may lead to asthma, urticaria, metabolic acidosis and other adverse reactions.
Paul deodorant E210 is also used as a beverage.
As the cream sweet perfume fragrance.
Can also be used for chocolate, lemon, orange, sub berries, nuts, candied fruit and other edible flavor type.
Tobacco flavor also commonly used.
In addition of E210 is also used as a pesticide, medicine, dye, mordant and plasticizer agent for the production of raw materials, polyamide resin and alkyd resin modifying agent and steel equipment anti rust agent.

Uses:
1. Used as a chemical reagent and preservative.

2. E210 is important type food preservative.
Under acidic conditions, E210 has inhibitory effects to mold, yeast and bacteria , but the effect is weak acid producing bacteria.
The most appropriate antimicrobial pH values is ranging from 2.5 to 4, generally lower, the pH value is appropriate from 4.5 to 5.
In the food industry with plastic barrels concentrated fruit and vegetable juice, the maximum use amount shall not be over 2.0g/kg; in jam (excluding canned), (taste) juice drink, soy sauce, vinegar in the maximum dose of 1.0g/kg, in soft candy, wine, wine in the maximum dose of 0.8 g/kg separately, in the low salt pickled vegetables, the sauce, candied fruit, maximum dose is 0.5 g/kg, in carbonated drinks in the largest amount of use is 0.2g/kg.
Due to E210, slightly soluble in water, its use can be a small amount of ethanol enable dissolved.

3.Preservative; anti microbial agents.
Due to the low solubility of E210 and use shall be stirring, or dissolved in a small amount of hot water or ethanol.
When used in the soft drink with fruit juice concentrate, for E210 easy volatile with the water vapor, so often used in the sodium salt, besides the above sodium equivalent to benzoic acid 0.847g.

4.Often used as a fixative agent or preservative.
Also used as a fruit juice aroma conservation agents.
As a perfume with perfume fragrance.
Can also be used for chocolate, lemon, orange, berries, nuts, candied fruit type edible essence.
Tobacco flavor is also commonly used.

5.E210 and its sodium salt are food preservatives. Under acidic conditions, it has inhibition of yeasts and molds.
When pH 3, antibacterial strength and when pH 6, many fungi effect is very poor, so the antibacterial optimum pH is 2.5-4.0.
E210 is mainly used for the production of sodium benzoate preservatives, dyes intermediates, pesticides, plasticizers, mordant, medicine, spice and also can be used as alkyd resin and polyamide resin modifier for the production of polyester, terephthalic acid and used equipment, iron and steel anti rust agent.

6.Mainly used for antifungal and antiseptic.

7.Used in medicine, dye carriers, plasticizer, spices and food preservatives such as production, and can also be used to paint of alkyd resin performance improvement, used as pharmaceutical and dye intermediates, used for the preparation of plasticizer and spices etc., as well as equipment, iron and steel anti rust agent.

Preparation
Industrial preparation method
The industrial E210 is mainly by toluene liquid phase air oxidation preparation.
The process was with cobalt naphthenate as catalyst, in response to temperature is 140-160 ℃ and operating pressure is 0.2-0.3MPa and response generation E210.
Reaction after steaming to toluene, and vacuum distillation and recrystallization to obtain the product.
The process uses cheap raw materials, high yield.
Therefore, it is industrial uses mainly the method.

Laboratory preparation method of the main reaction:
1.C6H5CH3+ KMnO4+H2O-C6H5 COOK+KOH+MnO2+H2O(water in fron of the manganese dioxide is supplied with water reaction environment)
2.C6H5 COOK+HCl--C6H5 COOH
Drug and dosage:
Toluene 1.5g (1.7ml, 0.016mol), potassium permanganate 5g (0.032mol), CTAB(cetyl trimethyl ammonium bromide) 0.1g.
Experimental operation:
With 100 ml round bottom flask.
Install a refluxing device.
Add 5g potassium permanganate, 0.1g of hexadecyl trimethyl ammonium bromide, 1.7 ml of toluene and 50 ml of water to the reaction flask, stir heated boiling (vigorous stirring, violent boiling), keep the reactant solution stable boiling.

When large amounts of brown precipitate, potassium permanganate purple shallow or disappeared, the toluene layer disappeared, reaction has basically ended.
Filter out of manganese dioxide precipitation, landfill leachate by concentrated hydrochloric acid, precipitation of E210 precipitation, filtering to the crude product.
The crude product water recrystallization.
In a boiling water bath for drying, weighing, measuring the melting point.

