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E214 Ethyl p-hydroxybenzoate is the ethyl ester of p-hydroxybenzoic acid.
E214 Ethyl p-hydroxybenzoate's formula is HO-C6H4-CO-O-CH2CH3.
E214 Ethyl p-hydroxybenzoate is a member of the class of compounds known as parabens.
CAS: 120-47-8
MF: C9H10O3
MW: 166.17
EINECS: 204-399-4
Synonyms
4-Carbethoxyphenol;nipaginaa;Nipazin A;nipazina;Para-hydroxybenzoic acid ethyl ester;p-Carbethoxyphenol;p-Hydroxybenzoic ethyl ester;p-hydroxy-benzoicaciethylester
E214 Ethyl p-hydroxybenzoate is used as an antifungal preservative.
As a food additive, it has E number E214.
Sodium ethyl para-hydroxybenzoate, the sodium salt of ethylparaben, has the same uses and is given the E number E215.
E214 Ethyl p-hydroxybenzoate is an ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol, It has a role as an antimicrobial food preservative, an antifungal agent, a plant metabolite and a phytoestrogen.
E214 Ethyl p-hydroxybenzoate is a paraben and an ethyl ester.
E214 Ethyl p-hydroxybenzoate, also known as E214, is an organic chemical compound from the paraben group.
E214 Ethyl p-hydroxybenzoate's molecule consists of a phenolic ring linked to an ester group, which gives it specific preservative properties.
E214 Ethyl p-hydroxybenzoate is widely used as a preservative in the food and pharmaceutical industries, preventing the growth of bacteria, mold and yeast in products.
Although E214 Ethyl p-hydroxybenzoate is synthetically produced, parabens, which include E214, are also present in small amounts in nature, such as in some fruits.
E214 Ethyl p-hydroxybenzoate is valued for its effectiveness and low toxicity compared to other preservatives.
E214 Ethyl p-hydroxybenzoate Chemical Properties
Melting point: 114-117 °C (lit.)
Boiling point: 297-298 °C (lit.)
density: 1.1708 (rough estimate)
vapor pressure: 0.00012 hPa (25 °C)
refractive index: 1.5286 (estimate)
Fp: 297-298°C
storage temp.: 2-8°C
solubility: Very slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
form: Crystalline Powder
pka: 8.31±0.13(Predicted)
color: White
PH: 4.5-5.5 (H2O, 20°C) (saturated solution)
Odor: at 100.00%. mild phenolic
Water Solubility: Slightly soluble in water.
Merck: 14,3837
BRN: 1101972
Henry's Law Constant: 2.1×103 mol/(m3Pa) at 25℃, HSDB (2015)
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
Cosmetics Ingredients Functions: PRESERVATIVE FRAGRANCE
Cosmetic Ingredient Review (CIR): Ethylparaben (120-47-8)
InChI: 1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3
InChIKey: NUVBSKCKDOMJSU-UHFFFAOYSA-N
LogP: 2.470
CAS DataBase Reference: 120-47-8(CAS DataBase Reference)
NIST Chemistry Reference: Ethylparaben(120-47-8)
EPA Substance Registry System: E214 Ethyl p-hydroxybenzoate (120-47-8)
E214 Ethyl p-hydroxybenzoate occurs as a white, odorless or almost odorless, crystalline powder.
E214 Ethyl p-hydroxybenzoate is a chemical that exhibits strong antibacterial and antifungal activity.
E214 Ethyl p-hydroxybenzoate is stable over a wide pH range, making it suitable for use in a variety of food products.
In addition, E214 Ethyl p-hydroxybenzoate is soluble in alcohols and oils, but only moderately in water, which should be taken into account when formulating products.
Chemical Properties
E214 Ethyl p-hydroxybenzoate occurs as a white, odorless or almost odorless, crystalline powder.
Uses
E214 Ethyl p-hydroxybenzoate is mainly used as antiseptics in cosmetics, food and medicine.
E214 Ethyl p-hydroxybenzoate is also can be used as feed preservatives and antiseptic for bacteria.
E214 Ethyl p-hydroxybenzoate is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination.
In most formulations, parabens are used at very low levels ranging from 0.01 to 0.3%.
Ethylparaben, a novel sorbent for solid-phase extraction, was used to study its retention property.
E214 Ethyl p-hydroxybenzoate has high extraction efficiency towards the compounds tested owing to the electrostatic interaction, hydrophobic interaction and hydrogen bonding.
E214 Ethyl p-hydroxybenzoate is mainly used as a preservative in the food and cosmetic industries.
E214 Ethyl p-hydroxybenzoate is added to many products such as beverages, dairy products, candy, cosmetic products and some medicines to extend their shelf life and prevent spoilage.
E214 Ethyl p-hydroxybenzoate's presence in products is regulated by relevant standards and regulations to ensure consumer safety.
E214 Ethyl p-hydroxybenzoate has broad spectrum bacteriostatic action.
And E214 Ethyl p-hydroxybenzoate is widely used in cosmetic and medical industry for preservation.
Pharmaceutical Applications
E214 Ethyl p-hydroxybenzoate is widely used as an antimicrobial preservative in cosmetics,food products, and pharmaceutical formulations.
E214 Ethyl p-hydroxybenzoate may be used either alone or in combination with other paraben esters or with other antimicrobial agents.
In cosmetics E214 Ethyl p-hydroxybenzoate is one of the most frequently used preservatives.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used.
However, E214 Ethyl p-hydroxybenzoate may cause the pH of poorly buffered formulations to become more alkaline.
Production Methods
E214 Ethyl p-hydroxybenzoate is prepared by the esterification of p-hydroxybenzoic acid with ethanol (95%).