Description
E210 is a colorless, crystalline solid also known as benzenecarboxylic acid. E210 is the simplest aromatic carboxylic acid, with a carboxyl group (-COOH) bonded directly to the benzene ring. E210 is found naturally in the benzoin resin of a number of plants.

Chemical Properties
E210,C6H5COOH, also known as benzene carboxylic acid and phenyl formic acid,is a colorless, monoclinic crystalline solid that has a melting point of 122.4"C and sublimes readily at 100·C.
E210 is an aromatic carboxylic acid that is slightly soluble in water and moderately soluble in alcohol and ether.
E210 is used as a preservative and its derivatives are valuable in medicine, commerce, and industry.

Physical properties
Colorless to white needles, scales, or powder with a faint benzoin or benzaldehyde-like odor.
Shaw et al. (1970) reported a taste threshold in water of 85 ppm.

Occurrence
Reported found in fresh apple, apricot (Prunus armeniaca L.), strawberry fruit, cherry (Prunus cerasus L.), butter, boiled and cooked beef, pork fat, white wine, black tea, green tea, fresh plum, mushroom, Bourbon vanilla (Vanilla planifolia Andrews), and other natural sources.
Reported as being a constituent of various oils, resins and flower absolutes, hyacinth, tuberose, neroli bigarade, Chinese cinnamon, cinnamon leaves, anise, vertiver, ylang-ylang, Tolu balsam and clove.
E210 is contained in fairly sizable amounts in gum benzoin, from which E210 is extracted by sublimation.

Uses:
Sodium benzoate is an important E210 derivative produced industrially by neutralization of E210 using sodium hydroxide or sodium bicarbonate solution.
Calcium benzoate, potassium benzoate, and other benzoate salts are also produced.
E210 and sodium benzoate (C6H5COONa) are used as food preservatives and added to foods, juices, and beverages that are acidic.

Calorimetry
E210 is the most commonly used chemical standard to determine the heat of capacity of a bomb calorimeter.
Feed stock
E210 is used to make a large number of chemicals, important examples of which are :
Benzoyl chloride, C6H5C(O)Cl, is obtained by treatment of benzoic with thionyl chloride, phosgene or one of the chlorides of phosphorus.
C6H5C(O) Cl is an important starting material for several E210 derivates like benzyl benzoate, which is used in artificial flavours and insect repellents.

Food preservative
E210 and its salts are used as a food preservatives, represented by the E-numbers E210 , E211 , E212 , and E213 . E210 inhibits the growth of mold, yeast and some bacteria.
E210 is either added directly or created from reactions with its sodium, potassium, or calcium salt. The mechanism starts with the absorption of E210 in to the cell.

Medicinal
E210 is a constituent of Whitfiel's ointment which is used for the treatment of fungal skin diseases such as tinea, ringworm, and athlete's foot.
As the principal component of benzoin resin, E210 is also a major ingredient in both tincture of benzoin and Fria's balsam.
Such products have a long history of use as topical antiseptics and inhalant decongestants.
E210 was used as an expectorant, analgesic, and antiseptic in the early 20th century.

Production Methods
Industrial preparations
E210 is produced commercially by partial oxidation of toluene with oxygen.
The process is catalyzed by cobalt or manganese naphthenates.
The process uses cheap raw materials, proceeds in high yield, and is considered environmentally green.

Laboratory synthesis
E210 is cheap and readily available, so the laboratory synthesis of E210 is mainly practiced for its pedagogical value.
E210 is a common undergraduate preparation.
For all syntheses, E210 can be purified by recrystallization from water because of its high solubility in hot water and poor solubility in cold water.
The avoidance of organic solvents for the recrystallization makes this experiment particularly safe.
Other possible recrystallization solvents include acetic acid (anhydrous or aqueous), benzene, acetone, petroleum ether, and a mixture of ethanol and water.
The solubility of E210 in over 40 solvents with references to original sources can be found as part of the Open Notebook Science Challenge.

General Description
Boric acid,H3B03, also known as boracic acid, orthoboric acid, and sassolite, is a white solid composed of triclinic crystals.
E210 is a derivative of barium oxide and is soluble in water.
A white crystalline solid.
Slightly soluble in water.
The primary hazard is the potential for environmental damage if released.
Immediate steps should be taken to limit spread to the environment.
Used to make other chemicals, as a food preservative, and for other uses.

Agricultural Uses
Fungicide, Insecticide:
Used in the manufacture of benzoates, plasticizers, benzoyl chloride, alkyd resins, in the manufacture of food preservatives, in use as a dye binder in calico printing, in curing of tobacco, flavors, perfumes, dentifrices, standard in analytical chemistry.
Not currently registered for use in the U.S. E210 is currently used in about a dozen European countries.

E210, the simplest benzene-based carboxylic acid, has been known since the 16th century.
One of its discoverers was the legendary clairvoyant Nostradamus.
Its most common natural source is gum benzoin, a resin found in the bark of trees of the genus Styrax.

Most E210 produced today is synthetic.
Its first industrial synthesis was the hydrolysis of benzotrichloride to calcium benzoate, followed by acidification.
This method has been completely displaced by the air oxidation of toluene, which avoids the problem of product contamination with chlorinated byproducts.

Many processed foods contain E210 or one of its salts as a preservative.
The acid inhibits the growth of bacteria, molds, and yeasts, it works best when the food has an acidic pH value.
E210 also is often found in topical antifungal preparations.

E210 is an organic compound which is described by the chemical formula C6H5COOH.
E210 consists of a carboxyl group attached to a benzene ring.
Therefore, E210 is said to be an aromatic carboxylic acid.
E210 exists as a crystalline, colorless solid under normal conditions.
The term ‘benzoate’ refers to the esters and salts of C6H5COOH.

The commercial production of E210 is done via the partial oxidation of toluene with oxygen, catalyzed by manganese or cobalt naphthenates. This chemical reaction is illustrated below.
Another industrial method of preparing E210 is by reacting tri-chlorotoluene with calcium hydroxide in the presence of water, and the treatment of the calcium benzoate product with hydrochloric acid.

Structure
The structure of a C6H5COOH molecule is illustrated below. This molecule consists of a benzene ring to which a carboxyl functional group is linked. The molecule consists of 7 carbon atoms, 6 hydrogen atoms, and 2 oxygen atoms.

Properties of E210
The physical and chemical properties of C6H5COOH are discussed in this subsection.

Chemical Data
E210 Formula: C7H6O2 or C6H5COOH
Molecular Weight/ Molar Mass: 122.12 g/mol
Density: 1.27 g/cm3 at 15oC
Boiling Point: 523K
Melting Point: 395 K

Physical Properties
E210 has a colourless appearance in its solid state, which is of a crystalline nature.
The crystal structure is monoclinic.
The presence of the aromatic ring gives E210 a faintly pleasant odour.
At a temperature of 130oC, the density of E210 reduces to 1.075 grams per cubic centimetre.

Chemical Properties
E210 is soluble in water, and the solubility at 25oC and 100oC is 3.44 g/L and 56.31 g/L respectively.
E210 is soluble in benzene, carbon tetrachloride, acetone, and alcohols.
The acid dissociation constant (pKa) of E210 corresponds to 4.2
Its reactions can occur at the carboxyl group or even at the aromatic ring.

Uses of E210
Some important uses of C6H5COOH are listed below.

The production of phenol involves the use of E210.
E210 is used in ointments that prevent or treat fungal skin diseases.
C6H5COOH is used as a preservative in the food industry.
E210 is an ingredient in many cosmetic products, such as lipsticks.
E210 is also a precursor to benzoyl chloride.
One of the components of toothpaste, mouthwash, and face wash creams is C6H5
E210 is also used in the manufacture of dyes and in insect repellants.

About E210
Helpful information
E210 is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 to < 1 000 000 tonnes per annum.

E210 is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Biocidal Uses
E210 is approved for use as a biocide in the EEA and/or Switzerland, for: veterinary hygiene, food and animals feeds.

E210 is being reviewed for use as a biocide in the EEA and/or Switzerland, for: preservation films, preservation of fibres, leather, rubber, or polymers.

Consumer Uses
E210 is used in the following products: cosmetics and personal care products, perfumes and fragrances, pharmaceuticals and washing & cleaning products.
Other release to the environment of E210 is likely to occur from: indoor use as processing aid and outdoor use as processing aid.

Article service life
Other release to the environment of E210 is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
E210 can be found in complex articles, with no release intended, vehicles.

Widespread uses by professional workers
E210 is used in the following products, coating products, fillers, putties, plasters, modelling clay, pH regulators and water treatment products and laboratory chemicals.
E210 is used in the following areas, health services and scientific research and development.
E210 is used for the manufacture of, machinery and vehicles.
Other release to the environment of E210 is likely to occur from, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Formulation or re-packing
E210 is used in the following products: cosmetics and personal care products, anti-freeze products, biocides (e.g. disinfectants, pest control products), lubricants and greases, pharmaceuticals and polymers.
Release to the environment of E210 can occur from industrial use, formulation of mixtures.

Uses at industrial sites
E210 is used in the following products, polymers, lubricants and greases, pharmaceuticals, cosmetics and personal care products, pH regulators and water treatment products and laboratory chemicals.
E210 has an industrial use resulting in manufacture of another substance (use of intermediates).
E210 is used in the following areas, formulation of mixtures and/or re-packaging.
Release to the environment of E210 can occur from industrial use, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, as processing aid and in processing aids at industrial sites.

Manufacture
Release to the environment of E210 can occur from industrial use, manufacturing of the substance.

IUPAC NAMES:
benzene carboxylic acid
Benzenecarboxylic acid
Benzoesäure
BENZOIC ACID
Benzoic Acid
Benzoic acid
benzoic acid
Benzoic Acid
Benzoic acid
Benzoic Acid Zone Refined (number of passes:20)
Benzonic acid
Phenylformic acid, Benzene carboxylic acid

SYNONYMS:
benzoic acid
65-85-0
Dracylic acid
benzenecarboxylic acid
Carboxybenzene
Benzeneformic acid
phenylformic acid
Benzenemethanoic acid
Phenylcarboxylic acid
Retardex
Benzoesaeure GK
Benzoesaeure GV
Retarder BA
Tenn-Plas
Acide benzoique
Salvo liquid
Solvo powder
Benzoesaeure
Flowers of benzoin
Flowers of benjamin
E210, tech.
Unisept BZA
HA 1 (acid)
Kyselina benzoova
Benzoic acid (natural)
Benzoate (VAN)
HA 1
Benzoesaeure [German]
Caswell No. 081
Diacylic acid
Oracylic acid
FEMA No. 2131
Acide benzoique [French]
Acido benzoico [Italian]
Benzenemethonic acid
Kyselina benzoova [Czech]
NSC 149
E 210
CCRIS 1893
Diacylate
HSDB 704
UNII-8SKN0B0MIM
AI3-0310
Salvo, liquid
Solvo, powder
AI3-03710
phenyl formic acid
EPA Pesticide Chemical Code 009101
Benzoic acid Natural
E210
CHEBI:30746
Aromatic carboxylic acid
Benzeneformate
Phenylformate
Benzenemethanoate
Phenylcarboxylate
Benzenecarboxylate
DSSTox_CID_143
DSSTox_RID_75396
DSSTox_GSID_20143
Acido benzoico
Benzoic-2,3,4,5,6-d5 acid
Carboxypolystyrene
Benzoic acid [USAN:JAN]
CAS-65-85-0
NSC7918
Benzoic acid (TN)
EINECS 200-618-2
Benzoic acid [USP:JAN]
phenylcarboxy
Vevovitall
Dracylate
benzoic aicd
benzoic-acid
bezoic acid
Aromatic acid
Menno-florades
benzenecarboxylic
Salvo powder
Acidum benzoicum
Benzoicum acidum
benzoic- acid
Retarder BAX
Benzoic Acid USP
Sodium benzoic acid
Benzoic Acid,(S)
Natural Benzoic Acid
Benzoic acid solution
BENZOICACID-D5
Benzoic acid-[13C7]
benzene-2-carboxylic acid
Benzoic Acid-[18O2]
Benzoic acid (e 210)
Benzoic acid, ACS reagent
Benzoic acid (JP17/USP)
Benzoic acid, AR, >=99%
Benzoic acid, LR, >=99%
Benzoic acid (7CI,8CI,9CI)
Benzoic acid, analytical standard
Benzoic acid, p.a., 99.5%
Benzoic acid, ReagentPlus(R), 99%
Benzoic acid 100 microg/mL in Acetone
Benzoic acid, >=99.5%, FCC, FG
Benzoic acid, ACS reagent, >=99.5%
Benzoic acid, USP, 99.5-100.5%
Benzoic acid, tested according to Ph.Eur.
SBI-0206720.P001
Benzoic acid, SAJ first grade, >=99.5%
Benzoic acid, natural, >=99.5%, FCC, FG
Benzoic acid, SAJ special grade, >=99.5%
Benzoic acid, Vetec(TM) reagent grade, 98%
Benzoic acid, meets USP testing specifications
Benzoic acid, purified by sublimation, >=99%
Benzoic Acid Zone Refined (number of passes:20)
Q191700
SR-05000001919
Benzoic acid, puriss. p.a., ACS reagent, 99.9%
SR-05000001919-1
0BE368DC-6DE6-4927-AECF-E4BB2968A4A0
Melting point standard 121-123C, analytical standard
Benzoic acid, NIST(R) SRM(R) 39j, calorimetric standard
Benzoic acid, Standard for quantitative NMR, TraceCERT(R)
Benzoic acid, European Pharmacopoeia (EP) Reference Standard
Mettler-Toledo Calibration substance ME 18555, Benzoic acid
Benzoic acid on polystyrene, 1.6-2.1 mmol/g@CRLFMFCD03456189
Benzoic acid, for calorimetrical determination (approx. 26460 J/g)
Benzoic acid, United States Pharmacopeia (USP) Reference Standard
SS Benzoic Acid, 2000 mug/mL in dichloromethane, analytical standard
Benzoic acid solution, 200 mug/mL in methylene chloride, analytical standard
Benzoic Acid Solution, certified reference material, 2000 mug/mL in methylene chloride
Benzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material
Benzoic acid, puriss. p.a., ACS reagent, reag. Ph. Eur., >=99.9% (alkalimetric)
Benzoic acid, certified reference material for titrimetry, certified by BAM according to ISO 17025, >=99.5%
Benzoic acid, meets analytical specification of Ph. Eur., BP, USP, FCC, E210, 99.5-100.5% (alkalimetric)
Carboxypolystyrene, 100-200 mesh, extent of labeling: 0.5-1.5 mmol/g loading, 1 % cross-linked
Carboxypolystyrene, 100-200 mesh, extent of labeling: 1.6-3.0 mmol/g loading, 1 % cross-linked
Mettler-Toledo Calibration substance ME 18555, Benzoic acid, analytical standard, for the calibration of the thermosystem 900, traceable to primary standards (LGC)
ScavengePore(TM) benzoic acid, macroporous, 40-70 mesh, extent of labeling: 0.5-1.5 mmol per g loading
210
a 1 (acid)
Acide benzoique
Benzoic aBenzoic acidcid
Mefenamic Acid Impurity D
Benzyl acid
SS Benzoic Acid
Glycopyrronium Bromide EP Impurity D
price benzoic acid
Benzoic acid Manufacturer
Food Additive Benzoic Acid
Nat.Benzoic acid
BENZOIC ACID, PRIMARY STANDARDBENZOIC ACID, PRIMARY STANDARDBENZOIC ACID, PRIMARY STANDARD
BENZOIC ACID, REAGENT (ACS)BENZOIC ACID, REAGENT (ACS)BENZOIC ACID, REAGENT (ACS)BENZOIC ACID, REAGENT (ACS)
Mefenamic Acid Impurity 4（Mefenamic Acid EP Impurity D）
acidebenzoique
acidebenzoique(french)
acidobenzoico
ai3-0310
alvo liquid
Benzenemethanoic acid
benzenemethanoicacid
Benzoesaeure
Benzoesaeure GK
Benzoesaeure GV
Benzoic acid, tech.
Diacylic acid
e210
epapesticidechemicalcode009101
Flowers of benjamin
Flowers of benzoin
flowersofbenjamin
flowersofbenzoin
ha1
ha1(acid)
henylcarboxy
Kyselina benzoova
kyselinabenzoova
kyselinabenzoova(czech)
Nipacide
olvo powder
Predominantly benzoic acid
Retarded BA
Retarder BA
Retarder BA, BAX
retarderba
Retardex
Salvo powder
Salvo, liquid
salvoliquid
salvopowder
Solvo, powder
solvopowder
Tenn-Plas
Benzoic Acid, Reagent Special
Melting point standard 121-123.C
BENZOIC ACID FOR ANALYSIS EMSURE
BENZOIC ACID VOLUMETRIC STANDARD, SECOND